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空间站结构数字化协同设计中的计划管理

载人航天 2019年第4期25卷 540-544页

作者：张帅林星翰北京空间飞行器总体设计部北京100094 北京医学院附属中学北京100191

针对传统基于二维图纸研制的计划管理模式不适应三维数字化结构协同设计的问题,分析了数字化结构协同设计的特点,围绕三维模型架构层次和信息交互,提出了技术流程逐层解耦的管理方法;应用模糊统计和平衡线调度原理,建立了三维模型投产... 详细信息

针对传统基于二维图纸研制的计划管理模式不适应三维数字化结构协同设计的问题,分析了数字化结构协同设计的特点,围绕三维模型架构层次和信息交互,提出了技术流程逐层解耦的管理方法;应用模糊统计和平衡线调度原理,建立了三维模型投产计划评估数学模型;基于模型层次化的协同方式优化了沟通管理模式。在空间站结构研制的管理过程中,要实现全过程的结构研制管控、调配合理的人力资源、制定科学的投产计划、促进高效的信息沟通,以确保空间站结构研制任务的完成。该计划管理方法为大型复杂航天器结构三维数字化协同设计的计划管理提供了良好的借鉴。

关键词：空间站大型复杂航天器结构数字化协同设计计划管理

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3D打印中央控制系统综述

机械设计与制造工程 2023年第1期52卷 1-6页

作者：林星翰北京工商大学人工智能学院北京100048

首先对3D打印中央控制系统中主要组成模块的研究现状进行了详细介绍,包括3D打印运动轨迹控制与优化和温度精确控制;其次描述了现有的控制系统与其他相关功能,主要包括限位控制、自动调平以及力控制,其中力控制为打印一些特殊器件提供了... 详细信息

首先对3D打印中央控制系统中主要组成模块的研究现状进行了详细介绍,包括3D打印运动轨迹控制与优化和温度精确控制;其次描述了现有的控制系统与其他相关功能,主要包括限位控制、自动调平以及力控制,其中力控制为打印一些特殊器件提供了可能;最后针对3D打印的相关应用领域与现存问题进行了介绍,包括航空航天和医疗领域的智能制造。

关键词： 3D打印中央控制系统运动轨迹夹持力智能制造

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神经网络在机械臂轨迹跟踪问题中的应用综述

机械设计与制造工程 2023年第3期52卷 49-53页

作者：林星翰北京工商大学人工智能学院北京100048

针对机械臂系统存在时变、非线性和强耦合的特点,提出了基于人工神经网络的机械臂控制方法。该方法可以在机械臂运行过程中通过训练不断提升对环境和任务的适应能力,从而提升控制精度,使机械臂具备很强的容错性和信息综合能力。相关工... 详细信息

针对机械臂系统存在时变、非线性和强耦合的特点,提出了基于人工神经网络的机械臂控制方法。该方法可以在机械臂运行过程中通过训练不断提升对环境和任务的适应能力,从而提升控制精度,使机械臂具备很强的容错性和信息综合能力。相关工作改进了神经网络方法的效率、稳定性和适用性。对机械臂轨迹跟踪问题的运动学和动力学模型进行分析,总结了基于神经网络控制方法的研究现状,并对基于强化学习和柔性臂模型的研究方向进行了展望。

关键词：机械臂轨迹跟踪 BP神经网络 RBF神经网络

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Neural substrates for regulating self-grooming behavior in rodents

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第10期25卷 841-856页

作者： Guanqing LI Chanyi LU Miaomiao YIN Peng WANG Pengbo ZHANG Jialiang WU Wenqiang WANG Ding WANG Mengyue WANG Jiahan LIU xinghan lin Jian-Xu ZHANG Zhenshan WANG Yiqun YU Yun-Feng ZHANG State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100101China School of Life Sciences Hebei UniversityBaoding 071002China State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Rehabilitation Medicine Tianjin Huanhu HospitalTianjin 300350China Medical Center for Human Reproduction Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100101China Department of Gastrointestinal Surgery the People’s Hospital of Zhaoyuan CityZhaoyuan 265400China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Otolaryngology EyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Ear Nose&Throat InstituteEyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Clinical and Research Center for Olfactory Disorders EyeEarNose&Throat HospitalFudan UniversityShanghai 200031China

Grooming,as an evolutionarily conserved repetitive behavior,is common in various animals,including humans,and serves essential functions including,but not limited to,hygiene maintenance,thermoregulation,de-arousal,stress reduction,and social *** rodents,grooming involves a patterned and sequenced structure,known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style,beginning from the nose to the face,to the head,and finally ending with body *** context-dependent occurrence of grooming behavior indicates its adaptive *** review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming *** further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models,holding promise for translational ***,we mainly focus on rodent ***(grooming being applied on one animal by its conspecifics via licking or carefully nibbling)and heterogrooming(a form of grooming behavior directing towards another animal,which occurs in other contexts,such as maternal,sexual,aggressive,or social behaviors)are not covered due to space constraints.

关键词： Grooming Repetitive behavior Syntactic chain Cephalocaudal progression Neuropsychiatric disorders

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山东省兽类分布新纪录——巢鼠

山东林业科技 2024年第2期54卷 65-66页

作者：邱晨高晓冬林星瀚崔伟佳李浩恬济宁市南四湖自然保护区服务中心山东济宁272053 曲阜师范大学生命科学学院山东曲阜273165 山东大学海洋学院山东威海264209 聊城大学生命科学学院山东聊城252059

2023年6月3日,在山东省济宁市南四湖省级自然保护区(116°35′6″E,35°17′14″N)的芦苇中观察到一个由植物茎、叶编织而成的球形巢穴,并拍摄到4只小型啮齿动物。经查阅文献,对比形态特征和巢穴形态后,鉴定为巢鼠(Micromys minutus),... 详细信息

2023年6月3日,在山东省济宁市南四湖省级自然保护区(116°35′6″E,35°17′14″N)的芦苇中观察到一个由植物茎、叶编织而成的球形巢穴,并拍摄到4只小型啮齿动物。经查阅文献,对比形态特征和巢穴形态后,鉴定为巢鼠(Micromys minutus),确认为山东省兽类分布新纪录。

关键词：巢鼠分布新纪录山东

A novel stiffness optimization model of space telescopic boom based on locking mechanism

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Frontiers of Mechanical Engineering 2024年第3期19卷 41-59页

作者： Kun XU xinghan ZHUANG Zhou SU Qiuhong lin Shouzhi REN Hang XIAO Xilun DING School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Beijing Institute of Spacecraft System Engineering Beijing 100094China

The deployable telescopic boom,whose mass and stiffness play crucial roles,is extensively used in the design of space-deployable ***,the most existing optimal design that neglects the influence of the locking mechanisms in boom joints cannot raise the whole stiffness while reducing the boom *** tackle this challenge,a novel optimization model,which utilizes the arrangement of the locking mechanisms to achieve synchronous improvement of the stiffness and mass,is *** proposed optimization model incorporates a novel joint stiffness model developed based on an equivalent parallel mechanism that enables the consideration of multiple internal stiffness factors of the locking mechanisms and tubes,resulting in more accurate representations of the joint stiffness *** analysis shows that the proposed stiffness model achieves more than at least 11% improved accuracy compared with existing ***,case verification shows that the proposed optimization model can improve stiffness while effectively reducing mass,and it is applied in boom optimization design.

关键词： deployable telescopic boom locking mechanism stiffness model clearance error optimization model

Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing

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Chinese Chemical Letters 2020年第6期31卷 1499-1503页

作者： xinghan Chen Pengfei Tan Ya Wen Wencheng Zhou Ying Cen Chao You lin Tan Meng Tian Department of Burns and Plastic Surgery and Neurosurgery Research LaboratoryWest China HospitalSichuan University.Chengdu 610041China College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Leather Chemistry and Engineering of Ministry of Education Sichuan UniversityChengdu 610065China

Surgical suture is commonly used in clinic due to its action in accelerating the process of wound ***,difficultly handling in minimally invasive surgery and bacteria-induced infection usually limit its use in a wide range of ***,we report a facile scalable strategy to fabricate surgical sutures with shape memory function and antibacterial activity for wound ***,a shape memory polyurethane(SMPU)with a transition temperature(Ttrans)at 41.3℃was synthesized by adjusting the mole ratio of the hard/soft segment,and then the shape memory surgical sutures containing polyhexamethylene biguanide hydrochloride(PHMB)as a model drug for antibacterial activity were fabricated by a facile scalable one-step wet-spinning approach,in which PHMB was directly dissolved in the coagulation bath that enable its loading into the sutures through the dual diffusion during the phase *** prepared sutures were characterized by their morphology,mechanical properties,shape memory,antibacterial activity,as well as biocompatibility before the wound healing capability was tested in a mouse skin suture-wound *** was demonstrated that the optimized suture is capable of both shape memory function and antibacterial activity,and promote wound healing,suggesting that the facile scalable one-step wet-spinning strategy provides a promising tool to fabricate surgical sutures for wound healing.

关键词： Wet-spinning Shape memory Antibacterial activity Surgical suture Wound healing

Cloning and biological activity of an anti-tumor peptide of Tumstatin

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Frontiers in Biology 2007年第3期2卷 276-283页

作者： WANG Shujing LIU Yan lin Xuesong FU Xue XU Jianyong LIU xinghan Bio-pharmaceutical Key Laboratory of Heilongjiang Province-Incubator of State Key Laboratory Harbin Medical UniversityHarbin 150086China Department of Biochemistry and Molecular Biology Harbin Medical UniversityHarbin 150028China Institute of Pharmacology Harbin Commercial UniversityHarbin 150028China

To obtain an anti-tumor peptide of Tumstatin and detect its biological activity,the nucleotide sequence encoding 185-203 amino acids(19peptide)of Tumstatin was synthesized and inserted into the fusion protein vector *** identification by sequencing and restriction endonucle-ases,the recombined vector was transformed into BL-21(DE3)*** competent *** *** BL-21(DE3)were induced by isopropyl-β-thiogalactopyranoside(IPTG),and then *** 1,4-dithiothreitol(DTT)reduction,the soluble 19peptide was obtained from a chitin affinity *** biological activity of 19peptide was determined by 3-[4,5-dimethylthiazol-2-y1]-2,5-dipheny-tetrazolium bromide(MTT)assay,cell growth curve,the effect of the ascitic fluid transfevent H22 hepatoma on mice and via histopathological *** purified 19peptide directly inhibited proliferation and migration of murine B16 melanoma cells,SMMC-7721hepatoma carcinoma cells and human umbilical vein endothelial cells(HUVEC).The tumor inhibition rate of mice ascitic fluid transfevent H22 hepatoma was 48.46%.Histopathological slices showed that it could promote tumor tissue necrosis and decrease the density of blood *** higher anti-tumor activity,19peptide has the potential to become a novel,potent anti-tumor agent.

关键词： Tumstatin protein expression protein purifica-tion tumor therapy

中国南方沿海13种石斑鱼类的分子系统进化关系分析

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中山大学学报（自然科学版） 2014年第4期53卷 123-130页

作者：陈兴汉郭梁李明明蒙子宁林浩然阳江职业技术学院生命科学与技术系广东阳江529566 中山大学水生经济动物研究所暨广东省水生经济动物良种繁育重点实验室广东广州510275

石斑鱼类(Groupers)是世界性海洋经济鱼类,也是中国南方沿海省份重要的海水增养殖对象,其种类繁多,由于缺乏明显的种间外部形态区别特征,石斑鱼的分类一直是鱼类系统分类学的一个难题,存在着较多的争议和混淆。为了从分子水平揭示石斑... 详细信息

石斑鱼类(Groupers)是世界性海洋经济鱼类,也是中国南方沿海省份重要的海水增养殖对象,其种类繁多,由于缺乏明显的种间外部形态区别特征,石斑鱼的分类一直是鱼类系统分类学的一个难题,存在着较多的争议和混淆。为了从分子水平揭示石斑鱼类的系统进化关系,应用线粒体细胞色素b基因(Cyt b)及两个核糖体RNA基因(16S和12S)序列联合构建系统进化树对中国近海石斑鱼亚科3属13种进行种类鉴定及亲缘关系分析,探讨了石斑鱼类的分子系统进化。结果表明:①线粒体基因序列在石斑鱼类种间存在较大的变异,种内变异极小,是进行石斑鱼类种类鉴定较为适宜的分子标记;②所研究的3属13种石斑鱼类中,石斑鱼属与九棘鲈属的亲缘关系较近,与鳃棘鲈属的较远;③赤点石斑鱼和青石斑鱼、蜂巢石斑鱼与鲑点石斑鱼、斜带石斑鱼与棕斑石斑鱼两两间具有较近的亲缘关系。

关键词：石斑鱼类 Cyt b 16S rRNA 12S rRNA 分子系统进化