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Microstructure evolution and strengthening mechanism of high -performance powder metallurgy TA15 titanium alloy by hot rolling

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1426-1436页

作者： Ying Gao Ce zhang Jiazhen zhang xin Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Ma-terials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China National Engineering Research Center for Advanced Rolling Technology National Engineering Research Center for Flat Rolling EquipmentInstitute of Engin-eering TechnologyUniversity of Science and Technology BeijingBeijing 100083China

Hot deformation of sintered billets by powder metallurgy(PM)is an effective preparation technique for titanium alloys,which is more significant for high-alloying *** this study,Ti–6.5Al–2Zr–Mo–V(TA15)titanium alloy plates were prepared by cold press-ing sintering combined with high-temperature hot *** microstructure and mechanical properties under different process paramet-ers were *** microscope,electron backscatter diffraction,and others were applied to characterize the microstructure evolution and mechanical properties strengthening *** results showed that the chemical compositions were uniformly dif-fused without segregation during sintering,and the closing of the matrix craters was accelerated by increasing the sintering *** block was hot rolled at 1200℃ with an 80%reduction under only two passes without *** strength and elongation of the plate at 20–25℃ after solution and aging were 1247 MPa and 14.0%,respectively,which were increased by 24.5%and 40.0%,respect-ively,compared with the as-sintered alloy at 1300℃.The microstructure was significantly refined by continuous dynamic recrystalliza-tion,which was completed by the rotation and dislocation absorption of the substructure surrounded by low-angle grain *** hot rolling combined with heat treatment,the strength and plasticity of PM-TA15 were significantly improved,which resulted from the dense,uniform,and fine recrystallization structure and the synergistic effect of multiple slip systems.

关键词： elemental powder powder metallurgy titanium alloy hot rolling strength and plasticity

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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng Cheng Lei zhang Jun-Jun Wang Ying Wang Ruo-Wen Guo xin-miao Ji Wen-Jing Xie Wei-Li Chen Chao Song xin zhang CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

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Hawking-Page transition and the dual relations of anti-de Sitter black holes surrounded by dark energy in general dimensions

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Communications in Theoretical Physics 2024年第7期76卷 94-104页

作者： zhang xin Xu Wei School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Recently,a dual relation T_(0)(n+1)=T_(HP)(n)between the minimum temperature(T_(0)(n+1))black hole phase and the Hawking-Page transition(T_(HP)(n))black hole phase in two successive dimensions was introduced by Wei et al(2020 ***.D10210411);this was reminiscent of the anti-de Sitter/conformal field theory(AdS/CFT)correspondence,as the Hawking-Page transition temperature could be treated as the temperature of the dual physical quantity on the boundary and the latter corresponds to that in the *** this paper,we discuss the Hawking-Page transition and the dual relations in Ads black holes surrounded by dark energy in general *** findings reveal the occurrence of the Hawking-Page transition between the thermal AdS radiation and thermodynamically stable large AdS black holes,in both the spacetime surrounded by phantom dark energy and the spacetime surrounded by quintessence dark *** discuss the effects of the phantom dark energy and quintessence dark energy on the Hawking-Page transition *** the dual relation in particular,it works well for the case of an AdS black holes surrounded by phantom dark *** the case of an Ads black hole surrounded by quintessence dark energy,the dual relation should be modified under an open assumption that the state parameter and the density parameter of the quintessence dark energy depend on the dimensions of the spacetime.

关键词： Hawking-Page transition dark energy black hole thermodynamics

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OsPRMT6a-mediated arginine methylation of OsJAZ1 regulates jasmonate signaling and spikelet development in rice

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Molecular Plant 2024年第6期17卷 900-919页

作者： Kun Dong Fuqing Wu Siqi Cheng Shuai Li Feng zhang xinxin xing xin Jin Sheng Luo miao Feng Rong miao Yanqi Chang Shuang zhang Xiaoman You Peiran Wang xin zhang Cailin Lei Yulong Ren Shanshan Zhu Xiuping Guo Chuanyin Wu Dong-Lei Yang Qibing Lin Zhijun Cheng Jianmin Wan State Key Laboratory of Crop Gene Resources and Breeding National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory for Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China

Although both protein arginine methylation(PRMT)and jasmonate(JA)signaling are crucial for regulating plant development,the relationship between these processes in the control of spikelet development remains *** this study,we used the CRISPR/Cas9 technology to generate two OsPRMT6a loss-of-function mutants that exhibit various abnormal spikelet ***,we found that OsPRMT6a can methylate arginine residues in JA signal repressors OsJAZ1 and *** showed that arginine methylation of OsJAZ1 enhances the binding affinity of OsJAZ1 with the JA receptors OsCOI1a and OsCOI1b in the presence of JAs,thereby promoting the ubiquitination of OsJAZ1 by the SCF^(OsCOI1a/OsCOI1b) complex and degradation via the 26S *** process ultimately releases OsMYC2,a core transcriptional regulator in the JA signaling pathway,to activate or repress JA-responsive genes,thereby maintaining normal plant(spikelet)***,in the osprmt6a-1 mutant,reduced arginine methylation of OsJAZ1 impaires the interaction between OsJAZ1 and OsCOI1a/OsCOI1b in the presence of *** a result,OsJAZ1 proteins become more stable,repressing JA responses,thus causing the formation of abnormal spikelet ***,we discovered that JA signaling reduces the OsPRMT6a mRNA level in an OsMYC2-dependent manner,thereby establishing a negative feedback loop to balance JA *** further found that OsPRMT6a-mediated arginine methylation of OsJAZ1 likely serves as a switch to tune JA signaling to maintain normal spikelet development under harsh environmental conditions such as high ***,our study establishes a direct molecular link between arginine methylation and JA signaling in rice.

关键词： protein arginine methylation jasmonate signaling negative feedback loop spikelet development adaptation to heat stress rice

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Strong Edge Coloring of Outerplane Graphs with Independent Crossings

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 467-477页

作者： Ke-Jie LI xin zhang School of Mathematics and Statistics Xidian UniversityXi’an 710071China

The strong chromatic index of a graph is the minimum number of colors needed in a proper edge coloring so that no edge is adjacent to two edges of the same *** outerplane graph with independent crossings is a graph embedded in the plane in such a way that all vertices are on the outer face and two pairs of crossing edges share no common end *** is proved that every outerplane graph with independent crossings and maximum degreeΔhas strong chromatic index at most 4Δ-6 if Δ≥4,and at most 8 ifΔ≤*** bounds are sharp.

关键词： outer-1-planar graph IC-planar graph strong edge coloring crossing

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Incidence Coloring of Outer-1-planar Graphs

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 840-848页

作者： Meng-ke QI xin zhang School of Mathematics and Statistics Xidian UniversityXi'an 710071China

A graph is outer-1-planar if it can be drawn in the plane so that all vertices lie on the outer-face and each edge crosses at most one another *** is known that every outer-1-planar graph is a planar *** this paper,we conjecture that every planar graph G has a proper incidence(Δ(G)+2)-coloring and confirm it for outer-1-planar graphs with maximum degree at least 8 or with girth at least ***,we prove that every outer-1-planar graph G has an incidence(Δ(G)+3,2)-coloring,and every outer-1-planar graph G with maximum degree at least 8 or with girth at least 4 has an incidence(Δ(G)+2,2)-coloring.

关键词： incidence coloring outer--planar graph planar graph

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Recent advances in high charge density triboelectric nanogenerators

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International Journal of Extreme Manufacturing 2024年第4期6卷 1-19页

作者： xin Cui Jiaheng Nie Yan zhang School of Physics University of Electronic Science and Technology of ChinaChengdu 611731People's Republic of China School of Cybersecurity Chengdu University of Information TechnologyChengdu 610225People's Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083People's Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People's Republic of China

Triboelectric materials with high charge density are the building-block for the commercial application of triboelectric nanogenerators(TENGs).Unstable dynamic processes influence the change of the charge density on the surface and inside of triboelectric *** charge density of triboelectric materials depends on the surface and the internal charge transfer *** focus of this review is on recent advances in high charge density triboelectric materials and advances in the fabrication of *** summarize the existing strategies for achieving high charge density in triboelectric materials as well as their fundamental *** then review current optimization methods for regulating dynamic charge transfer processes to increase the output charge density:first,increasing charge injection and limiting charge dissipation to achieve a high average surface charge density,and second,regulating the internal charge transfer process and storing charge in triboelectric materials to increase the output charge ***,we present the challenges and prospects in developing high-performance triboelectric materials.

关键词： triboelectric nanogenerator charge density charge transfer charge store

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Light-based 3D printing of stimulus-responsive hydrogels forminiature devices:recent progress and perspective

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Bio-Design and Manufacturing 2024年第5期7卷 721-746页

作者： Chen xin Neng Xia Li zhang Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China Multi-Scale Medical Robotics Center Hong Kong Science ParkShatin NTHong Kong 999077China Chow Yuk Ho Technology Center for Innovative Medicine The Chinese University of Hong KongHong Kong 999077China Department of Surgery The Chinese University of Hong KongHong Kong 999077China CUHK T Stone Robotics Institute The Chinese University of Hong KongHong Kong 999077China

Miniature devices comprising stimulus-responsive hydrogels with high environmental adaptability are now considered competitive candidates in the fields of biomedicine,precise sensors,and tunable *** and advanced fabricationmethods are critical formaximizing the application capabilities ofminiature ***-based three-dimensional(3D)printing technology offers the advantages of a wide range of applicable materials,high processing accuracy,and strong 3D fabrication capability,which is suitable for the development of miniature devices with various *** paper summarizes and highlights the recent advances in light-based 3D-printed miniaturized devices,with a focus on the latest breakthroughs in lightbased fabrication technologies,smart stimulus-responsive hydrogels,and tunable miniature devices for the fields of miniature cargo manipulation,targeted drug and cell delivery,active scaffolds,environmental sensing,and optical ***,the challenges in the transition of tunable miniaturized devices from the laboratory to practical engineering applications are *** opportunities that will promote the development of tunable microdevices are elaborated,contributing to their improved understanding of these miniature devices and further realizing their practical applications in various fields.

关键词： 3D printing Stimulus-responsive hydrogels Miniature devices Shape-morphing

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Dissipation-Driven Superradiant Phase Transition of a Two-Dimensional Bose-Einstein Condensate in a Double Cavity

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Chinese Physics Letters 2024年第6期41卷 44-48页

作者： Bo-Hao Wu xin-xin Yang Yu Chen Wei zhang Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Graduate School of China Academy of Engineering Physics Beijing 100193China Beijing Academy of Quantum Information Sciences Beijing 100193China

We study superradiant phase transitions in a hybrid system of a two-dimensional Bose–Einstein condensate of atoms and two cavities arranged with a tilt *** adjusting the loss rate of cavities,we map out the phase diagram of steady states within a mean field *** is found that when the loss rates of the two cavities are different,superradiant transitions may not occur at the same time in the two cavities.A first-order phase transition is observed between the states with only one cavity in superradiance and both in *** the case that both cavities are superradiant,a net photon current is observed flowing from the cavity with small decay rate to the one with large decay *** photon current shows a non-monotonic dependence on the loss rate difference,owing to the competition of photon number difference and cavity field phase *** findings can be realized and detected in experiments.

关键词： Einstein transitions decay

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The current role of dendritic cells in the progression and treatment of colorectal cancer

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Cancer Biology & Medicine 2024年第9期21卷 769-783页

作者： Yuanci zhang Songtao Ji Ge miao Shuya Du Haojia Wang Xiaohua Yang Ang Li Yuanyuan Lu xin Wang Xiaodi Zhao State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive Diseases Xijing Hospital Fourth Military Medical University Department of Gastroenterology Tangdu Hospital Fourth Military Medical University Department of Experimental Surgery Xijing Hospital Fourth Military Medical University Department of Gastroenterology the 988th Hospital of PLA Joint Logistics Support Force

Colorectal cancer(CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Dendritic cells(DCs) constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune responses. As a crucial component of the immune system, DCs have a pivotal role in the pathogenesis and clinical treatment of CRC. DCs cross-present tumor-related antigens to activate T cells and trigger an antitumor immune response. However, the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor microenvironment. This review systematically elucidates the specific characteristics and functions of different DC subsets, as well as the role that DCs play in the immune response and tolerance within the CRC microenvironment. Moreover, how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed, which will provide new perspectives and approaches for immunotherapy in patients with CRC.

关键词： Colorectal cancer dendritic cells treatment strategies tumor progression

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