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Communications in Theoretical Physics 2009年第10期52卷 588-592页

作者： wang xin-Wen yang Guo-Jian Department of Physics and Applied Optics Beijing Area Major Laboratory Beijing Normal University Beijing 100875China

We propose a scheme for generating a four-particle cluster state in an ion-trap *** scheme isinsensitive to the thermal motion of the ions,and needs less operations than previous *** such a setup,we alsodemonstrate a procedure for perfectly teleporting an arbitrary two-particle state via a single multipartite entanglementchannel,a four-particle cluster state.

关键词： cluster state teleportation ion-trap

Masses of the conjectured H-dibaryon at different temperatures

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Chinese Physics C 2024年第8期48卷 83-93页

作者： Liang-Kai Wu Han Tang Ning Li xin-yang wang School of Physics and Electronic Engineering Jiangsu UniversityZhenjiang 212013China Center for Fundamental Physics School of Mechanics and PhysicsAnhui University of Science and TechnologyHuainan 232001China

We present a lattice QCD determination of masses of the conjectured H-dibaryon,denoted as mH,at nine different temperatures:T/T_(c)=0.24,0.63,0.76,0.84,0.95,1.09,1.27,1.52,and *** masses of baryons N,Σ,Ξ,andΛat different temperatures were also *** simulations were performed on an anisotropic lattice with N_(f)=2+1 flavours of clover fermion at a quark mass corresponding to mπ=384(4)*** thermal ensembles were provided by the FASTSUM collaboration,whereas the zero temperature ensembles were provided by the Hadspec *** also calculated the spectral density of the correlation function of those *** spectral density distributions show a rich peak structure at the lowest temperature;at intermediate temperatures,the mass values of those particles obtained by the extrapolation method reflect a two-peak *** the spectral density for the octet baryon becomes smooth at T/T_(c)=1.27,1.52,and 1.90,the spectral density for the H-dibaryon becomes smooth at T/T_(c)=*** T/T_(c)=0.24,the mass difference of the H-dibaryon andΛpair,expressed asΔm=m_(H)−2m_(Λ),was estimated to beΔm=−14.6(6.2)MeV,which suggests the existence of a bound H-dibaryon state.

关键词： lattice QCD H-dibaryon spectral function clover fermion finite temperature

Entropy Evolution in the Interior Volume of a Charged f(R) Black Hole

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Communications in Theoretical Physics 2019年第6期71卷 718-722页

作者： Shad Ali xin-yang wang Wen-Biao Liu Department of Physics Beijing Normal University

Based on the 4-dimensional black hole solution of f(R) theory coupled to a nonlinear Maxwell field, we calculate the interior volume of a charged f(R) black hole using the method proposed by Christodoulou and *** massless scalar field in the interior volume and Hawking radiation carrying only energy, we calculate the entropy of the scalar field inside a charged f(R) black hole and investigate the evolution of the entropy under Hawking radiation. In the meantime, the evolution of the Bekenstein-Hawking entropy under Hawking radiation has also been calculated. Based on these results, the proportional relation is obtained between the evolution of the scalar field entropy and the evolution of Bekenstein-Hawking entropy under Hawking radiation. According to the result, we investigate and discuss how the modified coefficient b in f(R) gravity theory affects the evolution relation between the two types of entropy. It is shown that the radiation rate for Hawking radiation of a charged f(R) black hole can increase with the modified coefficient b.

关键词： f(R) black hole interior volume Hawking radiation Bekenstein-Hawking entropy

Synthesis and biological evaluation of novel farnesylthiosalicylic acid/salicylic acid hybrids as potential anti-tumor agents

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Chinese Chemical Letters 2014年第12期25卷 1545-1549页

作者： Zhi-Qiang wang Ren-An Chang Hai-Ying Huang Xue-Min wang xin-yang wang Li Chen Yong Ling Department of Natural Medicinal Chemistry China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University School of Pharmacy Nantong University Department of Hepatobiliary Surgery Affiliated HospitalNantong University

A series of FTS/salicylic acid hybrids was designed and synthesized and their in vitro antitumor activities were *** was found that the anti-proliferation activities of hybrids were better than that of *** 10 a displayed the strongest antitumor activities with IC50 values of 5.72-9.76 μmol/L and selectively inhibited tumor cell *** addition,10 a induced tumor cell apoptosis in a dosedependent manner by up-regulating the expression of Bax and caspase-3 and down-regulating *** findings suggest that these novel hybrids may hold a great promise as therapeutic agents for the intervention of human cancers.

关键词： Farnesylthiosalicylic acid Salicylic acid Antitumor activities Cell apoptosis

Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents

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Chinese Chemical Letters 2013年第8期24卷 727-730页

作者： You-An Xiao Zhi-Qiang wang Xue-Min wang Yi Hui Yong Ling xin-yang wang Li-Qin He Anhui University of Traditional Chinese Medicine Anhui Key Laboratory of Modernized Chinese Material Medical Medical College Nantong University Department of Natural Medicinal Chemistry China Pharmaceutical University

Novel 2-aminoimidazolone derivatives were *** compounds displayed strong anticancer activities against human carcinoma cells in *** 8a,8b and 8j exhibited optimal activity superior to 5-FU in most cancer cells ***,the lC_（50）s of 8b（12.6-21.5μmol/L） against five tumor cells were 1 -4 fold less than those of 5-FU（18.4-56.1μmol/L） in ***,comp以ound 8b could induce SMMC-7721 cell apoptosis in a dose-dependent ***,our novel findings may provide a new framework for the design of new 2-aminoimidazolone derivatives for the treatment of cancer.

关键词： Synthesis 2-Aminoimidazolone Anti-tumor agents Cytotoxic activities Cell apoptosis

Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents

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Chinese Chemical Letters 2012年第10期23卷 1141-1144页

作者： Yong Ling You An Xiao Guang Tong Chen Dong Geng wang Yu Qin Li xin yang wang Heng Zheng Department of Pharmacy School of MedicalNantong UniversityNantong 226001China Medicinal College Anhui College of Traditional Chinese MedicineHefei 230031China Department of Bioinformatics College of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 210009China

Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.

关键词： Synthesis Farnesylthiosalicylic acid 1,3,4-Thiodiazole Anti-tumor agents Cytotoxic activities Cell apoptosis

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI Feng wang Tao DUAN Kaijie yang Bin yang Chunmei wang xin TIAN Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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Knocking down AR promotes osteoblasts to recruit prostate cancer cells by altering exosomal circ-DHPS/miR-214-3p/CCL5 pathway

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Asian Journal of Andrology 2024年第2期26卷 195-204页

作者： Zhao yang Jia-Qi Chen Tian-Jie Liu Yu-Le Chen Zhen-Kun Ma Yi-Zeng Fan Zi-Xi wang Shan Xu Ke wang xin-yang wang Lei Li Hong-Jun Xie Department of Urology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)*** is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment,even bone metastases,through ***,we found that exosomes isolated from PCa cells after knocking down androgen receptor(AR)or enzalutamide treatment can facilitate the migration of prostate cancer cells to *** addition,AR silencing or treatment with the AR antagonist enzalutamide may increase the expression of circular RNA-deoxyhypusine synthase(circ-DHPS)in PCa cells,which can be transported to osteoblasts by ***-DHPS acts as a competitive endogenous RNA(ceRNA)against endogenous miR-214-3p to promote C-C chemokine ligand 5(CCL5)levels in *** the level of CCL5 in osteoblasts could recruit more PCa cells into the bone ***,blocking the circ-DHPS/miR-214-3p/CCL5 signal may decrease exosome-mediated migration of prostate cancer cells to osteoblasts.

关键词： androgen receptor circRNA exosome prostate cancer

A new peptide,VD11,promotes structural and functional recovery after spinal cord injury

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Neural Regeneration Research 2023年第10期18卷 2260-2267页

作者： Shan-Shan Li Bai-Yu Zhang Sai-Ge Yin Zi-Qi Wei Nai-xin Liu Yi-Lin Li Si-Yu wang Yu-Heng Shi Jian Zhao Li-Juan wang Yue Zhang Jun Sun Ying wang xin-wang yang Department of Anatomy and Histology&Embryology Faculty of Basic Medical ScienceKunming Medical UniversityKunmingYunnan ProvinceChina Key Laboratory of Chemistry in Ethnic Medicinal Resources&Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes State Ethnic Affairs Commission&Ministry of EducationSchool of Ethnic MedicineYunnan Minzu UniversityKunmingYunnan ProvinceChina Department of Urology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan ProvinceChina Yunnan Province Clinical Research Center for Chronic Kidney Disease First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan ProvinceChina

The regenerative capacity of the central nervous system is very limited and few effective treatments are currently available for spinal cord *** is therefore a priority to develop new drugs that can promote structural and functional recovery after spinal cord *** studies have shown that peptides can promote substantial repair and regeneration of injured *** amphibians have a pronounced ability to regenerate the spinal cord,few studies have investigated the effect of amphibian spinal cord-derived peptides on spinal cord *** we report for the first time the successful identification and isolation of a new polypeptide,VD11(amino acid sequence:VDELWPPWLPC),from the spinal cord of an endemic Chinese amphibian(Odorrana schmackeri).In vitro experiments showed that VD11 promoted the secretion of nerve growth factor and brain-derived neurotrophic factor in BV2 cells stimulated with lipopolysaccharide,as well as the proliferation and synaptic elongation of PC12 cells subjected to *** vivo experiments showed that intravertebral injection of VD11 markedly promoted recovery of motor function in rats with spinal cord injury,alleviated pathological damage,and promoted axonal ***,RNA sequencing and western blotting showed that VD11 may affect spinal cord injury through activation of the AMPK and AKT signaling *** summary,we discovered a novel amphibian-derived peptide that promotes structural and functional recovery after spinal cord injury.

关键词： Akt signaling pathway amphibian-derived bioactive peptide AMPK signaling pathway axonal regeneration brain-derived neurotrophic factor ischemia/reperfusion injury motor function nerve growth factor neuroprotective effect spinal cord injury

Festosterone regulates keratin 33B expression in rat penis growth through androgen receptor signaling

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Asian Journal of Andrology 2014年第6期16卷 817-823页

作者： Yan-Min Ma Kai-Jie Wu Qiang Dang Qi Shi yang Gao Peng Guo Shan Xu xin-yang wang Da-Lin He Yong-Guang Gong Department of Urology First Affiliated Hospital of Medical School Xi'an Jiaotong University Oncology Research Lab Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of the People's Republic of China Xi'an 710061 China

Androgen therapy is the mainstay of treatment for the hypogonadotropic hypogonadal micropenis because it obviously enhances penis growth in prepubescent microphallic patients. However, the molecular mechanisms of androgen treatment leading to penis growth are still largely unknown. To clarify this well-known phenomenon, we successfully generated a castrated male Sprague Dawley rat model at puberty followed by testosterone administration. Interestingly, compared with the control group, testosterone treatment stimulated a dose-dependent increase of penis weight, length, and width in castrated rats accompanied with a dramatic recovery of the pathological changes of the penis. Mechanistically, testosterone administration substantially increased the expression of androgen receptor （AR） protein. Increased AR protein in the penis could subsequently initiate transcription of its target genes, including keratin 33B （Krt33b）. Importantly, we demonstrated that KRT33B is generally expressed in the rat penis and that most KRT33B expression is cytoplasmic. Furthermore, AR could directly modulate its expression by binding to a putative androgen response element sequence of the Krt33b promoter. Overall, this study reveals a novel mechanism facilitating penis growth after testosterone treatment in precastrated prepubescent animals, in which androgen enhances the expression of AR protein as well as its target genes, such as Krt33b.

关键词： androgen receptor keratin 33B penis testosterone