Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predicts Cachexia and Prognosis in Hepatocellular Carcinoma Patients

作     者：Xin-xiang LI Bing LIU Yu-fei ZHAO Yang JIANG Ying CUI Xin-gui PENG Xin-xiang LI;Bing LIU;Yu-fei ZHAO;Yang JIANG;Ying CUI;Xin-gui PENG

作者机构：Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging&Interventional RadiologyDepartment of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing210009China Department of RadiologyThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230001China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2024年第44卷第5期

页      面：1018-1025页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from National Natural Science Foundation of China(No.82272064) Jiangsu Provincial Science and Technique Program(No.BK20221461) Zhongda Hospital Affiliated to Southeast University,Jiangsu Province High-level Hospital Paring Assistance Construction(No.zdlyg08) 

主　　题：cachexia hepatocellular carcinoma functional liver imaging score magnetic resonance imaging 

摘      要：Objective Cachexia occurs in approximately half of hepatocellular carcinoma(HCC)patients as the disease progresses and is correlated with a poor ***,early identification of HCC patients at risk of developing cachexia and their prognosis is *** study investigated the functional liver imaging score(FLIS)derived from gadoxetic acid-enhanced magnetic resonance imaging(MRI)to identify cachexia in HCC patients and their *** Pretreatment clinical and MRI data from 339 HCC patients who underwent gadoxetic acid-enhanced MRI scans were retrospectively *** weights were recorded for 6 months following the MRI scan to diagnose *** FLIS was calculated as the sum of the enhancement quality score,the excretion quality score,and the portal vein sign quality score.A Cox proportional hazards model was used to determine the significant factors affecting overall survival(OS).Multivariable logistic regression was then conducted to identify variables predicting cachexia in HCC patients,which were subsequently used to predict *** Cox regression analysis revealed a significant association between cachexia and worse *** FLIS(0–4 vs.5–6 points)(OR,9.20;95%CI:4.68–18.10;P100 ng/mL(OR,4.08;95%CI:2.13–7.83;P0.001)emerged as significant predictors of cachexia in patients with ***,FLIS(0–4 vs.5–6 points)(HR,1.73;95%CI:1.19–2.51;P=0.004)was significantly associated with *** in the FLIS 0–4 points group had shorter OS than those in the FLIS 5–6 points group[20 months(95%CI,14.7–25.3)vs.43 months(95%CI,27.7–58.3);P=0.001].Conclusion Cachexia was associated with worse *** functional liver imaging score emerged as a significant predictor of cachexia in HCC patients and their prognosis.