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A DNA Force Circuit for Exploring Protein-Protein Interactions at the Single-Molecule Level

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Chinese Journal of Chemistry 2024年第13期42卷 1456-1464页

作者： Kangkang Ma Luoan Xiong Zhuofei Wang xin Hu Lihua Qu Xuetong Zhao y.o Li Zhongbo y. State Key.Laboratory.of Medicinal Chemical Biology Frontiers Science Center for Cell Responsesand College of PharmacyNankai University38 Tongyan RoadTianjin 300350China School of Phy.ics and Key.Laboratory.of Functional Poly.er Materials of Ministry.of Education Nankai Universityand Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300071China

Protein-protein interactions(PPls)play.a crucial role in drug discovery.and disease ***,the development of effective drugs targeting PPls remains challenging due to limited methodologies for probing their spatiotemporal ***,we propose a single-molecule approach using a unique force circuit to investigate Ppl dy.amics and anisotropy.under mechanical *** conventional techniques,this approach enables the manipulation and real-time monitoring of individual proteins at specific amino acids with defined geometry.offering insights into molecular mechanisms at the single-molecule *** DNA force circuit was constructed using click chemistry.conjugation methods and genetic code expansion techniques,facilitating orthogonal conjugation between proteins and nucleic *** SET domain of the MLL1 protein and the tail of histone H3 were used as a model sy.tem to demonstrate the application of the DNA force *** the use of atomic force microscopy.and magnetic tweezers,optimized assembly.procedures were *** DNA force circuit provides an exceptional platform for study.ng the anisotropy.of PPis and holds promise for advancing drug discovery.research targeted at PPIs.

关键词： Single-molecule studies Protein-protein interactions Click chemistry Genetic code expansion Molecular dy.amics

Clathrate structure of y._(3)C_(3) for high-performance thermoelectrics with superior mechanical properties

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Journal of Materiomics 2024年第4期10卷 783-791页

作者： y.ngfan Cui Shuai Duan Xiaojun Wang Qinghang Tang Jiny.ng Xi Xiaobing Liu y.ngsheng Zhang xin Chen Laboratory.of High Pressure Phy.ics and Material Science(HPPMS) School of Physics and Physical EngineeringQufu Normal UniversityQufuShandong273165China Materials Genome Institute Shanghai UniversityShanghai200444China Advanced Research Institute of Multidisciplinary.Science Qufu Normal UniversityQufuShandong273165China

Exploring high-performance thermoelectric materials with improved mechanical properties is important for broadening the application scope and the assembly.requirement of stable *** work presents an effective strategy.to discover hard thermoelectric material by.inserting foreign atoms in the rigid covalent *** demonstrate this in boron-carbon clathrate VII structure,showing a promising candidate for highly.efficient thermoelectric energy.conversion,especially.with y.atom filled in the cage,with a peak zT of 0.73 at 1,000 *** ab initio calculations indicate that y._(3)C_(3) sy.tem has low lattice thermal conductivity.of 4.5 W/(m·K)at 1,000 K due to the strong rattling of encaged y.*** strongly.covalent framework provides highly.degenerate band structures consisting of heavy.and light electron pockets,which can maintain high carrier mobility.arising from small effective mass and thus large group ***,high power factor can be achieved in y._(3)C_(3) for both electron and hole *** addition,it exhibits well mechanical properties and a Vickers hardness of 23.7 GPa because of the strong covalent boron-carbon *** work provides a novel avenue for the search of high-performance thermoelectric materials with excellent mechanical properties,based on boron-carbon clathrate structure.

关键词： Clathrate structure Thermoelectric performance First-principles calculations Mechanical properties Thermal conductivity

A Versatile BenzimidazoleSubstituted Spirolactam Mechanophore:When Excited State Intramolecular Proton Transfer Couples with Rhodamine

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CCS Chemistry 2024年第7期6卷 1798-1809页

作者： Huan Hu xin Cheng Zhimin Ma Qingy.an y.ng Rint PSijbesma Zhiy.ng Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 College of Engineering Peking UniversityBeijing 100871 Department of Chemical Engineering and Chemistry Institute for Complex Molecular SystemsEindhoven University of Technology5600 MBEindhoven

Exploration of multicolor mechanochromic bulk poly.ers based on a single mechanophore is a big challenge to ***,we report a versatile benzimidazole-substituted spirolactam mechanophore where excited state intramolecular proton transfer(ESIPT)coupled with *** mechanophore was facilely.sy.thesized and then covalently.linked to poly.rethane(PU)*** PU film containing the mechanophore(1@PU)showed cooperative photochromism upon irradiation involving simultaneous enhancement of normalized enol and rhodol emissions based on a cooperative ESIPT process and the ring-opening reaction of ***,the film exhibited dual-mode multicolor mechanochromism upon stretching and *** normalized intensity.of enol emission increased and the fluorescence turned from light green to cy.n after stretching,then red coloration appeared from colorless after *** experiments and density.functional theory.calculations confirmed that the stretch-induced increase of enol emission was attributed to torsion of the dihedral angle between xanthene and benzimidazole in the mechanophore via force-induced disaggregation and direct force action on the isolated *** of the dihedral angle and the ring-opening reaction of spirolactam in a single mechanophore occurred sequentially.during compression,resulting in an observed red *** study.might provide a glimpse into the design of novel multicolor mechanochromic mechanophores.

关键词： mechanophore rhodamine excited state intramolecular proton transfer cooperative photochromism dual-mode mechanochromism

Effect of solidification mode on microstructure evolution and properties of magnesium alloy.with long-period stacking ordered phase

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Journal of Iron and Steel Research International 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei Chen Xu Zhang Qian-hao Zang Jing Zhang Di Feng y.n-xin Qiao y.-hang Guo School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina School of Metallurgy.and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employ.d to prepare Mg–6Gd–3y.xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy.microstructures and the changes in properties were analy.ed for different Zn *** has been observed that in alloy. without electromagnetic stirring,as the Zn content increases,the alloy.structure gradually.*** primary.second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloy. subjected to electromagnetic stirring,there is a relatively.higher content of the second phase,primarily.consisting of LPSO *** apply.ng electromagnetic stirring,the quantity.and the ty.e of LPSO phase in the alloy.*** alloy.structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloy. with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property

NF-κB in biology.and targeted therapy.new insights and translational implications

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1322-1358页

作者： Qing Guo y.zi Jin xiny. Chen Xiaomin y. xin Shen Mingxi Lin Cheng Zeng Teng Zhou Jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key.Laboratory.of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly.40 ***,NF-κB signaling was identified as a pivotal pathway.in mediating inflammatory.***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety.of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory.mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathway.,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch,hedgehog,and TLR *** phy.iological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety.of human diseases,including cancers,inflammatory.and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKls,non-coding RNAs,immunotherapy.and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKT diseases involvement

Innovative Mn_(3-x)O_(4-y.@NCA design:Leveraging Mn/O vacancies and amorphous architecture for enhanced sodium-ion storage

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Journal of Energy.Chemistry 2024年第10期97卷 747-756,I0015页

作者： Kaijun Xie xin Liu Kai Xia Lipeng Diao Ping Lu Mengmeng Wang Long Fang y.hui Zou Dongjiang y.ng Xiaodong Zhang College of Chemistry.and Chemical Engineering College of Environmental Science and EngineeringState Key Laboratory of Bio-fibers and Eco-textilesShandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsQingdao UniversityQingdao 266071ShandongChina Institute of Micro/Nano Materials and Devices Ningbo University of TechnologyNingbo 315211ZhejiangChina

Manganese-based oxide electrode materials suffer from severe Jahn-Teller(J-T)distortion,leading to severe cy.le instability.in sodium ion ***,it is difficult to adjust the electron at d orbitals exactly.to a low spin state to eliminate orbital degeneracy.and suppress J-T distortion *** article constructed concentration-controllable Mn/O coupled vacancy.and amorphous network in Mn_(3)O_(4) and coated it with nitrogen-doped carbon aerogel(Mn_(3-x)O_(4-y.@NCA).The existence of Mn/O vacancies has been confirmed by.scanning transmission electron microscopy.STEM)and positron annihilation lifetime spectroscopy.PALS).Atomic absorption spectroscopy.AAS)and X-ray.photoelectron spectroscopy.XPS)determine the most optimal ratio of Mn/O vacancies for sodium ion storage is 1:*** functional theory.DFT)calculations prove that Mn/O coupled vacancies with the ratio of 1:2could exactly.induce a low spin states and a d~4 electron configuration of Mn,suppressing the J-T distortion *** abundant amorphous regions can shorten the transport distance of sodium ions,increase the electrochemically.active sites and improve the pseudocapacitance *** the sy.ergetic effect of Mn/O coupled vacancies and amorphous regions,Mn_(3-x)O_(4-y.@NCA exhibits an energy.density.of 37.5 W h kg^(-1)and an ultra-high power density.of 563 W kg^(-1)in an asy.metric *** sodium-ion batteries,it demonstrates high reversible capacity.and exceptional cy.ling *** research presents a new method to improve the Na^(+)storage performance in manganese-based oxide,which is expected to be generalized to other structural distortion.

关键词： Manganese-based metal oxide Concentration-controllable Mn/O coupled vacancies Amorphous network Sodium ion supercapacitor Sodium ion battery

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大型绞吸挖泥船阻力预报的设置方法

中国造船 2024年第3期65卷 265-275页

作者：陈超余欣王有江陈新权何炎平上海交通大学海洋智能装备与系统教育部重点实验室上海200240 上海交通大学船舶与海洋工程设计研究所上海200240

绞吸挖泥船具有船体肥大、艏艉设有大型开槽等特征,与常规船型有显著区别。这增加了阻力预报的难度。为探究更为精确的阻力预报设置,论文以一艘性能经过船模试验验证的大型绞吸挖泥船为研究对象,基于STAR-CCM+软件,采用SST k-ω和Realiz... 详细信息

绞吸挖泥船具有船体肥大、艏艉设有大型开槽等特征,与常规船型有显著区别。这增加了阻力预报的难度。为探究更为精确的阻力预报设置,论文以一艘性能经过船模试验验证的大型绞吸挖泥船为研究对象,基于STAR-CCM+软件,采用SST k-ω和Realizable k-ε两种湍流模型,在y.(+)=1和y.(+)=50两种条件下进行了静水阻力预报计算。结果表明:在y.(+)=1的条件下计算得到的阻力预报结果相较于y.(+)=50条件下的精度提高了约6%,采用SST k-ω模型计算得到的结果相较于Realizable k-ε模型提高约4%。本研究成果将为自航式绞吸挖泥船的阻力预报提供可靠的参考依据。

关键词：绞吸挖泥船阻力预报计算流体力学

A BBS4 mutation causes autosomal dominant poly.y.tic liver disease

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Genes & Diseases 2024年第1期11卷 72-75页

作者： y.lu Cui Wenping Xu Jinpei Liu Shuqing Liu Wei Huang y.hai Shi xin Zhang Cuihua Lu Weifen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Gastroenterology Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Gastroenterology Affiliated Hospital of Nantong UniversityNantong UniversityNantongJiangsu 226001China

Autosomal dominant poly.y.tic liver disease(ADPLD)refers to a condition characterized by.the presence of numerous cholangiocy.es-lined and fluid-filled cy.ts in the liver and the absence of poly.y.tic kidney.disease.1 Although patients with ADPLD may.be asy.ptomatic,some patients suffer from abdominal pain,gastroesophageal reflux,and nausea,because of hepatomegaly.

关键词： liver poly.y.tic patients

Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly.mouse model

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Journal of Genetics and Genomics 2024年第4期51卷 419-432页

作者： Qing y.ng Qiang Cao y.e y. Xianxin Lai Jiahao Feng xinjie Li y.nan Jiang y.zhou Sun Zhong-Wei Zhou xin Li School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China Academy.of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key.Laboratory.of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous *** methy.ation and hy.roxy.ethy.ation play.important roles in regulating cerebral cortex ***,it remains unclear whether abnormal cerebral cortex development,such as microcephaly.could rescale the epigenetic landscape,potentially.contributing to dy.regulated gene expression during brain *** this study.we characterize and compare the DNA methy.ome/hy.roxy.ethy.ome and transcriptome profiles of the cerebral cortex across several developmental stages in wild-ty.e(WT)mice and Mcph1 knockout(Mcph1-del)mice with severe ***,we discover a global reduction of 5′-hy.roxy.ethy.cy.osine(5hmC)level,primarily.in TET1-binding regions,in Mcph1-del mice compared to WT mice during juvenile and adult ***,genes exhibiting diminished 5hmC levels and concurrently.decreased expression are essential for neurodevelopment and brain ***,genes display.ng a delay.d accumulation of 5hmC in Mcph1-del mice are significantly.associated with the establishment and maintenance of the nervous sy.tem during the adult *** findings reveal that aberrant cerebral cortex development in the early.stages profoundly.alters the epigenetic regulation program,which provides unique insights into the molecular mechanisms underpinning diseases related to cerebral cortex development.

关键词： Microcephaly Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hy.roxy.ethy.ome Transcriptome