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International Journal of Agricultural and Biological Engineering 2020年第3期13卷 57-63页

作者： li Guo Dongsen Zhao Bo Zhao Shuli Ma Xiaolin liu Mo li xin liu College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China Key Laboratory of Bionic Engineering Ministry of Education of ChinaJilin UniversityChangchun 130022China China Architecture Design Group Beijing 100044China

With the development of concentrated animal feeding operations in China,the air pollution problem has drawn widespread public *** living near farms are suffering from the emissions of particulate matter(PM)and ***,scientific data on the characteristics of these emissions are limited to the establishment and evaluation of mitigation strategies in *** study was conducted to provide fundamental information on the concentrations of PM inside and outside a typical ventilated laying hen house in northeastern *** results showed that outdoor PM concentrations of this laying hen house did not meet the requirements of the environmental quality standard of China’s livestock and poultry farms in the two days out of six sampling days in summer,while indoor PM concentrations met the environmental requirements during this *** indoor and outdoor PM concentrations were highly correlated in summer,and over 60%of particles indoor were emitted outside via mechanical *** were more fine particles dominated both inside and outside of the laying hen ***,twelve and nine elements were measured from the PM sources inside and outside laying hen house,*** control strategies may be adjusted based on the status of exhaust fans,the ages of laying hens,atmospheric conditions,and routine house management to well reduce PM emissions and improve control efficiency.

关键词： particulate matter ventilated laying hen house air emission animal feeding operation

Numerical simulation of the effect of waves on cavity dynamics for oblique water entry of a cylinder

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Journal of Hydrodynamics 2020年第6期32卷 1178-1190页

作者： Gui-yong Zhang Zhao Hou Tie-zhi Sun Hai-peng Wei ning li Bo Zhou Ying-jie Gao School of Naval Architecture Liaoning Engineering Laboratory for Deep-Sea Floating StructuresDalian University of TechnologyDalian 116024China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240China Beijing Institute of Astronautical Systems Engineering Beijing 100076China Marine Design and Research Institute of China Shanghai 200011China

The water entry process associated with complicated unsteady structures,with consideration of the influence of the waves,is not well *** the present work,the oblique water entry of a cylinder under different regular waves is numerically *** volume of fluid(VOF)method and the sub-grid scale(SGS)stress model based on the large eddy simulation(LES)method are adopted for the 3-D simulation with six degrees of *** present numerical model is based on a wave model,and as shown by the previous work that the predicted cavity evolution in the calm water agrees well with the experimental *** present model is validated and it is shown that it could be used to predict the correct wave periods and *** cavity evolution mechanism,the dynamic characteristics and the vortex structures are *** cavity of the water entry with waves closes more quickly than in the calm water ***,several parametric studies of the water entry with different wave heights and water entry locations are carried *** results provide insights into the effects of the waves on the cavity dynamics for oblique water entry problems.

关键词： Large eddy simulation(LES) wave oblique water entry cavity dynamics

Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen≤1500 IU/mL:An observational study

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World Journal of Gastroenterology 2020年第13期26卷 1525-1539页

作者： Feng-Ping Wu Ying Yang Mei li Yi-xin liu Ya-Ping li Wen-Jun Wang Juan-Juan Shi xin Zhang Xiao-li Jia Shuang-Suo Dang Department of Infectious Diseases the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)*** To evaluate the efficacy and safety of add-on peginterferonα-2a(peg-IFNα-2a)to an ongoing NA regimen in CHB *** In this observational study,195 CHB patients with HBsAg≤1500 IU/m L,hepatitis B e antigen(HBeAg)-negative(including HBeAg-negative patients or HBeAg-positive patients who achieved HBeAg-negative after antiviral treatment with NA)and hepatitis B virus-deoxyribonucleic acidliated Hospital of Xi'an Jiaotong University,*** were given the choice between receiving either peg-IFNα-2a add-on therapy to an ongoing NA regimen(add-on group,n=91)or continuous NA monotherapy(monotherapy group,n=104)after being informed of the benefits and risks of the peg-IFNα-2a *** therapy duration of peg-IFNα-2a was 48 *** patients were followed-up to week 72(24 wk after discontinuation of peg-IFNα-2a).The primary endpoint was the proportion of patients with HBsAg clearance at week *** Demographic and baseline characteristics were comparable between the two ***-to-treatment analysis showed that the HBsAg clearance rate in the add-on group and monotherapy group was 37.4%(34/91)and 1.9%(2/104)at week 72,*** HBsAg seroconversion rate in the add-on group was 29.7%(27/91)at week 72,and no patient in the monotherapy group achieved HBsAg seroconversion at week *** HBsAg clearance and seroconversion rates in the add-on group were significantly higher than in the monotherapy group at week 72(Pline HBsAg concentration,lower HBsAg concentrations at weeks 12 and 24,greater HBsAg decline from baseline to weeks 12 and 24 and the alanine aminotransferase≥2×upper limit of normal during the first 12 wk of therapy were st

关键词： Chronic hepatitis B Peginterferonα-2a Nucleos(t)ide analog Hepatitis B surface antigen clearance Hepatitis B surface antigen seroconversion Add-on therapy

Clinicopathological features and prognostic factors associated with gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in Chinese patients

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World Journal of Gastroenterology 2021年第7期27卷 624-640页

作者： Yu-Chen Huang ning-ning Yang Hong-Chun Chen Yuan-li Huang Wen-Tian Yan Ru-Xue Yang Nan li Shan Zhang Pan-Pan Yang Zhen-Zhong Feng Department of Pathology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Pathology Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Pathology The Second People's Hospital of HefeiHefei 230000Anhui ProvinceChina Department of Pathology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND The incidence of mixed neuroendocrine-non-neuroendocrine neoplasms(MiNEN)is *** improve our understanding of this rare tumor type and optimally guide clinical treatment,associated risk factors,clinical manifestations,and prognosis must be *** To identify risk factors that influence the prognosis of patients with gastroenteropancreatic MiNEN(GEP-MiNEN).METHODS We retrospectively analyzed the clinical data of 46 patients who were diagnosed with GEP-MiNEN at the First Affiliated Hospital of Bengbu Medical College(Anhui,China)between January 2013 and December *** factors influencing the prognosis of the patients were assessed using Kaplan-Meier curves and cox regression *** compared the results with 55 randomly selected patients with gastroenteropancreatic GEP neuroendocrine tumors,47 with neuroendocrine carcinomas(NEC),and 58 with poorly differentiated *** Among the 46 patients with GEP-MiNEN,thirty-five had gastric tumors,nine had intestinal tumors(four in the small intestine and five in the colon and rectum),and two had pancreatic *** median age of the patients was 66(41-84)years,and the male-to-female ratio was ***-three(71.7%)patients had clinical stage III and IV *** metastasis occurred in 14 patients,of which 13 had metastasis to the *** follow-up period was 11-72 mo,and the median overall survival was 30 ***-67 index≥50%,high proportion of NEC,lymph node involvement,distant metastasis,and higher clinical stage were independent risk factors affecting the prognosis of patients with *** median overall survival was shorter for patients with NEC than for those with MiNEN(14 mo vs 30 mo,P=0.001),but did not significantly differ from those with poorly differentiated adenocarcinoma and MiNEN(30 mo vs 18 mo,P=0.453).CONCLUSION A poor prognosis is associated with rare,aggressive ***-67 index,tumor composition,lymph node involvement,distant metastasis,and clinical st

关键词： Mixed neuroendocrine non-neuroendocrine neoplasm Mixed adenoneuroendocrine carcinoma Prognosis Gastro-entero-pancreatic tract

Identification and Characterization of a Novel Thymus Aging Related Protein Rwdd1

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Cellular & Molecular Immunology 2008年第4期5卷 279-285页

作者： ning Kang lian Duan Long Tang Shirong liu Chunman li Yonghai li Qingfeng liu Yu Hu lianxian Cui Wei He Department of Immunology School of Basic Medicine Peking Union Medical College and Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 China

By using DDRT-PCR and EST segment ligation, a novel mouse thymus involution related gene Rwddl was identified. The reading frame encoded a protein of 243 amino acid residues which contained an RWD domain at the N terminus. Rwddl expression in thymus was decreased in aged and oxidatively stressed mice. It was found to be expressed extensively in thymocytes and thymic epithelial cells. The expression level of Rwddl could affect the transactivation activity of androgen receptor （AR） in transiently transfected thymic epithelial cells. However, no direct interaction could be detected by fluorescence resonance energy transfer （FRET） analysis. In conclusion, Rwddl is a thymus involution related protein that may indirectly affect AR signaling pathway. Cellular ＆ Molecular Immunology. 2008;5（4）：279-285.

关键词： Rwdd 1 thymus aging androgen receptor

The Effect of Glycyl-Glutamine Dipeptide Concentration on Enzyme Activity, Cell Proliferation and Apoptosis of Jejunal Tissues from Weaned Piglets

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Agricultural Sciences in China 2011年第7期10卷 1088-1095页

作者： Wang Hui Jia Gang Chen Zheng-li Huang Lan Wu Cai-mei Wang Kang-ning Institute of Animal Nutrition Sichuan Agricultural University Ya＇an 625014 P.R.China College of Animal Medicine Sichuan Agriculture University Ya＇an 625014 P.R.China

An experiment was conducted in a singly factorial design to study the effect of glycyl-glutamine dipeptide on enzyme activity, cell proliferation and apoptosis of jejunal tissues from weaned piglets at different glycyl-glutamine concentration levels of 2, 4, 10, 20, and 30 mmol L-1, respectively. The glutaminase activity, diamine oxidase （DAO） activity, cell peoliferation, apoptosis, and perotein metabolism were measured by the tissue culture method in vitro using jejunal tissues. The immunohistochemical method was used to study the cell proliferation and apoptosis of jejunal tissues. The results showed that compared to the blank control, the percentage and MOD value of BrdU-positicve cells incubated with glycyl-glutamine dipeptide solution were significantly （P0.05） increased. Accordingly, the percentage and MOD value of caspase-3-positive cells from tissue incubated with glycyl-glutamine dipeptide were notably lower （P0.05） than that from the control treatment. The glycyl-glutamine dipeptide increased the glutaminase activity, DAO activity and protein content of jejunal tissues, as the dipeptide concentration was on the rise （P0.05）. These results indicated that glycyl-glutamine dipeptide affected the jejunum development and adaptation of weaned piglets, and the function might be fulfilled by enhancing the glutamine-related enzyme activity, thereby increasing the consumption of glutamine, and then improving the jejunal cell proliferation and suppressing cell apoptosis. The effects of glycyl-glutamine dipeptide relied in a dose-dependent manner, and the maximum effect was achieved at 20-30 mmol L-1 glycyl-glutamine dipeptide.

关键词： glycyl-glutamine dipeptide cell proliferation apoptosis diamine oxidase glutaminase

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基于蚁群聚类算法的模糊神经网络

华东理工大学学报（自然科学版） 2005年第2期31卷 215-218页

作者：曹晓辛李柠黄道华东理工大学自动化工程中心上海200237

提出了一种基于蚁群聚类的模糊神经网络算法,神经网络采用RBF网络结点结构,聚类采用二级结构蚁群聚类算法作为一级聚类而模糊C-均值聚类(FCM)用于二级聚类。将上述聚类方法用于模糊神经网络构建中,仿真结果表明具有并行实时性、聚类能... 详细信息

提出了一种基于蚁群聚类的模糊神经网络算法,神经网络采用RBF网络结点结构,聚类采用二级结构蚁群聚类算法作为一级聚类而模糊C-均值聚类(FCM)用于二级聚类。将上述聚类方法用于模糊神经网络构建中,仿真结果表明具有并行实时性、聚类能力强的特点。

关键词：蚁群算法聚类算法模糊神经网络模糊C-均值聚类(FCM) RBF

Simultaneous N-intercalation and N-doping of epitaxial graphene on 6H-SiC（0001） through thermal reactions with ammonia

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Nano Research 2013年第6期6卷 399-408页

作者： Zhou-jun Wang Mingming Wei li Jin Yanxiao ning liang Yu Qiang Fu xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics the Chinese Academy of Sciences Dalian 116023 China

Surface functionalization of epitaxial graphene overlayers on 6H-SiC（0001） has been attempted through thermal reactions in NH3. X-ray photoelectron spectroscopy and micro-region low energy electron diffraction results show that a significant amount of N is present at the NHB-treated graphene surface, which results in strong band bending at the SiC surface as well as decoupling of the graphene overlayers from the substrate. The majority of the surface N species can be removed by annealing in vacuum up to 850 ~C, weakening the surface band bending and resuming the strong coupling of graphene with the SiC surface. The desorbed N atoms can be attributed to the intercalated species between graphene and SiC. Low temperature scanning tunneling spectroscopy and density functional theory simulations confirm the presence of N dopants in the graphene lattice, which are in the form of graphitic substitution and can be stable above 850 ~C. This is the first report of simultaneous N intercalation and N doping of epitaxial graphene overlayers on SiC, and it may be employed to alter the surface physical and chemical properties of epitaxial graphene overlayers.

关键词： graphene SiC intercalation doping STM

Receiver function analysis for seismic structure of the crust and uppermost mantle in the liupanshan area,China

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Science China Earth Sciences 2007年第Z2期50卷 227-233页

作者： TONG WeiWei WANG liangShu MI ning XU MingJie li Hua YU DaYong li Cheng liU ShaoWen liU Mian Eric SanDvol Department of Earth Sciences Nanjing UniversityNanjing 200093China Department of Earth SciencesNanjing UniversityNanjing 200093China Department of Geological Science University of MissouriColumbiaMO 65211USA

A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block,*** seismic structure of the crust and uppermost mantle of the liupanshan area is obtained using receiver function analysis of teleseismic body *** crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver *** results reveal complex seismic phases in the liupanshan area,implying intense deformation at the boundary between the Tibetan Plateau and the Ordos *** average crustal thickness is 51.5 km in the northeast Tibetan Plateau,53.5 km in the liupan Mountain and 50 km in the southwest Ordos block,resulting in a concave Moho beneath the liupan *** Poisson's ratio of the liupanshan area varies between 0.27-0.29,higher than the value of 0.25-0.26 to the east and west of the liupan Mountain,suggesting partial melting in the lower *** variance in Poisson's ratio across the liupan Mountain indicates notable changes in the crustal composition and mechanical properties,which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision.

关键词： receiver function liupan Mountain crustal structure Poisson's ratio India-Eurasia collision

Multimodal collaborative BCI system based on the improved CSP feature extraction algorithm

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Virtual Reality & Intelligent Hardware 2022年第1期4卷 22-37页

作者： Cunbo li ning li Yuan QIU Yueheng PENG Yifeng WANG lili DENG Teng MA Fali li Dezhong YAO Peng XU The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation and School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Intelligent Engineering Zhengzhou University of AeronauticsZhengzhou 450015China

Background As a novel approach for people to directly communicate with an external device,the study of brain-computer interfaces(BCIs)has become ***,similar to the real-world scenario,where individuals are expected to work in groups,the BCI systems should be able to replicate group *** We proposed a 4-order cumulants feature extraction method(CUM4-CSP)based on the common spatial patterns(CSP)*** experiments conducted using motion visual evoked potentials(mVEP)EEG data verified the robustness of the proposed *** addition,to freely choose paradigms,we adopted the mVEP and steady-state visual evoked potential(SSVEP)paradigms and designed a multimodal collaborative BCI system based on the proposed CUM4-CSP *** feasibility of the proposed multimodal collaborative system framework was demonstrated using a multiplayer game controlling system that simultaneously facilitates the coordination and competitive control of two users on external *** verify the robustness of the proposed scheme,we recruited 30 subjects to conduct online game control experiments,and the results were statistically *** The simulation results prove that the proposed CUM4-CSP algorithm has good noise *** online experimental results indicate that the subjects could reliably perform the game confrontation operation with the selected BCI *** The proposed CUM4-CSP algorithm can effectively extract features from EEG data in a noisy ***,the proposed scheme may provide a new solution for EEG-based group BCI research.

关键词： Collaborative brain-computer interface(BCI) Motion visual evoked potentials(mVEP) Steady-state visual evoked potential(SSVEP) Game controlling system