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Functional liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predicts Cachexia and Prognosis in Hepatocellular Carcinoma Patients

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Current Medical Science 2024年第5期44卷 1018-1025页

作者： xin-xiang li Bing liU Yu-fei ZHAO Yang JIANG Ying CUI xin-gui PENG Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging&Interventional Radiology Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing210009China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230001China

Objective Cachexia occurs in approximately half of hepatocellular carcinoma(HCC)patients as the disease progresses and is correlated with a poor ***,early identification of HCC patients at risk of developing cachexia and their prognosis is *** study investigated the functional liver imaging score(FliS)derived from gadoxetic acid-enhanced magnetic resonance imaging(MRI)to identify cachexia in HCC patients and their *** Pretreatment clinical and MRI data from 339 HCC patients who underwent gadoxetic acid-enhanced MRI scans were retrospectively *** weights were recorded for 6 months following the MRI scan to diagnose *** FliS was calculated as the sum of the enhancement quality score,the excretion quality score,and the portal vein sign quality score.A Cox proportional hazards model was used to determine the significant factors affecting overall survival(OS).Multivariable logistic regression was then conducted to identify variables predicting cachexia in HCC patients,which were subsequently used to predict *** Cox regression analysis revealed a significant association between cachexia and worse *** FliS(0–4 vs.5–6 points)(OR,9.20;95%CI:4.68–18.10;P100 ng/mL(OR,4.08;95%CI:2.13–7.83;PliS(0–4 vs.5–6 points)(HR,1.73;95%CI:1.19–2.51;P=0.004)was significantly associated with *** in the FliS 0–4 points group had shorter OS than those in the FliS 5–6 points group[20 months(95%CI,14.7–25.3)vs.43 months(95%CI,27.7–58.3);P=0.001].Conclusion Cachexia was associated with worse *** functional liver imaging score emerged as a significant predictor of cachexia in HCC patients and their prognosis.

关键词： cachexia hepatocellular carcinoma functional liver imaging score magnetic resonance imaging

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Laparoscopic vs open abdominoperineal resection in the multimodality management of low rectal cancers

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World Journal of Gastroenterology 2015年第35期21卷 10174-10183页

作者： Yu-Wei Wang li-Yong Huang Cheng-li Song Chang-Hua Zhuo De-Bing Shi Guo-xiang Cai Ye Xu San-Jun Cai xin-xiang li Department of Colorectal Surgery Fudan University Shanghai Cancer Center Fudan University Department of Oncology Shanghai Medical CollegeFudan University Shanghai Institute for Minimally Invasive Therapy School of Medical Instrument and Food EngineeringUniversity of Shanghai for Science and Technology

AIM: To evaluate the safety and feasibility of laparoscopic abdominoperineal resection compared with the open procedure in multimodality management of rectal ***: A total of 106 rectal cancer patients who underwent open abdominoperineal resection(OAPR) were matched with 106 patients who underwent laparoscopic abdominoperineal resection(LAPR) in a 1 to 1 fashion, between 2009 and 2013 at Fudan University Shanghai Cancer Center. Propensity score matching was carried out based on age, gender, pathological staging of the disease and administration of neoadjuvant chemoradiation. Data regarding preoperative staging, surgical technique, pathologicalresults, postoperative recovery and complications were reviewed and compared between the LAPR and OAPR groups. Perineal closure around the stoma and pelvic floor reconstruction were performed only in OAPR, not in LAPR. Therefore, abdominoperineal resection procedure-specific surgical complications including parastomal hernia and perineal wound complications were compared between the open and laparoscopic procedure. Regular surveillance of the two cohorts was carried out to gather prognostic data. Diseasefree survival was analyzed using Kaplan-Meier estimate and log-rank test. Subgroup analysis was performed in patients with locally advanced disease treated with preoperative chemoradiation followed by surgical resection. RESULTS: No significant difference was found between the LAPR group and the OAPR group in terms of clinicopathological features. The operation time(180.8 ± 47.8 min vs 172.1 ± 49.2 min, P = 0.190), operative blood loss(93.9 ± 60.0 m L vs 88.4 ± 55.2 m L, P = 0.494), total number of retrieved lymph nodes(12.9 ± 6.9 vs 12.9 ± 5.4, P = 0.974), surgical complications(12.3% vs 15.1%, P = 0.549) and pathological characteristics were comparable between the LAPR and OAPR group, respectively. Compared with OAPR patients, LAPR patients showed significantly shorter postoperative analgesia(2.4 ± 0.7 d vs 2.7 ± 0.6

关键词： Abdominoperineal resection Laparoscopy Rectal canc

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Effective extraction of photoneutron cross-section distribution using gamma activation and reaction yield ratio method

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Nuclear Science and Techniques 2023年第11期34卷 103-111页

作者： Zhi‑Cai li Yue Yang Zong‑Wei Cao xin‑xiang li Yun Yuan Zong‑Qing Zhao Gong‑Tao Fan Hong‑Wei Wang Wen Luo School of Nuclear Science and Technology University of South ChinaHengyang 421001China Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

Photoneutron cross-section(PNCS)data are important in various current and emerging *** a few sophis-ticated methods have been developed,there is still an urgent need to study the PNCS *** this study,we propose the extraction of PNCS distributions using a combination of gamma activation and reaction yield ratio *** verify the validity of the proposed extraction method,experiments for generating^(62,64)Cu and^(85m,87m)Sr isotopes via laser-induced pho-toneutron reactions were performed,and the reaction yields of these isotopes were *** the proposed extraction method,the PNCS distributions of^(63)Cu and^(86)Sr isotopes(leading to^(85m)Sr isotope production)were successfully *** extracted PNCS distributions were benchmarked against available PNCS data or TALYS calculations,demonstrating the validity of the proposed extraction *** applications for predicting the PNCS distributions of the 30 iso-topes are further *** conclude that the proposed extraction method is an effective complement to the available sophisticated methods for measuring and evaluating PNCS data.

关键词： Photonuclear data Photoneutron cross section Gamma activation Reaction yield TALYS calculation

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FOREST LANDSCAPE PATTERN DYNAMICS OF LUONINGCOUNTY IN HENAN PROVINCE AND ITS DRIVING FORCES

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Chinese Geographical Science 2003年第3期13卷 247-253页

作者： DING Sheng-yan, QIAN Le-xiang, CAO xin-xiang, li Shuang, li Hao-min(College of Environment & Planning, Henan University, Kaifeng 475001, P. R. China) College of Environment & Planning Henan University Kaifeng P. R. China

With the help of ARC/INFOR and ERDAS software, based on the information from forest resources distribution maps and TM images, four indices were chosen to analyze spatial pattern changes of forest landscape of Luoning County, Henan Province from 1983 to 1999. The results showed that: 1) The number and total area of patches were rapidly increased with time changes. The fragmentation degree of the landscape was increasing greatly. 2) The area of some forest patch types, especially shrub forest, economic forest, Populus spp. forest, Quercus spp. forest, sparse forest, deserted grassland etc. had been greatly changed. 3) The fragemation degree of each forest patch type became greater from 1983 to 1999. 4) The transition probabilities of deserted forest, economic forest, Pi-nus tabulaeformis forest, Populus spp. forest exceed 85%,Robinia pseuoacacia forest, deserted grassland, 65% and Quercus spp. forest, non-forest, shrub forest had smaller ones, which were 26.5%, 29.1% and 45.3%, respectively. The main transition trends of various patches were non-forest and Quercus spp. forest. During the course of transition, the types that 50% of area was remained were Quercus spp. forest, non-forest and shrub forest. According to above analyses, the main driving forces, such as the management policies, market economy factors and influences of human activities etc. were brought out.

关键词： forest landscape pattern driving forces luoning county

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Simulation and test of the SLEGS TOF spectrometer at SSRF

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Nuclear Science and Techniques 2023年第3期34卷 171-184页

作者： Kai-Jie Chen Long-xiang liu Zi-Rui Hao Yu-Gang Ma Hong-Wei Wang Gong-Tao Fan Xi-Guang Cao Hang-Hua Xu Yi-Fei Niu xin-xiang li xin-Rong Hu Yu-Xuan Yang Sheng Jin Pan Kuang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Science Beijing 100080China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China

The Shanghai laser electron gamma source(SLEGS)is a powerful tool for exploring photonuclear physics,such as giant dipole resonance(GDR)and pygmy dipole resonance,which are the main mechanisms of collective nuclear *** goal of the SLEGS neutron time-of-flight(TOF)spectrometer is to measure GDR and specific nuclear structures in the energy region above the neutron *** SLEGS TOF spectrometer was designed to hold 20 sets of EJ301 and LaBr3 ***4 was used to simulate the efficiency of each detector and the entire spectrometer,which provides a reference for the selection of detectors and layout of the SLEGS TOF *** the events of 208Pb,implementations of coincidence and time-of-flight technology for complex experiments are available;thus,and neutron decay events can be *** performance of SLEGS TOF spectrometer was systematically evaluated using offline experiments,in which the time resolution reached approximately 0.9 ns.

关键词： SLEGS Time-of-flight Photoneutron nuclear reaction

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Measurements ofthe 197Au(n, γ) crosssectionupto100keV at the CSNSBack-nfacility

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Nuclear Science and Techniques 2021年第9期32卷 126-135页

作者： xin-Rong Hu Gong-Tao Fan Wei Jiang Jie Ren Long-xiang liu Hong-Wei Wang Ying-Du liu xin-xiang li Yue Zhang Zi-Rui Hao Pan Kuang Xiao-He Wang Ji-Feng Hu Bing Jiang De-xin Wang Suyalatu Zhang Zhen-Dong An Yu-Ting Wang Chun-Wang Ma Jian-Jun He Jun Su li-Yong Zhang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China xiangtan University Xiangtan 411105China Institute of Nuclear Physics Inner Mongolia University for the NationalitiesTongliao 028000China Sun Yat-sen University 510275 ZhuhaiChina Henan Normal University Xinxiang 453007China Beijing Normal University 100875 BeijingChina

The neutron capture cross section of 197 Au was measured using the time-of-flight(TOF)technique at the Back-n facility of the China Spallation Neutron Source(CSNS)in the 1 eV to 100 keV *** c-rays originating from neutron-induced capture events were detected by four C_(6)D_(6) liquid scintillator *** height weighting technology(PHWT)was used to analyze the *** results are in good agreement with ENDF/B-VIII.0,CENDL-3.1,and other evaluated libraries in the resonance region,and in agreement with both n TOF and GEliNA experimental data in the 5–100 keV ***,the resonance peaks in the energy range from 1eV to 1 keV were fitted by the SAMMY R-matrix code.

关键词： Cross section 197 Au(n,γ) Back-n C_(6)D_(6) Pulse height weighting technology

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Commissioning of laser electron gamma beamline SLEGS at SSRF

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Nuclear Science and Techniques 2022年第7期33卷 103-114页

作者： Hong-Wei Wang Gong-Tao Fan Long-xiang liu Hang-Hua Xu Wen-Qing Shen Yu-Gang Ma Hiroaki Utsunomiya Long-Long Song Xi-Guang Cao Zi-Rui Hao Kai-Jie Chen Sheng Jin Yu-Xuan Yang xin-Rong Hu xin-xiang li Pan Kuang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Science Beijing100049China Fudan University Shanghai200433China Department of Physics Konan UniversityKobe658-8501Japan ShanghaiTech University Shanghai201210China Zhengzhou University Zhengzhou450001China

The Shanghai Laser Electron Gamma Source(SLEGS)is a powerful gamma source that provides MeV gamma-ray beams for nuclear science and *** was developed as one of the 16 beamline stations in the Phase Ⅱ Project of the Shanghai Synchrotron Radiation *** slant-scattering mode is for the first time systematically employed in laser Compton scattering at SLEGS to produce energy-tunable quasi-monoenergetic gamma-ray *** SLEGS officially completed its commissioning from July to December *** rays in the energy range of 0.25-21.7 MeV with a flux of 2.1×10^(4)-1.2×10^(7) photons/s and an energy spread of 2-15% were produced during the *** paper reports the results from commissioning the SLEGS beamline.

关键词： SLEGS Laser Compton scattering Slant-scattering mode Backscattering mode

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Standard chemotherapy with cetuximab for treatment of colorectal cancer

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World Journal of Gastroenterology 2015年第22期21卷 7022-7035页

作者： xin-xiang li Lei liang li-Yong Huang San-Jun Cai Department of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University

AIM: To review and assess the evidence related to cetuximab treatment in metastatic colorectal cancer(mCRC) with regard to KRAS ***: PubMed, EMBASE, Cochrane database and American Society of Clinical Oncology meeting abstracts were searched for randomized controlled trials(RCTs) reporting the effect of KRAS status on efficacy of chemotherapy regimen with or without cetuximab in mCRC. Baseline information such as sex and age was summarized from the included *** ratios of progression-free survival(PFS) and overall survival(OS) as well as objective response based on KRAS status were extracted for ***: A total of 8 RCTs with 6780 patients were included. The combined analysis showed that cetuximab failed to improve the OS and PFS in patients with ***, in subgroup analysis, the pooled data showed that addition of cetuximab to irinotecan containing chemotherapy regimen was sufficient to improve OS and PFS in wild-type KRAS mCRC patients, but not in patients with mutant-type KRAS. The addition of cetuximab increased the incidence of adverse events such as diarrhea, rash, skin toxicity/rash, and nausea and vomiting. There was no significant publication bias existing in the included ***: The clinical benefit of cetuximab was only confirmed in patients with wild-type KRAS. KRAS status could be considered a biomarker of efficacy of cetuximab.

关键词： Cetuximab KRAS Standard chemotherapy Metastatic colorectal cancer Meta-analysis

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Core value of laparoscopic colorectal surgery

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World Journal of Gastrointestinal Endoscopy 2015年第18期7卷 1295-1299页

作者： xin-xiang li Ren-Jie Wang Department of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University

Since laparoscopy was first used in cholecystectomy in 1987, it has developed quickly and has been used in most fields of traditional surgery. People have now accepted its advantages like small incision, quick recovery, light pain, beauty and short hospital stays. In early times, there are still controversies about the application of laparoscopy in malignant tumor treatments, especially about the problems of oncology efficacy, incision implantation and operation security. However, these concerns have been fully eliminated by evidences on the basis of evidence-basis medicine. In recent years, new minimally invasive technologies are appearing continually, but they still have challenges and may increase the difficulties of radical dissection and the risks of potential complications, so they are confined to benign or early malignant tumors. The core value of the laparoscopic technique is to ensure the high quality of tumor's radical resection and less complications. On the basis of this, it is allowed to pursue more minimally invasive techniques. Since the development of laparoscopic colorectal surgery is rapid and unceasing, we have reasons to believe that laparoscopic surgery will become gold standard for colorectal surgery in the near future.

关键词： Laparoscopy Minimally invasive surgery Core value

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Laparoscopic segmental colectomy for colonic lymphangiomas: A definitive, minimally invasive surgical option

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World Journal of Gastroenterology 2014年第26期20卷 8745-8750页

作者： Chang-Hua Zhuo De-Bing Shi Min-Gang Ying Yu-Fan Cheng Yu-Wei Wang Wen-Ming Zhang San-Jun Cai xin-xiang li Department of Oncology Shanghai Medical CollegeFudan University Department of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Surgical Oncology Fujian Provincial Cancer HospitalTeaching Hospital of Fujian Medical University Department of Pathology Fudan University Shanghai Cancer Center Department of Endoscopy Fudan University Shanghai Cancer Center

Colonic lymphangioma is an unusual benign *** herein describe two cases.A 36-year-old woman was admitted with one year of intermittent abdominal pain;colonoscopy,abdominopelvic computed tomography and endoscopic ultrasonography(EUS)revealed enlarged cystic masses at the ascending *** another 40-year-old man,colonoscopy and EUS revealed an asymptomatic lobulated cystic mass with four small sessile polyps at the sigmoid *** patients underwent laparoscopic segmental *** masses were histologically confirmed as cystic lymphangiomas,and the patients were discharged without *** management of colonic lymphangioma depends on the individual situation;close surveillance or endoscopic therapy may be appropriate for asymptomatic lesions smaller than 2.5 cm in *** intervention can be considered for larger lesions or in patients who develop complication *** segmental colon resection may be recommended to excise relatively large submucosal lesions because it is a definitive,minimally invasive intervention with a fast postoperative recovery.

关键词： Cystic lymphangioma Colon neoplasm Laparoscopic surgery Colectomy Segmental resection

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