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Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam xinjie meng Zheng Peng Man Lung Yeung Jasper Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral ***,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 *** dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral *** further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster *** peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta

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基于维和参与政策的美国情报机制改革研究

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安徽警官职业学院学报 2017年第6期16卷 61-66页

作者：孟欣洁中国人民武装警察部队学院河北廊坊065000

联合国成立至今,已经开展了71次维和行动,在这些维和行动中,美国一直是情报的重要提供方。了解美国维和参与的特征,美国情报周期的特殊性,及其应对这些特殊性困境采取的手段尤为必要,这对我国参与联合国维和行动总体战略的制定具有借鉴... 详细信息

联合国成立至今,已经开展了71次维和行动,在这些维和行动中,美国一直是情报的重要提供方。了解美国维和参与的特征,美国情报周期的特殊性,及其应对这些特殊性困境采取的手段尤为必要,这对我国参与联合国维和行动总体战略的制定具有借鉴意义。

关键词：美国维和情报机制改革

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边防派出所基础信息采集研究

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中国公共安全(学术版) 2016年第4期 6-9页

作者：周颖刘智敏孟欣洁中国人民武装警察部队学院

边防派出所基础信息采集工作不仅是现代边境管理的重要内容,也是边防部门由传统的工作模式向情报主导警务模式转变的前提和基础。边防派出所要立足于自身的职能优势,借鉴公安派出所的成熟经验,努力把基础信息采集工作推向新的高度。

关键词：情报基础信息边防派出所采集

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Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan Jiang Yunfei Du Zhichen Wu Liang Xu xinjie Wang Xiaoguang Liu Wanhua Yu Wendong Xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

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Cell-scaffold interactions in tissue engineering for oral and craniofacial reconstruction

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Bioactive Materials 2023年第5期23卷 16-44页

作者： Fushi Wang xinjie Cai Ya Shen Liuyan meng The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Cariology and Endodontics Hospital of StomatologyWuhan UniversityWuhanChina Department of Prosthodontics Hospital of StomatologyWuhan UniversityWuhanChina Division of Endodontics Department of Oral Biological and Medical SciencesFaculty of DentistryUniversity of British ColumbiaVancouverCanada

Tissue engineering(TE)is critical in oral and craniofacial *** of the most popular topics on the biomaterial-based tissue regeneration process may be the interaction between cells and *** increasing number of studies have identified the variables affecting cell-scaffold *** creation and investigation of new scaffolds for TE and regenerative medicine based on specific interactions have become possible owing to these *** review discusses the effects of various types of scaffold materials on cells in *** the intrinsic properties of scaffolds are essential,the influence of the physical,chemical,mechanical,and biological characteristics of scaffold materials on cell-scaffold interaction that has been discovered in recent research is elaborated in this *** components carried by scaffolds,the degradation process,and the role of degraded products in cell-scaffold interactions are ***,the roles of cells,including cell types,functions,and adhesion mechanisms,and extracellular matrix are ***,the latest research progress on cell-scaffold interactions among various engineered tissues or organs in the oral and craniofacial region is summarized.A deeper understanding of cell-scaffold interactions is anticipated to benefit the development of TE and regenerative medicine.

关键词： Scaffolds Tissue engineering Interactions Cells

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NUMERICAL SOLUTIONS OF NONAUTONOMOUS STOCHASTIC DELAY DIFFERENTIAL EQUATIONS BY DISCONTINUOUS GALERKIN METHODS

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Journal of Computational Mathematics 2019年第3期37卷 419-436页

作者： xinjie Dai Aiguo Xiao School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105China School of Mathematics and Computational Science & Hunan Key Laboratory for Computation and Simulation in Science and Engineering Xiangtan UniversityXiangtan 411105China

This paper considers a class of discontinuous Galerkin method,which is constructed by Wong-Zakai approximation with the orthonormal Fourier basis,for numerically solving nonautonomous Stratonovich stochastic delay differential *** prove that the discontinuous Galerkin scheme is strongly convergent:globally stable and analogously asymptotically stable in mean square *** addition,this method can be easily extended to solve nonautonomous Stratonovich stochastic pantograph differential *** tests indicate that the method has first-order and half-order strong mean square convergence,when the diffusion term is without delay and with delay,respectively.

关键词： Discontinuous Galerkin method Wong-Zakai approximation Nonautonomous Stratonovich stochastic delay differential equation

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Molecular dynamics simulation for aggregation phenomena of nanocolloids

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Science China(Technological Sciences) 2009年第2期52卷 484-490页

作者： NI ZhongHua ZHANG xinjie School of Mechanical Engineering Southeast UniversityNanjing 210096China

Nonequilibrium molecular dynamics (MD) method was used to study the dielectrophoresis (DEP) motion of nanocolloids in non-uniform electric field. By changing the electric field strength and system temperature, aggregation phenomena of nanocolloids was analyzed. Simulation results showed that at normal temperature, though the Brownian force can affect the motion of colloids, the attractive force will increase quickly with the distance between colloids down to 12σ , which makes colloids aggregate. When the Brownian force is weak to colloid's motion, for the enhancement of electric field strength, the DEP force of colloid will increase and so did the attractive force, which finally quickens the aggregate speed. Simulation results also showed that the temperature' enhancement will increase the Brownian force of colloids, hence disturbing the colloids aggregation. Moreover, the DLVO theory was used to study the motion of a pair of interactional colloids, both the potential energy and the attractive force versus distance of colloids were presented, then the latter graph was used to compare with another graph elicited by MD method. Results showed that the two graphs were nearly the same, indicating the MD model accorded with the theory.

关键词： MD DEP nanocolloid aggregation DLVO theory

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Effect of modified Sanhuang Xiexin Tang plus additional herbs combined with ＂standard triple therapy＂ on Helicobacter pylori eradication

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Journal of Traditional Chinese Medicine 2018年第1期38卷 101-106页

作者： Yao xinjie Li Yan Department of Gastroenterology Shengjing Hospital Affiliated to China Medical University Shenyang 110002 China

OBJECTIVE： To determine the effectiveness of modified Sanhuang Xiexin Tang （SHXXT） plus additional herbs （MSAH） combined with ＂standard tri- ple therapy＂ for eradication of Helicobacter pylori （H. pylori） and amelioration of related symptoms in comparison with standard triple and standard quadruple therapies. METHODS： From October 2015 to May 2016, we recruited patients with dyspepsia symptoms con- firmed to have H. pylori infection by the ^13C urea breath test in our outpatient clinic. Patients were randomly divided into three treatment groups： Nexium standard triple therapy （group A, EAC）, Nexium standard quadruple therapy （group B, EBAC）, or Nexium standard triple therapy combined with MSAH （group C; EAC＋MSAH）. Comparisons of H. pylori eradication and symptom amelioration rates were made among the three groups at 2 or 6 weeks after group assignment. RESULTS： There was no difference in H. pylori eradication rates between groups B （EBAC） and C （EAC＋ MSAH）（P = 0.486）, and eradication rates in groups B and C were significantly higher than that in group A （EAC）（P Av, e = 0.001; P AvsC= 0.003）. There was no difference in the total symptom score among the groups before treatment. In all groups, the total symptom scores after treatment （2 or 6 weeks after group assignment） were significantly lower than those before treatment （P 〈 0.001 for all）. However, group C （EAC ＋ MSAH） demonstrated superior total symptom scores and symptom amelioration rates than groups A （EAC） and B （EBAC）. Group B also demonstrated better scores and rates than group A. There was no difference in symptom amelioration rates at 2 and 6 weeks within each group. CONCLUSION： There is no difference between MSAH combined with standard triple therapy and standard quadruple therapy containing bismuth with regard to H. pylori eradication rate. However, MSAH combined with standard triple therapy has a higher symptom amelioration rate and therefore appears to be an ideal treatment scheme for H. pyIori eradi

关键词： Helicobacter pylori Disease eradica-tion Symptom assessment Sanhuang Xiexin Tang

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Application of deep learning to estimate stratospheric gravity wave potential energy

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Earth and Planetary Physics 2022年第1期6卷 70-82页

作者： Yue Wu Zheng Sheng xinjie Zuo College of Meteorology and Oceanology National University of Defense TechnologyChangsha 410073China Northwest Institute of Nuclear Technology Xi’an 710024China High-tech Institute Fan Gong-ting South Street on the 12thQingzhou 262500China

One of the most important dynamic processes in the middle and upper atmosphere,gravity waves(GWs)play a key role in determining global atmospheric *** wave potential energy(GW Ep)is an important parameter that characterizes GW intensity,so it is critical to understand its global *** this paper,a deep learning algorithm(DeepLab V3+)is used to estimate the stratospheric GW *** deep learning model inputs are ERA5 reanalysis datasets and GMTED2010 terrain *** Ep averaged over 20−30 km from 60°S−60°N,calculated by COSMIC radio occultation(RO)data,is used as the measured value corresponding to the model *** results show that(1)this method can effectively estimate the zonal trend of GW ***,the errors between the estimated and measured value of Ep are larger in low-latitude regions than in mid-latitude regions,possibly due to the large number of convolution operations used in the deep learning ***,the measured Ep has errors associated with interpolation to the grid;this tends to be amplified in low-latitude regions because the GW Ep is larger and the RO data are relatively sparse,affecting the training accuracy.(2)The estimated Ep shows seasonal variations,which are stronger in the winter hemisphere and weaker in the summer hemisphere.(3)The effect of quasi-biennial oscillation(QBO)can be clearly observed in the monthly variation of estimated GW Ep,and its QBO amplitude may be less than that of the measured Ep.

关键词： deep learning stratospheric gravity wave potential energy

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Probabilistic Methods for Reliability Assessment of Floating Structures Based on Extreme Wave Simulation

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Journal of Ocean University of China 2022年第2期21卷 291-305页

作者： ZHAO Yuliang CHU xinjie DONG Sheng College of Engineering Ocean University of ChinaQingdao 266100China Drilling Technology Research Institute of Shengli Petroleum Engineering Corporation Limited SINOPECDongying 257017China

With the increasing application of floating platforms in deep waters and harsh environments,a proper assessment of the reliability of floating structures is important to ensure that these structures can operate safely during their design *** study outlines a practical methodology for reliability analysis of a semi-submersible platform based estimating the probability distribution of the extreme response in rough sea conditions(survival conditions).The Constrained NewWave(CNW)theory combined with Monte Carlo simulations was first applied to simulate the random wave surface elevation process in the time domain.A Gumbel distribution was the best fitting to describe the dynamically sensitive extreme response statistics under extreme waves(drift and mooring tension).The derived probability distribution of the extreme response was subsequently used in estimation of the associated limit state func-tion,and a reliability analysis of the floating structure was conducted using the Monte Carlo method.A semi-submersible platform in a water depth of 1500 m subjected to extreme wave loads was used to demonstrate the efficiency of the proposed *** probability of failure of the semi-submersible when considering mooring lines tension is greater than considering drift.

关键词： reliability assessment floating structure Constrained NewWave theory Monte Carlo simulation extreme response

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