Neural substrates for regulating self-grooming behavior in rodents

作     者：Guanqing LI Chanyi LU Miaomiao YIN Peng WANG Pengbo ZHANG Jialiang WU Wenqiang WANG Ding WANG Mengyue WANG Jiahan LIU Xinghan LIN Jian-Xu ZHANG Zhenshan WANG Yiqun YU Yun-Feng ZHANG Guanqing LI;Chanyi LU;Miaomiao YIN;Peng WANG;Pengbo ZHANG;Jialiang WU;Wenqiang WANG;Ding WANG;Mengyue WANG;Jiahan LIU;Xinghan LIN;Jian-Xu ZHANG;Zhenshan WANG;Yiqun YU;Yun-Feng ZHANG

作者机构：State Key Laboratory of Integrated Management of Pest Insects and RodentsInstitute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic InteractionsUniversity of Chinese Academy of SciencesBeijing 100101China School of Life SciencesHebei UniversityBaoding 071002China State Key Laboratory of Molecular Development BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Rehabilitation MedicineTianjin Huanhu HospitalTianjin 300350China Medical Center for Human ReproductionBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100101China Department of Gastrointestinal Surgerythe People’s Hospital of Zhaoyuan CityZhaoyuan 265400China School of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of OtolaryngologyEyeEarNose&Throat HospitalFudan UniversityShanghai 200031China EarNose&Throat InstituteEyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Clinical and Research Center for Olfactory DisordersEyeEarNose&Throat HospitalFudan UniversityShanghai 200031China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2024年第25卷第10期

页      面：841-856页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the National Natural Science Foundation of China(No.82371515) the Talent Initiation BaiRen Plan Start-up Funds(No.E251F811) the State Key Laboratory of Integrated Management of Pest Insects and Rodents(No.IPM2301),China 

主　　题：Grooming Repetitive behavior Syntactic chain Cephalocaudal progression Neuropsychiatric disorders 

摘      要：Grooming,as an evolutionarily conserved repetitive behavior,is common in various animals,including humans,and serves essential functions including,but not limited to,hygiene maintenance,thermoregulation,de-arousal,stress reduction,and social *** rodents,grooming involves a patterned and sequenced structure,known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style,beginning from the nose to the face,to the head,and finally ending with body *** context-dependent occurrence of grooming behavior indicates its adaptive *** review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming *** further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models,holding promise for translational ***,we mainly focus on rodent ***(grooming being applied on one animal by its conspecifics via licking or carefully nibbling)and heterogrooming(a form of grooming behavior directing towards another animal,which occurs in other contexts,such as maternal,sexual,aggressive,or social behaviors)are not covered due to space constraints.