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Laparoscopic *** surgery for gastrointestinal stromal tumors of esophagogastric junction:A multicenter,retrospective cohort analysis with propensity score weighting

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Chinese Journal of Cancer Research 2021年第1期33卷 42-52页

作者： Wenjun Xiong Yuting Xu Tao Chen xingyu feng Rui Zhou Jin Wan Yong Li Guoxin Li Wei Wang Department of Gastrointestinal Surgery Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of General Surgery Guangdong Academy of Medical ScienceGuangdong General HospitalGuangzhou 510120China department of General Surgery the Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510500China

Objective:Laparoscopic resection is increasingly performed for gastrointestinal stromal tumors(GISTs).However,the laparoscopic approach for GISTs located in the esophagogastric junction(EGJ-GIST)is surgically *** study compares the efficacy of laparoscopic surgery and the open procedure for EGJ-GIST through the propensity score weighting(PSW)***:Between April 2006 and April 2018,1,824 surgical patients were diagnosed with primary gastric GIST at four medical centers in South *** these patients,228 were identified as EGJ-GISTs and retrospectively reviewed clinicopathological characteristics,operative information,and long-term *** was used to create the balanced ***:PSW was carried out in laparoscopic and open-surgery cohorts according to year of surgery,sex,age,body mass index(BMI),tumor size,mitotic rates and recurrence *** PSW,438 patients consisting of 213 laparoscopic(L group)and 225 open surgery(O group)patients were *** PSW,the following measures in the L group were superior to those in the O group:median operative time[interquartile range(IQR)]:100.0(64.5-141.5)vs.149.0(104.0-197.5)min,P<0.001;median blood loss(IQR):30.0(10.0-50.0)vs.50.0(20.0-100.0)mL,P=0.002;median time to liquid intake(IQR):3.0(2.0-4.0)vs.4.0(3.0-5.0)d,P<0.001;median hospital stay(IQR):6.0(4.0-8.0)vs.7.0(5.0-12.0)d,P<0.001;and postoperative complications(10.3%vs.22.7%,P=0.001).The median follow-up was 55(range,2-153)months in the entire *** significant differences were detected in either relapse-free survival(RFS)[hazard ratio(HR):0.372,95%confidence interval(95%CI):0.072-1.910,P=0.236]or overall survival(OS)(HR:0.400,95%CI:0.119-1.343,P=0.138)between the two ***:Laparoscopic surgery for EGJ-GIST is associated with the advantages of shorter operative time,reduced blood loss,shorter time to liquid intake,and shorter length of stay,all without compromising postoperative outcomes and long-term survival.

关键词： Esophagogastric junction gastrointestinal stromal tumor laparoscopic surgery open surgery propensity score weighting

A modular approach to efficient thermally activated delayed fluorescence from metal-perturbed intraligand charge-transfer excited state of Au(Ⅰ)complexes

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Science China Chemistry 2024年第12期67卷 4149-4157页

作者： Jian-Gong Yang xingyu feng Guohua Xie Nengquan Li Jiayu Li Xiu-Fang Song Ming-De Li Jingling Zhang Xiaoyong Chang Kai Li Shenzhen Key Laboratory of New Information Display and Storage Materials Guangdong Provincial Key Laboratory of New Energy Materials Service SafetyCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518055China Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing Department of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan 430200China The Institute of Flexible Electronics(Future Technologies) Xiamen UniversityXiamen 361005China Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Department of ChemistryShantou UniversityShantou 515031China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

The efficient harvesting of triplet excitons is crucial to the realization of high-performance organic light-emitting diodes(OLEDs).Herein,we show that coordination of donor-acceptor(D-A)type molecules to a metal atom in a monodentate fashion can lead to thermally activated delayed fluorescence(TADF)emissions with wide color tunability only through varying the noncoordinating acceptor moiety.A panel of TADF gold(Ⅰ)complexes with emission maxima(λmax)of 545–645 nm from metal perturbed intraligand charge-transfer(MPICT)excited states have been *** effects of heavy atom-induced spin-orbit coupling(SOC),steric-induced donor-acceptor twisting and suppressed intramolecular motions lead to high emission efficiencies of 65%-85%in doped films with delayed fluorescence lifetime of as short as 2.0μ*** absorption spectroscopic studies on selected complexes determined the kISCto be 6.5×10^(9)s^(-1).Theoretical calculations confirmed the participation of minor d orbital into the lowest excited state,which led to an SOC value of 5.19 cm^(-1)between the lowest-lying singlet and triplet excited *** yellow to deep red solution-processed OLEDs based on the new gold(Ⅰ)complexes incorporated with various D-A ligands demonstrated promising *** study validates a modular design for TADF metal complexes,which will broaden the choices of metal centers and allow for facile color tuning via simple ligand synthesis.

关键词： gold(Ⅰ)complex OLED thermally activated delayed fluorescence(TADF) MPICT

Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China

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Chinese Journal of Cancer 2017年第10期36卷 497-505页

作者： Cheng Fang Wei Wang Yu Zhang xingyu feng Jian Sun Yujie Zeng Ye Chen Yong Li Minhu Chen Zhiwei Zhou Jie Chen Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road EastGuangzhou 510060 Guangdong P. R. China Department of Gastroenterology The First Affiliated Hospital of Sun Yatsen University Guangzhou 510080 Guangdong P. R. China Department of General Surgery Guangdong General HospitalGuangdong Academy of Medical Science Guangzhou 510080Guangdong P. R. China Department of Biliopancreatic Surgery The Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangzhou 510120 Guangdong P.R. China Department of Gastrointestinal Surgery The Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangzhou 510120 Guangdong P. R.China Department of Gastroenterology Nanfang Hospital of Southern Medical University Guangdong Provincial Key Laboratory of GastroenterologyGuangzhou 510515 Guangdong P. R. China

Background: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with ***: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan–Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards ***: The most common tumor location was the rectum(37.4%), followed by the pancreas(28.1%), stomach(20.7%), small intestine(7.2%), appendix(3.4%), and colon(3.3%). After initial definitive diagnosis, 1016(85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival(OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively(P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively(P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not(P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor(P y, M category, and sur= 0.031) or neuroendocrine carcinoma(P gery were found to be independent prog= 0.046). In multivariate analysis, age, grade, N categornostic ***: Patients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN

关键词： Gastroenteropancreatic neuroendocrine neoplasms Surgery Prognosis China

Prognostic factors of primary gastrointestinal stromal tumors： a cohort study based on high-volume centers

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Chinese Journal of Cancer Research 2018年第1期30卷 61-71页

作者： Xuechao Liu Haibo Qiu Peng Zhang xingyu feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China Department of Gastric Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 China Department ofGeneral Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of General Surgery Guangdong General Hospital Guangzhou 510080 China Department of General Surgery Southern Medical University Nanfang Hospital Guangzhou 510060 China

Objective： We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors（GISTs）.Methods： Data from 2,570 consecutive GIST patients from four medical centers in China（January2001–December 2015） were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic ***： Of the included patients, 1,375（53.5%） were male, and the patient age range was 18 to 95（median, 58）years. The tumors were mostly found in the stomach（64.5%）, small intestine（25.1%） and colorectal region（5.1%）.At the time of diagnosis, the median tumor size was 4.0（range： 0.1–55.0） cm, and the median mitotic index per 50 high power fields（HPFs） was 3（range： 0–254）. Of the 2,168 resected patients, 2,009（92.7%） received curative resection. According to the modified National Institutes of Health（NIH） classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1（DOG-1）, 8.0% for S-100, 31.0% for smooth muscle actin（SMA） and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib（P〈0.001）, whereas intermediate-risk patients did not（P=0.954）.Conclusions： Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies.

关键词： Gastrointestinal stromal tumor immunohistochemical analysis prognosis targeted therapy imatinib

Evaluation of early liquid drinking after radical gastrectomy in gastric cancer:a Chinese multicenter propensity score matching analysis

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Gastroenterology Report 2023年第1期11卷 331-339页

作者： Yue Zhang Kaixiong Tao Jinlong Yu Chao Chen Quan Zheng Sanlin Lei Xiaogang Zhong Lixin Liu Wei Wang Qiang Wang En Li Yuwen Luo Guanrong Zhang xingyu feng Yong Li Junjiang Wang Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhouGuangdongP.R.China Shantou University Medical College ShantouGuangdongP.R.China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of General Surgery Zhujiang Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery Huizhou Municipal Central HospitalHuizhouGuangdongP.R.China Department of Gastrointestinal Surgery Guangdong Second Provincial General HospitalGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunanP.R.China Department of Surgical Treatment of Gastrointestinal Hernia and Fistula The People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxiP.R.China Department of General Surgery The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery Guangzhou First People’s HospitalGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery Meizhou People’s HospitalMeizhouGuangdongP.R.China lnformation and Statistics Center Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhouGuangdongP.R.China

Background:Enhanced recovery after surgery is used in gastrointestinal *** study aimed to access the effects of early liquid drinking(ELD)on gastrointestinal function recovery in patients with gastric cancer(GC)who underwent radical gastrectomy,as high-quality evidence on the outcomes of ELD after gastrectomy is currently ***:Clinicopathological data of patients with GC from 11 centers were retrospectively *** outcomes were investigated in 555 patients,including 225 who started drinking liquid within 48 h(ELD group)of surgery and 330 who started drinking liquid after flatus resumption(traditional liquid drinking[TLD]group).Propensity score matching(PSM)analysis was performed using a match ratio of 1:1 and 201 patients were selected from each group for the *** outcome was time to first passage of *** outcomes included time to first defecation,post-operative hospitalization days,occurrence of short-term post-operative complications,and hospitalization ***:After PSM,baseline characteristics were not significantly different between the two *** time to first flatus(2.7261.08 vs 3.3661.39 days),first defecation(4.3461.85 vs 4.7761.61 days),and post-operative hospital stay(8.2764.02 vs 12.9464.43 days)were shorter in the ELD group than in the TLD group(all P<0.05).The ELD group had lower hospitalization costs than the TLD group([7.8362.44 vs 8.7863.41]104 RMB,P=0.041).No significant differences were observed in the incidence of post-operative ***:Compared with TLD,post-operative ELD could promote rapid recovery of gastrointestinal function and reduce hospitalization costs;moreover,ELD does not increase the risk of post-operative complications.

关键词： gastric cancer early liquid drinking traditional liquid drinking gastrointestinal function propensity score matching

Prognostic potential of an immune score based on the density of CD8＋ T cells, CD20＋ B cells, and CD33＋/p-STAT1＋ double-positive cells and HMGB1 expression within cancer nests in stage ⅢA gastric cancer patients

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Chinese Journal of Cancer Research 2016年第5期28卷 543-552页

作者： Jun Dong Jiao Li Shiming Liu xingyu feng Shi Chen Zhiwei Zhou Yingbo Chen Xiaoshi Zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Sun Yat-Sen University Cancer Center Guangzhou 510060 China Biotherapy Center Sun Yat-Sen University Cancer Center Guangzhou 510060 China Departanent of Oncology， The Second Affiliated Hospital of Guangzhou Medical University Guangzhou Institute of Cardiovascular Disease Guangzhou 510260 China Department of Cardiology The Second Affiliated Hospital of Guangzhou Medical University Guangzhou Institute of Cardiovascular Disease Guangzhou 510260 China Department of Gastric & Pancreatic Surgery Sun Yat-Sen University Cancer Center Guangzhou 510060 China

Objoctive： There is heterogeneity in the prognosis of gastric cancers staged according to the tumornodes-metastasis （TNM） system. This study evaluated the prognostic potential of an immune score system to supplement the TNM staging system. Mothodsg An immunohistochemical analysis was conducted to assess the density of T cells, B cells, and myeloid-derived suppressor cells （MDSCs） in cancer tissues from 100 stage IIIA gastric cancer patients; the expression of the high-mobility group protein B1 （HMGB1） was also evaluated in cancer cells. The relationship between the overall survival （OS）, disease-free survival （DFS）, and immunological parameters was ***： An immune score system was compiled based on the prognostic role of the density ofT cells, B cells, MDSCs, and the expression of HMGB1 in cancer tissues. The median 5-year survival of this group of patient was 32%. However, the 5-year survival rates of 80.0%, 51.7%, 0%, 5.8%, and 0% varied among the patients with an immune score of 4 to those with an immune score of 0 based on the immune score system, respectively. Similarly, differences in DFS rates were observed among the immune score subgroups. Concluslons： An immune score system could effectively identify the prognostic heterogeneity within stage IliA gastric cancer patients, implying that this immune score system may potentially supplement the TNM staging system, and help in identifying a more homogeneous group of patients who on the basis of prognosis can undergo adjuvant therapy.

关键词： Immune score gastric cancer CD33 STAT1 T cell B cell high-mobility group protein BI(HMGB1)

认知评价视角下工作压力对员工幸福感的影响机制研究——工作反刍和特质正念的作用

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管理评论 2024年第1期36卷 175-187页

作者：冯星宇韩平西安交通大学管理学院西安710049 过程管理与效率工程教育部重点实验室(西安交通大学) 西安710049

本研究以压力认知交互理论与持续性认知理论为基础,引入工作反刍(问题解决沉思和情感反刍)与特质正念作为中间变量,基于385份纵向问卷的结构方程建模结果,得到如下结论:(1)员工对工作压力源同时产生挑战、阻断和威胁性评价。挑战性压力... 详细信息

本研究以压力认知交互理论与持续性认知理论为基础,引入工作反刍(问题解决沉思和情感反刍)与特质正念作为中间变量,基于385份纵向问卷的结构方程建模结果,得到如下结论:(1)员工对工作压力源同时产生挑战、阻断和威胁性评价。挑战性压力源主要引发挑战性评价,而阻断性压力源主要诱发威胁性评价。(2)挑战性评价引发了员工在非工作时间的问题解决沉思,阻断和威胁性评价则诱发情感反刍。“压力源→认知评价→持续性认知→幸福感”的链式中介关系成立。(3)特质正念强化了员工对挑战性压力源的积极评价,减弱他们对该类压力源的负面评价,但员工对阻断性压力源的初步认知评价不受正念影响。(4)特质正念加快将员工对压力源的积极初步认知转化为积极持续认知,同时减缓他们对压力源的负面认知转化为负面持续性认知,最终有利于提高他们的幸福感。研究揭示了压力对幸福感的复杂作用机制,为管理者制定针对性的压力干预措施提供了启发。

关键词：工作压力工作相关反刍幸福感特质正念

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X120管线钢奥氏体长大规律研究

材料导报 2016年第6期30卷 137-140页

作者：齐亮彭凯蔡文彩冯兴宇江西理工大学材料科学与工程学院赣州341000

研究了不同保温温度和等温时间对奥氏体晶粒长大规律的影响,结果表明:随加热温度的升高和保温时间的延长,奥氏体晶粒尺寸逐渐增加。当温度低于1150℃时,奥氏体晶粒尺寸长大缓慢;加热温度超过1150℃后,晶粒尺寸长大速度显著增加,建立描述... 详细信息

研究了不同保温温度和等温时间对奥氏体晶粒长大规律的影响,结果表明:随加热温度的升高和保温时间的延长,奥氏体晶粒尺寸逐渐增加。当温度低于1150℃时,奥氏体晶粒尺寸长大缓慢;加热温度超过1150℃后,晶粒尺寸长大速度显著增加,建立描述X120管线钢奥氏体晶粒长大动力学模型为:D6.1-D06.1=2.08×1027t exp(-327028RT),拟合结果良好。

关键词： X120管线钢奥氏体晶粒长大动力学

税收稽查政策对影视行业的影响——基于上市企业的双重差分法分析

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当代电影 2020年第7期 81-85页

作者：冯星宇戴俊骋中央财经大学经济学院中央财经大学文化经济研究院

税收稽查政策对影视行业的冲击引起了社会的广泛关注,其影响程度和机制是一个值得探究的学理问题。本文采用双重差分法对34家上市影视企业和61家非影视领域的文化企业,在《关于进一步规范影视行业税收秩序有关工作的通知》政策出台前后... 详细信息

税收稽查政策对影视行业的冲击引起了社会的广泛关注,其影响程度和机制是一个值得探究的学理问题。本文采用双重差分法对34家上市影视企业和61家非影视领域的文化企业,在《关于进一步规范影视行业税收秩序有关工作的通知》政策出台前后的发展情况进行了实证分析。结果发现:自影视行业税收稽查政策实施以来,影视企业的生存压力明显上升,且通过窗宽范围变动和反事实模拟检验证明这种政策效应稳定且持续。对影响机制分析后发现,影视税收稽查政策既没有显著提升整个行业的生产成本,也没有显著降低整个影视行业的净利润。影视税收稽查政策虽然增加了影视企业的生存压力,但是并没有对整个行业产生彻底冲击,其与内容管治等其他政策的综合效应值得进一步探究。

关键词：税收稽查税收政策影视产业双重差分法文化经济