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多模态超声联合血清学指标在HFpEF患者心肌微循环及心功能评估中的应用研究

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中国超声医学杂志 2024年第4期40卷 414-417页

作者：李煦灵闫国珍张小青刘丽峰任娜李志远任星星内蒙古科技大学包头医学院研究生院内蒙古科技大学包头医学院第一附属医院

目的联合应用心肌声学造影、斑点追踪技术、三维超声心动图、血清学指标评估射血分数保留型心力衰竭(HFpEF)患者心肌微循环和心功能的变化，为临床对HFpEF的早期干预提供影像学依据。方法选取HFpEF患者120例，正常对照组40例，其中HF... 详细信息

目的联合应用心肌声学造影、斑点追踪技术、三维超声心动图、血清学指标评估射血分数保留型心力衰竭(HFpEF)患者心肌微循环和心功能的变化，为临床对HFpEF的早期干预提供影像学依据。方法选取HFpEF患者120例，正常对照组40例，其中HFpEF患者根据超声评估左心室舒张功能结果分为A、B、C 3组，比较各组间测量指标差异。结果 (1)各组间二尖瓣E峰减速时间(DT)、平均E/e′、E/A、RIMP、LAD、LAVI、RVEF差异有统计学意义(P<0.05),C组RVEF较A组和B组低，LAVI、平均E/e′、RIMP均高于A组和B组(P<0.05);(2)各组间LVGLS、LAGLS、RVGLS差异有统计学意义(P<0.05);(3)与其他3组相比，C组β、A值减低(P<0.05)。结论多模态超声联合血清学指标可全面反映HFpEF患者心肌重塑状态、心肌微循环和心功能变化，为临床提供准确的超声影像学诊断依据。

关键词：射血分数保留心力衰竭心肌声学造影斑点追踪技术心肌微循环心功能

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光干涉式甲烷测定器检定方法

上海计量测试 2024年第1期51卷 45-48页

作者：任星星田锐王海波山西兰花安全计量技术有限公司

提出了对光干涉式甲烷测定器测微组示值量化的建议及具体的检定方法,在检定过程中采用增加读数显微镜的原理将示值进行量化分析。应用不确定度评定原则,可有效降低由于光干涉式甲烷测定器示值所引入的不确定度误差分量,提高光干涉式甲... 详细信息

提出了对光干涉式甲烷测定器测微组示值量化的建议及具体的检定方法,在检定过程中采用增加读数显微镜的原理将示值进行量化分析。应用不确定度评定原则,可有效降低由于光干涉式甲烷测定器示值所引入的不确定度误差分量,提高光干涉式甲烷测定器检定的准确性和科学性。

关键词：光干涉式甲烷测定器读数显微镜读取示值不确定度

Selective immobilization of Pb(Ⅱ)by biogenic whewellite and its mechanism

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Journal of Environmental Sciences 2024年第3期137卷 664-676页

作者： xingxing Wang Kaiyan ren Kairui Jiao Wenjun Nie Xiaochi An Bin Lian College of Life Sciences College of Marine Science and EngineeringNanjing Normal UniversityNanjing 210023China

The development of bio-adsorbents with highly selective immobilization properties for specific heavy metals is a great challenge,but has important application *** whewellite(BW)with high selectivity for Pb(Ⅱ)was synthesized by mineral microbial *** selective immobilization properties and mechanism of BW for Pb(Ⅱ)were analyzed by combining mineral characterization technology and batch adsorption research *** results indicated that BW can efficiently and selectively immobilize Pb(Ⅱ)in single or composite heavy metal adsorption solutions,and the immobilized Pb(Ⅱ)is difficult to *** undergoes monolayer adsorption on Pb(Ⅱ),Qmax≈1073.17 mg/*** immobilization of Pb(Ⅱ)by BW is a physico-chemical adsorption process with spontaneous heat absorption and an accompanying increase in *** addition,the sequestration of Pb(Ⅱ)by BW remains around 756.99 mg/g even at p H=*** excellent selective immobilization properties of BW for Pb(Ⅱ)are closely related to its smaller Ksp,electrostatic repulsion effect,organic-inorganic composite structure,acid resistance and the formation of Pb(Ⅱ)*** study provides beneficial information about the recycling of lead in acidic lead-containing wastewater and composite heavy metal contaminated water bodies.

关键词： Aspergillus niger Biogenic whewellite Pb(Ⅱ) Selective adsorption Immobilization mechanism

Effects of acid mine drainage on photochemical and biological degradation of dissolved organic matter in karst river water

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Journal of Environmental Sciences 2024年第1期135卷 26-38页

作者： Linwei Li xingxing Cao Chujie Bu Pan Wu Biao Tian Yongheng Dai Yeye ren College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Karst Georesources and Environment Ministry of EducationGuizhou UniversityGuiyang 550025China Guizhou Karst Environmental Ecosystems Observation and Research Station Ministry of EducationGuizhou UniversityGuiyang 550025China

Dissolved organic matter(DOM)can be removed or transformed by photochemical and biological processes,producing the negative effect of transforming organic carbon into inorganic carbon,which plays a vital role in the karst carbon ***,acid mine drainage(AMD)will affect this process,so the degradation of DOM in karst river water(KRW)needs to be studied in this *** this study,to reveal the evolution processes of DOM under photochemical and biological conditions in AMD-impacted KRW,AMD and KRW were mixed in different ratios under conditions of visible light irradiation(VL),biodegradation(BD),ultraviolet irradiation(UV)and ultraviolet irradiation+biodegradation(UV+BD).The average DOC concentrations in samples after mixing AMD and KRW in different proportions decreased significantly(by 23%)in UV+BD,which was 1.2–1.4 times higher than under the other conditions and would lead to a significant release of inorganic *** analysis of the fluorescence parameters via parallel factor analysis(PARAFAC)revealed that the DOM fluorescence components in AMD comprised mainly protein-like substances derived from autochthonous components,while the DOM fluorescence components in KRW were mainly humic-like substances with both autochthonous and allochthonous ***,AMD could promote both the photochemical and biological degradation of DOM in karst receiving streams,resulting in the conversion of DOC to inorganic *** results showed that the synergistic effects of UV+BD and AMD accelerated the degradation of DOM and the release of inorganic carbon in KRW,thus affecting the stability of the karst carbon cycle.

关键词： Acid mine drainage Dissolved organic matter Karst river water Photochemical degradation Biological degradation

Combined insertion of basic and non-basic amino acids at hemagglutinin cleavage site of highly pathogenic H7N9 virus promotes replication and pathogenicity in chickens and mice

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Virologica Sinica 2022年第1期37卷 38-47页

作者： Aobaixue Zhou Jiahao Zhang Huanan Li Qiang Xu Yiqun Chen Bo Li Wanying Liu Guanming Su xingxing ren Guangjie Lao Baozheng Luo Ming Liao Wenbao Qi College of Veterinary Medicine South China Agricultural UniversityGuangzhou510642China National Avian Infiuenza Para-reference Laboratory South China Agricultural UniversityGuangzhou510642China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou510642China Gongbei Customs Technology Center Zhuhai519000China National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control Guangzhou510642China Key Laboratory of Zoonoses Ministry of AgricultureGuangzhou510642China Key Laboratory of Animal Vaccine Development Ministry of AgricultureGuangzhou510642China Key Laboratory of Zoonoses Prevention and Control of Guangdong Province Guangzhou510642China

Since mid-2016,the low pathogenic H7N9 influenza virus has evolved into a highly pathogenic(HP)phenotype in China,raising many concerns about public health and poultry *** insertion of a“KRTA”motif at hemagglutinin cleavage site(HACS)occurred in the early stage of HP H7N9 *** the co-circulation,the HACS of HP-H7N9 variants were more polymorphic in birds and *** HP-H7N9 variants,unlike the H5 subtype virus,exhibited the insertions of basic and non-basic amino acids,the underlying function of those insertions and substitutions remains *** results of bioinformatics analysis indicated that the PEVPKRKRTAR/G motif of HACS had become the dominant motif in ***,we generated six H7N9 viruses bearing the PEIPKGR/G,PEVPKGR/G,PEVPKRKRTAR/G,PEVPKGKRTAR/G,PEVPKGKRIAR/G,and PEVPKRKRR/G ***,after the deletion of threonine and alanine(TA)at HACS,the H7N9 viruses manifested decreased thermostability and virulence in mice,and the PEVPKRKRTAR/G-motif virus is prevalent in birds and humans probably due to its increased transmissibility and moderate *** contrast,the insertion of non-basic amino acid isoleucine and alanine(IA)decreased the transmissibility in chickens and virulence in ***,the I335V substitution of H7N9 virus enhanced infectivity and transmission in chickens,suggesting that the combination of mutations and insertions of amino acids at the HACS promoted replication and pathogenicity in chickens and *** ongoing evolution of H7N9 increasingly threatens public health and poultry industry,so,its comprehensive surveillance and prevention of H7N9 viruses should be pursued.

关键词： H7N9 Highly pathogenic Cleavage site Basic and non-basic amino acids Pathogenicity

Study on the interaction between volatile oil components and skin lipids based on molecular docking techniques

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Digital Chinese Medicine 2024年第2期7卷 148-159页

作者： ren Weishuo WULAN Tuya DAI xingxing ZHANG Yingying JIA Mingyue FENG Minfang SHI Xinyuan School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine Beijing Municipal Science&Technology CommissionBeijing 102488China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Objective To analyze the interactions between different structural types of volatile oil compo-nents(VOCs)and skin lipid molecules;and investigate the mechanism of volatile oil in Chi-nese materia medica(VOCMM)as penetration *** In this study;210 different structural types of VOCs were selected from the VOCMM penetration enhancer database;and the molecular docking experiments were conducted with three main lipid molecules of skin:ceramide 2(CER2);cholesterol(CHL);and free fatty acid(FFA).Each VOC was docked individually with each lipid *** analysis was used to explore the relationship between the binding energy of VOCs and their molecular *** specific pathogen-free(SPF)Sprague Dawley(SD)rats were randomly divided in-to Control;Nootkatone;and 3-Butylidenephthalide groups for in vitro percutaneous experi-ments;with three rats in each *** donor pool solutions were 3%gastrodin;3%gas-trodin+3%nootkatone;and 3%gastrodin+3%3-butylidenephthalide;*** pen-etration enhancing effects of VOCs with higher binding energy were evaluated by comparing the 12-hour cumulative percutaneous absorption of gastrodin(Q12;µg/cm²).Results(i)Most of the VOCs were non-hydrogen bonded to the hydrophobic parts of CHL and FFA;and hydrogen bonded to the head group of *** them;sesquiterpene ox-ides showed the most pronounced binding affinity to *** VOCs with 2-4 rings(in-cluding carbon rings;benzene rings;and heterocycles)demonstrated stronger binding affini-ty for three skin lipid molecules compared with the VOCs without intramolecular rings(P<0.01).(ii)According to the cluster analysis;most of the VOCs that bond well to CER2 had 2-3 intramolecular *** non-oxygenated VOCs were bonded to CER2 in a hydrophobic *** oxygenated VOCs were mostly bonded to CER2 by hydrogen bonding.(iii)The results of Franz diffusion cell experiment showed that the Q12 of Control group was 260.60±25.09µg/cm2;and the transdermal absorption o

关键词： Chinese materia medica Volatile oil Stratum corneum lipids Transdermal penetration-enhancing effects Molecular docking Ceramide 2(CER2) Penetration enhancers

由自身免疫性疾病引发的极度高三酰甘油血症：病例总结及文献复习

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中华内分泌代谢杂志 2016年第6期32卷 523-526页

作者：郑爽任星星胡耀敏上海交通大学医学院附属仁济医院内分泌代谢病科 200127

极度高三酰甘油血症是继酗酒和胆石症后第三大常见的引起急性胰腺炎的病因，也是造成心血管事件的重要危险因素。由自身免疫性疾病引发的极度高三酰甘油血症临床上较为少见，给该疾病的诊断和治疗带来了一定的困难。所以，了解该疾病的... 详细信息

极度高三酰甘油血症是继酗酒和胆石症后第三大常见的引起急性胰腺炎的病因，也是造成心血管事件的重要危险因素。由自身免疫性疾病引发的极度高三酰甘油血症临床上较为少见，给该疾病的诊断和治疗带来了一定的困难。所以，了解该疾病的临床特点、可能发病机制及相应治疗方法将为更加有效的治疗提供帮助，从而降低急性胰腺炎、心血管事件等并发症的风险，既提高患者的生存率，也改善了他们的生活质量。

关键词：极度高三酰甘油血症自身免疫性疾病三酰甘油高脂血症

淮北煤田太原组灰岩水水文地球化学形成作用及反向模拟研究

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煤炭学报 2021年第12期46卷 3999-4009页

作者：陈陆望任星星张杰陈逸飞郑忻合肥工业大学资源与环境工程学院安徽合肥230009

随着浅部煤炭资源开采殆尽,华北型隐伏煤田的煤炭开采正逐步向深部发展,破坏了地下水系统原有平衡,以致水文地质条件复杂化,从而使深部地下水动力条件和水化学特征发生改变。通过对淮北煤田石炭系太原组灰岩(简称"太灰")含水层地下水化... 详细信息

随着浅部煤炭资源开采殆尽,华北型隐伏煤田的煤炭开采正逐步向深部发展,破坏了地下水系统原有平衡,以致水文地质条件复杂化,从而使深部地下水动力条件和水化学特征发生改变。通过对淮北煤田石炭系太原组灰岩(简称"太灰")含水层地下水化学常规组分进行离子比例分析和主成分分析,探讨该含水层地下水水文地球化学形成作用及其控制因素,并选取淮北煤田南部的临涣矿区太灰含水层为研究示范,应用PHREEQC软件对其进行了反向水文地球化学模拟。研究结果表明:淮北煤田太灰含水层主要水文地球化学形成作用类型为溶滤溶解(包括方解石、白云石、石膏溶滤溶解和黄铁矿氧化)和阳离子交替吸附作用;反向水文地球化学模拟定量分析与离子比例以及主成分定性分析结果基本一致。随时间的延续,采动后淮北煤田南部太灰含水层溶滤溶解作用逐渐减弱,阳离子交替吸附作用逐渐增强,而北部太灰含水层因地层埋藏普遍较浅表现出与之相反的现象。淮北煤田南部太灰含水层水文地球化学形成作用受构造影响表现出较为明显的空间差异;而北部太灰含水层水文地球化学形成作用程度受其径流影响,表现出由东向西逐渐增强的特征。淮北煤田南部的临涣矿区太灰含水层反向水文地球化学模拟验证了水文地球化学形成作用及其空间差异性。

关键词：淮北煤田太灰含水层水文地球化学形成作用主成分分析水文地球化学模拟

新质生产力如何助力能源体系变革?——兼论新型能源体系构建

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暨南学报（哲学社会科学版） 2024年第6期46卷 130-148页

作者：陈星星任羽菲中国社会科学院大学应用经济学院中国社会科学院数量经济与技术经济研究所中国数量经济学会华北电力大学经济与管理学院

加快培育发展新质生产力是能源体系变革,推动能源科技实现高水平发展的重要机遇,是保障国家能源安全的必由之路。“十四五”规划以来,中国能源制度从加快构建现代能源体系为核心,到进一步提出加快建设新型能源体系,能源制度变迁显著推... 详细信息

加快培育发展新质生产力是能源体系变革,推动能源科技实现高水平发展的重要机遇,是保障国家能源安全的必由之路。“十四五”规划以来,中国能源制度从加快构建现代能源体系为核心,到进一步提出加快建设新型能源体系,能源制度变迁显著推动了中国能源体系绿色转型。以新一轮科技革命为代表的新质生产力,为能源体系建设发展提供了重要战略机遇,也是中国能源体系建设迈向高质量发展的关键抉择。新质生产力如何为能源体系变革提供持续动力,在供给侧与需求侧的牵引下实现能源体系产业跃迁,对未来能源体系建设发展具有重要意义。本文根据马克思主义生产力理论和马克思价值链分工思想,通过梳理中国能源制度的发展变迁和阶段特征,系统分析新质生产力在能源体系变革中的关键作用。在分析新型能源体系产业链全局供需关系现状的基础上,从体制侧、供给侧、需求侧和技术侧的角度,系统研究光伏、风电和新能源汽车三大支柱产业,在关键原材料和核心技术方面的壁垒、安全隐患和制约因素。研究表明,要落实统筹协调的机制改革,做好新型能源体系的“顶层设计”,激发能源产业的新质生产力。通过建立集约高效的跨区通道,优化能源供需体系,形成能源供给的新质生产力。加快释放冗余产能,推动产业融合发展,打造能源协同的新质生产力。提升自主可控水平,突破数字能源技术,发展数字能源的新质生产力。

关键词：新质生产力新型能源体系产业链数字能源能源新质生产力

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