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A pH-switched mesoporous nanoreactor for synergetic therapy

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Nano Research 2017年第5期10卷 1651-1661页

作者： Zhengqing Yan Andong Zhao xinping liu Jinsong Ren Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China

Zinc oxide nanoparticles （ZnO NPs）, as a new type of pH-sensitive drug carrier, have received much attention. ZnO NPs are stable at physiological pH, but can dissolve quickly in the acidic tumor environment （pH 〈 6） to generate cytotoxic zinc ions and reactive oxygen species （ROS）. However, the protein corona usually causes the non-specific degradation of ZnO NPs, which has limited their application considerably. Herein, a new type of pH-sensitive nanoreactor （ZnO-DOX@F-mSiO2-FA）, aimed at reducing the non-specific degradation of ZnO NPs, is presented. In the acidic tumor environment （pH 〈 6）, it can release cytotoxic zinc ions, ROS, and anticancer drugs to kill cancer cells effectively. In addition, the fluorescence emitted from fluorescein isothiocyanate （FITC）-labeled mesoporous silica （F-mSiO2） and doxorubicin （DOX） can be used to monitor the release behavior of the anticancer drug. This report provides a new method to avoid the non-specific degradation of ZnO NPs, resulting in synergetic therapy by taking advantage of ZnO NPs-induced oxidative stress and targeted drug release.

关键词： zinc oxide mesoporous nanoreactor non-specific degradation controllable release fluorescent imaging

Effects of rainfall patterns on annual plants in Horqin Sandy Land, Inner Mongolia of China

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Journal of Arid Land 2016年第3期8卷 389-398页

作者： YUE Xiangfei ZHANG Tonghui ZHAO Xueyong liu xinping MA Yunhua Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China

Growth of annual plants in arid environments depends largely on rainfall pulses. An increased understanding of the effects of different rainfall patterns on plant growth is critical to predicting the potential responses of plants to the changes in rainfall regimes, such as rainfall intensity and duration, and length of dry intervals. In this study, we investigated the effects of different rainfall patterns（e.g. small rainfall event with high frequency and large rainfall event with low frequency） on biomass, growth characteristics and vertical distribution of root biomass of annual plants in Horqin Sandy Land, Inner Mongolia of China during the growing season（from May to August） of 2014. Our results showed that the rainfall patterns, independent of total rainfall amount, exerted strong effects on biomass, characteristics of plant growth and vertical distribution of root biomass. Under a constant amount of total rainfall, the aboveground biomass（AGB）, belowground biomass（BGB）, plant cover, plant height, and plant individual and species number increased with an increase in rainfall intensity. Changes in rainfall patterns also altered the percentage contribution of species biomass to the total AGB, and the percentage of BGB at different soil layers to the total BGB. Consequently, our results indicated that increased rainfall intensity in future may increase biomass significantly, and also affect the growth characteristics of annual plants.

关键词： Horqin Sandy Land annual plants rainfall patterns biomass plant growth

Effects of gibberellic acid on tiller-bulb number and growth performance of Lilium davidii var. unicolor

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Research in Cold and Arid Regions 2019年第4期11卷 327-334页

作者： YuHui He ZhongKui Xie xinping liu YaJun Wang YuBao Zhang Yang Qiu Department of Ecology and Agriculture Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences

Lilium davidii ***(Lanzhou lily)is an important economic crop in the northwest cold and arid regions of *** regulation of tiller-bulb development and plant growth is the key to improving yield and quality of the *** study attempted to evaluate the effect of gibberellic acid(GA3)on tiller-bulb development and plant growth of Lanzhou lily by applying GA3 at various concentrations(0 mg/L,10 mg/L,30 mg/L,60 mg/L,and 100 mg/L)before planting and in the seedling *** showed that the 60-mg/L GA3 application had an inhibiting effect on tiller-bulb formation and increased the ratios of single and double bulbs but decreased the ratios of bulbs with three or more tiller bulbs,as com pared to the control(CK)and other GA3 *** difference in flower number did not reach significant levels among the *** tillering-related endogenous hormones IAA(indole-3-acetic acid)and Z(zeatin)content de creased,while IAA/Z increased with the 60-mg/L GA3 treatment during tiller *** also,the shoot-bulb number and total daughter-bulb number decreased significantly with the 60-mg/L GA3 ***,the 10-mg/L GA3 application promoted growth of Lanzhou lily significantly and resulted in an increase in plant height;bulb diameter;bulb circumference;and biomass of shoots,bulbs,fibrous roots,and the whole ***,GA3 application is promising as a new regulation method for inhibiting tiller-bulb development and promoting bulb growth in Lanzhou lily production.

关键词： Gibberellic acid tiller bulb endogenous hormone content height biomass

The response of Caragana microphylla seedlings to water table changes in Horqin Sandy Land,China

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Research in Cold and Arid Regions 2015年第1期7卷 88-93页

作者： YunHua Ma TongHui Zhang xinping liu Wei Mao XiangFei Yue Naiman Desertification Research Station Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences University of Chinese Academy of Sciences

This paper focuses on the growth response of Caragana microphylla seedlings to changes of artificially controlled water table in Horqin Sandy Land, China. Monitoring results of soil water content shows that soil moisture is closely correlated to groundwater depths. Soil volumetric water increased rapidly when close to water sources and finally stabilized in a saturated state. The soil moisture trend of CK （control） increased gradually at 0-50 cm of soil depth then decreased to 4% below 50 cm soil depth. C. microphylla can adapt to different soil environments by changes in ecological and physiological characteristics. By comparing the ecological characteristics of C. microphylla seedlings at various water tables, we found that a shallow water table of 40 cm depth inhibited seedling groundwater depth of 120 em was more advantageous for plant growth because of weak ecological characteristics. A height and canopy growth of C. microphylla seedlings. During the first two years, the most suitable water depth for root biomass was 120 cm, and 180 cm for root length. The growth of vertical roots is positively correlated with groundwater depth, and root thickness is the determinate factor for root biomass while the fine root is the determinate factor for root length. A thick root would grow much more in a natural drought environment while access to ground water promotes the growth of fine roots.

关键词： water table changes Caragana microphylla seedlings ecological characteristics Horqin Sandy Land

Reform Trend of China Natural Gas Price Policy

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China Oil & Gas 2012年第2期19卷 12-18页

作者： Du Wei liu xinping CNPC Economics & Technology Research Institute PetroChina Marketing Company

China's natural gas price policy reform lags behind refined oil price reform comparatively, and current natural gas price policy

关键词：价格改革价格政策天然气中国成品油

A Young Woman Millionaire

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Women of China 1998年第7期 6-8页

作者： liu xinping HONG liu

ZHANG Can is a young woman who likes to laugh. She is also the founder of a business kingdom worth 400 million yuan. Certainly, there were points in her career that were no laughing matter, but now she is general mana... 详细信息

关键词： Zhang A Young Woman Millionaire

Variation of China ROP Policy

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China Oil & Gas 2012年第1期19卷 16-21页

作者： Du Wei liu xinping CNPC Economics ＆ Technology Research Institute PetroChina Marketing Company

History and current state of China's ROP policy China's refined oil pricing mechanism belonged to the stage of single target price before 1983,the stage of dualprice mechanism between 1983 and 1993,and the stage of price consolidation between 1994 and *** the mechanism got rid of the bondage of planned economy and entered into the track of market *** 1998 the market reform of the mechanism advanced steadily based on

关键词：中国国情 ROP 定价机制市场化改革计划经济市场经济成品油

Subpixel imaging method with area-array CCD sensors and experiment

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Chinese Science Bulletin 2000年第2期45卷 137-139页

作者： xinping liu Zhan Gao Nianmao Deng Zhao Lu Lei Wu Baoqing An Yingcai Li Baochang Zhao Mingqiu Xue Chinese Acad Sci Xian Inst Opt & Precis Mech Xian 710068 Peoples R China

A novel high resolution imaging technique-subpixel imaging with area-array CCD sensors-is presented. The imaging method is practical as demonstrated by the computer simulation and expetimental results. It is useful to reduce the effective focal length and enhance the spatial resolution. As there are no moving elements, the subpixel imaging system will be suitable for space application.

关键词： subpixel imaging high resolution imaging CCD camera remote sensing.

Pictet-spengler/transamination cascade reaction of indoles for modular synthesis of marinoquinoline analogues

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Green Synthesis and Catalysis 2024年第4期5卷 310-314页

作者： Jinjin Chen Pingyu Jiang xinping liu Huawen Huang Guojiang Mao Guo-Jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan411105China School of Pharmaceutical Science Hengyang Medical SchoolUniversity of South ChinaHengyang421001China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang453007China

The Pictet-Spengler/transamination cascade reaction enables modular synthesis of marinoquinoline analoguesthrough three-component indole ring-expansion/cyclization in the manner of novel N1–C2 cleavage of *** metal-free protocol exhibits very broad functional group tolerance with up to quantitative yields. Preliminarystudies on the antitumor activity of the resultant marinoquinoline analogues reveal that the indolyl-attachedpyrrolo[2,3-c]quinoline product (5d) shows great potential (IC50 of 0.32 μg/mL to HeLa cells) as a promisinganticancer agent in clinic.

关键词： Pictet-spengler reaction Indole ring-expansion N1-C2 cleavage Indole Marinoquinoline analogues