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cGAS-STING: mechanisms and therapeutic opportunities

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Science China Life Sciences 2025年

作者： Mengyuan Zhang Changxin Wu Defen Lu xing wang Guijun Shang Shanxi Medical University School and Hospital of Stomatology Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province Institutes of Biomedical Sciences Shanxi University College of Life Sciences Shanxi Agricultural University

The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA(dsDNA) in the cytoplasm and triggering downstream signal transduction. Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural features of cGAS and STING proteins, with a particular emphasis on their activation and inhibition mechanisms. We also discuss the novel discovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and antagonists of cGAS and STING, shedding light on their mechanisms of action. Deciphering the molecular intricacies of the cGAS-STING pathway holds significant promise for the development of targeted therapies aimed at maintaining immune homeostasis within both innate and adaptive immunity.

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Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing Xin-Ran Liu xing-Hua wang Hui Han Sha-Sha Liang Xi-Meng Chen Dong-Hui Wei Lai-Sheng wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng xing-Yu wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Theoretical Study on the Stable Structures and Aromaticities for Pnictogen Dianionic Sb4^2-, Bi4^2-, and （SbBi）2^2- Clusters

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Chinese Journal of Chemical Physics 2009年第1期22卷 75-81页

作者： xing-bao wang Xian-xing Chi School of Physics and Electronic Information Wenzhou University Wenzhou 325027 China

Through the theoretical calculation of structural optimization, vibrational frequencies and atomization energies with one method of density functional theory （B3LYP） and two post- Hartree-Fock approaches （MP2, CCSD（T））, several stable isomers for new three pnictogen dianionic Sb4^2-, Bi4^2-, and （SbBi）2^2- species were determined. For two homoatomic Sb4^2- and Bi4^2- species, there are three stable isomers： square （D4h）, roof-shaped （C2v-1）, and C2v-2 structure with the square isomer being the ground state. For the heteroatomic dian- ionic （SbBi）2^2- species, there are also three stable isomers： rhombus （D2h）, roof-shaped （C1）, and C2v structures with the rhombic isomer being the ground state. The calculated NICS values show that nucleus-independent chemical shifts （NICS） values of roof-shaped isomers for Sb4^2-, Bi4^2-, and （SbBi）2^2- species are all negative, consequently indicating that these roof-shaped isomers possess aromaticities. NICS values for the planar ring isomers are all positive, suggesting that these three planar ring isomers have antiaromatic characters. The aromaticity for the two stable roof-shaped and square isomers are preliminarily explained and discussed with MO analysis.

关键词： Pnictogen cluster Ab initio Aromaticity Nucleus-independent chemical shift

Learning a discriminative high-fidelity dictionary for single channel source separation

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Journal of Systems Engineering and Electronics 2021年第5期32卷 1097-1110页

作者： TIAN Yuanrong wang xing School of Electronic Countermeasure National University of Defense TechnologyHefei 230037China Institute of Aeronautics Engineering Air Force Engineering UniversityXi’an 710038China

Sparse-representation-based single-channel source separation,which aims to recover each source’s signal using its corresponding sub-dictionary,has attracted many scholars’*** basic premise of this model is that each sub-dictionary possesses discriminative information about its corresponding source,and this information can be used to recover almost every sample from that ***,in a more general sense,the samples from a source are composed not only of discriminative information but also common information shared with other *** paper proposes learning a discriminative high-fidelity dictionary to improve the separation *** innovations are ***,an extra sub-dictionary was combined into a conventional union dictionary to ensure that the source-specific sub-dictionaries can capture only the purely discriminative information for their corresponding sources because the common information is collected in the additional ***,a task-driven learning algorithm is designed to optimize the new union dictionary and a set of weights that indicate how much of the common information should be allocated to each ***,a source separation scheme based on the learned dictionary is *** results on a human speech dataset yield evidence that our algorithm can achieve better separation performance than either state-of-the-art or traditional algorithms.

关键词： single channel source separation sparse representation dictionary learning discrimination high-fidelity

Molecular toxicity and defense mechanisms induced by silver nanoparticles in Drosophila melanogaster

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Journal of Environmental Sciences 2023年第3期125卷 616-629页

作者： Zhidi wang Liying Zhang xing wang College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China Beijing Key Laboratory of Biodiversity and Organic Farming Beijing 100193China

The widely use of silver nanoparticles(AgNPs) as antimicrobial agents gives rise to potential environmental risks. AgNPs exposure have been reported to cause toxicity in ***, the known mechanisms of AgNPs toxicity are still limited. In this study, we systematically investigated the toxicity of AgNPs exposure using Drosophila *** show here that AgNPs significantly decreased Drosophila fecundity, the third-instar larvae weight and rates of pupation and eclosion in a dose-dependent manner. AgNPs reduced fat body cell viability in MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)assays. AgNPs caused DNA damage in hemocytes and S2 cells. Interestingly, the mRNA levels of the entire metallothionein gene family were increased under AgNPs exposure as determined by RNA-seq analysis and validated by qRT-PCR, indicating that Drosophila responded to the metal toxicity of AgNPs by producing metallothioneins for detoxification. These findings provide a better understanding of the mechanisms of AgNPs toxicity and may provide clues to effect on other organisms, including humans.

关键词： Drosophila melanogaster Silver nanoparticles(AgNPs) Reactive oxygen species(ROS) DNA damage RNA-seq Metallothionein

Reinforcement Learning-Based Dynamic Order Recommendation for On-Demand Food Delivery

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Tsinghua Science and Technology 2024年第2期29卷 356-367页

作者： xing wang Ling wang Chenxin Dong Hao Ren Ke xing Department of Automation Tsinghua UniversityBeijing 100080China School of Mechanical and Automotive Engineering Qingdao Hengxing University of Science and TechnologyQingdao 266100China Meituan Beijing 100015China

On-demand food delivery(OFD)is gaining more and more popularity in modern *** a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform and the delivery experience of *** paper addresses the dynamism of the order recommendation problem and proposes a reinforcement learning solution *** actor-critic network based on long short term memory(LSTM)unit is designed to deal with the order-grabbing conflict between different ***,three rider sequencing rules are accordingly proposed to match different time steps of the LSTM unit with different *** test the performance of the proposed method,extensive experiments are conducted based on real data from Meituan delivery *** results demonstrate that the proposed reinforcement learning based order recommendation method can significantly increase the number of grabbed orders and reduce the number of order-grabbing conflicts,resulting in better delivery efficiency and experience for the platform and riders.

关键词： on-demand food delivery order recommendation reinforcement learning actor-critic network long short term memory

ON THE DIVIDED DIFFERENCE FORM OF FAA DI BRUNO＇S FORMULA

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Journal of Computational Mathematics 2006年第4期24卷 553-560页

作者： xing-hua wang He-yu wang Department of Mathematics Zhejiang University Hangzhou 310028 China Computer Science School Zhejiang University Hangzhou 310027 China Mathematics Department of Hong Kong Baptist University Kowloon Hong Kong

The n-divided difference of the composite function h ：= f o g of functions f, g at a group of nodes t0,t1,…,tn is shown by the combinations of divided differences of f at the group of nodes g（t0）,g（t1）,…,g（tm） and divided differences of g at several partial group of nodes t0,t1,…,tn, where m = 1,2,…,n. Especially, when the given group of nodes are equal to each other completely, it will lead to Faà di Bruno＇s formula of higher derivatives of function h.

关键词： Divided difference Newton interpolation Composite function FAA di Bruno's formula Bell polynomial

Electrochemical performance of aluminum niobium oxide as anode for lithium-ion batteries

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Rare Metals 2016年第3期35卷 256-261页

作者： Qi wang Fu-Chi wang xing-wang Cheng School of Material Science and Engineering Beijing Institute of Technology

AlNbO_4,as lithium-ion batteries（LIBs） anode,has a high theoretical capacity of 291.5 m Ah g^-***,AlNbO_4 anode materials were synthesized through a simple solid-state *** structure,morphology and electrochemical performances of AlNbO4 anode were systematically *** results show that AlNbO4 is monoclinic with C2/m space *** scanning electron microscopy（SEM） and transmission electron microscopy（TEM） characterizations reveal the AlNbO_4 particles with the size of 100 nm^–2 *** a lithium-ion batteries anode,AlNbO4 delivers a high reversible capacity and good rate *** discharge capacity is as high as 151.0 m Ah g^-1 after 50 charge and discharge cycles at 0.1 C corresponding to capacity retention of 90.7 %.When the current density increases to 5.0C,AlNbO4 anode displays reversible discharge capacity of 73.6 m Ah g^-1 at the50 th cycle.

关键词： Aluminum niobium oxide Electrochemical performance Anode Lithium-ion batteries