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Neuroprotective effect of chitosan nanoparticle gene delivery system grafted with acteoside (ACT) in Parkinson's disease models

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Journal of Materials Science & Technology 2020年第8期36卷 197-207页

作者： Yongyong Xue Na Wang Zhi zeng Jinpeng Huang Zhiming Xiang Yan-Qing Guan MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou510631China School of Life Science South China Normal UniversityGuangzhou510631China South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouChina Department of Radiology Guangzhou Panyu Center HospitalGuangzhou511400China

Developing new drugs to treat Parkinson's disease efficiently is challenging. Here we report that chitosan nanoparticles(APPDNs) could serve as novel candidates for the design of anti-PD drugs. In this study, we investigated the effects of chitosan poly ethyleneglycol-poly lactic acid(PEG-PLA) nanoparticles conjugated with nerve growth factor(NGF), acteoside(ACT) and plasmid DNA(p DNA) for PD therapy using in vitro and in vivo models. Using PD cell models, we demonstrated that APPDN had good neuroprotective effects. More significantly, experiments using mouse PD models demonstrated that APPDNs could ameliorate the behavioral disorders of sick mice. Immunohistochemical and western blot(WB) analyses demonstrated that APPDNs could significantly reverse dopaminergic(DA) neuron loss in the substantia nigra and striatum of sick mice. This study opens up a novel avenue to develop anti-PD drugs.

关键词： Parkinson's disease Chitosan nanoparticles Acteoside Gene therapy pDNA

Migration behavior of solid fuel particles during granulation process and its influence on combustion property

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Journal of Iron and Steel Research International 2023年第11期30卷 2153-2162页

作者： Zhi-yun Ji Yi-fan Wang Xiao-hui Fan Gai-ge Zhao Min Gan Le-yun Tang Yong Tu Xiao-long Wang Hao-xiang Zheng Xu-ling chen Xiao-xian Huang zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Iron ore sintering process is the main CO_(2) emission source throughout the integrate steelworks,which primarily comes from the combustion of solid *** the combustion efficiency and reducing the solid fuel consumption are important ways to reduce the CO_(2) emission in the sintering *** the efficient combustion of fuel,the migration behavior and combustion characteristics of solid fuel in the granulation process were *** results indicated that during the granulation process,fuel particles with size less than 0.5 mm mainly migrated into the granules with grain size of 1-3,3-5 and 5-8 mm;fuel particles with size of 0.5^(-1)mm mainly migrated into granules of 1-3 mm;fuel particles with size of 1-3,3-5 and 5-8 mm mainly entered the granules with the same grain *** the increase in fuel particles grain size from-0.5 to+8 mm,the combustion efficiency exhibited a firstly-increasing and then decreasing tendency,while the NO_(x) exhibited a decreasing *** reason can be described that finer fuel particles(-1 mm)easily distributed in the outer layer of the granules,which combusted fiercely due to its larger specific surface area,leading to the development of incomplete combustion and the conversion of fuel nitrogen;the combustion efficiency of larger fuel particles was restricted by the inner diffusion of O_(2),which then contributed to the reduction of NO_(x) under the inadequate combustion atmosphere.

关键词： Iron ore sintering Granulation Solid fuel distribution Pollutant emission Combustion efficiency

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信贷资产异质性对信贷组合损失的影响研究

系统工程理论与实践 2006年第12期26卷 55-61页

作者：曾健陈俊芳上海交通大学管理学院上海200030

在新巴塞尔协议的资本监管框架下,同一信用级别中的信贷资产被认为是同质的.本文结合Vasicek模型分析了资产异质性对信贷组合损失的影响,并比较了不同参数的异质性对损失的影响效果.分析结果显示,异质性对信用风险损失分布尤其是分布尾... 详细信息

在新巴塞尔协议的资本监管框架下,同一信用级别中的信贷资产被认为是同质的.本文结合Vasicek模型分析了资产异质性对信贷组合损失的影响,并比较了不同参数的异质性对损失的影响效果.分析结果显示,异质性对信用风险损失分布尤其是分布尾部有较大影响,忽略异质性一般会高估信用损失;较之资产的行业相关性,违约率和违约波动率的异质性影响可能更为显著;有关信贷组合分散化的探讨往往局限于正态假设,这将导致信用损失的低估.

关键词：信贷组合异质性信用风险损失

Effect of plastic strain and forming temperature on magnetic properties of low-carbon steel

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 210-219页

作者： Fan zeng Xue-jiao Bai cheng-liang Hu Min-jun Tang Zhen Zhao Institute of Forming Technology and Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China National Engineering Research Center of Die&Mold CAD Shanghai Jiao Tong UniversityShanghai 200030China Jiangsu Longcheng Precision Forging Co. Ltd.Changzhou 213000China

Claw poles are a key component of automobile *** output power performance of the generator is very dependent on the magnetic properties of its claw *** deformation is known to significantly change the magnetic behavior of ferromagnetic materials in claw *** this paper,changes in the magnetic properties of low-carbon steel,used for claw pole components due to their plastic deformation,were investigated for different strains and ***-shaped material samples were prepared by machining and their magnetic properties were *** surface roughness was first evaluated and a machining process with an arithmetic average of roughness Ra 1.6μm was selected as enabling the lowest measurement *** loops at different applied magnetic fields of the material were obtained for different plastic strains and forming *** magnetic parameters of magnetic flux density,coercivity,and remanence were obtained and compared with magnetic flux density as the primary *** showed that machining,cold forming,and hot forming all led to lower magnetic flux density,larger coercivity,and smaller *** flux density showed a sharp decrease at the start of plastic deformation,but as the strain increased,the decreasing trend gradually reached a constant *** decrease was much larger for cold forming than for hot *** example,at 500 A/m,the degradation of magnetic flux density with a reduction percentage of 5%at room temperature was about 50%,while that of hot forming at 1200°C was about 10%.Results of this research may provide a reference for the future process design of hot-forged claw poles.

关键词： low-carbon steel magnetic properties hot forming cold forming surface roughness

BACE1 in the retina:a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease

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Neural Regeneration Research 2016年第3期11卷 447-453页

作者： Lan Li Jia Luo Dan chen Jian-bin Tong Le-ping zeng Yan-qun Cao Jian Xiang Xue-gang Luo Jing-ming Shi Hui Wang Ju-fang Huang Department of Anatomy and Neurobiology School of Basic Medical SciencesCentral South University Department of Anesthesiology Third Xiangya Hospital of Central South University Department of Ophthalmology Second Xiangya HospitalCentral South University

Because of a lack of sensitive biomarkers,the diagnosis of Alzheimer＇s disease（AD） cannot be made prior to symptom ***,it is crucial to identify novel biomarkers for the presymptomatic diagnosis of *** brain lesions are a major feature of AD,retinal pathological changes also occur in *** this study,we investigated the temporal changes in β-site APP-cleaving enzyme 1（BACE1） expression in the retina and brain to determine whether it could serve as a suitable biomarker for early monitoring of ***/PS-1 transgenic mice,3,6 and 8 months of age,were used as an experimental group,and age-matched C57/BL6 wild-type mice served as the control *** the Morris water maze test,there were no significant differences in escape latency or in the number of crossings in the target area among mice of different *** with wild-type mice,no changes in learning or memory abilities were detected in transgenic mice at 3 months of ***,compared with wild-type mice,the escape latency was significantly increased in transgenic mice at 6 months,starting on day 3,and at 8 months,starting on day 2,during Morris water maze *** addition,the number of crossings of the target area was significantly decreased in transgenic *** learning and memory abilities of transgenic mice were further worsened at 8 months of *** staining revealed no BACE1 plaques in wild-type mice at 3,6 or 8 months or in transgenic mice at 3 months,but they were clearly found in the entorhinal cortex,hippocampus and prefrontal cortex of transgenic mice at 6 and 8 ***1 expression was not detected in the retina of wild-type mice at 3 months,but weak BACE1 expression was detected in the ganglion cell layer,inner plexiform layer and outer plexiform layer at 6 and 8 *** transgenic mice,BACE1 expression in the ganglion cell layer was increased at 3 months,and BACE1 expression in the ganglion cell layer,inner plexiform layer and outer plex

关键词： nerve regeneration neurodegenerative disease Alzheimer's disease retina amyloid-β β-site amyloid precursor protein cleaving enzyme 1 APP/PS-1 transgenic mouse neural regeneration

Millimeter-wave wireless communications for home network in fiber-to-the-room scenario

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Frontiers of Information Technology & Electronic Engineering 2021年第4期22卷 441-456页

作者： Chao HE Zhixiong REN Xiang WANG Yan zeng Jian FANG Debin HOU Le KUAI Rong LU Shilin YANG Zhe chen Jixin chen Huawei Technologies Co.Ltd. Shenzhen 518129China The State Radio Monitoring Center Beijing 100037China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

Millimeter-wave(mmWave)technology has been well studied for both outdoor long-distance transmission and indoor short-range *** the recently emerging fiber-to-the-room(FTTR)architecture in the home network of the fifth generation fixed networks(F5G),mmWave technology can be cascaded well to a new optical network terminal in the room to enable extremely high data rate communication(i.e.,>10 Gb/s).In the FTTR+mmWave scenario,the rapid degradation of the mmWave signal in long-distance transmission and the significant loss against wall penetration are no longer the bottlenecks for real ***,the surrounding walls of every room provide excellent isolation to avoid interference and guarantee *** paper provides insights and analysis for the new FTTR+mmWave architecture to improve the customer experience in future broadband services such as immersive audiovisual videos.

关键词： Fiber-to-the-room Millimeter wave Q-band Cloud virtual reality(cloud VR) Home network Beamforming Radio frequency integrated circuit(RFIC)

Data Exchange in Grid Workflow

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1330-1334页

作者： zeng Hongwei MIAO Huaikou School of Computer Engineering and Science ShanghaiUniversity Shanghai 200072 China

In existing web services-based workflow, data exchanging across the web services is centralized, the workflow engine intermediates at each step of the application sequence. However, many grid applications, especially data intensive scientific applications, require exchanging large amount of data across the grid services. Having a central workflow engine relay the data between the services would resu＇lts in a bottleneck in these cases. This paper proposes a data exchange model for individual grid workflow and multiworkflows composition respectively. The model enables direct communication for large amounts of data between two grid services. To enable data to exchange among multiple workflows, the bridge data service is used.

关键词： grid workflow bridge data service data exchange

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RP-3航空煤油层流燃烧特性的实验

航空动力学报 2015年第12期30卷 2888-2896页

作者：曾文陈欣马洪安刘宇陈潇潇胡二江沈阳航空航天大学航空航天工程学部(院) 沈阳110136 西安交通大学能源与动力工程学院动力工程多相流国家重点实验室西安710049

为了阐明RP-3航空煤油的燃烧特性，在定容燃烧反应器中实验测量了初始压力分别为0．1，0．3，0．5，0．7MPa、初始温度分别为390．420，450K、当量比范围为0．6～1．6时，RP-3航空煤油的层流燃烧速度与马克斯坦长度，分析了初始温度、... 详细信息

为了阐明RP-3航空煤油的燃烧特性，在定容燃烧反应器中实验测量了初始压力分别为0．1，0．3，0．5，0．7MPa、初始温度分别为390．420，450K、当量比范围为0．6～1．6时，RP-3航空煤油的层流燃烧速度与马克斯坦长度，分析了初始温度、压力以及当量比对火焰发展结构、层流燃烧速度及马克斯坦长度的影响．结果表明：随着初始温度的升高或初始压力的降低，RP-3航空煤油的层流燃烧速度逐渐升高；随着当量比由0．6升高至1．6，层流燃烧速度呈现先增加后降低的趋势，当当量比为1．2时，层流燃烧速度最大．随着初始压力或当量比的降低，马克斯坦长度逐渐增大，火焰稳定性增强；初始温度对马克斯坦长度的影响不明显，当当量比为0．9～1．1时，随着初始温度的升高，马克斯坦长度逐渐减小，但当当量比为1．2～1．5时，马克斯坦长度则有所增大．

关键词： RP-3航空煤油燃烧稳定性层流燃烧速度马克斯坦长度影响因素

Downregulation of serum mi R-17 and mi R-106b levels in gastric cancer and benign gastric diseases

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Chinese Journal of Cancer Research 2014年第6期26卷 711-716页

作者： Qinghai zeng Cuihong Jin Wenhang chen Fang Xia Qi Wang Fan Fan Juan Du Yihang Guo Changwei Lin Kaiyan Yang Jingjing Li Xiaowei Peng Xiaorong Li Ke Cao Department of Plastic and Reconstructive Surgery and Dermatology Third Xiangya Hospital Central South University Department of General Surgery Xiangya Hospital Central South University Department of Oncology Third Xiangya Hospital Central South University Department of Otolaryngology Xiangya Hospital Central South University Department of General Surgery Third Xiangya Hospital Central South University Department of Head and Neck Surgery and Oncology Plastic Surgery The Affiliated Cancer Hospital of Xiangya Medical School Central South University

Altered micro RNA（mi RNA） associated with gastric cancer（GC） development and mi R-17 and mi R-106 b were differentially expressed in GC tissues. This study detected serum levels of mi R-17 and mi R-106 b expression in GC, benign gastric disease（BGD） and healthy controls to assess them as tumor markers for GC. Serum samples from 40 GC, 32 BGD（10 gastric ulcer, 14 gastric polyps, and 8 gastric ulcer with polyps） and 36 healthy individuals were subjected to quantitative reverse transcription polymerase chain reaction（q RT-PCR） analysis of mi R-17 and mi R-106 b expression. The data showed that the serum levels of mi R-17 and mi R-106 b were significantly reduced in healthy individuals and BGD patients compared to GC patients. There was a significant association of mi R-17 and mi R-106 b expression with age, but not with other clinicopathological features, such as gender, tumor differentiation, stage and lymphatic metastasis. Further analysis showed that, in discriminating GC patients from healthy controls, mi R-17 could yield a receiver-operating characteristic（ROC） area under the curve（AUC） of 0.879 with 80.6% sensitivity and 87.5% specificity and mi R-106 b could yield an AUC of 0.856 with 75.0% sensitivity and 92.5% specificity. The combined AUC of mi R-17 and mi R-106 b was 0.913 with 83.3% sensitivity and 87.5% specificity. Collectively, these data suggest that detection of serum mi R-17 and mi R-106 b levels should be further evaluated as novel non-invasive biomarkers in early GC detection and surveillance of disease progression.

关键词： miR-17 miR-106b gastric cancer(GC) benign gastric disease(BGD) biomarker