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Hypoxia-mediated programmed cell death is involved in the formation of wooden breast in broilers

Journal of Animal Science and Biotechnology 2024年第5期15卷 1918-1931页

作者： Xinrui Zhang tong xing Lin Zhang Liang Zhao Feng Gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNo.1 WeigangNanjingJiangsu 210095P.R.China

Background Wooden breast(WB)myopathy is a common myopathy found in commercial broiler chickens *** examination has revealed that WB myopathy is accompanied by damage to the pectoralis major(PM)***,the underlying mechanisms responsible for the formation of WB in broilers have not been fully *** study aimed to investigate the potential role of hypoxia-mediated programmed cell death(PCD)in the formation of WB *** Histological examination and biochemical analysis were performed on the PM muscle of the control(CON)and WB groups.A significantly increased thickness of the breast muscle in the top,middle,and bottom portions(P<0.01)was found along with pathological structure damage of myofibers in the WB *** number of capillaries per fiber in PM muscle,and the levels of p O_(2) and s O_(2) in the blood,were significantly decreased(P<0.01),while the levels of p CO_(2) and TCO_(2) in the blood were significantly increased(P<0.05),suggesting hypoxic conditions in the PM muscle of the WB *** further evaluated the PCD-related pathways including autophagy,apoptosis,and necroptosis to understand the consequence response to enhanced hypoxic conditions in the PM muscle of birds with *** ratio of LC3 II to LC3 I,and the autophagy-related factors HIF-1α,BNIP3,Beclin1,AMPKα,and ULK1 at the m RNA and protein levels,were all significantly upregulated(P<0.05),showing that autophagy occurred in the PM muscle of the WB *** apoptotic index,as well as the expressions of Bax,Cytc,caspase 9,and caspase 3,were significantly increased(P<0.05),whereas Bcl-2 was significantly decreased(P<0.05)in the WB-affected PM muscle,indicating the occurrence of apoptosis mediated by the mitochondrial ***,the expressions of necroptosis-related factors RIP1,RIP3,and MLKL,as well as NF-κB and the pro-inflammatory cytokines TNF-α,IL-1β,and IL-6,were all significantly enhanced(P<0.05)in the WB-affected PM *** T

关键词： Apoptosis Autophagy Broiler chicken Hypoxia Necroptosis Wooden breast

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Structural color of metallic glass through picosecond laser

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Chinese Physics B 2024年第10期33卷 120-128页

作者： Yue’e Zhang xing tong Yuqiang Yan Shuo Cao Hai-Bo Ke Wei-Hua Wang College of Physics Liaoning UniversityShenyang 110036China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China

The alteration in surface color of metallic glasses(MGs)holds great significance in the context of microstructuredesign and commercial *** is essential to accurately describe the structures that are formed during the laser and colorseparation processes in order to develop practical laser coloring *** to the high oxidation sensitivity of Labasedmetallic glass,it can broaden the color range but make it more *** coloring by laser processing on thesurface of La-based metallic glass can be conducted after thermoplastic *** is particularly important to clarify therole of structure and composition in the surface coloring *** aim is to study the relationship between amorphoussurface structural color,surface geometry,and oxide formation by laser processing in metallic *** findings revealedthat the periodic structure primarily determines the surface color at laser energy densities below 1.0 J/mm^(2).In contrast,thesurface color predominantly depends on the proportion of oxides that are formed when energy densities exceed 1.0 J/mm^(2).Consequently,this study provides a novel concept for the fundamental investigation of laser coloring and establishes a newavenue for practical application.

关键词： metallic glass picosecond laser periodic structure oxides

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Diagnostic and prognostic role of LINC01767 in hepatocellular carcinoma

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World Journal of Hepatology 2024年第6期16卷 932-950页

作者： Li Zhang tong-xing Cui Xiang-Zhi Li Chong Liu Wen-Qin Wang Department of Thyroid and Breast Surgery The Affiliated People Hospital of Second Medical UniversityWeifang 266010Shandong ProvinceChina Department of General Surgery Qingdao Municipal Hospital GroupQingdao 266237Shandong ProvinceChina School of Life Sciences Shandong University(Qingdao)Qingdao 26637Shandong ProvinceChina School of Medicine Tsinghua UniversityBeijing 100084China

BACKGROUND Hepatocellular carcinoma(HCC)is a primary contributor to cancer-related mortality on a global ***,the underlying molecular mechanisms are still poorly *** noncoding RNAs are emerging markers for HCC diagnosis,prognosis,and therapeutic *** study of LINC01767 in HCC was *** To conduct a multi-omics analysis to explore the roles of LINC01767 in HCC for the first *** DESeq2 Package was used to analyze different gene *** operating characteristic curves assessed the diagnostic ***-Meier univariate and Cox multivariate analyses were used to perform survival *** least absolute shrinkage and selection operator(LASSO)-Cox was used to identify the prediction *** to the validation of LINC01767 expression in HCC fresh frozen tissues through quantitative real time polymerase chain reaction,next generation sequencing was performed following LINC01767 over expression(GSE243371),and Gene Ontology/Kyoto Encyclopedia of Genes and Genomes/Gene Set Enrichment Analysis/ingenuity pathway analysis was carried *** vitro experiment in Huh7 cell was carried *** LINC01767 was down-regulated in HCC with a log fold change=1.575 and was positively correlated with the cancer ***01767 was a good diagnostic marker with area under the curve(AUC)[0.801,95% confidence interval(CI):0.751-0.852,P=0.0106]and an independent predictor for overall survival(OS)with hazard ratio=1.899(95%CI:1.01-3.58,P=0.048).LINC01767 nomogram model showed a satisfied *** top-ranked regulatory network analysis of LINC01767 showed the regulation of genes participating various *** regression identified the 9-genes model showing a more satisfied performance than 5-genes model to predict the OS with AUC>***01767 was down-expressed obviously in tumor than para-tumor tissues in our cohort as well as in cancer cell line;the over expression of LINC01767 inhibit cell prolifer

关键词： Hepatocellular carcinoma LINC01767 Multi-omics analysis GSE243371 Cell proliferation Clone formation

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Laparoscopic left hemihepatectomy guided by indocyanine green fluorescence: A cranial-dorsal approach

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 409-418页

作者： xing-Ru Wang Xiao-Ju Li Dan-Dan Wan Qian Zhang Tian-Xi Liu Zong-Wen Shen Hong-xing tong Yan Li Jian-Wei Li Institute of Hepatobiliary Surgery First Affiliated HospitalArmy Medical UniversityChongqing 400038China Department of Hepatobiliary Surgery Qujing Central Hospital of Yunnan Regional Medical CenterQujing 655000Yunnan ProvinceChina School of Clinical Medicine Qujing Medical CollegeQujing 655000Yunnan ProvinceChina

BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)*** indocyanine green(ICG)fluorescence navi-gation technique has emerged as the most effective method for identifying hepatic regions,potentially overcoming the limitations of *** laparoscopic left hemihepatectomy(LLH)is a standardized procedure,there is a need for innova-tive strategies to enhance its *** anatomical markers,surgical skills,and ICG staining *** Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively *** cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad,isolating the Arantius ligament,exposing the middle hepatic vein,and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical *** surgical methods,as well as intra-and post-surgical data,were recorded and *** hospital’s Medical Ethics Committee approved this study(Ethical review:2022-019-01).RESULTS Intraoperative blood loss during LLH was 335.68±99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5%and 0%,*** overall incidence of complications throughout the follow-up(median of 18 months;range 1-36 months)was 21.6%.No mortality or severe complications(level IV)were *** LLH has the potential to become a novel,standardized approach that can effectively,safely,and simply expose the middle hepatic vein and meet the requirements of precision surgery.

关键词： Laparoscopic left hemihepatectomy Indocyanine green Cranial-dorsal approach Laparoscopic hepatectomy Arantius ligament Glissonean pedicle

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Tuning the Surface Field by Embedding Cations into Metals to Direct the Reaction Pathway of CO_(2) Electroreduction

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CCS Chemistry 2024年第3期6卷 631-640页

作者： Pei Zhang Meng Zhou Shiqiang Liu Xueqing xing Jiahao Yang Peng Chen Yaoyu Yin Yingying Cheng xing tong Jun Ma Qinggong Zhu Xiaofu Sun ZhongJun Chen Xinchen Kang Buxing Han Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesCenter for Carbon Neutral ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049 Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062 School of Chemistry University of Chinese Academy of SciencesBeijing 100049

The creation of universal strategies to affect the reaction route of the electroreduction of CO_(2) is ***,we report the first work to introduce cations into diverse metals such as Cu,Bi,In,and Sn via the electroreduction of related metallic oxides in quaternary ammonium surfactant *** to their physical adsorption,cations embedded into the electrodes have a more pronounced impact on the electrical field,which effectively influences the adsorption state of *** the increase of surface field,the hydrogen evolution reaction and*COOH route are significantly reduced,favouring the*OCHO pathway *** a result,hydrogen,CO,and C_(2+)products almost completely vanish at−0.5 V versus RHE in 0.1 M Na_(2)SO_(4)in an H-type cell after enough cations are embedded into the Cu electrode,and the faradaic efficiency of formate rises from 18.0%to 99.5%simultaneously.

关键词： CO_(2)electroreduction tuneable products electrical field reaction pathway cations embedding

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Critical state-induced emergence of superior magnetic performances in an iron-based amorphous soft magnetic composite

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Materials Futures 2024年第2期3卷 149-160页

作者： Liliang Shao Rongsheng Bai Yanxue Wu Jing Zhou xing tong Hailong Peng Tao Liang Zongzhen Li Qiaoshi Zeng Bo Zhang Haibo Ke Weihua Wang Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Institute of Physics Chinese Academy of SciencesBeijing 100190People’s Republic of China School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing 100096People’s Republic of China School of Materials Science and Engineering Central South UniversityChangsha 410083People’s Republic of China Center for High Pressure Science and Technology Advanced Research Shanghai 201203People’s Republic of China Jiangsu JITRI Advanced Energy Materials Research Institute Co. LtdChangzhou 213000People’s Republic of China

Soft magnetic composites(SMCs)play a pivotal role in the development of high-frequency,miniaturization and complex forming of modern ***,they usually suffer from a trade-off between high magnetization and good magnetic softness(high permeability and low core loss).In this work,utilizing the order modulation strategy,a critical state in a FeSiBCCr amorphous soft magnetic composite(ASMC),consisting of massive crystal-like orders(CLOs,∼1 nm in size)with the feature ofα-Fe,is *** critical-state structure endows the amorphous powder with the enhanced ferromagnetic exchange interactions and the optimized magnetic domains with uniform orientation and fewer micro-vortex *** comprehensive soft magnetic properties at high frequency emerge in the ASMC,such as a high saturation magnetization(Ms)of 170 emu g^(-1)and effective permeability(µ_(e))of 65 combined with a core loss(Pcv)as low as 70 mW cm^(-3)(0.01 T,1 MHz).This study provides a new strategy for the development of high-frequency ASMCs,possessing suitable comprehensive soft magnetic performance to match the requirements of the modern magnetic devices used in the third-generation semiconductors and new energy fields.

关键词： amorphous soft magnetic composites critical state soft magnetic property rotating magnetic field annealing magnetic domain

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社会保障学科发展的三个转向

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社会保障评论 2024年第2期8卷 3-11页

作者：童星南京大学政府管理学院

在中国式社会主义现代化进程中,社会保障的实践和理论研究随之发展。当前,社会保障学科发展将呈现以下三个重要转向。一是关注并参与人口问题的研究,厘清人口学的基本概念,把握人口学的基础理论。各项公共政策与管理都以人口政策与管理... 详细信息

在中国式社会主义现代化进程中,社会保障的实践和理论研究随之发展。当前,社会保障学科发展将呈现以下三个重要转向。一是关注并参与人口问题的研究,厘清人口学的基本概念,把握人口学的基础理论。各项公共政策与管理都以人口政策与管理为基础,社会保障作为福利政策与管理,也不例外。二是任何社会形态都有其“普照的光”,当今我国的“普照的光”已由“小康”转变成“共同富裕”。在其照耀下,社会保障体系建设的重点将由“扩面”“保底”“助弱”转移到“调结构”上来。三是社会保障的研究范式也相应地会由经济学、社会学为主导转向管理学为主导。

关键词：社会保障学科建设人口政策普照的光结构调整研究范式

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中国四大类型商业银行数字化转型发展的差异及分布动态

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经济问题 2024年第5期 43-51页

作者：邢彤宿玉海山东财经大学金融学院山东济南250001

基于2012—2020年的52家商业银行数字化转型数据,采用Dagum基尼系数和核密度非参数估计方法,探讨了中国四大类型商业银行数字化转型发展的差异和动态演进。研究结果表明,四大类型商业银行的数字化转型发展整体呈上升趋势,但不同类型商... 详细信息

基于2012—2020年的52家商业银行数字化转型数据,采用Dagum基尼系数和核密度非参数估计方法,探讨了中国四大类型商业银行数字化转型发展的差异和动态演进。研究结果表明,四大类型商业银行的数字化转型发展整体呈上升趋势,但不同类型商业银行的数字化转型发展水平存在显著差异。国有和股份制商业银行的数字化转型取得了显著进展,而城市和农村商业银行的数字化转型发展速度相对较慢。不同类型商业银行在数字化转型方面呈现出明显的分层效应,显示出两极或多极分化的倾向。最后依据结论提出相关政策启示。

关键词：商业银行数字化转型核密度基尼系数

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热挤压工艺对Bi_(2)Te_(2.7)Se_(0.3)材料热电性能和力学性能的影响

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硅酸盐学报 2024年第10期52卷 3243-3251页

作者：李泉邢通李小亚仇鹏飞史迅上海理工大学材料与化学学院上海200093 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室上海200050

碲化铋(Bi_(2)Te_(3))基化合物作为室温附近性能最优异的热电材料,在热电制冷及发电技术中已获得广泛商业化应用。目前商业化生产的Bi_(2)Te_(3)基热电材料主要采用区熔法制备,虽然具有优异的热电性能,但材料容易解理,力学性能较差,无... 详细信息

碲化铋(Bi_(2)Te_(3))基化合物作为室温附近性能最优异的热电材料,在热电制冷及发电技术中已获得广泛商业化应用。目前商业化生产的Bi_(2)Te_(3)基热电材料主要采用区熔法制备,虽然具有优异的热电性能,但材料容易解理,力学性能较差,无法满足微型热电器件的加工需求。本工作探索最佳热挤压工艺参数,采用热挤压技术在不同工艺条件下制备了n型Bi_(2)Te_(2.7)Se_(0.3)热电材料样品,并对样品进行物相分析、热电性能以及力学性能表征。结果表明,在确定的挤压比以及挤压速率下,提高挤压温度有利于减少样品裂纹,而过快的挤压速率则会导致样品断裂,最佳工艺参数为挤压温度400℃以及挤压速率0.05 mm/s。采用最佳工艺参数在不同工艺条件下制备的n型Bi_(2)Te_(2.7)Se_(0.3)样品中,通过放电等离子烧结结合热挤压所制备的样品热电性能最高,在400K时zT值可达到0.83,并且其力学性能显著提升,维氏硬度可达602.5 N/mm^(2),为区熔Bi_(2)Te_(2.7)Se_(0.3)材料的2倍。Bi_(2)Te_(2.7)Se_(0.3)材料的机械加工性能也随之提升,采用封装切割工艺可以加工出最小尺寸达到147μm的微型热电粒子,为后续Bi_(2)Te_(3)基微型热电器件的加工制备提供了材料基础。

关键词：热电材料碲化铋热挤压热电性能力学性能

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论中国家庭教育研究学科化的进程、定位和策略

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中国教育科学（中英文） 2024年第4期7卷 47-60页

作者：童星缪建东南京师范大学教育科学学院南京210097

我国家庭教育研究已成为学术研究的热点之一,目前正处于从研究领域向学科化的转向阶段。家庭教育学并不完全符合传统的学科评价标准,但符合现代学科对于独立学科的界定。新中国成立后,家庭教育研究的学科化进程大致可以分为三个阶段:新... 详细信息

我国家庭教育研究已成为学术研究的热点之一,目前正处于从研究领域向学科化的转向阶段。家庭教育学并不完全符合传统的学科评价标准,但符合现代学科对于独立学科的界定。新中国成立后,家庭教育研究的学科化进程大致可以分为三个阶段:新中国成立后前30年家庭教育研究的缓慢发展;从改革开放到20世纪末家庭教育研究的逐步铺开;进入21世纪以来家庭教育研究的深化与繁荣。家庭教育学的学科属性包括开放性、实践性和科学性。为加速家庭教育研究的学科化转向,建设中国特色的家庭教育学科,提出三点策略建议:第一,以问题为中心,通过科学化的研究促进家庭教育学科化发展,逐步形成自身知识体系;第二,由外促内,以外部建制搭建家庭教育研究平台,汇聚学科建设力量;第三,理论联系实际,开展循证家庭教育实践,提升家庭教育学科合法性。

关键词：家庭教育研究学科化学科评价标准学科属性学科建设

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