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Revealing essence of magnetostructural coupling of Ni-Co-Mn-Ti alloys by first-principles calculations and experimental verification

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Rare Metals 2022年第6期41卷 1933-1947页

作者： Zi-Qi Guan Jing Bai Yu Zhang jiang-Long Gu xin-jun jiang xin-Zeng Liang Run-Kai Huang Yu-Dong Zhang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials School of Material Science and EngineeringNortheastern University.Shenyang 110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004.China Hebei Provincial Laboratory for Dielectric and Electrolyte Functional Materials.Qinhuangdao 066004 China Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux.University of Lorraine Metz 57045France

In this work,the effects of Co doping on the magnetostructural coupling transformation of Ni_(50-x)Co_(x)Mn_(50-y)Ti_(y)(x=0-15,y=12.5-15)Heusler alloys were systematically investigated through the first-princi-ples calculations and experimental *** cal-culation result indicates that the doped Co atoms prefer to occupy the Ni *** Co atoms tend to flock together in terms of the lowest energy *** the formation energy of the austenite is higher than that of the martensite,the alloys will undergo martensitic transfor-mation for the Ni_(50-x)Co_(x)Mn_(37.5)Ti_(12.5)alloys(x=0-12.5).The magnetostructural coupling point of Ni_(50-x)Co_(x)Mn_(37.5)Ti_(12.5)alloys is predicted in the vicinity of x=*** on the computational composition Ni_(37.5)Co_(12.5)Mn_(37.5)Ti_(12.5),the Ni_(36)Co_(14)Mn_(36)Ti_(14)alloy with magnetostructural coupling near room temperature was experimentally developed by simultaneously increasing the Ti and Co *** largest magnetization change(ΔM)and magnetic entropy changes(ΔS_(m))obtained under magnetic field of 5 T for the martensitic transformation in the Ni_(36)Co_(14)Mn_(36)Ti_(14) alloy are about 87.6 A·m^(2)·kg^(-1)and 21 J·kg^(-1)·K^(-1),*** fracture strength and strain for non-textured polycrystalline Ni_(36)Co_(14)Mn_(36)Ti_(14)alloy reach 953 MPa and 12.3%,*** results show that the alloy not only possesses a large magne-tocaloric effect but also has excellent mechanical *** addition,the 6 M modulated martensite is evidenced in the Ni-Co-Mn-Ti alloys via transmission electron microscopy technique.

关键词： Ni-Co-Mn-Ti First-principles calculations Martensitic transformation Magnetostructural coupling Mechanical properties

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Current status of drug therapy for chronic hepatitis B

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World Journal of Gastroenterology 2025年第2期31卷 1-12页

作者： Chuang jiang Zhi-Hong Zhang Jia-xin Li Division of Liver Surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article by Meng et *** hepatitis B(CHB)is a significant global health problem,particularly in developing *** B virus(HBV)infection is one of the most important risk factors for cirrhosis and hepatocellular *** and treatment of HBV are key measures to reduce *** present,drug therapy can effectively control virus replication and slow disease progression,but completely eliminating the virus remains a ***-HBV treatment is a long-term process,and there are many kinds of antiviral drugs with different mechanisms of action,it is essential to evaluate the safety and efficacy of these drugs to reduce side effects and improve patients’*** will summarize the current status of CHB drug treatment,hoping to provide a reference for the selection of clinical antiviral drugs.

关键词： Chronic hepatitis B Hepatitis B virus Anti virus Drug treatment Therapy

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水-岩化学作用下灰砂岩的力学特性与参数损伤效应

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煤炭学报 2017年第1期42卷 227-235页

作者：王艳磊唐建新江君代张音舒国钧重庆大学煤矿灾害动力学与控制国家重点实验室重庆400044 重庆大学资源及环境科学学院重庆400044 重庆地质矿产研究院重庆400042 贵州大学矿业学院贵州贵阳550025

将灰砂岩作为试验和研究对象,基于不同pH值、不同浓度、不同成分的水化学溶液的侵蚀作用,进行一系列的浸泡试验和三轴压缩实验,对比分析了不同水化学环境下灰砂岩的微细观结构特征、变形特性、强度损伤及其力学参数劣化机制。结果表明:... 详细信息

将灰砂岩作为试验和研究对象,基于不同pH值、不同浓度、不同成分的水化学溶液的侵蚀作用,进行一系列的浸泡试验和三轴压缩实验,对比分析了不同水化学环境下灰砂岩的微细观结构特征、变形特性、强度损伤及其力学参数劣化机制。结果表明:水化学溶液的酸碱性越强、浓度越大,其对灰砂岩试件的腐蚀作用越强;化学腐蚀作用使灰砂岩试件有从脆性向延性转化的趋势,同时导致其力学参数劣化,相同条件下,黏聚力c的劣化程度大于内摩擦角φ,且在酸性溶液中的劣化程度大于碱性溶液;溶液中Ca^(2+),Mg^(2+)浓度、试件的孔隙变化率η均与试件力学参数的劣化程度呈正相关关系,而试件相对质量差Δm与之相反,呈负相关关系;新定义的孔隙率损伤参量能够准确的表达试件力学参数随水岩化学作用的损伤演化过程。

关键词：水岩化学作用灰砂岩力学参数损伤细观损伤参量腐蚀机理

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Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： xin-Yue Wei Wen-Bo Cao Sai-jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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一种新的三维欧式距离变换方法及在数字岩心中的应用

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科学通报 2017年第15期62卷 1662-1669页

作者：王鑫姚军蒋泽云张琦张臻段利亚贾欣鑫山东省科学院海洋仪器仪表研究所青岛266000 中国石油大学(华东)石油工程学院青岛266580 Institute of Petroleum Engineering in Heriot-Watt University Edinburgh UK EH14 4ASScotland 亚信科技中国研发中心北京100000

针对目前距离变换方法在三维数字岩心中应用时,搜索方向多、计算数据量大、耗费时间多、占用内存大等问题,提出一种基于几何拓扑学理论中空间邻居关系的新的距离化搜索算法.根据岩石内部孔隙结构与二维平面欧式距离求解方法,引入一个三... 详细信息

针对目前距离变换方法在三维数字岩心中应用时,搜索方向多、计算数据量大、耗费时间多、占用内存大等问题,提出一种基于几何拓扑学理论中空间邻居关系的新的距离化搜索算法.根据岩石内部孔隙结构与二维平面欧式距离求解方法,引入一个三维空间距离游标进行辅助计算.相比现有方法,新的算法简化了邻居域欧式距离值的比较规则,避免了复杂的欧式距离结构体带来的大量运算,且算法复杂度低,可以被更好地理解和应用.本文详细叙述了算法的具体实现过程,并将该方法推广到具有缝洞特征碳酸盐岩数字岩心的孔隙空间分割工作中.结果表明该方法准确高效,对于油气藏孔隙级微观描述具有现实意义.

关键词：距离变换数字岩心三维图像空间邻居关系几何拓扑学

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地下采空诱发含软弱夹层顺层岩质斜坡变形破裂的相似模拟

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煤炭学报 2016年第11期41卷 2714-2720页

作者：代张音唐建新江君邓月华刘姝张路重庆大学煤矿灾害动力学与控制国家重点实验室重庆400044 重庆大学资源及环境科学学院重庆400044 贵州大学矿业学院贵州贵阳550025 重庆地质矿产研究院重庆400042 四川省煤炭产业集团有限责任公司技术中心四川成都610091

以重庆武隆鸡尾山顺层岩质滑坡为例,依据相似原理,利用重庆大学变滑面顺层斜坡相似模拟试验装置,进行地下顺坡开采、逆坡开采、留设上下边界矿柱形成不同采空区影响下顺层岩质斜坡变形破裂响应相似模拟试验。试验结果表明:1顺层岩质斜... 详细信息

以重庆武隆鸡尾山顺层岩质滑坡为例,依据相似原理,利用重庆大学变滑面顺层斜坡相似模拟试验装置,进行地下顺坡开采、逆坡开采、留设上下边界矿柱形成不同采空区影响下顺层岩质斜坡变形破裂响应相似模拟试验。试验结果表明:1顺层岩质斜坡在滑动面下沉量变化最大位置,坡体变形破坏剧烈,裂隙发育明显。2同样地质环境和采矿条件下,逆坡开采后形成的采空区对斜坡变形破裂影响最严重,更易诱发坡体破坏失稳,其次是顺坡开采,留设上下边界矿柱开采相对影响斜坡变形破裂较小。斜坡下逆坡开采采空区范围较小,越易造成坡脚岩体发生断裂破坏崩滑。3不同的岩层性质及距滑动面法向距离,其形变移动响应特征不同,但坡体均出现沿滑动面向临空面的滑移。4地下采空区影响下含软弱夹层缓倾斜顺层斜坡的变形机制为弯曲-断裂、挤压-滑移-拉裂。

关键词：地下采空软弱夹层顺层斜坡相似模拟变滑面变形破裂

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Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-xin Zhang Guan-Yue Shan jun-Ya Cheng Duan-Rui Qiao Yi-Ying Liu Wen-Na Shi Hai-jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan jiang Wangrui Yuan xin Cao Liang Chen Qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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Homozygous phytosterolemia and a literature review:A case report

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World Journal of Clinical Cases 2025年第10期13卷 46-52页

作者： Chun-xin jiang Guang Yang Lian-Ping Shi Peng-Yu Su Department of Cardiovascular North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Phytosterolemia,also known as sitosterolemia,is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata,which is easily misdiagnosed as familial *** with homozygous phytosterolemia often have severe clinical manifestations,with xanthomata in childhood and premature *** patient had a milder clinical *** SUMMARY This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol(LDL-C)without xanthomata,arteriosclerosis,or hematological *** mutation of ABCG5 which encodes an ATP-binding cassette transporter,was detected by whole exome sequencing and diagnosed as *** of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol,rapeseed oil-derived plant sterol,andβ-glutaminol *** was started and a low plant sterol diet was *** patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C *** has similar clinical features as familial hypercholesterolemia,is highly susceptible to misdiagnosis,and has a very low incidence,and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid *** Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.

关键词： Hypercholesterolemia Cholesterol Low-density lipoprotein Phytosterolemia Liquid chromatography ABCG5/ABCG8 Sitosterolemia

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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