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Knockdown of fibrillin-1 suppresses retina-blood barrier dysfunction by inhibiting vascular endothelial apoptosis under diabetic conditions

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1403-1410页

作者： Yue Zhang Xiao-Jing Liu xin-ran zhai Yao Yao Bin Shao Yu-Han Zhen xin Zhang Zhe Xiao Li-Fang Wang Ming-Lian Zhang Zhi-Min Chen Hebei Eye Hospital Provincial Key Laboratory of OphthalmologyHebei Provincial Clinical Research Center for Eye DiseasesXingtai 054001Hebei ProvinceChina Department of Ophthalmology Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

AIM:To investigate the effects of fibrillin-1(FBN1)deletion on the integrity of retina-blood barrier function and the apoptosis of vascular endothelial cells under diabetic ***:Streptozotocin(STZ)-induced diabetic mice were used to simulate the diabetic conditions of diabetic retinopathy(DR)patients,and FBN1 expression was detected in retinas from STZ-diabetic mice and *** the Gene Expression Omnibus(GEO)database,the GSE60436 dataset was selected to analyze FBN1 expressions in fibrovascular membranes from DR *** lentivirus to knock down FBN1 levels,vascular leakage and endothelial barrier integrity were detected by Evans blue vascular permeability assay,fluorescein fundus angiography(FFA)and immunofluorescence labeled with tight junction marker in *** glucose-induced monkey retinal vascular endothelial cells(RF/6A)were used to investigate effects of FBN1 on the cells in *** vascular endothelial barrier integrity and apoptosis were detected by trans-endothelial electrical resistance(TEER)assay and flow cytometry,***:FBN1 mRNA expression was increased in retinas of STZ-induced diabetic mice and fibrovascular membranes of DR patients(GSE60436 datasets)using RNA-seq ***,knocking down of FBN1 by lentivirus intravitreal injection significantly inhibited the vascular leakage compared to STZ-DR group by Evans blue vascular permeability assay and FFA *** of tight junction markers in STZ-DR mouse retinas were lower than those in the control group,and knocking down of FBN1 increased the tight junction *** vitro,30 mmol/L glucose could significantly inhibit viability of RF/6A cells,and FBN1 mRNA expression was increased under 30 mmol/L glucose ***-regulation of FBN1 reduced high glucose(HG)-stimulated retinal microvascular endothelial cell permeability,increased TEER,and inhibited RF/6A cell apoptosis in ***:The expression level of FBN1 increases in reti

关键词： diabetic retinopathy fibrillin-1 retinablood barrier vascular leakage vascular permeability apoptosis retinal vascular endothelial cells

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Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen Nie Die Hu Zhiyao Zeng Yan Fan Yaxin zhai xin-Long Ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization

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Effect of Low-temperature Imidization on Properties and Aggregation Structures of Polyimide Films with Different Rigidity

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Chinese Journal of Polymer Science 2024年第8期42卷 1134-1146页

作者： Yan Jia Lei zhai Song Mo Yi Liu Li-xin Liu xin-Yu Du Min-Hui He Lin Fan Key Laboratory of Science and Technology on High-tech Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

The traditional high-temperature preparation process of polyimide can cause many problems and limits the wider application in extreme *** important challenge to be solved urgently is the reduction of imidization *** this work,twelve kinds of polyimide films with different chain rigidity were prepared at low temperature of 200℃,in the absence or presence of imidazole used as the *** molecular rigidity and free volume were theoretically calculated,and relationship between structure and properties were systematically *** results show that imidization reaction under low temperatures is significantly affected by the rigidity of molecula r *** rigid structure of polyimide is not conducive to the low-temperature imidization,but this adverse effect can be eliminated by adding catalyst,resulting the notably increased imidization *** optical and thermal properties can be improved to a certain extent for the chemically catalyzed system,resulting in relatively higher heat resistance and thermal *** the mechanical performance could be determined by com plicating factors,greatly different from polyimide films prepa red by high temperature *** investigate aggregation structures of film s,the effect of chain rigidity and catalyst on the stacking or orientation of molecular chains was further *** wo rk can contribute to the understanding of chemically catalyzed imidization that is rarely reported in the existing research,and will provide guidance for the low-temperature preparation of high-performance polyimides.

关键词： Polyimide Imidization Catalyst Structure and properties Aggregation structures

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ALTERNATING OPTIMIZATION METHOD FOR ISOGEOMETRIC TOPOLOGY OPTIMIZATION WITH STRESS CONSTRAINTS

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Journal of Computational Mathematics 2024年第1期42卷 134-155页

作者： Xiaoya zhai School of Mathematical Sciences University of Science and Technology of ChinaHefei 230071China

Topology optimization (TO) has developed rapidly recently. However, topology optimization with stress constraints still faces many challenges due to its highly non-linear properties which will cause inefficient computation, iterative oscillation, and convergence guarantee problems. At the same time, isogeometric analysis (IGA) is accepted by more and more researchers, and it has become one important tool in the field of topology optimization because of its high fidelity. In this paper, we focus on topology optimization with stress constraints based on isogeometric analysis to improve computation efficiency and stability. A new hybrid solver combining the alternating direction method of multipliers and the method of moving asymptotes (ADMM-MMA) is proposed to solve this problem. We first generate an initial feasible point by alternating direction method of multipliers (ADMM) in virtue of the rapid initial descent property. After that, we adopt the method of moving asymptotes (MMA) to get the final results. Several benchmark examples are used to verify the proposed method, and the results show its feasibility and effectiveness.

关键词： Isogeometric topology optimization Stress constraints The ADMM-MMA solver

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Current and Potential Roles of Ferroptosis in Bladder Cancer

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Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN Radheshyam Gupta Kun zhai Ya-ru WANG Wan-hai XU Yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

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DCVAE-adv:A Universal Adversarial Example Generation Method for White and Black Box Attacks

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Tsinghua Science and Technology 2024年第2期29卷 430-446页

作者： Lei Xu Junhai zhai College of Mathematics and Information Science Hebei UniversityBaoding 071002China

Deep neural network(DNN)has strong representation learning ability,but it is vulnerable and easy to be fooled by adversarial *** order to handle the vulnerability of DNN,many methods have been *** general idea of existing methods is to reduce the chance of DNN models being fooled by observing some designed adversarial examples,which are generated by adding perturbations to the original *** this paper,we propose a novel adversarial example generation method,called *** from the existing methods,DCVAE-adv constructs adversarial examples by mixing both explicit and implicit perturbations without using original ***,the proposed method can be applied to both white box and black box *** addition,in the inference stage,the adversarial examples can be generated without loading the original images into memory,which greatly reduces the memory *** compared DCVAE-adv with three most advanced adversarial attack algorithms:FGSM,AdvGAN,and AdvGAN++.The experimental results demonstrate that DCVAE-adv is superior to these state-of-the-art methods in terms of attack success rate and transfer ability for targeted *** code is available at https://***/xzforeverlove/DCVAE-adv.

关键词： deep neural network adversarial examples white box attack black box attack robustness

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Strong Antiferromagnetic Exchange-Coupling Observed in Hydride-Bridged Dimeric Dysprosium(Ⅲ)Single-Molecule Magnet

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Chinese Journal of Chemistry 2024年第4期42卷 391-396页

作者： Qian-Cheng Luo Ke-xin Yu Peng-Bo Jin Ye-Ye Liu Yuan-Qi zhai Yan-Zhen Zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentXi'an Key Laboratory of Electronic Devices and Materials ChemistrySchool of Chemistry and School of PhysicsXi'an Jiaotong University99 Yanxiang RoadXi'anShaanxi710054 China

One dihydride-bridged dimeric Dy(Ⅲ)guanidinate complex,formulated as[{(Me_(3)Si)_(2)NC(NiPr)_(2)}_(2)Dy(μ-H)]_(2)(1Dy),was successfully isolated and the introduction of hydride bridges significantly reduces the intramolecular Dy(Ⅲ)…Dy(Ⅲ)distance to only 3.688(1)Å.To investigate the effect of such a short Dy(Ⅲ)…Dy(Ⅲ)distance on magnetism,we also prepared its dibromide-bridged analogue[{(Me_(3)Si)_(2)NC(NiPr)_(2)}_(2)Dy(μ-Br)]_(2)(2Dy),which has a much longer Dy(Ⅲ)…Dy(Ⅲ)distance of 4.605(4)Å.Surprisingly,2Dy demonstrates much larger effective energy barrier for magnetization reversal(U_(eff))and higher blocking temperature(T_(B)).The worse performance of 1Dy is attributed to the concerted effect of strong antiferromagnetic interactions between Dy(Ⅲ)ions(J_(total)=–2.683 cm^(–1))and the unparallel arrangement of magnetic principle axes of the Dy(Ⅲ)ions for 1Dy.

关键词： Single-molecule magnets Lanthanides Guanidinate ligand Hydride bridge Magnetic properties Ab initio calculations

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Mechanism of microarc oxidation on AZ91D Mg alloy induced byβ-Mg_(17)Al_(12) phase

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 712-724页

作者： Dajun zhai Xiaoping Li Jun Shen College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

This work proposed a strategy of indirectly inducing uniform microarc discharge by controlling the content and distribution ofβ-Mg_(17)Al_(12)phase in AZ91D Mg *** kinds of nano-particles(ZrO_(2)and TiO_(2))were designed to be added into the substrate of Mg alloy by friction stir processing(FSP).Then,Mg alloy sample designed with different precipitated morphology ofβ-Mg_(17)Al_(12)phase was treated by microarc oxidation(MAO)in Na_(3)PO_(4)/*** characteristics and performance of the MAO coating was analyzed using scanning electron microscopy(SEM),energy dispersive spectrometer(EDS),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),contact angle meter,and potentiodynamic *** was found that the coarseα-Mg grains in extruded AZ91D Mg alloy were refined by FSP,and theβ-Mg_(17)Al_(12)phase with reticular structure was broken and *** nano-ZrO_(2)particles were pinned at the grain boundary by FSP,which refined theα-Mg grain and promoted the precipitation ofβ-Mg_(17)Al_(12)phase in *** effectively inhibited the“cascade”phenomenon of microarcs,which induced the uniform distribution of discharge *** MAO coating on Zr-FSP sample had good wettability and corrosion ***,TiO_(2)particles were hardly detected in the coating on TiFSP sample.

关键词： AZ91D Mg alloy microarc oxidation friction stir processing ZrO_(2) TiO_(2) β-Mg_(17)Al_(12)

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Advantageous properties of halide perovskite quantum dots towards energy-efficient sustainable applications

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Green Energy & Environment 2024年第6期9卷 949-965页

作者： Qian Zhao Shuo Wang Young-Hoon Kim Shekhar Mondal Qingqing Miao Simiao Li Danya Liu Miao Wang Yaxin zhai Jianbo Gao Abhijit Hazarika Guo-ran Li School of Materials Science and Engineering Nankai UniversityTianjin300350China Department of Energy Engineering Hanyang UniversitySeoul04763Republic of Korea Polymers and Functional Materials Division CSIR-Indian Institute of Chemical TechnologyUppal RoadTarnakHyderabad500007India Institute of Process Engineering Chinese Academy of SciencesBeijing100190China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangshHunan410081China Department of Chemistry Brock University1812 Sir Isaac WaySt CatharinesOntarioCanada

As lead halide perovskite(LHP)semiconductors have shown tremendous promise in many application fields,and particularly made strong impact in the solar photovoltaic area,low dimensional quantum dot forms of these perovskites are showing the potential to make distinct marks in the fields of electronics,optoelectronics and *** so-called perovskite quantum dots(PQDs)not only possess the most important features of LHP materials,i.e.,the unusual high defect tolerance,but also demonstrate clear quantum size effects,along with exhibiting desirable optoelectronic properties such as near perfect photoluminescent quantum yield,multiple exciton generation and slow hot-carrier ***,we review the advantageous properties of these nanoscale perovskites and survey the prospects for diverse applications which include lightemitting devices,solar cells,photocatalysts,lasers,detectors and memristors,emphasizing the distinct superiorities as well as the challenges.

关键词： Perovskite quantum dot Light-emitting Detector Laser Solar cell

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Dynamics modeling and electromechanical coupling characteristics analysis of cage induction motors

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Science China(Technological Sciences) 2024年第3期67卷 709-724页

作者： ZHOU ZiWei CHEN ZaiGang zhai WanMing State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China

Induction motors, as typical electromechanical energy conversion devices, have received limited attention in previous studies on electromechanical coupling vibrations, precise modeling, and the use of electromechanical coupling effects for fault diagnosis and condition assessment in motor drive systems. This study proposes a comprehensive model of cage induction motors that integrates the multiple coupled circuit model with a rotor-bearing dynamics model. The model accounts for the linear increase in the magnetomotive force across the slot and incorporates the skidding characteristics of bearings in the rotor-bearing system. By calculating the time-varying mutual inductance parameters based on the air-gap distribution in the vibration environment, the electromechanical coupling vibration of the cage motor is investigated. Furthermore, this study examines the electromechanical coupling vibration characteristics influenced by various factors, including bearing clearances, radial loads, and the vertical excitation frequencies of the stators. The results show that the proposed model improves the excitation inputs for the electrical and mechanical systems of the motor compared with conventional models. Increased bearing clearance and radial load affect the current and torque similarly but have opposite effects on the slip ratio. This study provides a deeper understanding of electromechanical coupling mechanisms and facilitates the use of such phenomena for fault diagnosis and condition assessment in motor-driven systems.

关键词： cage induction motors rotor-bearing dynamics mutual inductance electromechanical testing current signal analysis

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