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Endoscopic transsphenoidal approach to pituitary adenomas invading the cavernous sinus

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Chinese Medical Journal 2010年第24期123卷 3519-3523页

作者： TAO Yu-xin QU Qiu-yi wang Zhen-lin ZHANG Qiu-hang Department of Otolaryngology-Head and Neck Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Background Surgery of pituitary adenomas invading cavernous sinus has always been thought as a challenge due to the complex anatomical structures and high risk of complications. The purpose of this study was to evaluate endoscopic trarssphenoidal approach to pituitary adenomas invading cavernous *** The clinical data of 22 patients who admitted to Xuanwu Hospital with pituitary adenomas invading cavernous sinus were analyzed retrospectively. All patients underwent endoscopic transsphenoidal surgery. To expose the surgical field sufficiently, the opening of sellar floor was exceeded the bone overlying the invaded cavernous sinus, and synthetic dura was used to repair and strengthen the sella floor for preventing the leak of cerebrospinal *** Among 22 patients, total resection was achieved in 14, subtotal resection in 5, and partial resection in 3; no patient underwent insufficient resection. Visual symptoms improved in 7 of 9 patients. In one patient diplopia *** was relieved to various extents in all patients. No serious complications were found. Patient＇s hospital stay ranged from 7 to 20 *** These data suggest that the endoscopic transsphenoid approach is a safe, minimally invasive, and efficient surgical technique, which might be an important therapeutic strategy for the pituitary adenoms invading cavernous sinus.

关键词： endoscopy pituitary adenorna cavernous sinus invasion

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Syntheses and magnetochemistry of heterometallic MLn complexes

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Syntheses and magnetochemistry of heterometallic MLn complex...

中国化学会第八届全国配位化学会议

作者： Fu-xing Shen xin-yi wang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University

Molecular magnetic materials have attracted great attention in the past decades for their great potentials in high-density information storage devices,quantum computers and magnetocaloric *** single-molecule magnets(SMMs) are a fascinating class of materials that possess an energy barrier(U) to the inversion of the magnetic moment,resulting in slow relaxation of the magnetization below a blocking temperature(T).Because of small spin-flip contribution to zero field splitting parameter(D) in the case of large spin value(S) and vice versa,blocking of the magnetization cannot be easily achieved in pure 3 d *** excellent 4 f spin carriers possess of large total angular moment(J) and significant single ion anisotropy,but the limited radial extension of the 4 f orbital corresponds to very weak or even no exchange *** the strategy of combining 3 d and 4 f metal ions has proved useful,the intermediate magnetic exchange between heterometallic complexes containing 3 d-4 f ions may effectively suppress zerofield quantum tunneling mechanism(QTM) and increase the energy barrier for spin *** to now,plenty of 3 d-4 f SMMs have been reported,some of which can have rather high energy barriers,such as a[Fe Dy]complex with a record barrier(U= 319 cm-1(459 K)).However,it is still a great challenge for chemists to rationally design and synthesize 3 d-4 f complexes due to the complexity of the reaction ***,we obtained a series of heterometallic complexes[MLnL(NO)(MeOH)](X)·CH OH,[MLnL(NO)(MeOH)(CI)](X)·CH OH(M = Fe,Co,Mn,Cr,Zn;Ln= Tb,Dy,Ho,Er,Yb;X = NO,Cl).Magnetic investigations revealed the dominant antiferromagnetic interactions in these compounds,and the follow figures are SMM behaviour for compound ZnDy.

关键词： single-molecule magnets 3d–4f ions uniaxial anisotropy quantum tunneling mechanism magnetic exchange

Ferrimagnetic Ordering Below 80K for Two Three-Dimensional Heptacyanomolybdate-Based Magnets

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Ferrimagnetic Ordering Below 80K for Two Three-Dimensional H...

中国化学会第八届全国配位化学会议

作者： Xiao-Qin Wei xin-yi wang State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical Engineering Nanjing University

In the past few decades,the study of cyanide-based transition metal materials has been one of the major research trends in the field of molecule-based magnetism leading for example to roomtemperature magnets,photomagnetic properties,high-spin molecules,or single-molecule magnets.[1]Most of these remarkable physical properties have been obtained for materials incorporating[M(CN)] or[M(CN)] building blocks,but curiously heptacyanometalate precursors have not been studied well because of the instability in both solvent and ***,the high coordination numbers around the metal ions and various coordination geometries of[Mo(CN)] building block has strong potential owing to its high anisotropy and the possibility for engaging in anisotropic exchange interactions as predicted by *** using two amide ligand DMF(N,N-dimethyl formamide) and DEF(N,N-diethyl formamide),we synthesized two three-dimensional Mn-[Mo(CN)] magnets {[Mn(L)O][Mo(CN)]·nH O}(1:L = DMF,2:L =DEF).Detailed magnetic measurements revealed that these two compounds show analogous ferrimagnetic ordering below 80 K with a small hysteresis effect.

关键词： molecular magnetism [MoⅢ(CN)7]4- ferrimagnetic ordering

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小鼠胎肝细胞透明质酸3D培养体系的建立

生物化学与生物物理进展 2018年第5期45卷 567-574页

作者：颜洁心王怡王韫芳广西医科大学南宁530021 北京军事科学院军事医学研究院卫生勤务与血液研究所再生医学研究室北京100039

为了利用透明质酸建立小鼠胎肝细胞3D培养体系,分离获得胚胎12~14d胎肝细胞,利用KM培养基进行初步2D肝干/祖细胞的筛选培养,并利用透明质酸及KM培养基配制水凝胶建立3D细胞培养体系.胎肝细胞在2D体系中呈现克隆状生长.分离培养获得的肝... 详细信息

为了利用透明质酸建立小鼠胎肝细胞3D培养体系,分离获得胚胎12~14d胎肝细胞,利用KM培养基进行初步2D肝干/祖细胞的筛选培养,并利用透明质酸及KM培养基配制水凝胶建立3D细胞培养体系.胎肝细胞在2D体系中呈现克隆状生长.分离培养获得的肝干/祖细胞,克隆在透明质酸建立的3D培养体系保持增殖活性,并进一步获得肝细胞功能特性,表现为3D培养上清中白蛋白合成和尿素水平显著增加.定量PCR结果显示,随着3D培养时间的延长,其肝细胞干性标志如AFP、CK19、Ep CAM、Prox1等表达水平都大幅度降低且接近成年小鼠肝脏表达水平.本研究成功建立基于透明质酸的小鼠胎肝细胞的3D无血清培养体系,并可促进小鼠胎肝细胞的肝细胞功能进一步成熟.

关键词：胎肝细胞 3D培养透明质酸

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Hemorrhagic activity and mechanism of FIIa,a fibrinolytic enzyme from Agkistrodon acutus venom

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Acta Pharmacologica Sinica 2004年第4期25卷 116-123页

作者： Qing-qing wang2, Jia-shu CHEN, Xiu-xia LIANG3, Peng-xin QIU, yi-wen wang, Guang-mei YAN Department of Pharmacology, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510080, China Now in Beijing Universityof Chinese Medicine,Beijing 100029,China. Department of Pharmacology Zhongshan Medical College Sun Yat-Sen University Guangzhou 510080

AIM: To study the local hemorrhagic activity of a fibrinolytic enzyme (FIIa) from Agkistrodon acutus venom and its mechanism. METHODS: The local hemorrhagic activity was determined by subcutaneous injection on the back of mouse. The effects of FIIa on factor X, prothrombin, gelatin, and collagen were visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Platelet aggregation assays were performed in rat platelet- rich plasma (PRP). Human umbilical vein endothelial cells (HUVEC) were cultured and passaged in complete M199 medium. Cell viability and nuclear morphology change were determined by fluorescein diacetate (FDA) staining and Hoechst 33258 staining, respectively. RESULTS: The minimum hemorrhagic dose (MHD) of FIIa was 89 μg. In vitro, FIIa (0.25 g/L) degraded factor X, prothrombin, collagen, and gelatin, and dose-dependently (0.25, 0.50, 0.75, and 1.00 g/L) inhibited the platelet aggregation induced by ADP in rat PRP. When HUVEC in culture treated with FIIa, HUVEC showed detachment in a dose-dependent manner, but no apoptosis sign was observed. CONCLUSION: FIIahad local hemorrhagic activity, and the mechanism was related to the degradation of factor X, prothrombin, gelatin, and collagen, the inhibition of ADP-induced platelet aggregation, and inducement of HUVEC detachment.2Now in Beijing Universityof Chinese Medicine,Beijing 100029,China.3Correspondence to Dr Xiu-xia LIANG.

关键词： Agkistrodon acutus venom fibrinolytic enzyme hemorrhagic protease endothelial cells

Constructing Molecular Magnetic Materials with Macrocyclic Ligands

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Constructing Molecular Magnetic Materials with Macrocyclic L...

全国第十九届大环化学暨第十一届超分子化学学术讨论会

作者： Dong Shao xing-Cai Huang Kun Qian xin-yi wang State Key laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing University

In the past two decades, molecular magnetic materials have attracted extensive attention as they were considered as promising candidates for future devices. In particular, the studies of molecular nanomagnets have brought about an intriguing transitional regime between the fields of paramagnetism and bulk ***, the unique structural characteristics of molecular nanomagnets allow the possibility of retaining magnetic moment in a low dimensional *** this talk, I will present the strategies we have used in our lab for the construction of molecular magnetic materials using the macrocyclic *** on these macrocyclic ligands, new types of molecular magnetic materials, such as single-molecule magnets(SMMs), single-ion magnets(SIMs), single-chain magnets(SCMs) and higher dimensional magnetic materials have been synthesized and characterized.

关键词： Microcyclic ligands Molecular Magnetic Materials Single-ion Magnet

Bistable Molecular Magnetic Materials triggered by crystal-to-crystal transformation

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Bistable Molecular Magnetic Materials triggered by crystal-t...

2018年中西部地区无机化学化工学术研讨会

作者： Dong Shao Xiao-Qin Wei Dong-Qin Wu xin-yi wang Department of Chemistry and Chemical Engineering State Key Laboratory of Coordination ChemistryNanjing University

Molecular magnetic materials exhibiting bistability have invoked intense interest in the molecular materials.1 In the past few years, we were focusing on several different bistable materials, such as the single-ion magnets（SIMs）, single-molecule magnets（SMMs）, single-chain magnets（SCMs）, and spin crossover materials（SCOs）, emphasizing the ration design and detailed magneto-structural relationship investigation of these materials. The representative research achievements of these bistable molecular magnetic materials involving the single-crystal-to-single-crystal transformations prepared in our group will be discussed in this presentation: a series of three-atom ligand bridged magnetic bistable compounds with cation-dependent magnetic ordering at around room-temperature;the first SMM based on the heptacyanomolybdenum and its ON-OFF switching property;the ON-OFF switching of both SCO and SMM properties in one cobalt compound;the tunable spin-crossover compounds triggered by dynamic geometry transformation;the ON-OFF switching of the hysteresis behaviour of a cobalt SCO compound. 2-6.

关键词： Single-molecule magnets magnetic bistability heptacyanomolybdenum

Observation and mitigation of image distortion in high-energy electron radiography

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Nuclear Science and Techniques 2023年第6期34卷 69-77页

作者： Hao-Qing Li Liang Sheng Chang-Qing Zhang ying-Chao Du Zheng Zhou Xiu-Feng Weng Jia-Hao Xiao Hong-Qiao yin Bin Sun Kun Wei Yang Li Bao-Jun Duan Yong-Tang Liu Yan-Hong Zhang Mei Zhang Yan Song Xiao-Dong Zhang Jun Liu Zhu-Ming Fu Qing Xu Xue Du Jian-Peng Gao xin-yi wang xin-Jian Tan Dong-Wei Hei Department of Engineering Physics Tsinghua UniversityBeijing100084China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an710024China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang621900China Institute of Intelligent Machines Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China Zhongke Hefei Institutes of Collaborative Research and Innovation for Intelligent Agriculture Hefei231131China

Image distortion caused by the angular misalignment of quadrupole magnets in high-energy electron radiography has been studied *** propose that the distortion originates from the coupling of the electron motions in the transverse directions,based on a theoretical analysis and the transfer-matrix *** relative angular rotation between the second and third magnetic quadrupoles was identified as the main contributor to image *** was verified by both a beam-dynamics simulation and *** strategies to mitigate this image distortion are also explored,including magnets online tuning,higher beam energy and larger magnification *** study provides criteria for designing experiments and paves the way for achieving higher image precision.

关键词： Misalignment Angular rotation Russian quadruplet Transfer matrix

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma yi-Xiang He Jing Jin Hong-Lian wang Yun-Feng wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis