检索结果-南通市图书馆

Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

引用

Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma xing-Yao yin Zhao-Yun Zong Yuan-Yuan Tan Ya-Ming Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is indispensable.However,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the earth.Hence,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical experiments.Based on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic background.Further,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked rock.The analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity anisotropy.Moreover,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip angle.The increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip angle.By comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness coefficients.Moreover,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the orthorhombic rock.

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strengthening of the concrete face slabs of dams using sprayable strain-hardening fiber-reinforced cementitious composites

引用

Frontiers of Structural and Civil Engineering 2022年第2期16卷 145-160页

作者： Qinghua LI xing yin Botao HUANG Yifeng ZHANG Shilang XU Institute of Advanced Engineering Structures and Materials Zhejiang UniversityHangzhou 310058China

In this study,sprayable strain-hardening fiber-reinforced cementitious composites(FRCC)were applied to strengthen the concrete slabs in a concrete-face rockfill dam(CFRD)for the first time.Experimental,numerical,and analytical investigations were carried out to understand the flexural properties of FRCC-layered concrete slabs.It was found that the FRCC layer improved the flexural performance of concrete slabs significantly.The cracking and ultimate loads of a concrete slab with an 80 mm FRCC layer were 132%and 69%higher than those of the unstrengthened concrete slab,respectively.At the maximum crack width of 0.2 mm,the deflection of the 80-mm FRCC strengthened concrete slab was 144%higher than that of the unstrengthened concrete slab.In addition,a FE model and a simplified analytical method were developed for the design and analysis of FRCC-layered concrete slabs.Finally,the test result of FRCC leaching solution indicated that the quality of the water surrounding FRCC satisfied the standard for drinking water.The findings of this study indicate that the sprayable strain-hardening FRCC has a good potential for strengthening hydraulic structures such as CFRDs.

关键词： strain-hardening cementitious composites engineered cementitious composites sprayable shotcrete strengthening concrete-face rockfill dam digital image correlation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multifunctional Perovskite Photodetectors: From Molecular-Scale Crystal Structure Design to Micro/Nano-scale Morphology Manipulation

引用

Nano-Micro Letters 2023年第10期15卷 565-594页

作者： yingjie Zhao xing yin Pengwei Li Ziqiu Ren Zhenkun Gu Yiqiang Zhang Yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190People’s Republic of China

Multifunctional photodetectors boost the development of traditional optical communication technology and emerging artificial intelligence fields, such as robotics and autonomous driving. However, the current implementation of multifunctional detectors is based on the physical combination of optical lenses, gratings, and multiple photodetectors, the large size and its complex structure hinder the miniaturization, lightweight, and integration of devices. In contrast, perovskite materials have achieved remarkable progress in the field of multifunctional photodetectors due to their diverse crystal structures, simple morphology manipulation, and excellent optoelectronic properties. In this review, we first overview the crystal structures and morphology manipulation techniques of perovskite materials and then summarize the working mechanism and performance parameters of multifunctional photodetectors. Furthermore, the fabrication strategies of multifunctional perovskite photodetectors and their advancements are highlighted, including polarized light detection, spectral detection, angle-sensing detection, and selfpowered detection. Finally, the existing problems of multifunctional detectors and the perspectives of their future development are presented.

关键词： Perovskite materials Crystal structure design Micro/nano-structure manipulation Working mechanism Multifunctional photodetectors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis

引用

International Journal of Oral Science 2022年第3期14卷 360-370页

作者： Liyuan Yu Kai Xia Jing Zhou Zhiai Hu xing yin Chenchen Zhou Shujuan Zou Jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Stomatology Kunming Yan’an hospitalKunmingChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Human adipose-derived stem cells(hASCs)are a promising cell type for bone tissue regeneration.Circular RNAs(circRNAs)have been shown to play a critical role in regulating various cell differentiation and involve in mesenchymal stem cell osteogenesis.However,how circRNAs regulate hASCs in osteogenesis is still unclear.Herein,we found circ_0003204 was significantly downregulated during osteogenic differentiation of hASCs.Knockdown of circ_0003204 by si RNA or overexpression by lentivirus confirmed circ_0003204 could negatively regulate the osteogenic differentiation of hASCs.We performed dual-luciferase reporting assay and rescue experiments to verify circ_0003204 regulated osteogenic differentiation via sponging miR-370-3p.We predicted and confirmed that miR-370-3p had targets in the 3′-UTR of HDAC4 m RNA.The following rescue experiments indicated that circ_0003204 regulated the osteogenic differentiation of hASCs via miR-370-3p/HDAC4 axis.Subsequent in vivo experiments showed the silencing of circ_0003204 increased the bone formation and promoted the expression of osteogenic-related proteins in a mouse bone defect model,while overexpression of circ_0003204 inhibited bone defect repair.Our findings indicated that circ_0003204 might be a promising target to promote the efficacy of hASCs in repairing bone defects.

关键词： regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis miR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MBG/PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features

引用

Bioactive Materials 2022年第9期7卷 53-67页

作者： Jiangfeng Li Chunyi Wang Guoxing Gao xing yin Ximing Pu Bing Shi Yang Liu Zhongbing Huang Juan Wang Jingtao Li Guangfu yin College of Biomedical Engineering Sichuan UniversityChengdu610065PR China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu610041PR China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041PR China Shandong Provincial Key Laboratory of Biomedical Polymers Shandong Academy of Pharmaceutical SciencesJinan250101PR China

It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone grafts.In this study,we aimed to address this challenge by incorporating mesoporous bioactive glass(MBG)into poly(caprolactone-co-glycolide)(PGA-PCL)at gradient ratios.MBG/PGA-PCL(PGC/M)scaffolds with MBG incorporation ratio at 0,10%,25%and 40%(PGC/M0-40)were synthesized using a modified solvent casting-particulate leaching method,and their physiochemical and biological properties were comprehensively evaluated.PGC/M scaffolds exhibited highly perforated porous structure with a large-pore size of 300-450μm,with ordered MBGs of around 6.0 nm mesopores size uniformly dispersed.The increase in MBG incorporation ratio significantly improved the scaffold surface hydrophilicity,apatite-formation ability and pH stability,increased the weight loss rate while insignificantly influenced the molecular chains degradation of PGA-PCL component,and facilitated the attachment,spreading,viability and proliferation of rat bone marrow stromal cells(rBMSCs)on scaffolds.Moreover,rBMSCs cultured on PGC/M10-40 scaffolds demonstrated enhanced ALP activity and osteogenesis-related gene expression in a MBG dose-dependent manner as compared with those cultured on PGC/M0 scaffolds.When implanted to the rat cranial bone defect,PGC/M25 and PGC/M40 scaffolds induced significantly better bone repair as compared to PGC/M0 and PGC/M10 scaffolds.Besides,the biodegradability of PGC/M scaffolds correlated with the MBG incorporation ratio.These data suggested this novel PGC/M scaffolds as promising bone repair biomaterial with highly tunable hydrophilicity,bioactivity,cytocompatibility,osteogenic activity as well as biodegradability.

关键词： Mesoporous bioactive glasses Poly(caprolactone-co-glycolide) Osteogenic differentiation Bone repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling

引用

International Journal of Oral Science 2023年第3期15卷 437-449页

作者： Tiancheng Li Han Wang Yukun Jiang Shuo Chen Danyuan Huang Zuping Wu xing yin Chenchen Zhou Yuyu Li Shujuan Zou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Orthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghaiChina

Orthodontically induced tooth root resorption(OIRR)is a serious complication during orthodontic treatment.Stimulating cementum repair is the fundamental approach for the treatment of OIRR.Parathyroid hormone(PTH)might be a potential therapeutic agent for OIRR,but its effects still lack direct evidence,and the underlying mechanisms remain unclear.This study aims to explore the potential involvement of long noncoding RNAs(lncRNAs)in mediating the anabolic effects of intermittent PTH and contributing to cementum repair,as identifying lncRNA-disease associations can provide valuable insights for disease diagnosis and treatment.Here,we showed that intermittent PTH regulates cell proliferation and mineralization in immortalized murine cementoblast OCCM-30 via the regulation of the Wnt pathway.In vivo,daily administration of PTH is sufficient to accelerate root regeneration by locally inhibiting Wnt/β-catenin signaling.Through RNA microarray analysis,lncRNA LITTIP(LGR6 intergenic transcript under intermittent PTH)is identified as a key regulator of cementogenesis under intermittent PTH.Chromatin isolation by RNA purification(ChIRP)and RNA immunoprecipitation(RIP)assays revealed that LITTIP binds to mRNA of leucine-rich repeatcontaining G-protein coupled receptor 6(LGR6)and heterogeneous nuclear ribonucleoprotein K(HnRNPK)protein.Further cotransfection experiments confirmed that LITTIP plays a structural role in the formation of the LITTIP/Lgr6/HnRNPK complex.Moreover,LITTIP is able to promote the expression of LGR6 via the RNA-binding protein HnRNPK.Collectively,our results indicate that the intermittent PTH administration accelerates root regeneration via inhibiting Wnt pathway.The lncRNA LITTIP is identified to negatively regulate cementogenesis,which activates Wnt/β-catenin signaling via high expression of LGR6 promoted by HnRNPK.

关键词： involvement diagnosis cement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论数字经济与社会主义市场经济的深度融合

引用

中国工业经济 2024年第5期 5-19页

作者：洪银兴任保平南京大学长江三角洲经济社会发展研究中心南京大学数字经济与管理学院

数字经济与社会主义市场经济深度融合体现了制度与技术的协同,能够推动建设高水平社会主义市场经济体制。社会主义市场经济与数字经济同处于一个经济体中,两者的运行和作用融为一体形成合力。数字经济是以其技术手段融入社会主义市场经... 详细信息

数字经济与社会主义市场经济深度融合体现了制度与技术的协同,能够推动建设高水平社会主义市场经济体制。社会主义市场经济与数字经济同处于一个经济体中,两者的运行和作用融为一体形成合力。数字经济是以其技术手段融入社会主义市场经济,形成数字化市场经济,为社会主义市场经济有效运行提供技术平台和手段,推进高水平社会主义市场体制的建设。社会主义市场经济是以其制度要素融入数字经济,形成市场化数字经济。本文根据党的二十大提出的社会主义市场经济基础制度内容,分别考察数字经济与产权保护、市场准入、公平竞争、社会信用的双向深度融合。数字经济完善产权保护,涉及数据产权保护,实现数据要素在流通、使用中的价值增值;数字经济完善市场准入,数字经济的各类要素和数字经济主体自主进入市场,推动全国统一大数据市场建设;数字经济完善公平竞争,数字经济在提供反垄断和反不正当竞争手段的同时,自身也有反垄断和反不正当竞争的特定要求;数字经济以数字技术和平台完善社会信用制度的同时,自身也需要建设社会信用体系。

关键词：数字经济社会主义市场经济基础制度市场秩序

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Condition-based maintenance optimization for continuously monitored degrading systems under imperfect maintenance actions

引用

Journal of Systems Engineering and Electronics 2020年第4期31卷 841-851页

作者： CHEN Chuang LU Ningyun JIANG Bin xing yin College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China Jiangsu Key Laboratory of Internet of Things and Control Technologies Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China

Condition-based maintenance(CBM) is receiving increasing attention in various engineering systems because of its effectiveness. This paper formulates a new CBM optimization problem for continuously monitored degrading systems considering imperfect maintenance actions. In terms of maintenance actions,in practice, they scarcely restore the system to an as-good-as new state due to residual damage. According to up-to-data researches, imperfect maintenance actions are likely to speed up the degradation process. Regarding the developed CBM optimization strategy, it can balance the maintenance cost and the availability by the searching the optimal preventive maintenance threshold.The maximum number of maintenance is also considered, which is regarded as an availability constraint in the CBM optimization problem. A numerical example is introduced, and experimental results can demonstrate the novelty, feasibility and flexibility of the proposed CBM optimization strategy.

关键词： condition-based maintenance(CBM) imperfect maintenance maintenance cost availability constraint optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低氧条件下食管癌来源外泌体调控巨噬细胞M2型分化与自噬的机制研究

引用

中国免疫学杂志 2024年第2期40卷 299-304,311页

作者：尹星邢艳丽常欢周阳付民尹先哲南阳市第二人民医院肿瘤科一病区南阳473000

目的:探究低氧条件下食管癌外泌体对巨噬细胞分化和自噬的影响及机制。方法:50 ng/ml PMA诱导THP-1分化为M0型巨噬细胞,超速离心法提取并鉴定HEEC、Eca-109、缺氧诱导的Eca-109细胞分泌的外泌体(记为HEEC-exo、NomEca-109-exo、Hypo-Eca... 详细信息

目的:探究低氧条件下食管癌外泌体对巨噬细胞分化和自噬的影响及机制。方法:50 ng/ml PMA诱导THP-1分化为M0型巨噬细胞,超速离心法提取并鉴定HEEC、Eca-109、缺氧诱导的Eca-109细胞分泌的外泌体(记为HEEC-exo、NomEca-109-exo、Hypo-Eca-109-exo),激光共聚焦显微镜观察巨噬细胞对外泌体的摄取,将PBS、HEEC exo、Nom-Eca-109-exo、HypoEca-109-exo分别与M0型巨噬细胞共孵育,流式细胞术检测各组细胞CD14和CD206表达,ELISA检测细胞因子IL-1β、IL-12、TNF-α、Arg1、IL-10和TGF-β,qRT-PCR检测各组细胞CCR7、TLR2、CD206和CD14表达,Transwell检测各组细胞迁移和侵袭,Western blot检测各组细胞自噬相关蛋白LC3-Ⅰ、LC3-Ⅱ、Beclin-1和p62表达及PI3K、Akt、mTOR磷酸化水平。结果:提取的外泌体符合结构和生物学特征。相比于PBS组,与Nom-Eca-109-exo、Hypo-Eca-109-exo孵育后,各组M0型巨噬细胞CCR7、TLR2表达显著降低、CD206和CD14表达显著增加,IL-1β、IL-12、TNF-α分泌显著减少,Arg1、IL-10和TGF-β分泌显著增加,LC3-Ⅱ、Beclin-1表达显著增加,p62表达显著降低,细胞迁移和侵袭数显著增加,PI3K、Akt、mTOR磷酸化水平显著升高。相比于NomEca-109-exo组,Hypo-Eca-109-exo组细胞CD206和CD14表达显著增加,Arg1、IL-10和TGF-β分泌显著增加,LC3-Ⅱ、Beclin-1表达显著增加,p62表达显著降低,细胞迁移和侵袭数显著增加,PI3K、Akt、mTOR的磷酸化水平显著升高。结论:低氧诱导的食管癌细胞外泌体可显著促进M2型巨噬细胞分化和自噬,进而促进肿瘤迁移和侵袭,其机制为激活PI3K/Akt/mTOR信号通路。

关键词：低氧食管癌外泌体巨噬细胞分化自噬机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Autophagy in bone homeostasis and the onset of osteoporosis

引用

Bone Research 2019年第4期7卷 338-353页

作者： xing yin Chenchen Zhou Jingtao Li Renkai Liu Bing Shi Quan Yuan Shujuan Zou State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University

Autophagy is an evolutionarily conserved intracellular process,in which domestic cellular components are selectively digested for the recycling of nutrients and energy.This process is indispensable for cell homeostasis maintenance and stress responses.Both genetic and functional studies have demonstrated that multiple proteins involved in autophagic activities are critical to the survival,differentiation,and functioning of bone cells,including osteoblasts,osteocytes,and osteoclasts.Dysregulation at the level of autophagic activity consequently disturbs the balance between bone formation and bone resorption and mediates the onset and progression of multiple bone diseases,including osteoporosis.This review aims to introduce the topic of autophagy,summarize the understanding of its relevance in bone physiology,and discuss its role in the onset of osteoporosis and therapeutic potential.

关键词： homeostasis osteoporosis Autophagy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：