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Astronomical Site Monitoring System at Lijiang Observatory

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Research in Astronomy and Astrophysics 2020年第9期20卷 291-308页

作者： yu-xin xin Jin-Ming Bai Bao-Li Lun yu-Feng Fan Chuan-Jun Wang xiao-Wei liu xiao Guang yu Kai Ye Teng-Fei Song Liang Chang Shou-Sheng He Jji-Rong Mao Liang Xu ding-Rong xiong Xi-Liang Zhang Jian-Guo Wang Xu ding Hai-cheng Feng Xiang-Kun liu Yang Huang Bing-Qiu chen yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center for Astronomical Mega-Sciences Chinese Academy of SciencesBeijing 100101China South-Western Institute for Astronomy Research Yunnan UiversityKunming 650500China

We installed two sets of Astronomical Site Monitoring Systems(ASMSs)at Lijiang Observatory(GMG),for the running of the 2.4-meter Lijiang optical telescope(LJT)and the 1.6-meter Multi-channel Photometric Survey Telescope(Mephisto).The Mephisto is under *** ASMS has been running on robotic mode since *** core instruments:Cloud Sensor,All-Sky Camera and AutonomousDIMM that are developed by our group,together with the commercial Meteorological Station and Sky Quality Meter,are combined into the astronomical optical site monitoring *** new Cloud Sensor's Cloud-Clear Relationship is presented for the first time,which is used to calculate the All-Sky cloud *** designed the Autonomous-DIMM located on a tower,with the same height as *** seeing data have been observed for a full ***'s data for the year 2019 are also analysed in detail,which are valuable to observers.

关键词： Astronomical Site Monitoring System Lijiang Observatory Cloud Sensor Autonomous-DIMM

Management of regional citrate anticoagulation for continuous renal replacement therapy:guideline recommendations from Chinese emergency medical doctor consensus

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Military Medical Research 2023年第6期10卷 733-750页

作者： Shu-yuan liu Sheng-Yong Xu Lu Yin Ting Yang Kui Jin Qiu-Bin Zhang Feng Sun ding-yu Tan Tian-yu xin yu-Guo chen xiao-Dong Zhao Xue-Zhong yu Jun Xu Emergency Medical Doctor Branch of the Chinese Medical Doctor Association Emergency Department The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China State Key Laboratory of Complex Severe and Rare Diseases Emergency DepartmentPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Emergency Department Peking University Shenzhen HospitalShenzhen 518000China Emergency Department The First Affiliated Hospital of Kunming Medical UniversityKunming 650000China Emergency Department The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001China Emergency Department The Second Affiliated Hospital of Hainan Medical CollegeHaikou 570100China Emergency Department The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Emergency Depart‑ment Northern Jiangsu People’s HospitalClinical Medical College of Yang‑zhou UniversityYangzhou 225001China Emergency Department and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 100005China Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Jinan 100005China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Qilu Hospital of Shandong UniversityJinan 100005China Emergency Department The Fourth Medical CenterChinese PLA General HospitalBeijing 100048China Jiangxi Provincial People’s Hospital Nanchang330046China The Second Affiliated Hospital of Shenzhen University ShenzhenGuangdong 518035China The First Hos‑pital of Tsinghua University Beijing100016China The Affiliated Hospital and Medical School of Nantong University NantongJiangsu 226001China The First People’s Hospital of Lianyungang LianyungangJiangsu 222000China Shaanxi People’s Hospital Xi’an 710068China Renmin Hospital of Wuhan University Wuhan 430060China Shenzhen Hospital of South‑ern Medical University ShenzhenGuangdong 518000China The Second People’s Hospital of Huai’an Huai’anJiangsu 223002China The Affiliated Suqian Hospital of Xuzhou Medical Univers

Continuous renal replacement therapy(CRRT)is widely used for treating critically-ill patients in the emergency department in *** therapy is needed to prevent clotting in the extracorporeal circulation during *** citrate anticoagulation(RCA)has been shown to potentially be safer and more effective,and is now recommended as the preferred anticoagulant method for ***,there is still a lack of unified standards for RCA management in the world,and there are many problems in using this method in clinical *** Emergency Medical Doctor Branch of the Chinese Medical Doctor Association(CMDA)organized a panel of domestic emergency medicine experts and international experts of CRRT to discuss RCA-related issues,including the advantages and disadvantages of RCA in CRRT anticoagulation,the principle of RCA,parameter settings for RCA,monitoring of RCA(mainly metabolic acid-base disorders),and special issues during *** on the latest available research evidence as well as the paneled experts'clinical experience,considering the generalizability,suitability,and potential resource utilization,while also balancing clinical advantages and disadvantages,a total of 16 guideline recommendations were formed from the experts'consensus.

关键词： Continuous renal replacement therapy Emergency Anticoagulation Citrate Guideline Expert consensus

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

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Protein & Cell 2020年第10期11卷 723-739页

作者： Rui xiong Leike Zhang Shiliang Li yuan Sun Minyi ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong liuxin Xu yu chen Yingle liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu xiao Ke Lan Honglin Li Ke Xu State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus ***,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against ***,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted *** results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out *** work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not.

关键词： de novo pyrimidine biosynthesis DHODH inhibitors SARS-CoV-2 influenza viruses virus replication immuno-regulation

Lijiang 2.4-meter Telescope and its instruments

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Research in Astronomy and Astrophysics 2019年第10期19卷 95-108页

作者： Chuan-Jun Wang Jin-Ming Bai yu-Feng Fan Ji-Rong Mao Liang Chang yu-xin xin Ju-Jia Zhang Bao-Li Lun Jian-Guo Wang Xi-Liang Zhang Mei Ying Kai-xing Lu xiao-Li Wang Kai-Fan Ji ding-Rong xiong xiao-Guang yu Xu ding Kai Ye Li-Feng xing Wei-Min Yi Liang Xu Xiang-Ming Zheng yuan-Jie Feng Shou-Sheng He Xue-Li Wang Zhong liu Dong chen Jun Xu Song-Nian Qin Rui-Long Zhang Hui-Song Tan Zhi Li Ke Lou Jian Li Wei-Wei liu yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650216 China Center for Astronomical Mega-Science Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Astrophysics Center of Guangzhou University Guangzhou 510006China

The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory(LJO), in the southwest of China. The site has very good observational *** its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized.

关键词： telescopes Lijiang 2.4-m Telescope-instrumentation photometers-instrumentation spectrographs

Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

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World Journal of Gastroenterology 2022年第31期28卷 4417-4430页

作者： Zi-Xuan Shen Dan-Dan Wu Jie Xia Xian-Bo Wang xin Zheng Yan Huang Bei-Ling Li Zhong-Ji Meng Yan-Hang Gao Zhi-Ping Qian Feng liu xiao-Bo Lu Jia Shang Hua-Dong Yan yu-Bao Zheng Wen-Yi Gu Yan Zhang Jian-Yi Wei Wen-Ting Tan Yi-xin Hou Qun Zhang Yan xiong Cong-Cong Zou Jun chen Ze-Bing Huang Xiu-Hua Jiang Sen Luo yuan-yuan chen Na Gao Chun-Yan liu Wei yuan Xue Mei Jing Li Tao Li xin-Yi Zhou Guo-Hong Deng Jin-Jun chen xiong Ma Hai Li Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of HealthShanghai Jiao Tong UniversityShanghai 200001China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 430418Hubei ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China Tianjin Institute of Hepatology Nankai University Second People’s HospitalTianjin 300102China Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054XinjiangChina Department of Infectious Diseases Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases Hwamei HospitalThe Second Hospital of NingboUniversity of Chinese Academy of SciencesNingbo 315153Zhejiang ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 5

BACKGROUND Autoimmune liver disease(AILD)has been considered a relatively uncommon disease in China,epidemiological data for AILD in patients with cirrhosis and acute decompensation(AD)is *** To investigate the prevalence,outcome and risk factors for AILD in cirrhotic patients complicated with AD in *** We collected data from patients with cirrhosis and AD from two prospective,multicenter cohorts in hepatitis B virus endemic *** were regularly followed up at the end of 28-d,90-d and 365-d,or until death or liver transplantation(LT).The primary outcome in this study was 90-d LTfree ***-on-chronic liver failure(ACLF)was assessed on admission and during 28-d hospitalization,according to the diagnostic criteria of the European Association for the Study of the Liver(EASL).Risk factors for death were analyzed with logistic regression *** In patients with cirrhosis and AD,the overall prevalence of AILD was 9.3%(242/2597).Prevalence of ACLF was significantly lower in AILD cases(14%)than those with all etiology groups with cirrhosis and AD(22.8%)(P<0.001).Among 242 enrolled AILD patients,the prevalence rates of primary biliary cirrhosis(PBC),autoimmune hepatitis(AIH)and PBC-AIH overlap syndrome(PBC/AIH)were 50.8%,28.5%and 12.0%,*** ACLF patients,the proportions of PBC,AIH and PBC/AIH were 41.2%,29.4% and 20.6%.28-d and 90-d mortality were 43.8% and 80.0% in AILD-related *** etiology of AILD had no significant impact on 28-d,90-d or 365-d LTfree mortality in patients with cirrhosis and AD in both univariate and multivariate *** bilirubin(TB),hepatic encephalopathy(HE)and blood urea nitrogen(BUN)were independent risk factors for 90-d LT-free mortality in multivariate *** development of ACLF during hospitalization only independently correlated to TB and international normalized *** AILD was not rare in hospitalized patients with cirrhosis and AD in China,among which PBC was the m

关键词： Prevalence Autoimmune liver disease Cirrhosis and acute decompensation Mortality Acuteon-chronic liver failure

Prevalence of chronic kidney disease and prediabetes and associated risk factors： a community-based screening in Zhuhai, Southern China

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Chinese Medical Journal 2013年第7期126卷 1213-1219页

作者： GU Dong-feng SHI Yan-lin chen You-mingt liu Hong-mei ding Ya-nan liu xin-yu LI Yong-qiang SHAO xiao-fei LIANG Yan chen Ying-shan yuan Zhi-yong ZOU He-qun Department of Nephrology Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong 510630 China Clinical Laboratory Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong 510630 China Ultrasonic Angi-ology Laboratory Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong 510630 China Department of Cardiovascular Medicine Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong 510630 China Department of Nephrology First Affiliated Hospital of WenzhouMedical College Wenzhou Zhejiang 325035 China Department of Nephrology Zhangzhou Municipal Hospital ot Fuiian Province Zhangzhou Ft~iian 363000 China Department of Nephrology Zhuhai Wanzai Hospital Zhuhai Guangdong 519000 China

Background The prevalence of chronic kidney disease （CKD） and prediabetes has increased in China, and at different rates in different locations. Therefore a community-based screening research was conducted in order to determine the prevalence of CKD and prediabetes, and to analyze associated risk factors of CKD and prediabetes in a city of Southern *** A total of 7801 community residents aged 18 year and older from 6 communities were screened by a stratified random cluster sampling method. An estimated glomerular filtration rate （eGFR）, albuminuria, fasting plasma glucose （FPG）, and homeostatic model assessment of insulin resistance （HOMA-IR） were measured. Age-standardized prevalence was calculated by the direct method with the use of data on the population distribution in China in 2006. Multivariate logistic analysis was used to analyze the risk factors of CKD and ＂prediabetes, and association of insulin resistance （IR） with CKD and prediabetes was *** The age-standardized prevalence of CKD was 12.5%, eGFR 〈60 ***^-1.1.73 m2 was 2.7% and ACR （albumin to creatinine ratio）〉30 mg/g was 10.3%. The age-standardized prevalence of prediabetes was 12.1%. Logistic regression suggests that IR was a common independent risk factor of CKD and prediabetes. Further analysis show that HOMA-IR was increased with the aggravation of kidney injury and FPG. Conclusion CKD and prediabetes have become a major public health problem in Zhuhai, Southern China; insulin resistance may be an important risk factor.

关键词： chronic kidney disease," prediabetes homeostatic model assessment of insulin resistance," prevalence,"community-based screening

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

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Protein & Cell 2021年第1期12卷 76-80页

Figure *** of novel and potent DHODHi and their anti-influenza A virus activities.(A)The discovery and design of S312 and *** detailed descriptions of the discovery workflow are in *** analysis of S312(B)and S416(C).Thermodynamic analysis of the binding of S312 and S416 to DHODH was carried out at 25 C on a MicroCal iTC200 *** analysis of the binding of S312 and S416 to DHODH was performed with a Biacore T200 instrument.

关键词： Figure discovery ODH

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei Yang Yong-Hao chen Rong liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-Ping chen Zhong-Wei Wen Wei-Li Sun Han Yi xing-Yan liu Tao Ye Jiang-Bo Bai Qi An Jie Bao yu Bao Ping Cao Hao-Lei chen Zhen chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-cheng He Yang Hong Yi-Wei Hu Han-xiong Huang Xi-Ru Huang Hao-yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li xiao Li Yang Li Jie liu Shu-Bin liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-xin Tan Jing-yu Tang xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-yun Yang Li yu Tao yu Yong-Ji yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng liu xiao-Bo Lu Jun-Ping liu Hao-Tang Ren yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu xiao-Mei Xiang Yi Zhou Yi-xin Hou Qun Zhang Yan xiong Cong-Cong Zou Jun chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi yuan-yuan chen Na Gao Chun-Yan liu Wei yuan Xue Mei Jing Li Tao Li Rong-Jiong Zheng xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis