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高自旋多环芳烃的研究进展

广州化工 2024年第6期52卷 1-5页

作者：叶星根唐子龙房小靖曾望东湖南科技大学理论有机化学与功能分子教育部重点实验室湖南湘潭411100 湖南科技大学化学化工学院湖南湘潭411201 湖南科技大学材料科学与工程学院湖南湘潭411201

近年来,开壳多环芳烃由于其独特的光学、电学和磁学性质,受到了科学家们广泛的关注,尤其以碳材料为中心的开壳多环芳烃材料有了广泛的报道和研究。高自旋多环芳烃作为开壳多环芳烃的重要组成部分,由于高反应活性而导致其制备与表征极具... 详细信息

近年来,开壳多环芳烃由于其独特的光学、电学和磁学性质,受到了科学家们广泛的关注,尤其以碳材料为中心的开壳多环芳烃材料有了广泛的报道和研究。高自旋多环芳烃作为开壳多环芳烃的重要组成部分,由于高反应活性而导致其制备与表征极具挑战。本文将对具有高自旋基态的非那烯类中性自由基和三角烯及其衍生物的制备与表征进行详细的总结与说明。

关键词：开壳多环芳烃高自旋非那烯自由基 [n]三角烯

COUPLING EFFECT BETWEEN RELIABILITY OF BEDDING LAYER AND STABILITY OF DOWNSTREAM CONCRETE SLAB OF OVERFLOW EARTH-ROCK COFFERDAM

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Journal of Hydrodynamics 2007年第5期19卷 613-622页

作者： HU Zhi-gen FAN Xi-e HUAI Wen-xin LIU Quan ZHU Ming-xing State Key Laboratory of Water Resource and Hydropower Engineering Science Wuhan University Wuhan 430072 China China Gezhouba （Group） Corporation Yichang 443002 China

The protection of downstream concrete slab is a key issue for the stability of overflow earth-rock cofferdam. The coupling effect between bedding layer and concrete slab was taken into account when the stability of downstream concrete slab was researched. The characteristics of overflow and seepage over the downstream concrete slab were investigated when floodwater passes over the cofferdam. Firstly a limit equation of seepage failure for the bedding layer was derived with the consideration of geometric and mechanical factors, and a reliability model was established and numerically simulated. Then based on the reliability calculation for the bedding layer, the coupling effect between bedding layer and downstream concrete slab was analyzed. Under the most unfavorable pressure condition for the concrete slab, its instability criterion was put forward, which offers a structural design tool of downstream concrete slab for overflow earth-rock cofferdam. Compared with model tests, it shows that the model of reliability calculation of bedding layer and the stability analysis of downstream concrete slab are effective.

关键词： overflow earth-rock cofferdam couplingeffect reliability calculation stability analysis Monte Carlomethod

Impact of Long-Term Fertilization on Community Structure of Ammonia Oxidizing and Denitrifying Bacteria Based on amoA and nirK genes in a Rice Paddy from Tai Lake Region,China

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Journal of Integrative Agriculture 2014年第10期13卷 2286-2298页

作者： JIN Zhen-jiang LI Lian-qing LIU Xiao-yu PAN gen-xing Qaiser Hussein LIU Yong-zhuo Institute of Resource Ecosystem and Environment of AgricultureNanjing Agricultural University Guilin University of Technology

Ammonia oxidizing （AOB） and denitrifying bacteria （DNB） play an important role in soil nitrogen transformation in natural and agricultural ecosystems. Effects of long-term fertilization on abundance and community composition of AOB and DNB were studied with targeting ammonia monooxygenase （amoA） and nitrite reductase （nirK） genes using polymerase chain reaction- denaturing gradient gel electrophoresis （PCR-DGGE） and real-time PCR, respectively. A field trial with different fertilization treatments in a rice paddy from Tai Lake region, centre East China was used in this study, including no fertilizer application （NF）, balanced chemical fertilizers （CF）, combined organic/inorganic fertilizer of balanced chemical fertilizers plus pig manure （CFM）, and plus rice straw return （CFS）. The abundances and riehnesses of amoA and nirK were increased in CF, CFM and CFS compared to NF. Principle component analysis of DGGE profiles showed significant difference in nirK and amoA genes composition between organic amended （CFS and CFM） and the non-organic amended （CF and NF） plots. Number of amoA copies was significantly positively correlated with normalized soil nutrient richness （NSNR） of soil organic carbon （SOC） and total nitrogen （T-N）, and that of nirK copies was with NSNR of SOC, T-N plus total phosphorus. Moreover, nitrification potential showed a positive correlation with SOC content, while a significantly lower denitrification potential was found under CFM compared to under CFS. Therefore, SOC accumulation accompanied with soil nutrient richness under long-term balanced and organic/inorganic combined fertilization promoted abundance and diversity of AOB and DNB in the rice paddy.

关键词： long-term fertilization ammonia oxidizing bacteria denitrifying bacteria abundance rice paddy

Factors in fluencing farmers' participation in crop intensification program in Rwanda

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Journal of Integrative Agriculture 2017年第6期16卷 1406-1416页

作者： Alphonse Nahayo Morris O.Omondi ZHANG Xu-hui LI Lian-qing PAN gen-xing Stephen Joseph Institute of Resources Ecosystem and Environment of Agriculture Nanjing Agricultural University Nanjing 210095 P.R. China College of Agriculture Animal Science and Veterinary Medicine University of Rwanda Musanze P. O. Box 210 Rwanda University of New South Wales School of Material Science and Engineering Sydney NSW 2052 Australia

The crop intensification program（CIP）was introduced in Rwanda in 2007 by the Ministry of Agriculture and Animal Resources（MINAGRI）,Rwanda,as a solution to the land fragmentation,low use of agricultural inputs and low access to extension ***,due to the voluntary nature of farmers’participation and their reluctance to participate,this study aimed at assessing the factors that influence their *** were collected from 340 respondents through a household survey in Mayange and Rusarabuye *** statistics and binary logistic regression model were used to analyze the *** show that the factors that significantly influenced the farmers’participation in the CIP include gender,non-farm income,farmland size,farming experience,land acquisition means,market access,trust and agro-ecological *** fact,the non-farm income significantly increased the farmers’decisions to participate in the CIP（P〈0.001）as it eases the financial capital needed to invest in the CIP *** the land acquisition means,the farmers who inherited or bought the land positively and significantly participated in the CIP（P〈0.05）because they had the land tenure ***,the participation in the CIP was hindered by inadequate irrigation and mechanization facilities,lack of farmers’participation in the CIP planning process,inadequate extension services,inadequate agricultural inputs and inadequate post-harvest *** collaboration between farmers,local leaders,extension agents and agricultural service providers as well as the farmers’practical skills in irrigation and mechanization could enhance the participation to the ***,there is a need on the part of policymakers to empower farmers with adequate knowledge on better cropping practices and agricultural technologies through appropriate extension services and bottom-up based program.

关键词： chemical fertilizers crop intensification program extension services improved seeds post-harvest techniques institutional factors socio-economic factors constraints

基于高通量方法对高浓度单克隆抗体A的稳定性预测

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药物生物技术 2024年第2期31卷 124-131页

作者：昌根琼林军肖红星曹天助罗顺江西中医药大学药学院江西南昌330049 澳斯康生物(南通)股份有限公司江苏南通226100 长三角药物高等研究院江苏南通226133

通过高通量方法研究单抗分子的溶解特性、热稳定性、胶体稳定性等稳定性相关特性,建立稳定性预测方法,快速评估单抗分子的可开发性特性。采用聚乙二醇(Polyethylene glycol,PEG)沉淀法这种高通量的方法同时结合扩散相互作用系数(Diffusi... 详细信息

通过高通量方法研究单抗分子的溶解特性、热稳定性、胶体稳定性等稳定性相关特性,建立稳定性预测方法,快速评估单抗分子的可开发性特性。采用聚乙二醇(Polyethylene glycol,PEG)沉淀法这种高通量的方法同时结合扩散相互作用系数(Diffusion interaction parameter,kD)、Kirkwood-Buff integrals(G_(22))以及不同处方条件下的等温稳定性来预测单抗的溶解度、胶体稳定性和热稳定性等特性。本研究通过高通量方法确定的kD、G_(22)、C_(mid)等指标组合,确定了预测单抗在高浓度条件下稳定性的初步方法。预测的较优处方条件(20 mmol/L Histidine-HCl,200 mmol/L ArgCl,pH 6.0)可以保证单抗产品在高浓度条件下的溶解度以及胶体稳定性,这也得到了加速稳定性的证实。此研究通过采用多种高通量预测指标组合,为准确高效地开展制剂处方尤其是高浓度制剂处方开发提供了一定的依据。

关键词：高浓度单抗高通量稳定性溶解度聚乙二醇测定法蛋白与蛋白相互作用

Whole-brain CT Perfusion at Admission and During Delayed Time-window Detects the Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage

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Current Medical Science 2023年第2期43卷 409-416页

作者： Feng YOU Wen-juan tanG Chao ZHANG Ming-quan YE xing-gen FANG Yun-feng ZHOU Department of Radiology the First Affiliated Hospital of Wannan Medical CollegeWuhu241001China Department of Radiology Affiliated Hangzhou First People’s HospitalHangzhou310000China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Medical Information Wannan Medical CollegeWuhu241001China Department of Neurosurgery the First Affiliated Hospital of Wannan Medical CollegeWuhu241001China

Objective To evaluate the utility of computed tomography perfusion(CTP)both at admission and during delayed cerebral ischemia time-window(DCITW)in the detection of delayed cerebral ischemia(DCI)and the change in CTP parameters from admission to DCITW following aneurysmal subarachnoid *** Eighty patients underwent CTP at admission and during *** mean and extreme values of all CTP parameters at admission and during DCITW were compared between the DCI group and non-DCI group,and comparisons were also made between admission and DCITW within each *** qualitative color-coded perfusion maps were ***,the relationship between CTP parameters and DCI was assessed by receiver operating characteristic(ROC)*** With the exception of cerebral blood volume(P=0.295,admission;P=0.682,DCITW),there were significant differences in the mean quantitative CTP parameters between DCI and non-DCI patients both at admission and during *** the DCI group,the extreme parameters were significantly different between admission and *** DCI group also showed a deteriorative trend in the qualitative color-coded perfusion *** the detection of DCI,mean transit time to the center of the impulse response function(Tmax)at admission and mean time to start(TTS)during DCITW had the largest area under curve(AUC),0.698 and 0.789,*** Whole-brain CTP can predict the occurrence of DCI at admission and diagnose DCI during *** extreme quantitative parameters and qualitative color-coded perfusion maps can better reflect the perfusion changes of patients with DCI from admission to DCITW.

关键词： aneurysmal subarachnoid hemorrhage delayed cerebral ischemia admission time window computed tomography perfusion

高血压合并脑梗死老年患者潜在用药安全风险及Lasso-logistic回归分析

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中国新药与临床杂志 2024年第7期43卷 529-534页

作者：叶根深吴纪霞余兴群宦娣刘忠明李佳会忻志鸣蚌埠市第一人民医院药学部安徽蚌埠233000 蚌埠市第一人民医院神经内科安徽蚌埠233000

目的探讨高血压合并脑梗死老年患者潜在不适当用药(PIM)情况并建立影响因素Lasso-logistic回归列线图模型。方法纳入2020年1月至12月高血压合并脑梗死多重用药治疗的出院患者105例,以《中国老年人潜在不适当用药判断标准》评价PIM情况,L... 详细信息

目的探讨高血压合并脑梗死老年患者潜在不适当用药(PIM)情况并建立影响因素Lasso-logistic回归列线图模型。方法纳入2020年1月至12月高血压合并脑梗死多重用药治疗的出院患者105例,以《中国老年人潜在不适当用药判断标准》评价PIM情况,Lasso-logistic回归分析PIM风险影响因素,建立PIM风险影响因素列线图模型,评价模型区分度和准确度。结果105例患者PIM为85例(81.0%),涉及26种药品、184例次,排第1位是氯吡格雷48例次(26.1%)。Lasso-logistic回归提示,用药种数(P=0.003,OR=1.412,95%CI:0.582~2.868)、糖尿病(P<0.001,OR=0.081,95%CI:-3.899~-1.129)对PIM影响显著。ROC曲线下面积(AUC)为85.3%(95%CI:0.772~0.933),提示模型精准度和区分度良好;Bootstrap法(重采样次数B=1000)内部验证提示模型预测能力一般。结论基于Lasso-logistic回归构建的PIM风险影响因素列线图能较好识别PIM风险,高血压合并脑梗死多重用药治疗住院老年患者PIM风险高,有必要减少用药种数以降低PIM风险。

关键词：高血压脑梗死潜在不当用药清单 logistic模型列线图

Developmental characteristics and response to iron toxicity of root border cells in rice seedlings

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 261-264页

作者： Cheng-hua xing Mei-hong ZHU Miao-zhen CAI Peng LIU gen-di XU Shao-hui WU Bioengineering Institute Jinhua College of Profession and Technology Jinhua 321007 China College of Chemistry and Life Sciences Zhejiang Normal University Jinhua 321004 China

To investigate the Fe^2＋ effects on root tips in rice plant, experiments were carried out using border cells in vitro. The border cells were pre-planted in aeroponic culture and detached from root tips. Most border cells have a long elliptical shape. The number and the viability of border cells in situ reached the maxima of 1600 and 97.5%, respectively, at 20---25 mm root length. This mortality was more pronounced at the first 1-12 h exposure to 250 mg/L Fe^2＋ than at the last 12-36 h. After 36 h, the cell viability exposed to 250 mg/L Fe^2＋ decreased to nought, whereas it was 46.5% at 0 mg/L Fe^2＋. Increased Fe^2＋ dosage stimulated the death of detached border cells from rice cultivars. After 4 h Fe^2＋ treatment, the cell viabilities were _〉80% at 0 and 50 mg/L Fe^2＋ treatment and were 〈62% at 150, 250 and 350 mg/L Fe^2＋ treatment; The viability of border cells decreased by 10% when the Fe^2＋ concentration increased by 100 mg/L. After 24 h Fe^2＋ treatment, the viabilities of border cells at all the Fe^2＋ levels were 〈65%; The viability of border cells decreased by 20% when the Fee＋ concentration increased by 100 mg/L. The decreased viabilities of border cells indicated that Fe^2＋ dosage and treatment time would cause deadly effect on the border cells. The increased cell death could protect the root tips from toxic harm. Therefore, it may protect root from the damage caused by harmful iron toxicity.

关键词： Rice plant Border cells Iron toxicity

Volum etric Properties of Sodium Chlorobenzoatein N,N-Dim ethylform am ide/waterMixtures at 298.15K

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Chemical Research in Chinese Universities 1999年第3期15卷 253-257页

作者： LI Shu-qin HU Xin-gen YU Jia-miao LIN Rui-sen ZONG Han-xing Department of Chemistry Zhejiang UniversityHangzhou 310027P.R.China

Densities of sodium chlorobenzoate( o , m , p ) were measured in solutions up to 80 weight percent dimethylformamide(DMF) at 298 15 K with an oscillating tube densimeter. From these densities, apparent molar volumes of sodium chlorobenzoate in DMF H 2O mixtures were calculated, and partial molar volumes at infinite dilution were evaluated. Substituent and solvent effects on transfer volumes of each isomer from water to DMF H 2O mixed solvents were obtained. The results are explained in terms of solvent structure and solute solvent interaction.

关键词： Sodium chlorobenzoate DMF water mixed solvent Volumetric property