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基于GIS与ANN的土地转化模型在城市空间扩展研究中的应用--以北京市为例

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北京大学学报（自然科学版） 2008年第2期44卷 262-270页

作者：徐颖吕斌北京大学城市与环境学院城市与区域规划系北京100871 中国城市规划设计研究院北京100044

结合GIS强大的空间分析功能与人工神经网络(ANN)处理非线性适应性信息的独特能力建立一种土地转化模型(land transformation model,LTM),用以定量分析城市土地扩展与社会、政策、环境等因子之间关系,并基于此对城市空间扩展的动态进行... 详细信息

结合GIS强大的空间分析功能与人工神经网络(ANN)处理非线性适应性信息的独特能力建立一种土地转化模型(land transformation model,LTM),用以定量分析城市土地扩展与社会、政策、环境等因子之间关系,并基于此对城市空间扩展的动态进行模拟与预测。LTM模型的运行主要分为3步:因子选取与数据预处理;建立人工神经网络并输入数据对其进行训练与仿真;应用PID法对人工神经网络的输出进行分析,同时在GIS平台上模拟出城市扩展的动态分布。选取相应的影响因子并运用该模型对北京市的城市扩展进行实证模拟检验与预测,结果表明此LTM模型确实提供了一种定量分析和预测城市空间扩展的方法,能够为城市规划与城市发展政策的制定提供重要的科学参考。

关键词：城市空间扩展土地转化模型(LTM) GIS 人工神经网络(ANN)

SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response

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The Journal of Biomedical Research 2021年第3期35卷 216-227页

作者： Zhi Liu Jianwei Wang Yiyue Ge Yuyu xu Mengchen Guo Kai Mi Rui xu Yang Pei Qiankun Zhang Xiaoting Luan Zhibin Hu ying Chi xingyin Liu State Key Laboratory of Reproductive Medicine Center of Global HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Pathogen Biology-Microbiology Division Key Laboratory of Pathogen of Jiangsu ProvinceSchool of Basic Medical ScienceNanjing Medical UniversityNanjingJiangsu 211166China National Health Commission Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Center for Diseases Control and PreventionNanjingJiangsu 210009China Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjingJiangsu 211166China

The outbreak of COVID-19 caused by SARS-CoV-2 is spreading worldwide,with the pathogenesis mostly *** virus and host-derived microRNA(miRNA)play essential roles in the pathology of virus *** study aims to uncover the mechanism for SARS-CoV-2 pathogenicity from the perspective of *** scanned the SARS-CoV-2 genome for putative miRNA genes and miRNA targets and conducted in vivo experiments to validate the virus-encoded miRNAs and their regulatory role on the putative *** of such virus-encoded miRNAs,MR147-3p,was overexpressed that resulted in significantly decreased transcript levels of all of the predicted targets in human,i.e.,EXOC7,RAD9A,and TFE3 in the virus-infected *** analysis showed that the immune response and cytoskeleton organization are two of the most notable biological processes regulated by the infection-modulated ***,the genomic mutation of SARS-CoV-2 contributed to the changed miRNA repository and targets,suggesting a possible role of miRNAs in the attenuated phenotype of SARS-CoV-2 during its *** study provided a comprehensive view of the miRNA-involved regulatory system during SARS-CoV-2 infection,indicating possible antiviral therapeutics against SARS-CoV-2 through intervening miRNA regulation.

关键词： COVID-19 SARS-CoV-2 virus-encoded miRNA host miRNA virus infection immune response

Convex Reformulation for Two-sided Distributionally Robust Chance Constraints with Inexact Moment Information

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 1060-1065页

作者： Lun Yang Yinliang xu Zheng xu Hongbin Sun TsinghuaBerkeley Shenzhen Institute Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Electrical Engineering State Key Laboratory of Power SystemsTsinghua UniversityBeijing 100084China

Constraints on each node and line in power systems generally have upper and lower bounds,denoted as twosided *** existing power system optimization methods with the distributionally robust(DR)chance-constrained program treat the two-sided DR chance constraint separately,which is an inexact *** letter derives an equivalent reformulation for the generic two-sided DR chance constraint under the interval moment based ambiguity set,which does not require the exact moment *** derived reformulation is a second-order cone program(SOCP)formulation and is then applied to the optimal power flow(OPF)problem under *** results on several IEEE systems demonstrate the effectiveness of the proposed SOCP formulation and show the differences with other DR chance-constrained OPF approaches.

关键词： Two-sided chance constraint distributionally robust conic reformulation interval moment optimal power flow

Sorafenib combined with embolization plus hepatic arterial infusion chemotherapy for inoperable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 663-676页

作者： Bao-Jiang Liu Song Gao xu Zhu Jian-Hai Guo xin Zhang Hui Chen Xiao-Dong Wang Ren-Jie Yang Department of Interventional Therapy Peking University Cancer Hospital and InstituteKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Beijing 100142China

BACKGROUND There is little evidence of combining sorafenib with hepatic arterial infusion chemotherapy(HAIC)after transarterial chemoembolization(TACE)for intermediate and advanced hepatocellular carcinoma(HCC).It is important to identify that patients with intermediate and advanced HCC are most likely to benefit from this combination *** To investigate the safety and clinical outcomes of sorafenib combined with HAIC with folinic acid,5-fluorouracil(5-FU),and oxaliplatin(FOLFOX)after TACE for intermediate and advanced *** This prospective phase II study enrolled patients with intermediate and advanced HCC who underwent treatment with sorafenib combined with *** patients initially received the standard 400 mg dose of sorafenib twice daily before *** at our institute with intermediate and advanced HCC underwent routine ***,the catheter used for embolization was kept in place in the hepatic artery,and oxaliplatin was intraarterially administered for 6 h,followed by 5-FU for 18 h,and folinic acid was intravenously administered for 2 *** primary endpoints were safety,as evaluated by the Common Terminology and Criteria for Adverse Events version 4.0,and 12-mo progression-free survival(PFS),as analyzed by the Kaplan-Meier *** secondary endpoints,the objective response rate(ORR)was evaluated by the modified Response Evaluation Criteria for Solid Tumors,and survival time[overall survival(OS)]was analyzed by the Kaplan-Meier *** Sixty-six participants at our institute with intermediate and advanced HCC were enrolled in this prospective study(mean age,53.3±11.7 years).Approximately 56.1%of participants had Barcelona Clinic Liver Cancer(BCLC)stage C disease,and 43.9%had BCLC stage B *** ORR was 42.4%.The disease control rate was 87.9%.The grade 3-4 toxicities consisted of thrombocytopenia(4.5%),neutropenia(3.0%),and elevated aspartate aminotransferase(12.2%).Hand-foot skin reaction was also observed(40

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Hepatic arterial infusion chemotherapy Oxaliplatin Fluorouracil Sorafenib

Submucosal tunneling endoscopic biopsy and myotomy for management of unknown esophageal stenosis

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Gastroenterology Report 2022年第1期10卷 635-637页

作者： Xiao-Yue xu Zi-Han Geng Tian-Yin Chen Quan-Lin Li Ming-Yan Cai Jia-xin xu Dan-Feng Zhang Jian-Wei Hu Ping-Hong Zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai Collaborative Innovation Center of EndoscopyShanghaiP.R.China

Introduction Esophageal stenosis is usually congenital or secondary to esophageal injury,esophagitis,and esophageal neoplasia[1,2].The mainstay treatment for benign esophageal stenosis is dilatation with either balloons or esophageal bougienage[3,4].A self-expandable metal stent(SEMS)is recommended for malignant and refractory esophageal stenosis[5].The treatment can be distinct according to different *** ultrasonography-guided fine-needle aspiration/biopsy(EUS-FNA/FNB)may be conducive to clarifying the etiology of esophageal ***,the small amount of tissue obtained by EUS-FNA/FNB may provide less pathological *** we report a new technique—submucosal tunneling endoscopic biopsy and myotomy(STEBM)derived from the peroral endoscopic myotomy(POEM)procedure to relieve stenosis and get a sufficient amount of tissue to make a definite diagnosis.

关键词： esophageal stenosis biopsy

Computation of the cohomology rings of Kac-Moody groups, their flag manifolds and classifying spaces

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Frontiers of Mathematics in China 2022年第3期17卷 437-454页

作者： xu-an ZHAO School of Mathematical Sciences Beijing Normal UniversityKey Laboratory of Mathematics and Complex SystemsMinistry of EducationBeijing 100875China

In this paper we introduce the history and present situation of the computation of the cohomology rings of Kac-Moody groups,their flag manifolds and classifying spaces,and give some problems and conjectures that deser... 详细信息

关键词： Kac-Moody groups flag manifolds classifying spaces cohomology rings spectral sequences

Variable integral and smooth exponent Besov spaces associated to non-negative self-adjoint operators

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Frontiers of Mathematics in China 2020年第6期15卷 1245-1263页

作者： Jingshi xu School of Mathematics and Computing Science Guilin University of Electronic TechnologyGuilin 541004China

We introduce the variable integral and the smooth exponent Besov spaces associated to non-negative self-adjoint *** we give the equivalent norms via the Peetre type maximal functions and atomic decomposition of these ... 详细信息

关键词： Besov space variable exponent maximal function non negative self-adjoint operators atomic decomposition

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双旋流器燃烧室壁温试验

航空动力学报 2010年第6期25卷 1227-1232页

作者：党新宪赵坚行颜应文刘勇徐榕张欣南京航空航天大学能源与动力学院中国人民解放军94580部队航空理论教研室

采用红外热像仪对带双级旋流器的模型燃烧室火焰筒壁面温度进行了测量,试验研究不同进气温度、油气比和主燃孔参数对火焰筒壁面温度分布的影响.试验研究表明:主燃孔参数变化对火焰筒壁面温度分布有较大的影响;火焰筒壁面温度值随着进气... 详细信息

采用红外热像仪对带双级旋流器的模型燃烧室火焰筒壁面温度进行了测量,试验研究不同进气温度、油气比和主燃孔参数对火焰筒壁面温度分布的影响.试验研究表明:主燃孔参数变化对火焰筒壁面温度分布有较大的影响;火焰筒壁面温度值随着进气温度的增加而明显升高,但壁面温度分布变化不大;油气比的变化对壁面温度值影响不太大,但对温度梯度影响较大.所得的试验结果可为新燃烧室设计提供一定的参考依据.

关键词：燃烧双旋流器燃烧室红外热像仪壁温测量

Prognostic value of perioperative leukocyte count in resectable gastric cancer

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World Journal of Gastroenterology 2016年第9期22卷 2818-2827页

作者： Xiao-Feng Chen Jing Qian Dong Pei Chen Zhou Oluf Dimitri R?e Fang Zhu Shao-Hua He ying-ying Qian Yue Zhou Jun xu Jin xu Xiao Li Guo-Qiang Ping Yi-Qian Liu Ping Wang Ren-Hua Guo Yong-Qian Shu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology Department of Molecular Cell Biology and Toxicology Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

AIM: To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric ***: A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hematologic parameters and overall survival was assessed statistically, adjusted for known prognostic ***: The mean white blood cell count(WBC) significantly decreased after surgery, and 107/614(17.4%) patients developed p-leukopenia, which was defined as a preoperative WBC ≥ 4.0 × 109/L and postoperative WBC < 4.0 × 109/L, with an absolute decrease ≥ 0.5 × 109/L. The neutrophil count decreased significantly more than the lymphocyte count. P-leukopenia significantly correlated with poor tumor differentiation and preoperative WBC. A higher preoperative WBC and p-leukopenia were independent negative prognostic factors for survival [hazard ratio(HR) = 1.602, 95% confidence interval(CI): 1.185-2.165; P = 0.002, and HR = 1.478, 95%CI: 1.149-1.902; P = 0.002, respectively] after adjusting for histology, Borrmann type, p TNM stage, vascular or neural invasion, gastrectomy method, resection margins, chemotherapy regimens, and preoperative WBC count. The patients with both higher preoperative WBC and p- leukopenia had a worse prognosis compared to those with lower baseline WBC and no p-leukopenia(27.5 mo vs 57.3 mo, P < 0.001). CONCLUSION: Preoperative leukocytosis alone or in combination with postoperative leukopenia could be independent prognostic factors for survival in patients with resectable gastric cancer.

关键词： Gastric cancer Leukocytosis Leukopenia Postoperative Prognosis