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基于遗传算法的不等间距阵优化方法

应用声学 2024年第1期43卷 24-31页

作者：陈新华段文彬郑恩明中国科学院声学研究所北京100190 中国科学院大学北京100049

阵元数一定情况下,针对不等间距拖线阵高频信号处理存在的空间增益和无栅瓣兼容问题,提出一种基于遗传算法的不等间距拖线阵阵型优化方法。该方法以频带交互下最大旁瓣级最小作为约束因子,通过模拟生物自然进化过程搜索全局最优解,得到... 详细信息

阵元数一定情况下,针对不等间距拖线阵高频信号处理存在的空间增益和无栅瓣兼容问题,提出一种基于遗传算法的不等间距拖线阵阵型优化方法。该方法以频带交互下最大旁瓣级最小作为约束因子,通过模拟生物自然进化过程搜索全局最优解,得到优化后的阵元位置。优化后阵型在保证低频信号处理空间增益不变情况下,实现对高频信号高空间增益、无栅瓣处理。计算机仿真结果表明:相比未优化阵型,在高频信号处理方面,优化后阵型在无栅瓣情况下,空间增益提升值近似理论值提升值;在低频信号处理方面,优化后阵型具有相同的空间增益。为实际不等间距拖线阵阵型优化和应用提供了一种思路。

关键词：不等间距拖线阵阵型优化空间增益栅瓣

Impact of diabetes on prognosis of gastric cancer patients performed with gastrectomy

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Chinese Journal of Cancer Research 2020年第5期32卷 631-644页

作者： xinhua chen Yuehong chen Tao Li Luo Jun Tian Lin Yanfeng Hu Huilin Huang Hao chen Hao Liu Tuanjie Li Guoxin Li Jiang Yu Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China

Objective: This study aimed to determine the impact of type 2 diabetes mellitus(T2 DM) on clinical outcomes of gastric cancer(GC) patients and explore whether metformin use and good glycemic control could reverse it.Methods: Clinicopathologic data of consecutive GC patients who underwent gastrectomy at Nanfang Hospital between October 2004 and December 2015 were included. Propensity score matching(PSM) was performed to balance the important factors of the disease status between non-T2 DM and T2 DM group. The last follow-up time was January 2019.Results: A total of 1,692 eligible patients(1,621 non-T2 DM vs. 71 T2 DM) were included. After PSM, nonT2 DM group(n=139) and T2 DM group(n=71) were more balanced in baseline variables. The 5-year cancerspecific survival(CSS) rate in T2 DM group(47.0%) was inferior to that in non-T2 DM group(58.0%), but did not reach statistical significance [hazard ratio(HR)=1.319, 95% confidence interval(95% CI): 0.868-2.005, P=0.192].While the 5-year progress-free survival(PFS) rate of T2 DM group(40.6%) is significantly worse than that in nonT2 DM group(56.3%)(HR=1.516, 95% CI: 1.004-2.290, P=0.045). Univariate and multivariate analyses showed that T2 DM was an independent risk factor for PFS but not for CSS. In T2 DM group, metformin use subgroup was associated with superior 5-year CSS and PFS in compared with non-metformin use subgroup, although the difference was not statistically significant(5-year CSS: 48.0% vs. 45.4%, HR=0.680, 95% CI: 0.352-1.313,P=0.246;5-year PFS: 43.5% vs. 35.7%, HR=0.763, 95% CI: 0.400-1.454, P=0.406). The 5-year CSS rate was47.5% in good glycemic control subgroup and 44.1% in poor glycemic control subgroup(HR=0.826, 95% CI:0.398-1.713, P=0.605). And both two subgroups yielded a similar 5-year PFS rate(42.2% vs. 36.3%, HR=0.908,95% CI: 0.441-1.871, P=0.792).Conclusions: DM promoted disease progress of GC after gastrectomy but had not yet led to the significant discrepancy of CSS. For GC patients with T2 DM, metformin use was associated with superior survival

关键词： Gastric cancer diabetes mellitus prognosis metformin glycemic gastrectomy

Fructose promotes growth and antifungal activity of Penicillium citrinum

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Protein & Cell 2016年第7期7卷 527-532页

作者： Chang-wen Wu Xiaojun Wu Chao Wen Bo Peng Xuan-xian Peng xinhua chen Hui Li Center for Proteomics and Metabolomics State Key Laboratory of Bio-Control MOE Key Lab Aquatic Food Safety School of Life Sciences Sun Yat-sen University University City Guangzhou 510006. China Key Laboratory of Marine Biogenetic Resources Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China

Dear Editor, Fungal infection involves the invasion of tissues by one or more species of fungi, and this is a serious problem in both medical settings and agriculture [Brown et al., 2012]. Thus, the development of efficient strategies for management of these infections is urgently needed [Rodriguez-Martfn et al., 2010]. Recently, a number of antifungal proteins have been reported, including AFP from Aspergillus giganteus, PAF from Penicillium chrysogenum, NAF from Penicillium nalviogense, and AnAFP from Aspergillus niger [Marx et al., 2008; Geisen 2000]. These proteins have demonstrated antifungal activity against opportunistic plant and animal pathogens, such as Fusanum sp., Botrytis sp., and Asper- gillus sp. [Meyer, 2008]. We have previously characterized an antifungal protein （PcPAF） from the culture supernatant of the fungal strain Penicillium citrinum W1, which was isolated from sediment obtained from the Southwest Indian Ocean. PcPAF is thermostable and displays antifungal activity against various pathogenic fungi, including Trichoderma viride, Fusarium oxysporum, Alternaria Iongipes, and Pae- cilomyces variotii [Wen et al., 2014]. Therefore, large-scale production of PcPAF would enable the further drug development of this compound.

关键词： Fructose Antifungal Activity Fatty Acid Biosynthesis Antifungal Protein Differential Abundance

“互联网+”就业模式下劳动关系认定的实证分析

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邢台学院学报 2024年第1期39卷 57-61,68页

作者：陈新华陈婧文惠州学院广东惠州516007 福建农林大学福建福州350002

近十年来,“互联网+”新业态快速发展,加剧了资强劳弱的格局,也加大了对劳动关系从属性的认定难度。以外卖骑手和网络主播为例,司法实务中对新业态劳动关系认定存在的分歧主要聚焦于合同属性、人格从属性、经济从属性和组织从属性等方... 详细信息

近十年来,“互联网+”新业态快速发展,加剧了资强劳弱的格局,也加大了对劳动关系从属性的认定难度。以外卖骑手和网络主播为例,司法实务中对新业态劳动关系认定存在的分歧主要聚焦于合同属性、人格从属性、经济从属性和组织从属性等方面。上述分歧产生的根本原因在于新业态以隐性构建方式表面弱化实则强化了劳动关系“从属性”,而实务审查仍拘泥于传统显性构建要素,导致难以公平准确地认定新业态下的劳动关系。因此,破解新业态劳动关系认定困境的关键一是应以用工事实为基础,注重“从属性”标准的实质审查;二是应加强平台与关联企业之间内部关系的信息披露,构建起与社会发展相适应、注重保护劳动者合法权益的社会主义新型劳动关系,促进社会主义新经济的健康良性发展。

关键词： “互联网+”就业模式外卖骑手网络主播劳动关系从属性

Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy

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Chinese Journal of Cancer Research 2020年第2期32卷 186-196页

作者： Jun Luo Yuming Jiang xinhua chen Yuehong chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036China

Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains controversial.This study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction nomogram.Methods:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were included.The first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were assessed.Multivariate analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm vs.PM≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM>5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 cm.In patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size>5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM>5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM groups.In the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,respectively.Conclusions:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more advanced GC is a systemic disease.Different type

关键词： Gastric cancer margin distance nomograms distal gastrectomy

Comprehensive insight into the occurrence characteristics,influencing factors and risk assessments of antibiotics in the Chaohu Basin

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 57-71页

作者： Shuanggang Hu Hongzhi Zhang Yongjie Yang Kangping Cui Junjie Ao Xuneng Tong Mengchen Shi Yi Wang Xing chen chenxuan Li Yihan chen School of Resources and Environmental Engineering Hefei University of TechnologyHefei230009China Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai200092China Department of Civil & Environmental Engineering National University of SingaporeSingapore117576Singapore College of Resources and Environment Anhui Agricultural UniversityHefei230036China

The pollution of antibiotics in aquatic environments has received extensive attention.Yet,research on antibiotic contamination in river-lake systems,a significant form of modern aquatic environments,still needs to be explored.This study focuses on the Chaohu Basin(China)investigating the occurrence characteristics,influencing factors,and risk assessments of antibiotics in the river-lake system.The total antibiotic concentrations in the water phase and sediment phase were 3.14–1887.49 ng/L and 0.92–1553.75 ng/g,respectively.Clindamycin was the predominant antibiotic in the water phase,whereas tetracycline prevailed in the sediment phase.Notable differences in concentration and structural composition of antibiotics between the tributaries(river system)and Chaohu Lake were observed,indicating the involvement of various geochemical processes in the attenuation of antibiotics during transport to the receiving lake.Spatial analysis suggested that the western river is the primary source of antibiotics in Chaohu Lake.Controlling nutrient influx in heavily polluted areas is crucial to addressing the escalating issue of antibiotic pollution in the river-lake system.The widespread occurrence of clindamycin in the waters is likely due to wastewater treatment plant discharges,and high-intensity human activities continue to exacerbate antibiotic contamination.Risk assessment indicated that sulfamethoxazole,tetracycline,lincomycin,and clindamycin ranked in the top four with the highest risks to the most sensitive aquatic organisms.Nonetheless,the antibiotics presented no risk to consumer health.This study provides valuable insights for controlling antibiotic pollution in riverlake systems.

关键词： Antibiotics Occurrence characteristics Influencing factors Risk assessments River-lake system

基于自适应强跟踪Kalman滤波的GNSS跟踪环路设计

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传感技术学报 2024年第1期37卷 35-41页

作者：盛开宇陈熙源汤新华闫晣高宁东南大学仪器科学与工程学院江苏南京210096 微惯性仪表与先进导航技术教育部重点实验室江苏南京210096

为提高GNSS接收机跟踪环路在复杂环境下的跟踪性能,提出一种基于自适应强跟踪Kalman滤波(ASTKF)的跟踪环路,在传统跟踪环路的基础上,以鉴相器输出为观测量进行自适应强跟踪Kalman滤波,滤波结果用于计算导航滤波器的观测量,同时将伪码频... 详细信息

为提高GNSS接收机跟踪环路在复杂环境下的跟踪性能,提出一种基于自适应强跟踪Kalman滤波(ASTKF)的跟踪环路,在传统跟踪环路的基础上,以鉴相器输出为观测量进行自适应强跟踪Kalman滤波,滤波结果用于计算导航滤波器的观测量,同时将伪码频率和载波多普勒频率反馈到码NCO和载波NCO,在ASTKF中使用基于卡方分布的渐消因子计算方法,提升跟踪环路鲁棒性。半物理仿真实验表明,相比于基于Kalman滤波的跟踪环路和基于强跟踪Kalman滤波(STKF)的跟踪环路,所提出方法在水平方向上的位置误差和速度误差减小20%以上,有效提高了卫星导航接收机的定位性能。

关键词：卫星导航自适应强跟踪Kalman滤波渐消因子卡方分布软件接收机

In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou chen Mo chen chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi chen Yunxia Li Yuefeng Hao Sijia Feng Jun chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage therapy.In this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their administration.The delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)group.Both Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with ICT.Our results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

Robust high-resolution beam-forming based on high order cross sensor processing method

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Journal of Systems Science & Complexity 2015年第5期28卷 932-940页

作者： Enming Zheng xinhua chen Huabing Yu Changyu Sun Institute of Acoustics Chinese Academy of Science

In order to obtain the robust high-resolution beamforming, a high order cross sensor processing(CSP) approach is developed. According to the relation ship between the target bearing and the phase difference of each element receiving signal, this method exploits the property that the same diagonal of covariance matrix with the same phase difference and obtains(2M-1)(N-1)virtual elements(N is the original array number) by executing M order CSP. The extended virtual elements can effectively increase the physical aperture of linear array, reduce the main lobe width of beam-forming, and improve the bearing resolution. The CSP method accumulates the data on the same sub-diagonal of the covariance matrix, which can decrease the impact of background noise on beam-forming. The theoretical analysis and experimental results both show that this method has high resolution in bearing estimation, compared with the MUSIC method, which has better robustness under the lower signal-to-noise ratio(SNR).

关键词：波束形成鲁棒性高分辨传感器高阶协方差矩阵虚拟单元 CSP