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Ex-PRESS implantation versus trabeculectomy in Chinese patients with POAG:fellow eye pilot study

International Journal of Ophthalmology(English edition) 2017年第1期10卷 56-60页

作者： Wei Wang Min-Wen Zhou Wen-Bin Huang xin-bo gao Xiu-Lan Zhang Zhongshan Ophthalmic Center State Key Laboratory of Oph-thalmologySun Yat-Sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM： To compare the outcomes of Ex-PRESS implantation in one eye versus trabeculectomy with mitomycin C in the fellow eye in Chinese patients with primary open-angle glaucoma （POAG）. METHODS： This was a prospective, non-randomized comparative study. Forty-eight eyes of 24 patients with bilateral POAG necessitating surgery were included and underwent Ex-PRESS implantation under the scleral flap in one eye and trabeculectomy in the other eye according to patients’ choice. Primary outcome measures included mean intraocular pressure （IOP） and success rate. Secondary outcome measures were aqueous flare, postoperative medication use, visual acuity, and incidence of ***： All 24 patients finished a 1-year follow-up. both groups maintained significant reductions in IOP after surgery throughout the follow-up period. At any point in time, the IOP of the two groups did not differ significantly. The Kaplan-Meier survival curve analysis showed no significant differences in success between the two groups （P=0.289）. The mean number of anti-glaucoma medicines and visual acuity in both groups were not significantly different. Eyes with Ex-PRESS implantation had lower aqueous flare values on days 1 and 3 （both P〈0.05）. Instances of early postoperative hypotony and choroidal effusion were significantly fewer in frequency after Ex-PRESS implantation under the scleral flap compared with those after trabeculectomy （P〈0.001）. CONCLUSION： Ex-PRESS is comparable to trabeculectomy in terms of IOP, success rate, number of glaucoma medications used, and visual acuity. However, Ex-PRESS resulted in fewer cases of inflammation and a lower rate of complications.

关键词： Ex-PRESS trabeculectomy primary open-angle glaucoma Chinese

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Evaluation of the learning curve of laser peripheral iridectomy:the 20^(th)case reaches the turning point

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1960-1965页

作者： Yao Liu Yu-Ying Zhou Cheng-Guo Zuo Yun-Ru Liao Jia-Wei Ren Hui-Shan Lin xin-bo gao Ming-Kai Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Longgang District Maternity&Child Healthcare Hospital of Shenzhen City Shenzhen 518172Guangdong ProvinceChina

AIM:To explore the learning curve for ophthalmologists at the start of laser peripheral iridectomy(LPI)***:The learning curve of 4 doctor groups without previous LPI experience was *** main parameters of LPI were reviewed:total energy,argon energy and neodymium-doped yttrium aluminum garnet(Nd:YAG)*** were evaluated in cohorts of 20 cases to identify the turning points of the three ***:There was no significant difference in terms of age or eye among the 4 doctor *** were stable trends on the learning curve for the Doctor A and C groups regarding total energy and argon *** addition,the turning points on the learning curve were determined after the 20th procedure for the Doctor B and D groups regarding total energy and argon ***,the Nd:YAG energy was relatively stable since the first ***:It requires approximately 20 procedures for a beginner to reach a turning point on the learning curve regarding *** can serve as a point of reference or guideline for training beginners to perform LPI.

关键词： learning curve laser peripheral iridectomy primary angle-closure glaucoma

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Factors influencing postoperative mortality one year after surgery for hip fracture in Chinese elderly population

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Chinese Medical Journal 2013年第14期126卷 2715-2719页

作者： LI Shao-guang SUN Tian-sheng LIU Zhi REN Ji-xin LIU bo gao Yang Department of Orthopedics Beijing Army General Hospital Beijing 100700 China

Background Disability and death following hip fracture is becoming more common as the population ages. Previous reports have focused on the selection of internal fixation methods and the analysis of the perioperative therapeutic results in the Chinese population. Few studies have focused on factors influencing medium and long term survival after surgery for hip fracture. We conducted a retrospective study on the factors influencing survival one year after hip fracture surgery in our elderly Chinese population to provide a reference for improved treatment and to enhance efficacy. Methods Records from patients undergoing treatment for hip fracture at our hospital from October 2009 through June 2011 were retrospectively reviewed. Through telephone follow-up, the health condition of each patient was surveyed, and the 1-year postoperative mortality was analyzed. The patients＇ age, gender, fracture type, pre-injury health condition, mobility, complications, surgical timing, surgical types, methods of anesthesia, and postoperative complications were analyzed. Univariate and multivariate regression analysis was performed on relevant influencing factors. Results A total of 184 patients had complete data and were followed-up for 12-23 months （average, 16.5 months）. There were 30 deaths （16.3%） at one-year. Univariate analysis revealed that factors such as age, gender, fracture-type, number of co-existing diseases, complications such as chronic obstructive pulmonary disease or sequelae of stroke, American society of Anesthesiology （ASA） scores, anesthesia methods, pre-injury activity, and post-operative complications were significantly different between survival versus mortality groups （P 〈0.05）. Multivariate regression analysis revealed that age, ASA score, pre-injury mobility and combined chronic obstructive pulmonary disease were independent risk factors for death. Conclusion Full consideration of medium-/long-term risk factors in the treatment of hip fracture in the elderl

关键词： elderly hip fracture mortality risk factors

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang xin Liu Jian Zhang Ya gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou bo Ma Yan Luan xin Wang xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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基于知识图谱技术的计算机网络链路漏洞检测研究

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现代电子技术 2025年第1期48卷 97-101页

作者：辛瑞雯高云山西大学山西太原030006 山西大同大学计算机与网络工程学院山西大同037009

计算机网络链路的漏洞信息具有类型复杂、来源广及数量庞大等特点,导致此类漏洞的威胁判断尤为困难。知识图谱技术具有数据整合及统一表示特性,可以统一结构化整合呈现复杂特点的漏洞信息,为此,文中提出基于知识图谱技术的计算机网络链... 详细信息

计算机网络链路的漏洞信息具有类型复杂、来源广及数量庞大等特点,导致此类漏洞的威胁判断尤为困难。知识图谱技术具有数据整合及统一表示特性,可以统一结构化整合呈现复杂特点的漏洞信息,为此,文中提出基于知识图谱技术的计算机网络链路漏洞检测方法。收集计算机网络链路的各种数据源漏洞信息,抽取其中的漏洞实体知识与关系知识,构建网络链路漏洞知识图谱。运用卷积神经网络模型学习该知识图谱中的漏洞知识,通过训练后的模型实现网络链路漏洞检测。结果显示,该方法可针对包含不同类型、数量链路漏洞的工况,实现漏洞知识图谱的构建,并且漏洞威胁检测精度始终保持在90%以上。因此,说明所研究检测方法的检测结果精准可靠,可为计算机网络链路数据安全传输提供保障。

关键词：知识图谱计算机网络链路漏洞漏洞实体知识关系知识知识抽取网络安全

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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui Pan xin-xing Zeng Zheng-Zheng Li bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

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Influence of multiple laser shock peening treatments on the microstructure and mechanical properties of Ti-6Al-4V alloy fabricated by electron beam melting

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International Journal of Minerals,Metallurgy and Materials 2022年第9期29卷 1780-1787页

作者： Liang Lan Ruyi xin xinyuan Jin Shuang gao bo He School of Material Engineering Shanghai University of Engineering ScienceShanghai 201620China Research Center of High-temperature Alloy Precision Forming Shanghai University of Engineering ScienceShanghai 201620China

Laser shock peening(LSP)is an attractive post-processing method to tailor surface microstructure and enhance mechanical performances of additive manufactured(AM)*** effects of multiple LSP treatments on the microstructure and mechanical properties of Ti-6Al-4V part produced by electron beam melting(EBM),as a mature AM process,were studied in this ***,surface topography,residual stress,and tensile performance of EBM-manufactured Ti-6Al-4V specimens were systematically analyzed subjected to different LSP *** distribution of porosities in EBM sample was assessed via X-ray computed *** results showed that EBM samples with two LSP treatments possessed a lower porosity value of 0.05%compared to the value of 0.08%for the untreated *** strength of EBM samples with two LSP treatments was remarkably raised by 12%as compared with the as-built *** grains ofαphase were refined in near-surface layer,and a dramatic increase in the depth and magnitude of compressive residual stress(CRS)was achieved in EBM sample with multiple LSP *** grain refinement ofαphase and CRS with larger depth were responsible for the strength enhancement of EBM samples with two LSP treatments.

关键词： additive manufacturing laser shock peening electron beam melting residual stress Ti-6Al-4V alloy mechanical properties

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Study of thermal decoherence of harmonic oscillators

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原子与分子物理学报 2025年第5期42卷 108-114页

作者： LI Jian ZHOU gao-Liang YAN Zheng-xin LIU Wei WANG Zhao-Qi College of Science Xi’an University of Science and TechnologyXi’an 710054China

The thermal decoherence of harmonic oscillators is investigated *** quantum system presented here is a one-dimensional oscillator with angular frequency,which is surrounded by a thermal bath of environmental *** are various environmental oscillators with different angular frequency(below an ultraviolet cutoff).At the beginning,the quantum system is a pure state and the environmental oscillators are in thermodynamic equilibrium with *** a period,the system-environment interactions inspire significant decoherence of the quantum *** decoherence is displayed by explicit calculations of the purity and von Neumann entropy of the quantum *** is worth noting that the decoherence could be significant even in the weak coupling and low temperature case due to the large amount of environmental degrees of *** the decoherence process is inspired between the quantum system and an ordinary thermal environment here,the thermal decoherence result is quite general.

关键词： Quantum decoherence Grand canonical ensemble Oscillators

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Influence of friction-lubrication characteristics varying with rolling speed on instability of chatter and slip in cold tandem rolling process

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Journal of Iron and Steel Research International 2024年第4期31卷 894-908页

作者： Yan-li xin Zhi-ying gao bo Tian Qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

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