检索结果-南通市图书馆

Initial transcatheter thrombolysis for acute superior mesenteric venous thrombosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第18期20卷 5483-5492页

作者： Shuo-Fei Yang Bao-Chen Liu Wei-Wei Ding Chang-Sheng He xing-jiang wu Jie-Shou Li Research Institute of General Surgery Jinling HospitalMedical School of Nanjing University

AIM: To determine the optimal initial treatment modality for acute superior mesenteric vein thrombosis (ASMVT) in patients with circumscribed peritonitis.

关键词： Acute superior mesenteric venous thrombosis Transcatheter thrombolysis Initial management Circumscribed peritonitis

Delayed liver laceration following transjugular intrahepatic portosystemic shunt for portal hypertension

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第48期18卷 7405-7408页

作者： Kai Liu Xin-Xin Fan Xu-Lin Wang xing-jiang wu Research Institute of General Surgery Jinling HospitalClinical School of MedicineNanjing University

The transjugular intrahepatic portosystemic shunt(TIPS) is an acceptable procedure that has proven benefits in the treatment of patients who have complications from portal hypertension due to liver *** liver laceration is a rare complication of the TIPS *** describe a patient with portal hypertension due to liver cirrhosis,who suddenly presented with abdominal hemorrhage and liver laceration 8 d after *** reports have described complications after TIPS *** the best of our knowledge,this is the first report describing delayed liver *** potential and serious complication appears to be specific and fatal for TIPS in portal *** advocate careful attention to the technique to avoid this complication,and timely treatment is extremely important.

关键词： Transjugular intrahepatic portosystemic shunt Portal hypertension Liver cirrhosis Postoperative complications Hemorrhage

Scientific workflow execution system based on mimic defense in the cloud environment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2018年第12期19卷 1522-1536页

作者： Ya-wen WANG jiang-xing wu Yun-fei GUO Hong-chao HU Wen-yan LIU Guo-zhen CHENG National Digital Switching System Engineering Technology Research Center

With more large-scale scientific computing tasks being delivered to cloud computing platforms, cloud workflow systems are designed for managing and arranging these complicated tasks. However, multi-tenant coexistence service mode of cloud computing brings serious security risks, which will threaten the normal execution of cloud workflows. To strengthen the security of cloud workflows, a mimic cloud computing task execution system for scientific workflows is proposed. The idea of mimic defense contains mainly three aspects: heterogeneity, redundancy, and dynamics. For heterogeneity, the diversities of physical servers, hypervisors, and operating systems are integrated to build a robust system framework. For redundancy, each sub-task of the workflow will be executed simultaneously by multiple executors. Considering efficiency and security, a delayed decision mechanism is proposed to check the results of task execution. For dynamics, a dynamic task scheduling mechanism is devised for switching workflow execution environment and shortening the life cycle of executors, which can confuse the adversaries and purify task executors. Experimental results show that the proposed system can effectively strengthen the security of cloud workflow execution.

关键词： Scientific workflow Mimic defense Cloud security Intrusion tolerance

Loss Aware Feature Attention Mechanism for Class and Feature Imbalance Issue

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 751-775页

作者： Yuewei wu Ruiling Fu Tongtong xing Fulian Yin College of Information and Communication Engineering Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

In the Internet era,recommendation systems play a crucial role in helping users find relevant information from large *** imbalance is known to severely affect data quality,and therefore reduce the performance of recommendation *** to the imbalance,machine learning algorithms tend to classify inputs into the positive(majority)class every time to achieve high prediction *** can be categorized such as by features and classes,but most studies consider only class *** this paper,we propose a recommendation system that can integrate multiple networks to adapt to a large number of imbalanced features and can deal with highly skewed and imbalanced datasets through a loss *** propose a loss aware feature attention mechanism(LAFAM)to solve the issue of feature *** network incorporates an attention mechanism and uses multiple sub-networks to classify and learn *** better results,the network can learn the weights of sub-networks and assign higher weights to important *** propose suppression loss to address class imbalance,which favors negative loss by penalizing positive loss,and pays more attention to sample points near the decision *** on two large-scale datasets verify that the performance of the proposed system is greatly improved compared to baseline methods.

关键词： Imbalanced data deep learning e-commerce recommendation loss function big data analysis

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You wu Lijie Yang Wanrong jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

Innuence of portal pressure change on intestinal permeability in patients with portal hypertension

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2002年第4期1卷 510-514页

作者： Wei-Hua Xu xing-jiang wu Jie-Shou Li the Dapartment of General Surgery, Jinling Hospital, Nanjing 210002, China

Objective: To investigate intestinal permeability in patients with portal hypertension and its relationship with portal pressure. Methods: Twenty patients with portal hypertension were divided into two groups (A, B), 10 patients per group. In group A, patients were treated with com- bined transjugular intrahepatic portosystemic shunt (TIPS) and modified Sugiura. In group B, patients were treated with modified Sugiura only. Intestinal permeability was assessed before operation, two weeks after TIPS. and two weeks after modified Sug- iura; 20 healthy control subjects were also assessed. Results: Intestinal permeability was significantly higher in the patients than in the control group (P< 0. 01). In group A, portal pressure, intestinal per- meability decreased two weeks after TIPS (P< 0. 05), and no obvious change was noted two weeks after modified Sugiura; but they were significantly lower than those before TIPS (P<0. 05). In group B, intestinal permeability was not different before and after operation. Intestinal permeability in group A was not different from that in group B before treatment, but significantly lower after modified Su- giura (P<0. 05). Portal pressure was significantly correlated with intestinal permeability (r=0. 627, P <0. 01). Conclusions: This study shows that combined TIPS and modified Sugiura can lower portal pressure and intestinal permeability, and enhance the therapeutic efficacy on portal hypertension.

关键词： portal hypertension portasystemic shunt surgery intestinal permeability

在线全文

学校读者我要写书评

暂无评论

美丽乡村建设与农业遗产保护耦合发展研究

中国农史 2017年第1期36卷 136-142页

作者：魏家星姜卫兵武涛南京农业大学园艺学院江苏南京210019

中国悠久的农业历史留下了丰富的农业遗产,农业遗产的保护对乡村建设及可持续发展等具有重要意义,随着近年来美丽乡村建设的如火如荼,如何在大规模建设中有效保护农业遗产已成为一个严峻而迫切的课题,本文剖析了美丽乡村建设与农业遗产... 详细信息

中国悠久的农业历史留下了丰富的农业遗产,农业遗产的保护对乡村建设及可持续发展等具有重要意义,随着近年来美丽乡村建设的如火如荼,如何在大规模建设中有效保护农业遗产已成为一个严峻而迫切的课题,本文剖析了美丽乡村建设与农业遗产保护的内在关系,从政府政绩、土地政策、规划水平、财政投入、管理体制等五个方面,探究美丽乡村建设对农业遗产保护的不利影响因素,最后提出了基于农业遗产保护的美丽乡村发展对策,以达到两者之间的耦合。

关键词：美丽乡村建设农业遗产保护耦合对策

在线全文

学校读者我要写书评

暂无评论

茶树茶氨酸的代谢及其育种研究进展

园艺学报 2016年第9期43卷 1791-1802页

作者：方开星姜晓辉吴华玲广东省农业科学院茶叶研究所广东省茶树资源创新利用重点实验室广州510640

茶氨酸是茶树特征性生化物质,不仅能调节茶树氮代谢及转运,影响茶叶品质,同时对人体还具有镇静、安神等保健功能。茶氨酸含量是数量性状,在茶树体内合成不仅受基因调控且易受环境影响。对茶氨酸的分布及变化规律、代谢途径及相关基因、... 详细信息

茶氨酸是茶树特征性生化物质,不仅能调节茶树氮代谢及转运,影响茶叶品质,同时对人体还具有镇静、安神等保健功能。茶氨酸含量是数量性状,在茶树体内合成不仅受基因调控且易受环境影响。对茶氨酸的分布及变化规律、代谢途径及相关基因、外界影响因子及高茶氨酸品种选育等研究现状进行了综述,旨在为高茶氨酸茶树种质筛选及其高含量形成的机制研究提供参考。

关键词：茶树茶氨酸育种基因

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting xing Peng Yin Shihua Li Xiao-jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor