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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3125-3146页

作者： xingli wu Huchang Liao Shuxian Sun Zhengjun Wan Business School Sichuan UniversityChengdu610064China National Institute of Measurement and Testing Technology Chengdu610021China

Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and *** literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of *** this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision *** enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference *** linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise *** address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of ***,we conduct a case study and comparative *** reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information.

关键词： Multiple criteria analysis preference disaggregation inconsistency probability linguistic preference relation investment project selection

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詹姆逊的乌托邦思想研究

马克思主义哲学研究 2024年第1期33卷 231-238,339页

作者：武星丽西南政法大学马克思主义学院

在想象一种他者性未来变得日益困难的同质化图景中,詹姆逊唤起的乌托邦思想的超越性和批判性开辟了重建集体性统一的可能性空间。他以政治阐释为绝对视阈,在文化批判中揭示隐匿的政治渗透,图绘晚期资本主义社会被封堵的总体,探索新的政... 详细信息

在想象一种他者性未来变得日益困难的同质化图景中,詹姆逊唤起的乌托邦思想的超越性和批判性开辟了重建集体性统一的可能性空间。他以政治阐释为绝对视阈,在文化批判中揭示隐匿的政治渗透,图绘晚期资本主义社会被封堵的总体,探索新的政治实践可能的理论尝试,对抵抗资本的普遍拓展具有重要意义。

关键词：乌托邦文化批判总体性

健脾复方联合卡培他滨治疗Ⅲ期结直肠癌临床观察

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辽宁中医杂志 2024年第1期51卷 82-86,I0004页

作者：刘湘君任建琳袁晨越陆鑫熠刘怡黄人可储金砚吴杏黎上海中医药大学附属市中医医院上海200071

目的观察健脾复方联合卡培他滨治疗Ⅲ期结直肠癌(colorectal cancer,CRC)的临床疗效及安全性。方法将2018年10月—2021年6月上海市中医医院肿瘤科82例Ⅲ期术后接受卡培他滨维持化疗CRC患者,采用随机数字表分为治疗组41例和对照组41例,... 详细信息

目的观察健脾复方联合卡培他滨治疗Ⅲ期结直肠癌(colorectal cancer,CRC)的临床疗效及安全性。方法将2018年10月—2021年6月上海市中医医院肿瘤科82例Ⅲ期术后接受卡培他滨维持化疗CRC患者,采用随机数字表分为治疗组41例和对照组41例,治疗组给予健脾复方联合卡培他滨,对照组给予单药卡培他滨,经过8个疗程(6个月)治疗,记录两组患者治疗前后的终点指标、中医证候疗效、肿瘤指标(CEA、CA199)、生活质量评分、化疗不良反应等指标,分析评价中西医结合的疗效及中医治疗的优势。结果①治疗后,两组无进展生存期(PFS)差异无统计学意义(P=0.23),但治疗组总体生存率高于对照组。②治疗后,治疗组患者的中医证候疗效有效率为97.56%(40/41),对照组为26.83%(11/41),治疗组中医证候总体有效率优于对照组(P0.05),其余各方面疗效优于对照组,差异有统计学意义(P<0.05)。④治疗后,两组患者的CEA、CA199水平较治疗前均显著降低(P<0.05),且治疗组患者的CEA、CA199水平明显低于对照组(P<0.01)。⑤治疗后,治疗组Ⅱ-Ⅳ级各不良反应发生率低于对照组(P<0.05)。结论相较于单药卡培他滨疗法,健脾复方联合卡培他滨可更好改善Ⅲ期术后CRC患者临床症状,减轻化疗不良反应,降低肿瘤指标水平,提高生存率。

关键词：结直肠癌健脾复方维持化疗卡培他滨疗效评价

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Establishing of the Transplanted Animal Models for Human Lung Cancer

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Journal of Nanjing Medical University 2009年第1期23卷 1-5页

作者： xingli Zhang Jinchang wu Department of Radiotherapy of Suzhou Municipal Hospital Affiliated to Nanjing Medical University Suzhou 215001 China

Lung cancer is the leading cause of cancer mortality *** with the applications of excision, radiotherapy, chemotherapy, and gene therapy, the 5 year survival rate is only 15% in the USA. Clinically relevant laboratory animal models of the disease could greatly facilitate understanding of the pathogenesis of lung cancer, its progression, invasion and metastasis. Transplanted lung cancer models are of special interest and are widely used today. Such models are essential tools in accelerating development of new therapies for lung cancer. In this communication we will present a brief overview of the hosts, sites and pathways used to establish transplanted animal lung tumor models.

关键词： lung cancer transplanted animal models establish animal models

Allosteric probe-modified liposome loading bufalin-fluorouracil complex for targeted colorectal cancer therapy

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Oncology and Translational Medicine 2022年第5期8卷 239-246页

作者： Fajiang Mao xingli wu Chenyue Yuan Haiyan Huang Yanyan Qiu Jianlin Ren Peihao Yin Department of Oncology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Interventional Cancer Institute of Chinese Integrative Medicine Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China

Objective Bufalin,the main active anti-tumor monomer of toad venom,is crucial in cancer ***,intrinsic issues,such as poor solubility and systematic toxicity,have considerably mitigated its anticancer functions and caused unwanted side *** is essential to develop innovative targeting systems to precisely and efficiently deliver anticancer drugs to achieve satisfying therapeutic *** This work established a novel and more efficient system for simultaneously detecting and killing colorectal cancer *** proposed method designed two allosteric probes,a report probe and a recognize *** method exhibited high sensitivity towards cell detection via the recognizing probe identifying target cancer cells and the report probe’s signal *** bufalin and fluorouracil endowed better tumor cell *** We observed significantly enhanced fluorescence dots surrounding the HCT-116 cell *** fluorescence increments in the other three cells were identified,indicating that the established liposome complex could specifically bind with target *** addition,the best ratio of bufalin to fluorouracil was 0.15 and 0.5,*** improved the anti-tumor effects and achieved more than 60%tumor cell *** This method will provide new opportunities for intracellular biomolecule detection and targeted cancer cell therapy.

关键词： bufalin fluorouracil colorectal cancer imaging therapy

C-reactive protein as a predictor for cardiac events in Chinese elderly patients with coronary heart disease

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Journal of Geriatric Cardiology 2006年第2期3卷 78-81页

作者： Guangyong HUANG Caiyi LU xingli wu Yuxiao ZHANG Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Cardiology Liaocheng People''s Hospital Liaocheng Shandong 252000 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Background and objective To assess the predictive value of C-reactive protein(CRP) for major adverse cardiac events and the association between CRP level and the coronary lesion morphology and extent in patients with coronary heart disease (CHD).Methods CRP was measured on admission in 177 consecutive elderly (age≥60 years) patients with CHD who underwent coronary angiography. Patients were divided into high CRP group (CRP≥3mg/L) and normal CRP group (CRP ＜3mg/L). The association between CRP levels and the coronary lesion features, including severity of stenosis (mild, moderate, severe), extent of lesion (diffused or nondiffused), eccentricity of the plaque (eccentric or non-eccentric) were analyzed. Patients were followed up for a mean of 8 months for the occurrences of major adverse cardiac events (MACE). Results Compared with patients in normal CRP group, patients in high CRP group were more frequently to have unstable angina, multi-vessel, diffuse, eccentric lesions, positive remodeling, and non-smooth plaques (P＜0.01). Kaplan-Meier analysis showed patients in high CRP group had a significantly lower MACE-free survival rate than patients in normal CRP group (Log-rank = 12.0, P＜0.01); Cox regression analysis indicated CRP level as an independent predictor for the occurrence of MACE (OR=3.16, P＜0.05) Conclusions High CRP level is associated with more extend, severe and eccentric coronary lesions and is an independent predictor for MACE in elderly patients with CHD.

关键词： C-reaction protein coronary artery disease angiography major adverse cardiac events

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2467-2479页

作者： Yong Tang Jing Wei Xiao-Fang Wang Tao Long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu xingli Xiao Xueyuan Hu Jing Zeng Qin Xu Anguo wu Jianming wu Dalian Qin Xiaogang Zhou Betty Yuen-Kwan Law Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administrative RegionChina Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical UniversityLuzhouSichuan ProvinceChina Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection of Chengdu University of TCM ChengduSichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Neurology The First People’s Hospital of NeijiangNeijiangSichuan ProvinceChina

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s *** Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains *** the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first *** Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of *** addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo ***,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was *** importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease *** revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

关键词： Alzheimer’s disease amyloid-beta apoptosis autophagy Caenorhabditis elegans Citri Reticulatae Semen

基于液晶弹性体和液态金属的人造肌肉纤维的制备及分析

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材料导报 2022年第14期36卷 208-211页

作者：逯海卿吴兴丽张鹏叶超超魏文庆潍坊学院机电与车辆工程学院山东潍坊261061 沈阳工业大学机械工程学院沈阳110870

本工作提出一种高效、低成本的新型人造肌肉纤维的制备方法。该方法将液态金属加热器完全嵌入到人造肌肉纤维中,使新型肌肉纤维同时具备液晶弹性体优异的致动性能和液态金属的类液态可变形性能,该结构可以避免肌肉纤维在发生较大变形时... 详细信息

本工作提出一种高效、低成本的新型人造肌肉纤维的制备方法。该方法将液态金属加热器完全嵌入到人造肌肉纤维中,使新型肌肉纤维同时具备液晶弹性体优异的致动性能和液态金属的类液态可变形性能,该结构可以避免肌肉纤维在发生较大变形时,由于加热器损伤而导致的肌肉纤维失效现象。利用红外摄像机和拉力试验机对新型人造肌肉纤维材料的驱动性能进行实验分析,包括其表面温度、收缩率和拉力受电流大小、加热时间和材料尺寸的变化所产生的影响等。结果表明,新型人造肌肉纤维材料具有较好的柔韧性、驱动性和高可变形性能,对液晶弹性体驱动机构的柔性设计和开发具有一定的指导意义,此方法可广泛应用于软体机器人、假肢及生物医疗设备的设计开发中。

关键词：人造肌肉液晶弹性体液态金属电流

Evaluation of coronary plaque and stent deployment by intravascular optical coherence tomography in elderly patients with unstable angina and non-ST-elevation myocardial infarction

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Journal of Geriatric Cardiology 2007年第1期4卷 3-9页

作者： Caiyi LU Shiwen WANG Wei YAN xingli wu Yuxiao ZHANG Qiao XUE Muyang YAN Peng LIU Rui CHEN Jinyue ZHAI Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853China

Objective To evaluate the feasibility and efficacy of intravascular optical coherence tomography(OCT)in the assessment of plaque characteristics and drug eluting stent deployment quality in the elderly patients with unstable angina(UA)and non-ST segment elevation myocardial infarction(NSTEMI).Methods OCT was used in elderly patients undergoing percutaneous coronary *** patients,9 males and 6 females with mean age of 72.6±5.3 years(range 67-92 years)were enrolled in the *** were obtained before initial balloon dilatation and following stent *** plaque characteristics before dilation,vessel dissection,tissue prolapse,stent apposition and strut distribution after stent implantation were *** Fifteen lesions were selected from 32 angiographic lesions as study lesions for OCT imaging after diagnostic coronary *** were 7 lesions in the left anterior descending artery,5 lesions in the right coronary artery and 3 lesions in the left circumflex coronary *** them,12(80.0%)were lipid-rich plaques,and 10(66.7%)were vulnerable plaques with fibrous cap thickness 54.2±7.3μ*** ruptured culprit plaques(46.7%)were found;4 in UA patients and 3 in NSTEMI *** prolapse was observed in 11 lesions(73.3%).Irregular stent strut distribution was detected in 8 lesions(53.3%).Vessel dissections were found in 5 lesions(33.3%).Incomplete stent apposition was observed in 3 stents(20%)with mean spacing between the struts and the vessel wall 172±96 mm(range 117-436 mm).Conclusions 1)It is safe and feasible to perform intravascular OCT to differentiate vulnerable coronary plaque and monitor stent deployment in elderly patients with UA and USTEMI.2)Coronary plaques in elderly patients with UA and USTEMI could be divided into acute ruptured plaque,vulnerable plaque,lipid-rich plaque,and stable plaque.3)Minor or critical plaque rupture is one of the mechanisms of UA in elderly patients.4)Present drug eluting stent

关键词： optical coherence tomography acute coronary syndrome percutaneous coronary intervention stent elderly

The Current Situation and Countermeasures of the Aged Poor in the Rural Areas of the Three-Gorge-Reservoir Area in Wanzhou,Chongqing

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The Current Situation and Countermeasures of the Aged Poor i...