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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

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Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue ZHANG xin-xin yang Yiguo ZHOU Shan-shan ZHANG Jun-lian yang Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

P-Laplace Equation for the Grushin Type Operator

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Acta Mathematica Sinica,English Series 2023年第5期39卷 923-938页

作者： Ji Zheng HUANG xin xin yang School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China

Let Gλ,λ>0,be a Grushin type operator on Rn×*** this paper,we will first establish existence and uniqueness for the p-Laplace equation for Gλ,then we prove the regularity of *** order to prove our results,we will ... 详细信息

关键词： solutions. inequality uniqueness

Phosphine oxide directing-group-enabled atroposelective C-H bond acyloxylation via an eight-membered palladacycle intermediate

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Chinese Chemical Letters 2023年第5期34卷 277-280页

作者： Peng-Bo Bai Ming-Ying Wu xin-xin yang Gang-Wei Wang Shang-Dong yang State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Herein,we report the first atroposelective C(sp^(2))-H bond acyloxylation enabled by a phosphine oxide directing ***,this transformation is shown to proceed through an eight-membered palladacycle intermediate,as opposed to the kinetically and thermodynamically favored five-membered palladacycle ***,L-pGlu-OH,a cheap and abundant chiral amino acid derivative,was identified as the best chiral ligand to promote this atroposelective remote C-H functionalization reaction.

关键词： Palladiumcatalyst Axially chiral Acetylation Dibenzophosphorus oxide

Solvent-controlled regioselective arylation of indoles and mechanistic explorations

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Organic Chemistry Frontiers 2022年第4期9卷 1023-1032页

作者： Yuan Niu Chao-Xian Yan xin-xin yang Peng-Bo Bai Pan-Pan Zhou Shang-Dong yang State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

The ability to manipulate the site selectivity in C–H bond functionalization reactions is an important goal in modern ***,we report a new reaction strategy for the regioselective arylation of indoles at C2 or C3 posi... 详细信息

关键词： chemistry group indole

Love wave propagation in one-dimensional piezoelectric quasicrystal multilayered nanoplates with surface effects

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 619-632页

作者： xin FENG Liaoliang KE yang GAO College of Science China Agricultural UniversityBeijing 100083China School of Mechanical Engineering Tianjin UniversityTianjin 300350China

The exact solutions for the propagation of Love waves in one-dimensional(1D)hexagonal piezoelectric quasicrystal(PQC)nanoplates with surface effects are *** electro-elastic model is developed to investigate the anti-plane strain problem of Love wave *** introducing three shape functions,the wave equations and electric balance equations are decoupled into three uncorrelated *** the boundary conditions of the top surface on the covering layer,the interlayer interface,and the matrix,a dispersive equation with the influence of multi-physical field coupling is provided.A surface PQC model is developed to investigate the surface effects on the propagation behaviors of Love waves in quasicrystal(QC)multilayered structures with nanoscale thicknesses.A novel dispersion relation for the PQC structure is derived in an explicit closed form according to the non-classical mechanical and electric boundary *** examples are given to reveal the effects of the boundary conditions,stacking sequence,characteristic scale,and phason fluctuation characteristics on the dispersion curves of Love waves propagating in PQC nanoplates with surface effects.

关键词： piezoelectric quasicrystal(PQC)material multilayered plate dispersion characteristic surface effect

Repair tolerance assessment for aircraft composite structures using Bayesian updating

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Chinese Journal of Aeronautics 2024年第6期37卷 360-391页

作者： xin LI Hongfu ZUO Bin yang School of Automotive and Rail Transit Nanjing Institute of TechnologyNanjing 211167China Civil Aviation Key Laboratory of Aircraft Health Monitoring and Intelligent Maintenance College of Civil AviationNanjing University of Aeronautics and AstronauticsNanjing 211106China

Detection and repair of composite damage is crucial to ensure the safety and reliability of aircraft structures.A novel approach to quantitatively evaluate the repair tolerance of composite structures in civil aircraft based on Bayesian updating is *** method incorporates historical damage inspection data to determine the prior distribution of damage size,which is then updated with newly collected damage size data using Bayesian *** Carlo simulation is employed to investigate the probability of failure and estimate maintenance costs,considering various factors such as the frequency and timing of damage events,damage detection,structural strength,gust loads,and maintenance expenses throughout the lifecycle of composite *** and economic factors are considered to establish a lower threshold for repairs and an upper threshold for maintenance based on the occurrence of accidental impact *** of the effectiveness and feasibility of a quantitative assessment method for repair tolerance is conducted using damage statistics data from civil aircraft routes utilizing the structural skin panels of composite outer *** results demonstrate that the method proposed in conjunction with extensive simulations and full utilization of field damage inspection data can effectively simulate unexpected impact damage situations that may occur during civil aircraft service and evaluate the reliability and economic feasibility of the repair of *** research findings hold significant theoretical and practical value for the preparation of documents for continued airworthiness of composite structures,including structural repair manuals and maintenance programs.

关键词： Composite structures Repairtolerance Maintenance Bayesian updating Probabilityof failure

Selection Method for New Energy Output Guaranteed Rates Considering Optimal Energy Storage Configuration

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 539-547页

作者： xin Cheng Tong Wu Wei Yao Yan yang Guangdong Power Grid Corporation Guangzhou 510620China State Key Laboratory of Advanced Electromagnetic Engineering and Technology and School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The output of new energy represented by wind power and photovoltaic power features volatility and randomness. It is a practical approach to use the guaranteed rate with statistical characteristics to analyze the output coefficient of new energy. However, there is a lack of analysis and demonstration on the value of the new energy output guaranteed rate. To solve this problem, a selection method for the new energy output guaranteed rate considering optimal energy storage configuration is proposed. First, the influence of the new energy output guaranteed rate on the new energy output coefficient is analyzed. Secondly, with the goal of minimizing the comprehensive costs, an optimal configuration model of energy storage based on the output guaranteed rate of new energy is constructed, and particle swarm optimization is used for the optimization solution. Then, according to the optimal energy storage configuration results under different guaranteed rates, a reasonable new energy output guaranteed rate is determined by maximizing the comprehensive benefits obtained from energy storage. Finally, an example applied to the power grid in an area of Guangdong in Southern China is provided to illustrate the effectiveness of the proposed method.

关键词： Energystorage optimization guaranteed output guaranteed rate new energy consumption

Randomized trial estimating effects of hypnosis versus progressive muscle relaxation on medical students’test anxiety and attentional bias

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World Journal of Psychiatry 2022年第6期12卷 801-813页

作者： yang Zhang xin-xin yang Jing-Yi Luo Meng Liang Ni Li Qian Tao Li-Jun Ma Xiao-Ming Li Affiliated Psychological Hospital Anhui Medical UniversityHefei 230032Anhui ProvinceChina The Fourth People’s Hospital Hefei 230032Anhui ProvinceChina Anhui Mental Health Center Hefei 230032Anhui ProvinceChina Department of Medical Psychology School of Mental Health and Psychological ScienceAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Psychology School of Basic MedicineJinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Psychology Anqing Normal UniversityAnqing 246011Anhui ProvinceChina

BACKGROUND Test anxiety is prevalent among medical students and leads to impaired academic ***-related attentional bias has been identified as an important maintaining factor in test-anxious *** To evaluate whether hypnosis and progressive muscle relaxation(PMR)could modify medical college students’test anxiety and attentional *** A total of 598 medical students were *** participants were divided into higher and lower test anxiety groups according to their scores on the test anxiety scale(TAS).Ninety medical college students with high TAS score were randomly assigned to a hypnosis or PMR *** 45 students with low TAS score were included,forming a baseline control *** intervention was conducted weekly for 6 wk,and each session lasted approximately 30 *** total intervention time and the number of intervention sessions for the hypnosis and PMR groups were *** were collected at the pretest,posttest,and 2-mo *** Hypnosis group participants had a significantly lower TAS score at posttest(t=-21.827,P<0.001)and at follow-up(t=-14.824,P<0.001),compared to that at *** group participants also had a significantly lower TAS score at posttest(t=-10.777,P<0.001)and at follow-up(t=-7.444,P<0.001),compared to that at *** the posttest level,the hypnosis group had a significantly lower TAS score than the PMR group(t=-3.664,P<0.001).At the follow-up level,the hypnosis group also had a significantly lower TAS score than the PMR group(t=-2.943,P=0.004).Clinically significant improvement was found in both the hypnosis and PMR groups(hypnosis=64.0%;PMR=62.22%).Hypnosis was more effective than PMR in reducing test anxiety among medical college *** could modify attentional bias toward threatening stimuli,but PMR could *** These results suggest that attentional bias plays an important role in test anxiety treatment.

关键词： Test anxiety Hypnosis Progressive muscle relaxation Attentional bias Randomized controlled trial

Data Driven Vibration Control:A

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1898-1917页

作者： Weiyi yang Shuai Li xin Luo Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714 Chongqing School University of Chinese Academy of SciencesChongqing 400714China Faculty of Information Technology and Electrical Engineering University of OuluOulu 90570 VTT-Technology Research Center of Finland Oulu 90570Finlan College of Computer and Information Science Southwest UniversityChongqing 400715China

With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests from both the industrial and academic *** shaping(IS),as a simple and effective feedforward method,is greatly demanded in DDVC *** convolves the desired input command with impulse sequence without requiring parametric dynamics and the closed-loop system structure,thereby suppressing the residual vibration *** on a thorough investigation into the state-of-the-art DDVC methods,this survey has made the following efforts:1)Introducing the IS theory and typical input shapers;2)Categorizing recent progress of DDVC methods;3)Summarizing commonly adopted metrics for DDVC;and 4)Discussing the engineering applications and future trends of *** doing so,this study provides a systematic and comprehensive overview of existing DDVC methods from designing to optimizing perspectives,aiming at promoting future research regarding this emerging and vital issue.

关键词： Data driven vibration control(DDVC) data science designing method feedforward control industrial robot input shaping optimizing method residual vibration