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World Journal of Hepatology 2024年第4期16卷 537-549页

作者： Jing-Jing Li Jia-Xi Mao Han-Xiang Zhong Yuan-Yu Zhao Fei Teng xin-yi lu Li-Ye Zhu Yang Gao Hong Fu Wen-Yuan Guo Department of Liver Surgery and Organ Transplantation Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China

The tumor microenvironment is a complex network of cells,extracellular matrix,and signaling molecules that plays a critical role in tumor progression and *** and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage ***,recent studies have shown that lymphatic endothelial cells(LECs)and blood endothelial cells(BECs)also play multifaceted roles in the tumor microenvironment beyond their structural functions,particularly in hepatocellular carcinoma(HCC).This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC,including their involvement in angiogenesis,immune modulation,lymphangiogenesis,and *** providing a detailed account of the complex interplay between LECs,BECs,and tumor cells,this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.

关键词： Lymphatic endothelial cells Blood endothelial cells Hepatocellular carcinoma Tumor microenvironment

Finesse measurement for high-power optical enhancement cavity

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Chinese Physics B 2024年第1期33卷 414-421页

作者：陆心怡柳兴田其立王焕汪嘉俊颜立新 Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging Ministry of EducationBeijing 100084China

Finesse is a critical parameter for describing the characteristics of an optical enhancement cavity(OEC). This paper first presents a review of finesse measurement techniques, including a comparative analysis of the advantages, disadvantages, and potential limitations of several main methods from both theoretical and practical perspectives. A variant of the existing method called the free spectral range(FSR) modulation method is proposed and compared with three other finesse measurement methods, i.e., the fast-switching cavity ring-down(CRD) method, the rapidly swept-frequency(SF) CRD method, and the ringing effect method. A high-power OEC platform with a high finesse of approximately 16000 is built and measured with the four methods. The performance of these methods is compared, and the results show that the FSR modulation method and the fast-switching CRD method are more suitable and accurate than the other two methods for high-finesse OEC measurements. The CRD method and the ringing effect method can be implemented in open loop using simple equipment and are easy to perform. Additionally, recommendations for selecting finesse measurement methods under different conditions are proposed, which benefit the development of OEC and its applications.

关键词： optical enhancement cavity finesse measurement cavity ring-down ringing effect

Expression profiles and function of Toll-like receptors in human corneal epithelia

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Chinese Medical Journal 2007年第10期120卷 893-897页

作者： WU xin-yi GAO Jian-lu REN Mei-yu Department of Ophthalmology Qilu Hospital Shandong University Jinan 250012 China

Background Toll-like receptors play an important role in the human immune system. This study was conducted to investigate the expression profiles and function of Toll-like receptor （TLR）1-9 in human corneal epithelium. Methods The expression of TLR1-9 mRNA in 20 human donor corneal epithelia samples abraded during photorefractive keratotomy （PRK） and cultivated telomerase-immortalized human corneal epithelial cells （THCEs） was examined by semi-quantitative reverse-transcriptase polymerase chain reaction （RT-PCR） analysis. Human peripheral blood mononuclear cells （PBMCs） were used as positive controls. The expression of the TLR2 and TLR4 proteins was detected by Western analysis. ELISA was used to detect IL-8 secretion from THCEs challenged with ligands for TLR3 and TLR4 with and without antibody blockade. Results The expression of TLR1-9 at the mRNA level was detected in the epithelia of 20 patients and in THCE. Significant differences among individuals were observed. One patient was found to lack of the expression of TLR3, 4, 6 and 8, whereas another did not express TLRS. The expression of TLR2 and TLR4 protein was detected in human corneal epithelial cells. As THCE cells express TLR1-9, cells were challenged with lipopolysaccharides （LPS） and poly I：C to determine whether TLR4 and TLR3 were functional. The results showed that secretion of IL-8 by cells stimulated with LPS and Poly I：C was 7 to 10 fold greater than secretion by unchallenged cells. Blocking TLR4 with an anti-TLR4 antibody significantly inhibited the LPS-induced IL-8 production by THCE （P〈0.05）. Conclusion Human corneal epithelial cells express multiple TLRs and are able to recognize LPS and poly I：C. Different expression profiles among individuals suggest that differences in the susceptibilities and sensitivities to bacterial and viral infection in human populations relate to different patterns of TLR expression.

关键词： Toll-like receptors corneal epithelium, human gene expression ligand

Chemoselective hydrogenation of α,β-unsaturated aldehydes with modified Pd/C catalyst

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Chinese Chemical Letters 2012年第7期23卷 773-776页

作者： Wen Qiang Du Ze Ming Rong Yan Liang Yong Wang xin yi lu yi Fan Wang Lian Hai lu State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024China

Selective hydrogenation of α, β-unsaturated aldehydes with modified Pd/C catalyst was *** reduction of C=O bond could be efficiently inhibited by the addition of carbonates,and high selectivity to the corresponding saturated aldehydes was achieved under mild *** protocol provides an alternative for efficient preparation of saturated aldehydes.

关键词： Pd/C catalyst α,β-Unsaturatcd aldehydes Hydrogenation Selectivity

Highly effective direct synthesis of DMC from CH_3OH and CO_2 using novel Cu-Ni/C bimetallic composite catalysts

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Chinese Chemical Letters 2009年第3期20卷 352-355页

作者： Jun Bian Min Xiao Shuan Jin Wang yi xin lu Yue Zhong Meng State Key Laboratory of Optoelectronic Materials and Technologies~Institute of Optoelectronic and Functional Composite Materials Sun Yat-Sen University Guangzhou 510275 PR China Department of Chemistry & Medicinal Chemistry Program Office of Life Sciences National University of Singapore 3 Science Drive 3 Singapore 117543 Republic of Singapore

Novel Cu-Ni/C has been prepared and utilized as an efficient catalyst system in direct synthesis of DMC from CH3OH and CO2.

关键词： Dimethyl carbonate Carbon dioxide Bimetallic catalyst Catalysis

Acid-induced topological morphology modulation of graphitic carbon nitride homojunctions as advanced metal-free catalysts for OER and pollutant degradation

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Journal of Materials Science & Technology 2021年第27期86卷 210-218页

作者： Hua-Wei Zhang yi-xin lu Bo Li Gui-Fang Huang Fan Zeng Yuan-Yuan Li Anlian Pan yi-Feng Chai Wei-Qing Huang Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education&Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha410082China College of Materials Science and Engineering Hunan UniversityChangshaHunan410082China School of Physics and Electronics Science Hunan University of Science and TechnologyXiangtan411201China

Topological morphology that dominates the surface electronic properties of nanostructures plays a key role in producing desired materials for versatile functions and applications in many fields,but its modulation for specific functions remains a big ***,we report an acid-induced method to prepare S-doped graphitic carbon nitride/graphitic carbon nitride(S-CN/CN)homojunction by simply pyrolyzing a supramolecular precursor synthesized from melamine and H_(2)SO_(4).The topological morphology and electronic structure of CN homojunction can be easily adjusted only by changing the ratio of raw ***,the topological morphology of S-CN/CN homojunction can be further adjusted from hollow cocoon to 2D nanosheets by changing the annealing *** optimized S-CN/CN homojunction shows highly efficient in charge transfer and separation and exhibits superior OER activity and high ability to degrade organic ***,S-CN/CN nanosheets only demand low overpotential of301 m V to drive a current density of 10 m Acm^(-2)in 1 M KOH media,and the corresponding Tafel slope is only 57.71 m V/dec,which is superior to the most advanced precious metal Ir O_(2)***,under visible light irradiation,its photodegradation kinetic rate of Rh B is 2.38,which is 47.6 times higher than that of bulk *** work provides useful guidance for designing and developing efficient multifunctional metal-free catalysts.

关键词： Topological morphology Acid-induced Molecular self-assembly S-CN/CN homojunction OER

Effects of Mo promoters on the Cu-Fe bimetal catalysts for the DMC formation from CO_2 and methanol

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Chinese Chemical Letters 2013年第4期24卷 307-310页

作者： ying-Jie Zhou Min Xiao Shuan-Jin Wang Dong-Mei Han yi-xin lu Yue-Zhong Meng The Key Laboratory of Low-carbon Chemistry & Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen University Department of Chemistry & Medicinal Chemistry Program Office of Life SciencesNational University of Singapore

The Mo-promoted Cu-Fe bimetal catalysts were prepared and used for the formation of dimethyl carbonate （DMC） from CO2 and methanol. The catalysts were characterized by X-ray diffraction （XRD）, temperature programmed reduction （TPR）, laser Raman spectra （LRS）, energy dispersive spectroscopy （EDS） and temperature programmed desorption （TPD） techniques. The experimental results demonstrated that the Mo promoters can decrease the reducibility and increase the dispersion of Cu-Fe clusters, The concentration balance of base-acid sites can be readily adjusted by changing the Mo content. The moderate concentration balance of acid and base sites was in favor of the DMC formation, Under optimal experimental conditions, the highest methanol conversion of 6,99% with a DMC selectivity of 87.7% can be obtained when 2.5 wt% of Mo was loaded.

关键词： Dimethyl carbonateCarbon dioxideCatalysisBimetal catalyst

Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 877-882页

作者： ying Gao Rong-xin lu Yun Tang xin-yi Yang Hu Meng Chang-Lin Zhao yi-lu Chen Feng Yan Qian Cao Department of Ophthalmology Sir Run Run HospitalNanjing Medical UniversityNanjing 211112Jiangsu ProvinceChina Department of Ophthalmology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Thoracic Surgery the First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Medical School Nanjing UniversityNanjing 210093Jiangsu ProvinceChina Department of Ophthalmology Taikang Xianlin Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210046Jiangsu ProvinceChina

AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were *** study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)*** relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic ***:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(PluSION:The NLR,PLR,and SII may be used as predictors of DR.

关键词： diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index

Ex vivo liver resection and auto-transplantation as an alternative for the treatment of liver malignancies: Progress and challenges

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 117-122页

作者： xin Yang lu lu Wen-Wei Zhu yi-Feng Tao Cong-Huan Shen Jin-Hong Chen Zheng-xin Wang lun-Xiu Qin Hepatobiliary Surgery and Liver Transplantation Centers Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan UniversityShanghai 200040China

Hepatectomy is still the major curative treatment for patients with liver ***,it is still a big challenge to remove the tumors in the central posterior area,especially if their location involves the retrohepatic inferior vena cava and hepatic *** vivo liver resection and auto-transplantation(ELRA),a hybrid technique of the traditional liver resection and transplantation,has brought new hope to these patients and therefore becomes a valid alternative to liver *** to its technical difficulty,ELRA is still concentrated in a few hepatobiliary centers that have experienced surgeons in both liver resection and liver *** efficacy and safety of this technique has already been demonstrated in the treatment of benign liver diseases,especially in the advanced alveolar ***,the application of ELRA for liver malignances has gained more ***,standardization of clinical practice norms and international consensus are still *** prognostic impact in these oncologic patients also needs further *** this review,we summarized the principles and recent progresses on ELRA.

关键词： Ex vivo liver resection Liver auto-transplantation Oncology Liver malignancies

Self-Driven Photo-Polarized Water Molecule-Triggered Graphene-Based Photodetector

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Research 2024年第2期2023卷 273-283页

作者： Shisheng Lin Chang Liu xin Chen yi Zhang Hongtao Lin Xutao Yu Yujiao Bo Yanghua lu College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027P.R.China Hangzhou Gelanfeng Technology Co.Ltd Hangzhou 310051P.R.China State Key Laboratory of Modern Optical Instrumentation Zhejang UniversityHangzhou 310027P.R.China Key Laboratory of Wide Bandgap Semiconductor Materials and Devices HCSemitek CorporationYiwu 322009P.R.China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100P.R.China

Flowing water can be used as an energy source for generators,providing a major part of the energy for daily ***,water is rarely used for information or electronic ***,we present the feasibility of a polarized liquid-triggered photodetector in which polarized water is sandwiched between graphene and a *** to the polarization and depolarization processes of water molecules driven by photogenerated carriers,a photo-sensitive current can be repeatedly produced,resulting in a high-performance *** response wavelength of the photodetector can be fine-tuned as a result of the free choice of semiconductors as there is no requirement of lattice match between graphene and the *** zero voltage bias,the responsivity and specific detectivity of Gr/NaCl(0.5 M)W/N-GaN reach values of 130.7 mA/W and 2.3×10^(9)Jones under 350 nm illumination,***,using a polar liquid photodetector can successfully read the photoplethysmography signals to produce accurate oxygen blood saturation and heart *** with the commercial pulse oximetry sensor,the average errors of oxygen saturation and heart rate in the designed photoplethysmography sensor are~1.9%and~2.1%,*** study reveals that water can be used as a high-performance photodetector in informative industries.

关键词： polarization polarized saturation