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General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang Yan-Chang Yang Yu-Han Hu Fu-Quan Fang lang Wang Xing-Hua Qian Patrick M.McQuillan Hui Xiong Jian-Hang Leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial *** perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity *** are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and *** are increasingly interested in the effects of general anesthetic agents on *** agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and *** this review,we summarize the effects of general anesthetic agents on *** anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

多目标协同正弦优化算法求解分布式流水车间调度问题

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控制理论与应用 2024年第6期41卷 1029-1037页

作者：郎峻顾幸生华东理工大学能源化工过程智能制造教育部重点实验室上海200237

针对最小化最大完工时间(makespan)、总拖期以及平均空闲时间的多目标序列相关准备时间分布式流水车间调度问题,本文提出一种多目标协同正弦优化算法(MCSOA).算法主要包括4个核心阶段:在多邻域搜索阶段,提出了基于关键工厂的搜索策略,... 详细信息

针对最小化最大完工时间(makespan)、总拖期以及平均空闲时间的多目标序列相关准备时间分布式流水车间调度问题,本文提出一种多目标协同正弦优化算法(MCSOA).算法主要包括4个核心阶段:在多邻域搜索阶段,提出了基于关键工厂的搜索策略,并通过正弦优化算法控制搜索范围;在破坏重构阶段,设计了一种迭代搜索策略引导个体的进化方向,同时使用正弦优化算法平衡全局开发与局部搜索;在选择阶段,使用非支配排序与参考点的方法筛选优质解,外部档案集用于存储所有非支配解;在协同阶段,设计种群间共享与竞争机制,平衡3个目标的优化.本文通过多目标优化的均匀性、反世代距离和覆盖率3项性能指标验证算法的有效性,并使用非参数检验证明所提出的算法具有显著性优势.

关键词：多目标优化分布式流水车间调度序列相关准备时间正弦优化算法协同优化

Mechanisms of Dangua Fang(丹瓜方)in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics

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Journal of Traditional Chinese Medicine 2024年第2期44卷 334-344页

作者： HENG Xianpei WANG Zhita LI Liang YANG Liuqing HUANG Suping JIN lang HE Weidong Department of Endocrinology People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122China Faculty of Humanities and Management Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Geriatrics People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To explore the mechanism of Dangua Fang(丹瓜方,DGR)in multi-target and multi-method regulation of glycolipid metabolism based on ***:Sprague-Dawley rats with normal glucose levels were randomly divided into three groups,including a conventional diet control group(Group A),high-fat-highsugar diet model group(Group B),and DGR group(Group C,high-fat-high-sugar diet containing 20.5 g DGR).After 10 weeks of intervention,the fasting blood glucose(FBG),2 h blood glucose[PBG;using the oral glucose tolerance test(OGTT)],hemoglobin A1c(HbA1c),plasma total cholesterol(TC),and triglycerides(TG)were tested,and the livers of rats were removed to calculate the liver ***,hepatic portal TG were tested using the Gross permanent optimization-participatiory action planning enzymatic method and phosphoproteomics was performed using liquid chromatography with tandem mass spectrometry(LC-MS/MS)analysis followed by database search and bioinformatics ***,cell experiments were used to verify the results of *** mitogen-activated protein kinase kinase kinase kinase 4(MAP4k4)and phosphorylated adducin 1(ADD1)were detected using western ***:DGR effectively reduced PBG,TG,and the liver index(P1.2),DGR upregulated the modification of 228 phosphorylation sites involving 204 corresponding function proteins,and downregulated the modification of 358 phosphorylation sites involving 358 corresponding function proteins,which includ

关键词： phosphoproteomics glycolipid metabolism therapeutic mechanism compound formula Dangua Fang

Parthenolide enhances the metronomic chemotherapy effect of cyclophosphamide in lung cancer by inhibiting the NF-kB signaling pathway

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World Journal of Clinical Oncology 2024年第7期15卷 895-907页

作者： Zheng Cai lang Gao Kai Hu Qi-Ming Wang Department of Internal Medicine The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008Henan ProvinceChina Department of Oncology The No.1 Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021Yunnan ProvinceChina

BACKGROUND Parthenolide(PTL),a sesquiterpene lactone derived from the medicinal herb Chrysanthemum parthenium,exhibits various biological effects by targeting NF-kB,STAT3,and other *** has emerged as a promising adjunct therapy for multiple *** To evaluate the in vitro and in vivo effect of PTL on cyclophosphamide(CTX)metronomic *** The cytotoxicity of PTL and CTX on Lewis lung cancer cells(LLC cells)was assessed by measuring cell activity and *** anti-tumor efficiency was evaluated using a tumor xenograft mice model,and the survival of mice and tumor volume were ***,the collected tumor tissues were analyzed for tumor microenvironment indicators and inflammatory *** In vitro,PTL demonstrated a synergistic effect with CTX in inhibiting the growth of LLC cells and promoting *** vivo,metronomic chemotherapy com-bined with PTL and CTX improved the survival rate of tumor-bearing mice and reduced tumor growth ***,metronomic chemotherapy combined with PTL and CTX reduced NF-κB activation and improved the tumor immune microenvironment by decreasing tumor angiogenesis,reducing Transforming growth factorβ,andα-SMA positive *** PTL is an efficient compound that enhances the metronomic chemotherapy effects of CTX both in vitro and in vivo,suggesting its potential as a supplementary therapeutic strategy in metronomic chemotherapy to improve the chemotherapy effects.

关键词： Lung cancer Parthenolide Cyclophosphamide Rhythmic chemotherapy NF-κB pathway

央行数字货币跨境支付系统:模式、风险及其治理之探

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金融监管研究 2024年第3期 43-59页

作者：郎平河北大学法学院

目前,各国尝试建立的央行数字货币跨境支付系统主要有三种模式:升级实时全额支付系统、双边跨境支付系统、多边跨境支付系统。然而,因数字技术赋能升级的央行数字货币跨境支付系统一旦落地,运营中不仅存在异化传统风险的可能性,还可能... 详细信息

目前,各国尝试建立的央行数字货币跨境支付系统主要有三种模式:升级实时全额支付系统、双边跨境支付系统、多边跨境支付系统。然而,因数字技术赋能升级的央行数字货币跨境支付系统一旦落地,运营中不仅存在异化传统风险的可能性,还可能滋生新的风险。基于此,本文立足上述三种央行数字货币跨境支付系统模式,依托数字技术研判央行数字货币跨境支付系统中的风险,主要包括流动性风险、网络安全风险、区块链技术风险以及系统重要性风险。面对央行数字货币跨境支付系统中的潜在风险,可从主权国家的货币主权和国际金融监管合作这两个方面进行治理。而今,我国积极参与的“多边央行数字货币桥项目”已启动测试,落地之势蓄势待发。面对央行数字货币跨境支付系统潜含的风险,我国应未雨绸缪,提前对数字人民跨境支付系统中潜在的风险制定防控措施,从而为数字人民币的跨境支付提供安全的制度保障。

关键词：央行数字货币跨境支付系统风险治理数字人民币

钴催化α-氯代羰基化合物与酮亚胺的对映选择性还原加成构建β-叔氨基酸类似物

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有机化学 2024年第4期44卷 1379-1381页

作者：田朗李法宝湖北大学化学化工学院武汉430062

手性β-氨基酸广泛存在于天然产物、药物和生物活性分子中[1],其广泛性和重要性鼓励着众多化学家去探索构建手性的方法.合成手性β-仲氨基酸的方法已非常普遍[2-3],然而,合成手性β-叔氨基酸的策略依然稀缺.从α-羰基亲电试剂出发,利用... 详细信息

手性β-氨基酸广泛存在于天然产物、药物和生物活性分子中[1],其广泛性和重要性鼓励着众多化学家去探索构建手性的方法.合成手性β-仲氨基酸的方法已非常普遍[2-3],然而,合成手性β-叔氨基酸的策略依然稀缺.从α-羰基亲电试剂出发,利用α-羰基自由基与酮亚胺进行不对称自由基加成反应有望解决该合成难点,为合成各种手性β-叔氨基酸提供新的途径(Scheme 1)[4-6].

关键词：羰基化合物亲电试剂自由基加成反应天然产物生物活性分子酮亚胺对映选择性还原加成

Participant Heterogeneity of Systemic Scleroderma Interventional Trials Worldwide

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International Journal of Dermatology and Venereology 2024年第2期7卷 99-107页

作者： Li-Qing Shi Shi-Hang Zhou Ping-lang Ruan Bo Zhang Yue Xin Cheng Zhao Xu Yao Jing-Ru Tian Qian-Jin Lu Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases Chinese Academy of Medical SciencesNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs NanjingJiangsu 210042China Department of Dermatology Hunan Key Laboratory of Medical Epigenomicsthe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

Objective:Heterogeneity of participants in clinical trials distorts intervention ***,factors associated with participant heterogeneity in randomized clinical trials(RCTs)focusing on systemic sclerosis(SSc)are not *** conducted this systematic review to establish normative standards for future research and help develop management ***:Three databases and 4 registries were searched to identify characteristics of SSc RCTs across different *** of bias was assessed by the Cochrane Collaboration’s tool and logistic regression was performed to calculate crude and adjusted odds ***:In total,261 trials met our inclusion *** quality of SSc RCTs worldwide was relatively poor,with no trend of improvement in recent years,and only 12.2%were ranked as having a low risk of *** with a low risk of bias as well as single-center,single-country,or open-label trials tended to have better participant adherence than trials with a high risk of bias and multiple-center,multiple-country,or double-blind ***,trial registration and primary outcome definition contributed to high *** income was also relevant;participant adherence in high-income countries,but not in upper-and lower-middle-income countries,was significantly altered by different ***:Overall,the risk of bias,national income,and trial design may lead to participant heterogeneity of SSc RCTs and ultimately confound the general clinical utility of the *** with a rigorous design and transparent conduction protocol are crucial for obtaining unbiased data that can serve as a reference and for maintaining the fundamental repeatability of SSc RCTs.

关键词： systemic sclerosis randomized clinical trials heterogeneity participant adherence national income risk of bias

浪漫、古典与写实——李长之古代诗人批评的美学构造及运作

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中国文艺评论 2024年第5期 30-41,125,126页

作者：金浪重庆大学中文系

抗战时期李长之围绕古代诗人写下的系列批评论著,离不开美学的深度参与。“写实”与“浪漫”的对立、“古典”与“浪漫”的并立,作为文艺批评背后交错叠加的美学构造,为其文艺批评实践开拓了充足的理论空间。如果说对李白在道教徒和诗... 详细信息

抗战时期李长之围绕古代诗人写下的系列批评论著,离不开美学的深度参与。“写实”与“浪漫”的对立、“古典”与“浪漫”的并立,作为文艺批评背后交错叠加的美学构造,为其文艺批评实践开拓了充足的理论空间。如果说对李白在道教徒和诗人双重身份拉扯下之永恒痛苦的分析,是基于对立构造写就的代表作,那么,对司马迁身上儒家精神、道家精神与诗人气质的阐发,则堪称融合对立与并立构造的新经典。

关键词：李长之抗战古代诗人浪漫古典写实

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新高考改革背景下等级赋分制政策研究

教学与管理 2024年第4期 65-70页

作者：郎平中国地质大学(武汉)教育研究院武汉430074

自2014年新高考改革正式启动以来,各省陆续采用等级赋分制进行高考计分,而等级赋分制直接影响选考制度的实施效果,进而影响新高考的改革质量。运用文本分析法对我国21个省市的60份等级赋分制相关政策文件进行分析研究,其结果表明,各省... 详细信息

自2014年新高考改革正式启动以来,各省陆续采用等级赋分制进行高考计分,而等级赋分制直接影响选考制度的实施效果,进而影响新高考的改革质量。运用文本分析法对我国21个省市的60份等级赋分制相关政策文件进行分析研究,其结果表明,各省市等级赋分制的相关政策文件在发布、实施的过程中存在下述问题:政策调整不及时;高考改革政策数量繁多而缺乏等级赋分制专项政策;实践先于政策出台;政策工具使用单一。这些问题不利于等级赋分制的优化发展以及新高考的平稳推进。为此,教育主管部门应该及时调整并完善政策文件,尽快出台等级赋分制专项政策,对政策工具的使用进行优化组合,促进等级赋分制的合理完善,以推动新高考改革实践的良性发展。

关键词：等级赋分制新高考改革政策文本选考制度