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The quality of escalator signage for public safety in Malaysia:an observational study

Global Health Journal 2021年第4期5卷 198-203页

作者： Chii-Chii Chew Chee-Tao Chang xin-jie lim Hasni-Adha Ibrahim Hamiazwa Azmi Nur-Ilyana Wahabi Nur-Shuhaida Hamdan Nurul-Atiqah Nazan Nur-Haliana Karim Nurfarahdila-Ahmad Malawi Ying-Ling Oon Norshazila-Julia MS Amar-Singh HSS Clinical Research Center Hospital Raja Permaisuri BainunLevel 4Ambulatory Care CenterJalan Raja Ashman ShahIpohPerak 30450Malaysia Allied Health Science College Sultan Azlan Shah Ministry of HealthTanjong RambutanIpohPerak Darul Ridzuan 31250Malaysia Department of Paediatric Hospital Raja Permaisuri BainunMinistry of HealthJalan Raja Ashman ShahIpohPerak 30450Malaysia

Objective:Escalator signage could be playing a vital role to alert users for safe use of *** study aimed to evaluate the availability,standardization,and content of safety information on escalator signage in the shopping ***:An observational study was conducted from November 2017 to February 2018 to assess the availability,standardization of safety information among the signage inside the shopping mall,and the content of safety information for public safety in Malaysia.A checklist was developed by adapting escalator safety guidelines from seven countries and regions including *** collctors identified from the selected states were required to capture three photographs at different angles of the escalator signage for each ascending and descending directions at each entrance of the *** analysis was performed;each criterion was presented in frequency and ***:A total of 268 escalators from 84 shopping malls in 9 states of Malaysia were *** operating escalators were not equipped with *** than one-ifth(23.0%)of the signage was not standardized within the *** majority of safety information was displayed in the form of a pictogram,a minority of signage displayed information in both pictogram and text format:"children must hold hand"(12.7%)and"be careful of long clothing"(10.8%),***,"toddlers should be carried"(8.6%)and"take extra care with rubber shoes/tied shoes/laces"(30.2%)were found absent in most of the ***:Escalator signage was present in almost all of the escalators ***,non-standardization of the signage of escalators should warrant the attention of relevant authorities to revise the safety guideline s and improve the quality of escalator.

关键词： Elevators and escalators Safety Transportation facilities Environment and public health Malaysia

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou xin Huang xing Zhou jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-jie Wu Ya-xin Qin xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui Pan xin-xing Zeng Zheng-Zheng Li Bo-Fan Chen Hai-Min Zeng jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Converting Molecular Vibration to Mechanical Wave for Bond-Selective Imaging of Deep Tissue

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Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： jie Hui Ji-xin Cheng Department of Physics and Astronomy Purdue University West Lafayette Indiana 47907 USA Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 47907 USADepartment of Chemistry Purdue University West Lafayette Indiana 47907 USA

As an emerging label-free imaging modality with chemical selectivity and millimeter-depth resolvability, vibrational photoacoustic imaging provides a new avenue to map chemical content in biological tissue. It heralds the potential for detection of white matter loss and regeneration, assessment of breast tumor margin, and clinical diagnosis of vulnerable plaques in atherosclerosis. In this work, we provide an overview of the development of bond-selective photoacoustic imaging and various biomedical applications enabled by this new technology.

关键词： Label-free Vibrational spectroscopy Chemical imaging

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Numerical analysis for the matching of the core driven compression system in a double bypass engine

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航空动力学报 2011年第5期26卷 1066-1076页

作者： ZHANG xin LIU Bao-jie National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100191 China

The numerical analysis for the matching of the core driven compression system in a double bypass variable cycle engine was presented in this *** system consists of a one-stage-core driven fan stage(CDFS),an inner bypass duct and a five-stage high pressure compressor(HPC),providing two basic operating modes: the single bypass mode and the double bypass *** vanes are necessary to realize the mode switch of the *** correct matching in the double bypass mode requires a proper combination of the mass flow,total pressure ratio and blade *** work capacity of the system decreases in the double bypass mode and the pressure ratio tends to decrease more for the CDFS and the front stages of the *** overall system efficiency is higher in the double bypass *** radial distributions of aerodynamic parameters are similar in different *** notable redistribution of mass flow downstream the CDFS in the single bypass mode leads to strong radial flows and additional mixing *** absolute flow angles into the inner bypass increase for the inner span and decrease for the outer span when the system is switched from the single bypass mode to the double bypass mode.

关键词： numerical analysis aerodynamic double bypass variable cycle engine core driven compression system core driven fan stage operating mode

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Temperature Rise at the Edges of Dark Molecular Clouds

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Chinese Physics Letters 2000年第1期17卷 67-69页

作者： MAO xin-jie Astronomy Department Beijing Normal UniversityBeijing 100875 Chinese Academy of Sciences-Peking University Joint Beijing Astrophysical Center Peking UniversityBeijing 100871

Two-fluid magnetohydrodynamic equations are applied to dark molecular clouds that are composed of neutrals mixed with minor charged particles,weakly ionized gas *** result shows the temperatures are higher at the cloud edges than at their inner regions,the cause of which is that the cloud potential,released as clouds contract particularly at their edges,along with some dissipated rotational kinetic energy is converted into *** cloud contracting is due to the loss of the magnetic field that threads it through ambipolar ***,without the support of the magnetic and the centrifugal forces in the direction of the magnetic Held assumed to be parallel to the cloud rotating axis,the cloud collapses in that direction when its mass is over the Jeans mass.

关键词： rotating systems. assumed

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Interactive multiobjective evolutionary algorithm based on decomposition and compression

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Science China(Information Sciences) 2021年第10期64卷 166-181页

作者： Lu CHEN Bin xin jie CHEN School of Automation Beijing Institute of Technology State Key Laboratory of Intelligent Control and Decision of Complex Systems

Many real-world optimization problems involve multiple conflicting objectives. Such problems are called multiobjective optimization problems(MOPs). Typically, MOPs have a set of so-called Pareto optimal solutions rather than one unique optimal solution. To assist the decision maker(DM) in finding his/her most preferred solution, we propose an interactive multiobjective evolutionary algorithm(MOEA)called iDMOEA-εC, which utilizes the DM’s preferences to compress the objective space directly and progressively for identifying the DM’s preferred region. The proposed algorithm employs a state-of-the-art decomposition-based MOEA called DMOEA-εC as the search engine to search for solutions. DMOEA-εC decomposes an MOP into a series of scalar constrained subproblems using a set of evenly distributed upper bound vectors to approximate the entire Pareto front. To guide the population toward only the DM’s preferred part on the Pareto front, an adaptive adjustment mechanism of the upper bound vectors and two-level feasibility rules are proposed and integrated into DMOEA-εC to control the spread of the population. To ease the DM’s burden, only a small set of representative solutions is presented in each interaction to the DM,who is expected to specify a preferred one from the set. Furthermore, the proposed algorithm includes a two-stage selection procedure, allowing to elicit the DM’s preferences as accurately as possible. To evaluate the performance of the proposed algorithm, it was compared with other interactive MOEAs in a series of experiments. The experimental results demonstrated the superiority of iDMOEA-εC over its competitors.

关键词： multiobjective optimization interactive decision making preference incorporation decomposition compression

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