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Rare Metals 2023年第9期42卷 2840-2867页

作者： yu Zheng Xue-Xia Lan xing-yu xiong Bin yuan Ren-Zong Hu School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou510640China

Fascinating with high specific capacity and moderate lithiation potential,SnO_(x)-based materials have been intensively investigated as one of the most promising anodes for lithium-ion ***,due to poor cycling stability,sluggish reaction kinetics,and limited electrochemical reaction reversibility,the development of SnO_(x)-based anodes has been *** the current preparation and modification routes for SnO_(x)-based anodes lack direct and specific ***,modification routes for SnO_(x)-based anodes have been ***,to provide more direct instructions,the tuning routes of morphological structure for SnO_(x)-based electrodes(including slurry-based and self-supported)have been thoroughly discussed from the preparation ***,according to the properties of SnO_(x)-based anodes,the phase structure design ideas have also been properly classified and organized for addressing chemical reaction kinetics or thermodynamic ***,for future-oriented studies,new insights into the development and commercialization prospects of SnO_(x)-based anodes are also *** review,with comprehensive information on SnO_(x)-based anodes,aims to bring more specific guidance and valuable inspiration for peer researchers who are promoting the application of SnO_(x)-based materials for energy conversion and storage devices.

关键词： Lithium-ion battery(LIB) SnO_(x)-based anodes Reaction kinetics Morphological structure tuning Phase structure design

The comparison of survival between active surveillance or watchful waiting and focal laser ablation in patients with low-risk prostate cancer

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Asian Journal of Andrology 2022年第5期24卷 494-499页

作者： Jia-Kun Li Chi-Chen Zhang Shi Qiu Kun Jin Bo-yu Cai Qi-Ming yuan xing-yu xiong Lian-Sha Tang Di Jin Xiang-Hong Zhou Yi-Ge Bao Lu Yang Qiang Wei Department of Urology Institute of UrologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of Biotherapy Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041China

Prostate cancer(PCa)is the second-most common cancer among *** active surveillance or watchful waiting(AS/WW)and focal laser ablation(FLA)can avoid the complications caused by radical *** to make the choice between these options in clinical practice needs further ***,this study aims to compare and analyze their effects based on overall survival(OS)and cancer-specific survival(CSS)to obtain better long-term *** included patients with low-risk PCa from the Surveillance Epidemiology and End Results database of 2010–*** Cox proportional hazard analyses were conducted for OS and CSS in the two *** eliminate bias,this study applied a series of sensitivity ***,Kaplan–Meier curves were plotted to obtain survival status.A total of 18841 patients with low-risk PCa were included,with a median of 36-month *** to the multivariate Cox proportional hazard regression,the FLA group presented inferior survival benefits in OS than the AS/WW group(hazard ratio[HR]:2.13,95%confidence interval[CI]:1.37–3.33,P<0.05).After adjusting for confounders,the result persisted(HR:1.69,95%CI:1.02–2.81,P<0.05).According to the results of the sensitivity analysis,the inverse probability of the treatment weighing model indicated the same result in *** conclusion,AS/WW and FLA have the advantage of fewer side effects and the benefit of avoiding overtreatment compared with standard *** study suggested that AS/WW provides more survival benefits for patients with low-risk *** relevant researches and data will be needed for further clarity.

关键词： active surveillance cancer-specific survival focal laser ablation low-risk prostate cancer overall survival watchful waiting

Neoadjuvant chemotherapy for patients with locally advanced penile cancer:an updated evidence

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Asian Journal of Andrology 2022年第2期24卷 180-185页

作者： Xian-Yan-Ling Yi De-Hong Cao Ping-Hong You xing-yu xiong Xiao-Nan Zheng Ge Peng Da-Zhou Liao Hong Li Lu Yang Jian-Zhong Ai Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology People’s Hospital of Deyang CityDeyang 618000China Department of Endocrinology and Metabolism West China Hospital of Sichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy(NAC)has shown promising results in patients with locally advanced penile ***,no consensus exists on its applications for locally advanced penile ***,it is unclear which kind of chemotherapy regimen is the best ***,a systematic search of PubMed,Web of Science,and EMBASE was performed in March 2021 to assess the efficacy and safety of NAC for the treatment of patients with locally advanced penile *** Newcastle–Ottawa Scale was used to assess the risk of bias in each *** study synthesized 14 published *** study revealed that patients who achieved an objective response to NAC obtained a better survival outcome compared with those who did not achieve an objective *** addition,the objective response rates(ORRs)and pathological complete response(pCR)rates were 0.57 and 0.11,*** incidence of grade≥3 toxicity was *** analysis found that the ORR and pCR of the taxane–platinum(TP)regimen group performed better than those of the nontaxane–platinum(NTP)regimen group(0.57 vs 0.54 and 0.14 vs 0.07,respectively).Moreover,the TP regimen group had more frequent toxicity than the NTP regimen group(0.41 vs 0.26).However,further studies were warranted to confirm the findings.

关键词： chemotherapy regimen locally advanced penile cancer neoadjuvant chemotherapy response rate

The role of prostate-specific antigen density and negative multiparametric magnetic resonance imaging in excluding prostate cancer for biopsynaive men:clinical outcomes from a high-volume center in China

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Asian Journal of Andrology 2022年第6期24卷 615-619页

作者： Chi-Chen Zhang Xiang Tu Tian-Hai Lin Di-Ming Cai Ling Yang Ling Nie Shi Qiu Zhen-Hua Liu Kun Jin Jia-Kun Li xing-yu xiong Lu Yang Qiang We Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Ultrasound West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Department of Pathology and Laboratory of Pathology State Key Laboratory of BiotherapyWest China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041China

This study aimed to assess the role of prostate-specific antigen density(PSAD)and negative multiparametric magnetic resonance imaging(mpMRI)in predicting prostate cancer for biopsy-naive men based on a large cohort of the Chinese *** a prostate biopsy database between March 2017 and July 2021,we retrospectively identified 240 biopsy-naive patients with negative prebiopsy mpMRI(Prostate Imaging Reporting and Data System version 2[PI-RADS v2]score<3).Logistic regression analysis was performed to select the potential predictors for clinically significant prostate cancer(csPCa).Receiver operating characteristic(ROC)curve analysis and area under the ROC curve(AUC)were performed to assess the diagnostic *** negative predictive values of mpMRI in excluding any cancer and csPCa were 83.8%(201/240)and 90.8%(218/240),respectively.R0C curve analysis indicated that PSAD was the most promising predictor,with an AUC value of 0.786(95%confidence interval[CI]:0.699-0.874),and multiparametric logistic regression analysis confirmed that higher PSAD remained a significant marker for predicting csPCa(odds ratio[0R]:10.99,95%CI:2.75-44.02,P<0.001).Combining negative mpMRI and PSAD below 0.20 ng ml^(-2)obviously increased the predictive value in excluding PCa(91.0%,101/111)or csPCa(100.0%,111/111).If a PSAD below 0.20 ng ml^(-2)was set as the criterion to omit biopsy,nearly 46.3%of patients(463 per 1000)with negative mpMRI could safely avoid unnecessary biopsy,with approximately 4.2%of patients(42 per 1000)at risk of missed diagnosis of PCa and no patients with csPCa missed.A PI-RADS v2 score<3 and a PSAD<0.20 ng ml^(-2)could be potential criteria for the Chinese population to omit prompt biopsy safely.

关键词： biopsy magnetic resonance imaging predictive value prostate cancer prostate-specific antigen density transrectal ultrasound

ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

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Military Medical Research 2024年第5期11卷 643-662页

作者： Hang Xu Yi-Fan Li Xian-Yan-Ling Yi Xiao-Nan Zheng Yang Yang Yan Wang Da-Zhou Liao Jia-Peng Zhang Ping Tan xing-yu xiong Xi Jin Li-Na Gong Shi Qiu De-Hong Cao Hong Li Qiang Wei Lu Yang Jian-Zhong Ai Department of Urology West China HospitalSichuan UniversityChengdu610041China Institute of Urology West China HospitalSichuan UniversityChengdu610041China Animal Experimental Center West China HospitalSichuan UniversityChengdu610041China Research Core Facility West China HospitalSichuan UniversityChengdu610041China

Background Cell metabolism plays a pivotal role in tumor progression,and targeting cancer metabolism might effectively kill cancer *** aimed to investigate the role of hexokinases in prostate cancer(PCa)and identify a crucial target for PCa *** The Cancer Genome Atlas(TCGA)database,online tools and clinical samples were used to assess the expression and prognostic role of ADP-dependent glucokinase(ADPGK)in *** effect of ADPGK expression on PCa cell malignant phenotypes was validated in vitro and in *** proteomics,metabolomics,and extracellular acidification rate(ECAR)and oxygen consumption rate(OCR)tests were performed to evaluate the impact of ADPGK on PCa *** underlying mechanisms were explored through ADPGK overexpression and knockdown,co-immunoprecipitation(Co-IP),ECAR analysis and cell counting kit-8(CCK-8)*** ADPGK was the only glucokinase that was both upregulated and predicted worse overall survival(OS)in prostate adenocarcinoma(PRAD).Clinical sample analysis demonstrated that ADPGK was markedly upregulated in PCa tissues ***-PCa *** ADPGK expression indicates worse survival outcomes,and ADPGK serves as an independent factor of biochemical *** vitro and in vivo experiments showed that ADPGK overexpression promoted PCa cell proliferation and migration,and ADPGK inhibition suppressed malignant ***,proteomics,and ECAR and OCR tests revealed that ADPGK significantly accelerated glycolysis in ***,ADPGK binds aldolase C(ALDOC)to promote glycolysis via AMP-activated protein kinase(AMPK)*** was positively correlated with ADPGK,and high ALDOC expression was associated with worse survival outcomes in *** In summary,ADPGK is a driving factor in PCa progression,and its high expression contributes to a poor prognosis in PCa *** accelerates PCa glycolysis and progression by activating ALDOC-AMPK signaling,suggesting

关键词： Prostate cancer(PCa) ADP-dependent glucokinase(ADPGK) Aldolase C(ALDOC) AMPK Glycolysis

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Effects of Ginkgo biloba extract 50 on myocardial function in myocardium ischemic rats

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Effects of Ginkgo biloba extract 50 on myocardial function i...

低浓度高热导率的石墨烯/树脂复合物及其应用

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ai-Hua LIU,Yi-Min BAO,xing-yu WANG,Zhi-xiong ZHANG~* Shanghai University of Traditional Chinese Medicine,Shanghai 201203

＜正＞Objective:To study the effects of Ginkgo biloba extract 50（GBE50） on myocardial function,area at risk and myocardial ultra-structure in myocardium ischemic ***:Myocardium ischemia was induced by the left anterior descending（LAD） coronary artery occlusion and myocardial function was *** vitro myocardial infarction was measured by 2,3,5-triphenyltetrazolium chloride（TTC） and Evans blue staining of heart *** hematoxylin and eosin（HE） staining was used for morphological evaluation by light microscopy. Results:Hemodynamic experiments in vivo showed that postischemic cardiac contractile function was reduced in ischemic ***（7.5 g/kg/d×7） and GBE50（100 mg/kg/d×7） improved postischemic cardiac diastolic dysfunction. The area at risk was significantly reduced and myocardial structure was better-preserved in hearts of GBE50 group and SM ***:GBE50 could attenuate myocardium damage induced by ischemia and provide potent myocardial protection.

关键词： GBE50 cardiac ischemia myocardial function area at risk ultra-structure

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工程热物理学报 2016年第2期37卷 366-371页

作者：张海燕林锦邢羽雄张丹枫洪浩群李春辉广东工业大学材料与能源学院广州510006 广东省功能软凝聚态物质重点实验室广州510006

当多个LED密集排列组成大功率照明系统时,散热问题成为影响LED灯发光性能的主要技术瓶颈之一,因此解决散热问题已成为功率型LED应用的先决条件。本文将功能化石墨烯与硅树脂复合制备出了低填充量高导热性能的石墨烯/硅树脂复合材料。石... 详细信息

当多个LED密集排列组成大功率照明系统时,散热问题成为影响LED灯发光性能的主要技术瓶颈之一,因此解决散热问题已成为功率型LED应用的先决条件。本文将功能化石墨烯与硅树脂复合制备出了低填充量高导热性能的石墨烯/硅树脂复合材料。石墨烯(Graphene)填充质量分数为0.015时,复合材料的热导率高达2.758 W/(m·K),比纯硅脂基体提高了13倍;添加石墨烯后明显改善了硅树脂的热稳定性。将该复合材料作为热界面材料应用于大功率LED芯片模组基板与灯具冷却外壳之间的散热,能获得很好的增强效果,结果表明石墨烯填充质量分数仅为0.008时,基板与外壳之间的温度差究可达到小于5℃,满足大功率LED灯具的散热要求。

关键词：石墨烯热导系数大功率LED 照明光源

低浓度高热导率的石墨烯/树脂复合物及其应用

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工程热物理学报 2015年第11期36卷 2445-2450页

作者：张海燕林锦邢羽雄张丹枫洪浩群李春辉广东工业大学材料与能源学院广州510006 广东省功能软凝聚态物质重点实验室广州510006

当多个LED密集排列组成大功率照明系统时,散热问题成为影响LED灯发光性能的主要技术瓶颈之一,因此解决散热问题已成为功率型LED应用的先决条件。本文将功能化石墨烯与硅树脂复合制备出了低填充量高导热性能的石墨烯/硅树脂复合材料。石墨烯(Graphene)填充质量分数为0.015时,复合材料的热导率高达2.758 W/(m.K),比纯硅脂基体提高了13倍;添加石墨烯后明显改善了硅树脂的热稳定性。将该复合材料作为热界面材料应用于大功率LED芯片模组基板与灯具冷却外壳之间的散热,能获得很好的增强效果,结果表明石墨烯填充质量分数仅为0.008时,基板与外壳之间的温度差可达到小于5℃,满足大功率LED灯具的散热要求。

关键词：石墨烯热导系数大功率LED 照明光源

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白细胞介素-8在前列腺癌发生发展中的作用

医学新知 2021年第5期31卷 383-389页

作者：王晟熊性宇杨璐四川大学华西医院泌尿外科成都610041 四川大学华西医院泌尿外科研究所成都610041 四川大学华西临床医学院成都610041

前列腺癌(prostate cancer,PCa)作为男性最常见的恶性肿瘤之一,严重威胁着中老年男性健康。目前PCa在预测、诊断、治疗和预后等方面面临着诸多挑战,虽然现阶段应用于临床的PCa生物标志物具有一定意义,但尚不能充分满足临床需求。细胞因... 详细信息

前列腺癌(prostate cancer,PCa)作为男性最常见的恶性肿瘤之一,严重威胁着中老年男性健康。目前PCa在预测、诊断、治疗和预后等方面面临着诸多挑战,虽然现阶段应用于临床的PCa生物标志物具有一定意义,但尚不能充分满足临床需求。细胞因子白细胞介素-8(interleukin-8,IL-8)已被证实在PCa的发生发展中起着重要作用,本文总结了IL-8在前列腺组织中的表达、IL-8相关信号传递通路以及其促进PCa发生和进展的机制,以期能够为PCa的诊断、治疗和预后评估提供参考。

关键词：前列腺癌白细胞介素-8 靶向治疗