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Reconstruction of complex orbital fracture with titanium implants

International Journal of Ophthalmology(English edition) 2012年第4期5卷 488-492页

作者： Wen-Shu Yi, xin-rong ou Department of Ophthalmology Xiangya Hospital Central South University Changsha 410008 Hunan Province China Department of Neurologic Xiangya Hospital Central South University Changsha 410008 Hunan Province China Department of Oral and Maxillofacial Xiangya Hospital Central South University Changsha 410008 Hunan Province China

AIM: To evaluate the effectiveness and safety of complex orbital fracture reconstruction with titanium implants. METHODS: A retrospective review of 46 patients treated with complex orbital fractures reconstruction using titanium implants from January 2005 to December 2008 was conducted. The following data were recorded: age, gender, mechanism of injury, preoperative and postoperative orbital CT, visual acuity, diplopia, ocular motility and Hertel exophthalmometer. RESULTS: The most common cause was motor vehicle accident (47.8%), followed by industrial injury (30.4%). All patients had improved appearance after operation and CT scan at one week after operation showed the fracture defects of orbit and neighboring areas had been reconstructed. Forty-six cases had various degrees of enophthalmos before operation. Among them, 32 cases were completely corrected, 11 cases improved obviously and 3 cases had no improvement after operation. Thirty-six patients with visual acuity =20/60 revealed diplopia of various degrees, including 26 patients had diplopia in right ahead and/or reading positions. At the sixth month after operation, diplopia disappeared in five patients, 7 patients still had diplopia in right ahead and/or reading positions, 14 patients had diplopia in positions rather than right ahead and reading positions (20 degrees). All patients had various degrees of ocular motility disorders before operation. At the sixth month after operation, eyeball movement disorder disappeared in 9 patients, 31 patients showed improvement and 6 patients had no improvement. Complications of implant infection, rejection and displacement were not reported after operation. CONCLUSION: The application of titanium implants in the repair of complex orbital fractures greatly improves the appearance and functional results, which is a favorable material for plastic surgery of complex orbital fracture.

关键词： complex orbital fractures titanium reconstruction

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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水解胶原蛋白口服液中肽分子量分布测定

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食品科技 2011年第8期36卷 263-265页

作者：徐昕荣区雪连朱斌黄思静马瑜璐华南理工大学分析测试中心广州510640

建立了水解胶原蛋白口服液中肽分子量分布的基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF-MS)检测方法。实验探讨了基质的选择、基质与样品的配比及检测方式对测定的影响,结果表明,采用合适的基质与样品的配比,在正离子反射模式下,以2... 详细信息

建立了水解胶原蛋白口服液中肽分子量分布的基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF-MS)检测方法。实验探讨了基质的选择、基质与样品的配比及检测方式对测定的影响,结果表明,采用合适的基质与样品的配比,在正离子反射模式下,以2,5-二羟基苯甲酸(DHB)为基质,可得到水解胶原蛋白口服液中肽分子量分布的质谱图,该水解胶原蛋白口服液中肽的分子量主要集中在0.6～1.5ku。该方法简单快速,有较高的准确性,且提高了检测效率,可实现批量检测。

关键词：基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF-MS) 水解胶原蛋白分子量分布

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π-conjugated chromophore functionalized high-nuclearity titanium-oxo clusters containing structural unit of anatase for photocatalytic selective oxidation of sulfides

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Rare Metals 2024年第4期43卷 1736-1746页

作者： Ling-rong Liao Dong-Chun Zheng Pin-Xi ou Qi-xin Zhao Wei-Min Xuan Qi Zheng State Key Laboratory for Modification of Chemical Fibers and Polymer Materials&College of Materials Science and Engineering Donghua UniversityShanghai201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials and College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China

N-doping has significant influence in manipulating the properties of TiO_(2),and this has stimulated the development of N-donor-functionalized titanium-oxo clusters(TOCs)as molecular models to study the structure-property ***,the structural type and photoresponsive application are still limited for such TOCs,especially regarding the high-nuclearity TOCs that contain structure unit of TiO_(2)for ***,we showed the synthesis of a series of high-nuclearity TOCs 1-3 compounds usingπ-conjugated 1,10-phenanthroline(phen)as chromophore and N-donor functional *** 1 features cocrystal structure composed of one[Ti_(26)]~(2+)and half[Ti_(22)]~(2+),which renders it as the first cocrystallized TOC containing two positively charged species and phen-functionalized TOC showing the highest nuclearity up to 37 Ti *** adjusting the synthetic conditions,the individual{Ti_(22)}and{Ti_(26)}clusters can also be isolated as Compounds 2 and 3,*** core structure of{Ti_(22)}is mainly constructed from four lacunary{Ti_(4)}derived from pentagonal{Ti(Ti)_5}unit,while{Ti_(26)}is built from four complete{Ti(Ti)_5}***,a{Ti_8O_(14)}structure unit of anatase TiO_(2)can be identified in{Ti_(26)}.Based on the unique structural features and proper photophysical and photochemical properties of Compounds 1-3,they are applied for photocatalytic *** to the presence of anatase structure unit in{Ti_(26)}and the synergistic effect from{Ti_(22)}and{Ti_(26)},the catalytic performance presents in the order of Compound 1>Compound 3>Compound *** work provides excellent models to understand the structureproperty relationship from the perspective of cocrystallization and Ti-O binding model and will further promote the application of TOCs as functional catalysts for organic transformation.

关键词： Titanium-oxo cluster Molecular model of anatase TiO_(2) High nuclearity π-conjugated chromophore Photocatalytic sulfoxidation

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Estimation of the sheath power dissipation induced by ion cyclotron resonance heating

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Plasma Science and Technology 2020年第6期22卷 81-90页

作者： xin AN Jing ou Zongzheng MEN Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China Center for Magnetic Fusion Theory Chinese Academy of SciencesHefei 230031People's Republic of China

During ion cyclotron resonance heating,the sheath power dissipation caused by ion acceleration in the radio frequency(RF)sheath is one of the main causes of RF power loss in the tokamak edge *** estimate the power dissipation of an RF sheath in the ion cyclotron range of frequency(ICRF),a 1 D fluid model for the multi-component plasma sheath driven by a sinusoidal disturbance current in the ICRF is *** investigation of the sheath potential and ion flux at the wall,it is shown that the larger frequency and lower amplitude of the disturbance current can cause smaller sheath power *** effect of the energetic ion on the sheath power dissipation depends on the disturbance *** large amplitude of disturbance current,the increase in the concentration and energy of the energetic ion leads to a decrease in sheath power *** for a small disturbance current,the sheath power dissipation demonstrates non-monotonic variation with the concentration and energy of the energetic *** addition,the sheath power dissipation is found to have a small increase in the presence of light impurity ions with low valence.

关键词： sheath power dissipation RF sheath energetic ion disturbance current

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Investigation on Effects of Mooring Line Fractures and Connector Failures for A Hybrid Modular Floating Structure System

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China Ocean Engineering 2022年第6期36卷 880-893页

作者： LIU Ya-qiong REN Nian-xin ou Jin-ping School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China College of Civil Engineering and Architecture Hainan UniversityHaikou 570228China

The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction *** effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring line tensions,module motions,connector loads and wave power production)of the HMFS system under typical sea con-ditions are comparatively *** results indicate that the mooring tension distribution,certain module motions(surge,sway and yaw)and connector loads(Mz)are significantly influenced by mooring line *** adjacent mooring line of the fractured line on the upstream side suffers the largest tension among the remaining mooring lines,and the case with two fractured mooring lines in the same group on the upstream side is the most dangerous among all cases of two-line failures in view of mooring line tensions,module motions and connector ***-fore,one emergency strategy with appropriate relaxation of a proper mooring line has been proposed and proved effective to reduce the risk of more progressive mooring line *** addition,connector failures substantially affect certain module motions(heave and pitch),certain connector loads(Fz and My)and wave power *** present work can be helpful and instructive for studies on malfunction conditions of modular floating structure(MFS)systems.

关键词： Hybrid Modular Floating Structure(HMFS)system mooring line fractures connector failures hydrodynamic responses emergency strategy

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lncRNA cytoskeleton regulator RNA(CYTOR):Diverse functions in metabolism,inflammation and tumorigenesis,and potential applications in precision oncology

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Genes & Diseases 2023年第2期10卷 415-429页

作者： Chunlin ou Xiaoyun He Yong Liu xin Zhang Department of Otolaryngology Head and Neck Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Departments of Ultrasound Imaging Xiangya HospitalCentral South UniversityChangshaHunan 410008China Otolaryngology Major Disease Research Key Laboratory of Hunan ProvinceChangshaHunan 410008China Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province ChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) ChangshaHunan 410008China

Long non-coding RNAs(lncRNAs)are a novel class of non-coding RNA(ncRNA),that have been studied extensively in the field of tumor research in recent *** the case of tumor-associated lncRNAs,lncRNA cytoskeleton regulator RNA(CYTOR)displays extensive functions in tumorigenesis,including invasion,metastasis,malignant proliferation,glycolysis,and inflammatory ***,the dysregulation of CYTOR is closely related to clinicopathological characteristics,such as tumor stage,lymph node metastasis and infiltration,and poor prognosis of tumor *** this review,we provide a novel strategy to summarize the biological functions and clinical value of CYTOR in tumors through an overview of the literature combined with gene set enrichment analysis.A deeper understanding of the role of CYTOR in tumorigenesis may provide new diagnostic,prognostic and therapeutic markers for human tumors.

关键词： CYTOR GSEA Inflammation LncRNAs Therapy Tumorigenesis

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Efficient stochastic analysis of unsaturated slopes subjected to various rainfall intensities and patterns

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Geoscience Frontiers 2023年第1期14卷 346-359页

作者： xin Gu Lin Wang Qiang ou Wengang Zhang School of Civil Engineering Chongqing UniversityChongqing 400045China

Rainfall infiltration poses a disastrous threat to the slope stability in many regions around the *** paper proposes an extreme gradient boosting(XGBoost)-based stochastic analysis framework to estimate the rainfall-induced slope failure *** unsaturated slope under rainfall infiltration in spatially varying soils is selected in this study to investigate the influences of the spatial variability of soil properties(including effective cohesion c',effective friction angleφ'and saturated hydraulic conductivity k_(s)),as well as rainfall intensity and rainfall pattern on the slope failure *** show that the proposed framework in this study is capable of computing the failure probability with accuracy and high *** spatial variability of k_(s)cannot be overlooked in the reliability ***,the rainfall-induced slope failure probability will be *** is found that the rain-fall intensity and rainfall pattern have significant effect on the probability of ***,the failure probabilities under various rainfall intensities and patterns can be easily obtained with the aid of the proposed framework,which can provide timely guidance for the landslide emergency management departments.

关键词： Slope stability Rainfall infiltration Stochastic analysis Sspatial variability

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WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2055-2064页

作者： Kaiyuan Deng Liang Liu Xiaoming Tan Zhen Zhang Jianjun Li Yang ou xin Wang Shuang Yang rong Xiang Peiqing Sun School of Medicine Nankai UniversityTianjin 30071China Departments of Immunology and Microbial Science The Scripps Research InstituteLa JollaCA 92037USA Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA Department of Respiratory Disease South CampusRenji HospitalSchool of Medicine Shanghai Jiaotong UniversityShanghaiChina

Cancer stem cells(CSCs)are a small population of stem cell-like cancer cells that can initiate tumors in vivo,and are the major source of cancer initiation,relapse,and drug *** previously reported that the p38 MAPK,through its downstream effectors MK2 and HSP27,suppressed CSC properties by downregulating the expression of transcription factors that mediate stemness in non-small-cell lung cancer(NSCLC)cells,and that despite unaltered total expression of total p38 proteins,the levels of activated p38 were reduced in NSCLC ***,the mechanism underlying the reduced levels of activated p38 in NSCLC is *** this study,we identified WIP1,a p38 phosphatase frequently overexpressed in cancer,as a suppressor of p38 in a pathway that regulates CSC properties in *** WIP1 expression correlated with reduced levels of activated p38,and with increased levels of a CSC marker in NSCLC *** investigation revealed that WIP1 promoted stemness-related protein expression and CSC properties by inhibiting p38 activity in NSCLC ***1 inhibitors are currently under development as anticancer drugs based on their ability to reactivate *** found that a WIP1 inhibitor suppressed stemness-related protein expression and CSC properties by activating p38 in NSCLC cells in vitro and in *** studies have identified the WIP1–p38–MK2–HSP27 cascade as a novel signaling pathway that,when altered,promotes CSC properties in NSCLC development,and have defined novel mechanisms underlying the oncogenic activity of WIP1 and the anticancer efficacy of WIP1 inhibitors.

关键词： HSP27 NSCLC drugs

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