Phosphine oxide directing-group-enabled atroposelective C-H bond acyloxylation via an eight-membered palladacycle intermediate

作     者：Peng-Bo Bai Ming-Ying Wu Xin-Xin Yang Gang-Wei Wang Shang-Dong Yang Peng-Bo Bai;Ming-Ying Wu;Xin-Xin Yang;Gang-Wei Wang;Shang-Dong Yang

作者机构：State Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000China State Key Laboratory for Oxo Synthesis and Selective OxidationLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第5期

页      面：277-280页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Natioal Natural Science Foundation of China(NSFC,No.22171119) Gansu Province Science and Technology Plan Project(Nos.21YF5WA114 and 21ZD4WA021)for financial support 

主　　题：Palladiumcatalyst Axially chiral Acetylation Dibenzophosphorus oxide 

摘      要：Herein,we report the first atroposelective C(sp^(2))-H bond acyloxylation enabled by a phosphine oxide directing ***,this transformation is shown to proceed through an eight-membered palladacycle intermediate,as opposed to the kinetically and thermodynamically favored five-membered palladacycle ***,L-pGlu-OH,a cheap and abundant chiral amino acid derivative,was identified as the best chiral ligand to promote this atroposelective remote C-H functionalization reaction.