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张虹教授从脑-肝-肾理论辨治PTSD经验

中医康复 2024年第3期1卷 30-33,37页

作者：张绪赟李航宇屈晓凤张虹成都中医药大学四川成都610075 全国名老中医药专家张虹传承工作室四川成都610015

创伤后应激障碍综合征(PTSD)作为临床常见的精神障碍性疾病,严重影响着患者的身心健康与生活质量。目前对该病的治疗主要从药物和心理干预两方面着手,但这些疗法往往因治疗周期长、易产生依赖性、副作用大等问题让患者难以坚持治疗。自... 详细信息

创伤后应激障碍综合征(PTSD)作为临床常见的精神障碍性疾病,严重影响着患者的身心健康与生活质量。目前对该病的治疗主要从药物和心理干预两方面着手,但这些疗法往往因治疗周期长、易产生依赖性、副作用大等问题让患者难以坚持治疗。自汶川地震以来,张虹教授致力于PTSD的临床实践和科研,对PTSD的发病机制、病情演变、系统理论等方面有着独到的见解,其依托临床和科研实验,从脑-肝-肾理论出发,创立辨治PTSD的特色疗法,据此施治取得了显著疗效,且成本较低、副作用小,易于推广。笔者在跟随张虹教授临床学习过程中,系统总结了其辨治PTSD经验,以期为临床提供参考。

关键词：创伤后应激障碍综合征脑-肝-肾理论临床经验张虹

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建行信用卡系统全栈国产化改造研究

计算机技术与发展 2024年第6期34卷 192-200页

作者：金磐石张晓东邢磊李晓栋彭云杨永李铮中国建设银行股份有限公司北京100033 建信金融科技有限责任公司上海200120 华为技术有限公司广东深圳518129

信用卡业务是业务逻辑最复杂的银行业务之一,其对可用性、可靠性、处理性能要求较高。从技术发展角度来看,多技术栈融合的新型IT架构,符合云计算资源池化的趋势。从业务角度来看,为满足不同的业务需求,同样存在多技术栈融合架构的诉求... 详细信息

信用卡业务是业务逻辑最复杂的银行业务之一,其对可用性、可靠性、处理性能要求较高。从技术发展角度来看,多技术栈融合的新型IT架构,符合云计算资源池化的趋势。从业务角度来看,为满足不同的业务需求,同样存在多技术栈融合架构的诉求。然而,多计算架构并非简单实现一个全新的技术栈即可,需要解决架构改造与设计、系统验证、兼容性以及故障切换等一系列问题。面对上述挑战,该文面向金融IT系统高并发、高性能以及高可用需求,介绍了建行面向金融行业的高性能、高可用和高安全可靠的x86、ARM双平台混合架构系统中的设计与思考。通过一系列的代码迁移、应用迁移以及系统垂直优化技术,实现高性能、高可用和高安全的诉求,并在建行得到了大规模、长时间的真实系统验证。

关键词： ARM 多计算架构服务器信用卡系统代码迁移

Osimertinib induced adverse cardiac events: a case report

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老年心脏病学杂志:英文版 2023年第9期20卷 702-706页

作者： Shang-Xin LU yun-li xing Ye MIAO xiao-Jie zhang Hong-Wei li Department of Geriatrics Beijing Friendship HospitalCapital Medical UniversityBeijingChina Radiology Department Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityYongan RoadBeijingChina

Osimertinib is a third-generation epidermal growth factor receptor(EGFR)—tyrosine kinase inhibitors(TKI)selective for both EGFR-TKI sensitizing and T790M resistance *** is also recommended as firstline therapy for patients with non-small-cell lung cancer(NSCLC)who have targetable EGFR mutations.[1]Recently,some emerging evidence revealed the significant cardiac toxicity induced by ***,osimertinib-induced dilated cardiomyopathy and congestive heart failure has never been reported in ***,we report a rare case of dilated cardiomyopathy with heart failure exacerbation which developed during osimertinib treatment.

关键词： cardiac cardiomyopathy dilated

稻纵卷叶螟对氯虫苯甲酰胺的抗性监测及其抗氯虫苯甲酰胺种群对其他双酰胺类杀虫剂的交互抗性

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昆虫学报 2024年第4期67卷 498-506页

作者：王立董蓓蓓刘思彤陈韵箫杨凤霞张帅高聪芬南京农业大学植物保护学院绿色农药创制与应用技术国家地方联合工程研究中心南京210095 云南农垦产业研究院有限公司昆明650106 全国农业技术推广服务中心北京100026

【目的】本研究旨在明确稻纵卷叶螟Cnaphalocrocis medinalis对氯虫苯甲酰胺的抗性水平、抗性稳定性及其抗氯虫苯甲酰胺种群对其他双酰胺类杀虫剂是否存在交互抗性。【方法】采用稻苗浸渍法测定我国9省(自治区)稻纵卷叶螟32个田间种群... 详细信息

【目的】本研究旨在明确稻纵卷叶螟Cnaphalocrocis medinalis对氯虫苯甲酰胺的抗性水平、抗性稳定性及其抗氯虫苯甲酰胺种群对其他双酰胺类杀虫剂是否存在交互抗性。【方法】采用稻苗浸渍法测定我国9省(自治区)稻纵卷叶螟32个田间种群对氯虫苯甲酰胺和四唑虫酰胺的抗性,并测定了两个氯虫苯甲酰胺抗性种群对其他双酰胺类杀虫剂的交互抗性,以及湖南攸县、安徽潜山、安徽庐江和广西兴安田间种群在室内不接触药剂饲养后对氯虫苯甲酰胺的抗性稳定性。【结果】2019-2022年间,稻纵卷叶螟田间种群对氯虫苯甲酰胺的抗性逐年上升,2022年首次监测到庐江、兴安、武穴、丹阳和潜山种群对氯虫苯甲酰胺达到高水平抗性(102.3~135.1倍),其他种群亦达到中等水平抗性(10.3~97.1倍);2019-2021年监测的所有田间种群对四唑虫酰胺均表现为敏感,2022年所监测种群对四唑虫酰胺达到中等水平抗性(41.9~98.0倍)。交互抗性试验结果表明,对氯虫苯甲酰胺抗性约100倍的浙江嘉兴和安徽潜山种群对氟氯虫双酰胺、四唑虫酰胺、溴氰虫酰胺、环丙虫酰胺和四氯虫酰胺也表现出31.6~100.5倍中等至高水平抗性。稻纵卷叶螟田间种群在室内不接触药剂连续饲养2~4代后,对氯虫苯甲酰胺的抗性表现出快速下降的现象。【结论】稻纵卷叶螟田间种群对氯虫苯甲酰胺和四唑虫酰胺已产生中等至高水平抗性,且对氯虫苯甲酰胺产生抗性的稻纵卷叶螟田间种群对其他5种双酰胺类药剂也存在中等至高水平的交互抗性;鉴于当前稻纵卷叶螟田间种群对氯虫苯甲酰胺的抗性尚不稳定,建议可通过限制或暂停使用该类药剂,以延缓其抗性发展和延长使用寿命。

关键词：稻纵卷叶螟抗药性监测氯虫苯甲酰胺交互抗性抗性稳定性

5-min mindfulness audio induction alleviates psychological distress and sleep disorders in patients with COVID-19

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World Journal of Clinical Cases 2022年第2期10卷 576-584页

作者： Jing li yun-yun zhang xiao-Yin Cong Shu-Rong Ren xiao-Ming Tu Jin-feng Wu Department of Geriatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Psychology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Nanjing Medical University Nanjing 211166Jiangsu ProvinceChina

BACKGROUND Mindfulness meditation is beneficial to mitigate the negative effects of the coronavirus disease 2019(COVID-19)pandemic in the general population,but no study examined such meditation in the COVID-19 patients *** To explore the short-term efficacy of mindfulness meditation in alleviating psychological distress and sleep disorders in patients with *** This prospective study enrolled patients with mild COVID-19 treated at Wuhan Fangcang Hospital in February *** patients were voluntarily divided into either a mindfulness or a conventional intervention *** patients were evaluated before/after the intervention using the Short Inventory of Mindfulness Capability(SMI-C),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI).RESULTS Seventy-five participants were enrolled in this study,with 43 and 32 in the mindfulness and conventional groups,*** the intervention,there were no differences in SMI-C,HADS,or PSQI scores between the two *** the 2-wk intervention,the mindfulness level(from 30.16±5.58 to 35.23±5.95,Plity(from 12.85±3.06 to 9.44±3.86,Plity(9.44±3.86 vs 11.87±4.06,P=0.011)were significantly higher in the mindfulness group than in the conventional *** decreased in the mindfulness group(from 14.15±3.21 to 12.50±4.01,P=0.038),but there was no difference between the two *** Short-term mindfulness meditation can increase the mindfulness level,improve the sleep quality,and decrease the depression of patients with COVID-19.

关键词： COVID-19 Mindfulness Mental health Sleep quality

Biallelic mutations in spermatogenesis and centriole-associated 1 like(SPATC1L)cause acephalic spermatozoa syndrome and male infertility

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Asian Journal of Andrology 2022年第1期24卷 67-72页

作者： You-Zhu li Na li Wen-Sheng liu Yan-Wei Sha Rong-feng Wu Ya-ling Tang xing-Shen Zhu xiao-li Wei xiao-Ya zhang Yi-feng Wang Zhong-Xian Lu Fu-xing zhang Reproductive Medicine Center The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Intensive Care Unit Fujian Medical University Xiamen Humanity HospitalXiamen 361009China Obstetrics and Gynecology Center Department of Obstetrics and GynecologyZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Pharmaceutical Sciences State Key Laboratory of Cellular Stress BiologyXiamen UniversityXiamen 361102China Department of Andrology United Diagnostic and Research Center for Clinical GeneticsWomen and Children’s Hospital and School of MedicineXiamen UniversityXiamen 361005China Department of Obstetrics and Gynecology First Affiliated Hospital of Xiamen UniversityXiamen 361003China Department of General Surgery First Affiliated Hospital of Xiamen UniversityXiamen 361003China

Acephalic spermatozoa syndrome is a rare type of teratozoospermia that severely impairs the reproductive ability of male patients,and genetic defects have been recognized as the main cause of acephalic spermatozoa *** and centrioleassociated 1 like(SPATC1L)is indispensable for maintaining the integrity of sperm head-to-tail connections in mice,but its roles in human sperm and early embryonic development remain largely ***,we conducted whole-exome sequencing(WES)of 22 infertile men with acephalic spermatozoa *** in silico analysis of the candidate variants was conducted,and WES data analysis was performed using another cohort consisting of 34 patients with acephalic spermatozoa syndrome and 25 control subjects with proven *** identified biallelic mutations in SPATC1L(c.910C>T:***304Cys and c.994G>T:***332X)from a patient whose sperm displayed complete *** SPATC1L variants are rare and ***1L is mainly expressed at the head–tail junction of elongating *** containing pathogenic variants decreased the level of SPATC1L in ***,none of the patient’s four attempts at intracytoplasmic sperm injection(ICSI)resulted in a transplantable embryo,which suggests that SPATC1L defects might affect early embryonic *** conclusion,this study provides the first identification of SPATC1L as a novel gene for human acephalic spermatozoa ***,WES might be applied for patients with acephalic spermatozoa syndrome who exhibit reiterative ICSI failures.

关键词： acephalic spermatozoa syndrome biallelic mutations spermatogenesis and centriole-associated 1 like whole-exome sequencing

Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing:implications for neurodegeneration mechanisms

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Neural Regeneration Research 2022年第3期17卷 608-617页

作者： Hui-Min Xie xing Su feng-Yuan zhang Chao-Lun Dai Rong-Hua Wu Yan li xiao-xiao Han xing-Mei feng Bin Yu Shun-xing Zhu Song-lin Zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina Laboratory Animals Center Nantong UniversityNantongJiangsu ProvinceChina

Glial cells play an important role in signal transduction,energy metabolism,extracellular ion homeostasis and neuroprotection of the central nervous ***,few studies have explained the potential effects of exosomes from glial cells on central nervous system health and *** this study,the genes expressed in exosomes from astrocytes and microglia were identified by deep RNA *** Encyclopedia of Genes and Genomes analysis indicated that several pathways in these exosomes are responsible for promoting neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease and Huntington's *** ontology analysis showed that extracellular exosome,mitochondrion and growth factor activity were enriched in exosomes from the unique astrocyte group,while extracellular exosome and mitochondrion were enriched in exosomes from the unique microglia ***,combined with the screening of hub genes,the protein-protein interaction network analysis showed that exosomes from astrocytes influence neurodegenerative diseases through metabolic balance and ubiquitin-dependent protein balance,whereas exosomes from microglia influence neurodegenerative diseases through immune inflammation and oxidative *** there were differences in RNA expression between exosomes from astrocytes and microglia,the groups were related by the hub genes,ubiquitin B and heat shock protein family A(Hsp70) member *** B appeared to be involved in pleiotropic regulatory functions,including immune regulation,inflammation inhibition,protein catabolism,intracellular protein transport,exosomes and oxidative *** results revealed the clinical significance of exosomes from glia in neurodegenerative *** study was approved by the Animal Ethics Committee of Nantong University,China(approval No.S20180102-152) on January 2,2018.

关键词： astrocyte bioinformatics analysis central nervous system exosomes microglia neurodegenerative disease RNA transcriptomics UBB

豫北地区18个秋播饲用燕麦品种抗倒伏特性及生产性能评价

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草业学报 2024年第8期33卷 74-85页

作者：桑瑞娟崔超杰何云张晓霞姚晋董春阳孙浩史莹华朱晓艳李德锋河南农业大学动物科技学院河南郑州450046 河南省草地资源创新与利用重点实验室河南郑州450046 河南省牧草工程技术研究中心河南郑州450046 青岛农业大学资源与环境学院山东青岛266109 河南科技学院动物科学学院河南新乡453003 河南省畜牧技术推广总站河南郑州450008

为了解秋播饲用燕麦在豫北地区的抗倒伏特性和生产性能,本研究测定了18个品种的干草产量、分蘖数、越冬率和不同时期倒伏率,分析了燕麦倒伏与株高、穗位高及茎秆形态的关系。结果表明:80%的燕麦品种从抽穗期开始倒伏,乳熟中期收获时倒... 详细信息

为了解秋播饲用燕麦在豫北地区的抗倒伏特性和生产性能,本研究测定了18个品种的干草产量、分蘖数、越冬率和不同时期倒伏率,分析了燕麦倒伏与株高、穗位高及茎秆形态的关系。结果表明:80%的燕麦品种从抽穗期开始倒伏,乳熟中期收获时倒伏率为10.0%~95.0%,其中,贝利和大富豪两个品种倒伏率较低;第1节和第2节茎粗、第2节干重等反映茎秆强度的指标与倒伏率呈显著负相关(P<0.05);18个燕麦品种生育期为182~207 d,干草产量、株高、越冬率和返青期分蘖数分别为11.99~20.46 t·hm^(-2)、1.11~1.52 m、83.7%~96.6%和5.3~8.5个·株-1,贝利、爱沃和燕王3个品种干草产量较高,达20 t·hm^(-2)。综合抗倒伏特性、干草产量和营养品质,本研究认为贝利、燕王和大富豪3个品种适宜在豫北地区秋播种植。

关键词：饲用燕麦抗倒伏性生产性能越冬率

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A Double Azole-bridged Dinuclear Copper(Ⅱ) Complex Containing 4-Pyridyl-NH-1,2,3-triazoles: Synthesis, Structure and Magnetism

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Chinese Journal of Structural Chemistry 2020年第5期39卷 918-926页

作者： zhang Xin JIANG xiao-feng CHEN yun-Zhou CHEN yun-feng DING li-li JIA li-Hui Key Laboratory for Green Chemistry Process of Ministry of Education School of Chemistry and Environmental EngineeringWuhan Institute of TechnologyWuhan 430073China Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Function Molecules Hubei UniversityWuhan 430062China

A new dinuclear copper(Ⅱ)compound[Cu2(CH3COO)2(L)2(H2O)2]·4H2O(1,HL=4-pyridyl-NH-1,2,3-triazole)has been synthesized and ***-crystal X-ray diffraction showed that complex 1 crystallizes in monoclinic space group P21/c with a=0.8427(1),b=1.0981(1),c=1.3610(1)nm,β=93.364(4)°,V=1.2573(1)nm^3,Mr=643.56,Z=2,Dc=1.700 g/cm^3,μ=1.760 mm-1,R=0.0376,wR=0.0981,and possesses a planar Cu2N4 six-membered ring,in which both Cu(Ⅱ)ions are bridged by two 1,2,3-triazole *** neighboring dinuclear molecules are bound by strong intermolecular hydrogen bonds to create 1-D chains expanding along the b axis,which further form a 3-D supramolecular *** susceptibility measurement indicated the presence of weak antiferromagnetic interactions within the *** best fit using spin Hamiltonian yields the magnetic coupling constant J=–14.82 cm^-1 above 30 *** magnetic data are compared to those obtained for related double diazine bridged dinuclear copper(Ⅱ)complexes and magnetostructural correlations are discussed.

关键词： dinuclear Cu(Ⅱ)complexes 4-pyridyl-NH-1,2,3-triazole magnetic properties magneto-structural correlation