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RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China Life Sciences 2024年

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su xin-ran zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu Tian Xia Xue-Min zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical Analysis School of Basic Medical Sciences Fudan University Department of Basic Medical Sciences School of Medicine Tsinghua University

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid （CSF） flow by beating their motile cilia coordinately. The ependymal denudation or ciliary dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of Gprotein signaling 22 （RGS22） results in severe congenital hydrocephalus in both mice and rats. Interestingly, RGS22 is specifically expressed in ependymal cells within the brain. Using conditional knock-out mice, we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus. Mechanistically, we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis. This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor （LPAR） signaling under Rgs22–/–condition, as the LPAR blockade effectively alleviates hydrocephalus in Rgs22–/–rats. Therefore, our findings unveil a previously unrecognized role of RGS22 in the central nervous system, and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

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Wearable multi-sensing double-chain thermoelectric generator

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Microsystems & Nanoengineering 2020年第1期6卷 471-483页

作者： Dan-Liang Wen Hai-Tao Deng xin Liu Guo-Ke Li xin-ran zhang Xiao-Sheng zhang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Wearable electronics play a crucial role in advancing the rapid development of artificial intelligence,and as an attractive future vision,all-in-one wearable microsystems integrating powering,sensing,actuating and other functional components on a single chip have become an appealing ***,we propose a wearable thermoelectric generator(ThEG)with a novel double-chain configuration to simultaneously realize sustainable energy harvesting and multi-functional *** contrast to traditional single-chain ThEGs with the sole function of thermal energy harvesting,each individual chain of the developed double-chain thermoelectric generator(DC-ThEG)can be utilized to scavenge heat energy,and moreover,the combination of the two chains can be employed as functional sensing electrodes at the same *** mature mass-fabrication technology of screen printing was successfully introduced to print n-type and p-type thermoelectric inks atop a polymeric substrate to form thermocouples to construct two independent chains,which makes this DC-ThEG flexible,high-performance and *** emerging material of silk fibroin was employed to cover the gap of the fabricated two chains to serve as a functional layer for sensing the existence of liquid water molecules in the air and the *** powering and sensing functions of the developed DC-ThEG and their interactions were systematically studied via experimental measurements,which proved the DC-ThEG to be a robust multi-functional power source with a 151 mV open-circuit *** addition,it was successfully demonstrated that this DC-ThEG can convert heat energy to achieve a 3.3 V output,matching common power demands of wearable electronics,and harvest biothermal energy to drive commercial electronics(i.e.,a calculator).The integration approach of powering and multi-functional sensing based on this new double-chain configuration might open a new chapter in advanced thermoelectric generators,especially in the ap

关键词： temperature generator double

Digital interventions empowering mental health reconstruction among students after the COVID-19 pandemic

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World Journal of Psychiatry 2023年第6期13卷 397-401页

作者： xin-Qiao Liu Yu-xin Guo xin-ran zhang Lin-xin zhang Yi-fan zhang School of Education Tianjin UniversityTianjin 300350China

With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently *** interventions offer advantages such as high accessibility,anonymity,and accurate identification,which can promote the reconstruction of students’mental health through the provision of psychological support platforms,psychological assessment tools,and online mental health ***,we recognize that digital interventions must undergo many adjustments,and corresponding ethical norms require further *** is crucial for different stakeholders to collaborate and work toward maximizing the effectiveness of digital interventions for the reconstruction of mental health after the COVID-19 pandemic.

关键词： Digital interventions Artificial intelligence Big data Students Mental health

Stretchable multifunctional sensor based on porous silver nanowire/silicone rubber conductive film

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Nano Research 2023年第5期16卷 7618-7626页

作者： Hai-Tao Deng Dan-Liang Wen Jing-Rui Liu xin-ran zhang Yi-Lin Wang Peng Huang Beomjoon Kim Xiao-Sheng zhang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China CIRMM Institute of Industrial ScienceThe University of TokyoTokyo 153-8505Japan

As one of the promising human–machine interfaces,wearable sensors play an important role in modern society,which advances the development of wearable fields,especially in the promising applications of electronic skin(e-skin),robotics,prosthetics,*** the last decades,wearable sensors tend to be capable of attractive capabilities such as miniaturization,multifunction,smart integration,wearable properties such as lightweight,flexibility,stretchability,conformability for wider *** this work,we developed a stretchable multifunctional sensor based on porous silver nanowire/silicone rubber conductive film(P-AgNW/SR).Its unique structural configuration,i.e.,an assembly of the P-AgNW/SR with good conductivity,stability,resistance response,the insulated silicone rubber layer,provided the feasibility for realizing multiple sensing ***,porous microstructures of the P-AgNW/SR made the device to be used for pressure sensing,exhibiting outstanding dynamic and static resistive responsive behaviors and having a maximum sensitivity of 9.062%∙N^(−1) in a continuous compressive force range of~16 *** the merit of the good piezoresistive property of AgNW/SR networks embedded into the surface of micropores of the P-AgNW/SR,the device was verified to be a temperature sensor for detecting temperature changes in the human body and *** temperature sensor had good sensitivity of 0.844%∙℃^(−1),high linearity of 0.999 in the range of 25–125℃,remarkable dynamic ***,the developed sensor was demonstrated to be a single electrode-triboelectric sensor for active sensing,owing to the unique assembly of the conductive PAgNW/SR electrode and the silicone rubber friction *** on the coupling effect of the triboelectrification and electrostatic induction,the generated electrical signals could be used to sense the human motions,according to the quantitative correlation between the human motions and the features in amplitude and

关键词： wearable electronics porous microstructures multiple sensors pressure sensing temperature sensing triboelectric sensing

Silk Fibroin‑Based Wearable All‑Fiber Multifunctional Sensor for Smart Clothing

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Advanced Fiber Materials 2022年第4期4卷 873-884页

作者： Dan‑Liang Wen Yu‑xing Pang Peng Huang Yi‑Lin Wang xin‑ran zhang Hai‑Tao Deng Xiao‑Sheng zhang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Wearable sensing technology enables the interaction between the physical world and the digital world,as takes an irreplaceable role in development of the Internet of Things(IoT),and artificial intelligence(AI).However,increasing requirements posed by rapid development of wearable electronic information technology bring about many for wearable sensing technology,such as the demands for ultrahigh flexibility,air permeability,excellent biocompatibility,and multifunctional ***,we propose a wearable all-fiber multifunctional sensor(AFMS)based on a biocompatible material,i.e.,silk fibroin.A simple two-layer configuration of a silk fiber film and an interdigital Ag nanowires(AgNWs)electrode was designed to construct the AFMS,in which silk fibroin simultaneously serves as a fundamental supporting component and a functional sensing *** and spray coating technologies were introduced to process the silk fiber film and the AgNWs *** all-fiber configuration allows AFMS to possess ultrahigh flexibility and good air permeability,and silk fibroin enables the AFMS to have excellent *** importantly,benefiting from the all-fiber structure and the environmentally sensitive dielectric property of silk fibroin,the AFMS presented multiple sensing characteristics,including pressure sensing,temperature sensing,and humidity *** them,the pressure sensing function reached a high sensitivity of 2.27 pF/kPa(7.5%/kPa)and a remarkable resolution of~26 Pa in the low pressure ***,the outstanding mechanical reliability and sensing stability of AFMS were proven by a systematic *** addition,the AFMS was successfully applied for smart mask for breathing monitoring and a smart glove for bending angle recognition of finger *** sensing characteristics combined with prominent fundamental features enable the AFMS tremendous potential in the smart sensing field,e.g.,smart clothing.

关键词： Wearable electronics Silk fibroin Multifunctional sensing Smart clothing

Prediction for permeability index of blast furnace based on VMD-PSO-BP model

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Journal of Iron and Steel Research International 2024年第3期31卷 573-583页

作者： Xiao-jie Liu Yu-jie zhang xin Li Zhi-feng zhang Hong-yang Li ran Liu Shu-jun Chen School of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina Chengde Branch HBIS Group Co.Ltd.Chengde 067000HebeiChina

The permeability index is one of the important production indicators to monitor the operation of blast *** is crucial to grasp the trends of changes in the new permeability index in *** the complex vibration spectrum of the permeability index,a prediction model of the permeability index based on the VMD-PSO-BP(variational mode decomposition-particle swarm optimization-back propagation)method was ***,the key factors that affect the permeability index of blast furnace were studied from multiple ***,the permeability index was divided into multiple sub-modes based on the difference of frequency bands by the VMD algorithm,and a PSO-BP prediction model was established for each ***,the prediction results of each sub-mode were summed to obtain the final *** results show that the composite prediction accuracy by using the VMD algorithm is 3%higher than that of the traditional prediction method,which has better applicability.

关键词： Big data-Blast furnace Air permeability Variational mode decomposition Particle swarm optimization Back propagation Model prediction

Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

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China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE Shuang-yi GAO Jian LI Yong-ran JIANG Shu-xin zhang Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly *** effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency *** results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked *** model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile *** ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

Cutting performance of saw blades with microtextured rougher and finisher sawteeth

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Advances in Manufacturing 2024年第2期12卷 317-334页

作者： Yang Lu Jian-xin Deng Zhi-Hui zhang Jia-xing Wu ran Wang Yi-Chen Bao Key Laboratory of High Efficiency and Clean Mechanical Manufacture of MOE School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China

The problems of severe sawtooth wear,harsh sawing noise,and low surface quality during the processing of circular saw blades need to be *** improve the cutting performance of TiC-based cermet saw blades,microtextures parallel to the cutting edge were fabricated on rough and fine sawteeth by laser *** cutting tests were performed on a sawing platform under lubricated *** of the sawing arc length and working sawtooth cutting force variations were developed for sawing steel pipes,and the accuracy of the sawing force model was verified *** results indicate that the variations in the sawing force are proportional to the sawing arc *** circular saw blades with microtextures that did not penetrate the sawtooth rake face exhibited the lowest cutting force,sawing noise,and highest machined surface ***,the worn-out distance of the rougher and finisher sawteeth was reduced by approximately 7.4%and 44.1%,respectively,compared with conventional circular saw *** main failure modes of sawteeth were tip wear,rake face adhesion,and oxidative *** addition,the mechanism by which the textures improve the cutting and wear properties of TiC-based circular saw blades was *** study provided a significant concept for enhancing the cutting performance of circular saw blades and improving the machined surface quality.

关键词： Circular saw blades Micro textures Cutting performance Wear performance

Metallurgy and Solidification Microstructure Control of Fusion-Based Additive Manufacturing Fabricated Metallic Alloys:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 29-53页

作者： Qiang Li xing-ran Li Bai-xin Dong Xiao-Long zhang Shi-Li Shu Feng Qiu Lai-Chang zhang Zhi-Hui zhang Key Laboratory of Bionic Engineering(Ministry of Education) and College of Bionic Science and EngineeringJilin UniversityChangchun130022China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun130025China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130025China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

The metal-based additive manufacturing(AM),also referred to as metal 3D printing,has drawn particular interest because it enables direct creation,aided by computationally-directed path design,of intricate components with site-specific compositions and geometrical requirements as well as low buy-to-fly *** the last two decades,the objective of this revolutionary technology has been shifting from only“rapid prototyping”to advanced manufacturing of special high-end products or devices,which,in many aspects,outperform conventional manufacturing *** fusion-based AM,significant progress has been achieved in understanding the processing window of macroscopic scales,non-equilibrium metallurgy of mesoscale scales,and grain evolution of microscopic *** the versatile capacity of AM facilitates new avenues for discovering advanced materials and structures,their potential has still not been fully *** the unique non-equilibrium solidification during the AM process,coarse columnar grains with strong textures are usually developed along the build direction,which downgrades the mechanical *** push the limits of this digital manufacturing,this review attempts to provide in-depth and comprehensive overviews of the recent progress in understanding the evolution and control of the as-built microstructure that has been made recently and the challenges encountered during the AM process.

关键词： Additive manufacturing Temperature field Microstructure control Nanoparticles Functionally graded materials