SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response

作     者：Zhi Liu Jianwei Wang Yiyue Ge Yuyu Xu Mengchen Guo Kai Mi Rui Xu Yang Pei Qiankun Zhang Xiaoting Luan Zhibin Hu Ying Chi Xingyin Liu Zhi Liu;Jianwei Wang;Yiyue Ge;Yuyu Xu;Mengchen Guo;Kai Mi;Rui Xu;Yang Pei;Qiankun Zhang;Xiaoting Luan;Zhibin Hu;Ying Chi;Xingyin Liu

作者机构：State Key Laboratory of Reproductive MedicineCenter of Global HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Pathogen Biology-Microbiology DivisionKey Laboratory of Pathogen of Jiangsu ProvinceSchool of Basic Medical ScienceNanjing Medical UniversityNanjingJiangsu 211166China National Health Commission Key Laboratory of Enteric Pathogenic MicrobiologyJiangsu Provincial Center for Diseases Control and PreventionNanjingJiangsu 210009China Key Laboratory of Human Functional Genomics of Jiangsu ProvinceNanjing Medical UniversityNanjingJiangsu 211166China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2021年第35卷第3期

页      面：216-227页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China(NSFC)grant No.81671983 and 81871628 to X.L.,NSFC grant No.81703306 China Postdoctoral Science Foundation(2017M611867) Postdoctoral Science Foundation of Jiangsu Province(1701119C)to Z.L.,NSFC grant No.81902027 Natural Science Foundation of Jiangsu Province to J.W.(BK20171045) 

主　　题：COVID-19 SARS-CoV-2 virus-encoded miRNA host miRNA virus infection immune response 

摘      要：The outbreak of COVID-19 caused by SARS-CoV-2 is spreading worldwide,with the pathogenesis mostly *** virus and host-derived microRNA(miRNA)play essential roles in the pathology of virus *** study aims to uncover the mechanism for SARS-CoV-2 pathogenicity from the perspective of *** scanned the SARS-CoV-2 genome for putative miRNA genes and miRNA targets and conducted in vivo experiments to validate the virus-encoded miRNAs and their regulatory role on the putative *** of such virus-encoded miRNAs,MR147-3p,was overexpressed that resulted in significantly decreased transcript levels of all of the predicted targets in human,i.e.,EXOC7,RAD9A,and TFE3 in the virus-infected *** analysis showed that the immune response and cytoskeleton organization are two of the most notable biological processes regulated by the infection-modulated ***,the genomic mutation of SARS-CoV-2 contributed to the changed miRNA repository and targets,suggesting a possible role of miRNAs in the attenuated phenotype of SARS-CoV-2 during its *** study provided a comprehensive view of the miRNA-involved regulatory system during SARS-CoV-2 infection,indicating possible antiviral therapeutics against SARS-CoV-2 through intervening miRNA regulation.