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Neuroscience Bulletin 2023年第9期39卷 1375-1395页

作者： Yuxing Zhang xin Zhao Chun guo Ying Zhang Fukang Zeng Qian Yin Zhong Li Le Shao Desheng Zhou lijuan Liu Department of Neurology The First Hospital of Hunan University of Chinese MedicineChangsha410007China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases Changsha410208China Hunan University of Chinese Medicine Changsha410006China Laboratory of Prevention and Transformation of Major Diseases in Internal Medicine of Traditional Chinese Medicine Changsha410007China

Ischemic stroke is a major public health problem *** the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains *** the present study,we determined that environmental circadian disruption(ECD)increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model,by measuring the infarct volume,neurological tests,and angiogenesis-related *** further report that Bmal1 plays an irreplaceable role in *** of Bmal1 promoted tube-forming,migration,and wound healing,and upregulated the vascular endothelial growth factor(VEGF)and Notch pathway protein *** promoting effect was reversed by the Notch pathway inhibitor DAPT,according to the results of angiogenesis capacity and VEGF pathway protein *** conclusion,our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway.

关键词： Circadian clock Ischemic stroke Angiogenesis VEGF Notch pathway

Effect of maternal pregestational diabetes mellitus on congenital heart diseases

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World Journal of Pediatrics 2023年第4期19卷 303-314页

作者： Zhi-Yan Chen Shuang-Fa Mao Ling-Hong guo Jian qin Li-xin Yang Yin Liu Department of Basic Medical Sciences Sichuan Vocational College of Health and RehabilitationZigong643000China Department of Pharmacology West China School of Basic Sciences and Forensic MedicineSichuan UniversityChengdu610041China Department of Anesthesiology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu610000China Animal Research Institute Sichuan UniversityChengduChina

Background The increasing population of diabetes mellitus in adolescent girls and women of childbearing age contributes to a large number of pregnancies with maternal pregestational diabetes *** heart diseases are a common adverse outcome in mothers with pregestational diabetes ***,there is little systematic information between maternal pregestational diabetes mellitus and congenital heart diseases in the *** sources Literature selection was performed in *** hundred and seven papers were cited in our review,includ-ing 36 clinical studies,26 experimental studies,31 reviews,eight meta-analysis articles,and six of other *** Maternal pregestational diabetes mellitus poses a high risk of congenital heart diseases in the offspring and causes variety of phenotypes of congenital heart *** such as persistent maternal hyperglycemia,oxidative stress,polymorphism of uncoupling protein 2,polymorphism of adiponectin gene,Notch 1 pathway,Nkx2.5 disorders,dysregula-tion of the hypoxia-inducible factor 1,and viral etiologies are associated with the occurrence of congenital heart diseases in the offspring of mothers with pregestational diabetes *** options including blood sugar-reducing,anti-oxidative stress drug supplements and exercise can help to prevent maternal pregestational diabetes mellitus from inducing congenital heart *** Our review contributes to a better understanding of the association between maternal pregestational diabetes mellitus and congenital heart diseases in the offspring and to a profound thought of the mechanism,preventive and therapeutic measurements of congenital heart diseases caused by maternal pregestational diabetes mellitus.

关键词： Congenital heart disease Maternal pregestational diabetes mellitus Mechanism Prevention

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海南地区糖尿病足坏疽的风险因素分析

中国热带医学 2024年第5期24卷 584-590页

作者：麦惠盈张德昊潘南芳覃颖鲜宋菲菲王欣梁萍王清华郭洪花海南省人民医院海南海口570311 海南医学院海南海口571199 海南省第五人民医院海南海口570206

目的基于糖尿病足是海南地区最常见慢性创面类型,旨在明确海南糖尿病足患者的严重程度和糖尿病足坏疽的风险因素,为降低糖尿病足患者的截肢发生率提供科学依据。方法研究采用现况调查设计,于2022年7月—2023年6月对海南省11个市县19家... 详细信息

目的基于糖尿病足是海南地区最常见慢性创面类型,旨在明确海南糖尿病足患者的严重程度和糖尿病足坏疽的风险因素,为降低糖尿病足患者的截肢发生率提供科学依据。方法研究采用现况调查设计,于2022年7月—2023年6月对海南省11个市县19家医院就诊的457名糖尿病足患者进行深入调查。收集的数据包括人口学特征、糖尿病及糖尿病足相关信息等。计数资料采用频数与百分比描述,组间差异比较采用χ^(2)检验,采用二项logistic回归多因素分析并在回归中设置2组递增模型以检验潜在混杂因素对结果的影响。结果海南地区糖尿病足患者中坏疽发生的占比为56.01%(95%CI:51.21%~61.49%)高于其他地区。单因素分析结果显示,年龄、行为习惯、药物治疗、合并症/并发症、家族史和创面细菌感染情况等因素与发生糖尿病足坏疽的风险相关。多因素logistic回归分析结果进一步确认,未接受糖尿病药物治疗、有糖尿病合并症/并发症、未每日检查双足等是糖尿病足坏疽发生的独立风险因素。亚组分析中未发现性别与上述因素之间有显著的交互作用。结论海南地区糖尿病足患者中发生坏疽的占比高于其他地区,发生的风险因素与缺乏规范、及时的救治和患者对糖尿病和糖尿病足的知识缺乏有关,建议加快基层医院创面治疗中心建设,提升糖尿病足的救治水平,并重视糖尿病和糖尿病足的宣教,提高患者配合治疗的依从性,以做到早发现、及时诊治,降低糖尿病足的严重程度和坏疽的发生风险。

关键词：海南地区糖尿病足坏疽风险因素

Quantitative estimation of hourly precipitation in the Tianshan Mountains based on area-to-point kriging downscaling and satellite-gauge data merging

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Journal of Mountain Science 2022年第1期19卷 58-72页

作者： LU xin-yu CHEN Yuan-yuan TANG guo-qiang WANG Xiu-qin LIU Yan WEI Ming Institute of Desert Meteorology China Meteorological Administration.Urumqi 830002China Central-Asia Research Center of Atmosphere Science Urumqi 830002China College of Environment Zhejiang University of TechnologyHangzhou 310014China University of Saskatchewan Coldwater Lab Canmore T1W 3G1Canada Center for Hydrology University of SaskatchewanSaskatchewan S7N 5A2Canada Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China

Precipitation, a basic component of the water cycle, is significantly important for meteorological, climatological and hydrological research. However, accurate estimation on the precipitation remains considerably challenging because of the sparsity of gauge networks and the large spatial variability of precipitation over mountainous regions. Moreover, meteorological stations in mountainous areas are often dispersed and have difficulty in accurately reflecting the intensity and evolution of precipitation events. In this study,we proposed a novel method to produce high-quality,high-resolution precipitation estimates in the Tianshan Mountains, China, based on area-to-point kriging(ATPK) downscaling and a two-step correction, i.e., probability density function matching-optimum interpolation(PDF-OI). We obtained 1-km hourly precipitation data in the Tianshan Mountains by merging estimates from the Integrated Multisatellite Measurement(IMERG) product with observations from 1065 meteorological stations in the warm season(May to September) during 2016–2018. The spatial resolution and accuracy of the merged precipitation data greatly increased compared to *** to a cross-validation with gauged observations, the correlation coefficient(CC),probability of detection(POD) and critical success index(CSI) increased from 0.30, 0.50 and 0.24 for IMERG to 0.63, 0.65 and 0.38, respectively, for the merged estimates, and the root mean squared error(RMSE), mean error(ME) and false alarm ratio(FAR)decreased from 0.46 to 0.38 mm/h, 0.06 to 0.05 mm/h and 0.69 to 0.52, respectively. The proposed method will be useful for developing high-resolution precipitation estimates in mountainous areas such as central Asia and the Belt and Road Initiative regions.

关键词： Hourly precipitation Downscaling merging Tianshan Mountains IMERG Area-to-point kriging(ATPK)

Multicenter evaluation of a simple and sensitive nucleic acid self-testing for SARS-CoV-2

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Virologica Sinica 2023年第4期38卷 620-626页

作者： xin-xin Shen Feng-Yu Li Meng qin guo-Hao Zhang Meng-Yi Zhang Hong Liu Xiu-Li Sun Zhen-Jiang xin Xue-Jun Ma NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Hebei Medical University Shijiazhuang050031China Fengtai District Center for Disease Control and Prevention of Beijing Beijing100071China Beijing Baicare Biotechnology Co. Ltd.Beijing102206China Shandong University of Technology School of Life Sciences and MedicineZibo255000China

A rapid and accurate COVID-19 diagnosis is a prerequisite for blocking the source of infection as soon as possible and taking the appropriate medical ***,we developed GeneClick,a device for nucleic acid self-testing of SARS-CoV-2,consisting of three modules:a sampling kit,a microfluidic chip-based disposable cartridge,and an amplification *** addition,we evaluated the clinical performance of GeneClick using 2162 nasal swabs collected at three medical institutions,using three commercial RT-qPCR kits and an antigen self-test as *** to RT-qPCR,the sensitivity and specificity of the GeneClick assay were 97.93%and 99.72%,respectively,with a kappa value of 0.979(P<0.01).Of the 2162 samples,2076 were also tested for SARS-CoV-2 *** the 314 positive samples identified by GeneClick assay,63 samples were undetected by antigen ***,the GeneClick nucleic acid self-test demonstrated higher accuracy than the antigen-based *** on the additional features,including simple operation,affordable price,portable device,and reliability of smartphone APP-driven sampling and result reporting,GeneClick offers a powerful tool for field-based SARS-CoV-2 detection in primary healthcare institutions or at-home use.

关键词： Nucleic acid self-testing SARS-CoV-2 RT-qPCR Antigen-test

Comparison of the fraction of olfactory receptor pseudogenes in wolf (Canis lupus) with domestic dog (Canis familiaris)

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Journal of Forestry Research 2011年第2期22卷 275-280页

作者： ZHANG Hong-hai WEI qin-guo ZHANG Huan-xin CHEN Lei College of Life Science Qufu Normal University Qufu 273165 Shandong Province China.

Olfactory receptors（ORs）,the first dedicated molecules with which odorants physically interact to arouse an olfactory sensation,constitute the largest gene family in *** and wolves,like many other mammals,have a highly developed capability to detect and identify odorant molecules,even at minimum *** this study,the olfactory receptor repertoire from domestic dog and its closest relative,the wolf,were sequenced to estimate the fraction of pseudogenes in each *** fraction of disrupted olfactory receptor genes in dog was 17.78%,whereas,that in wolf was 12.08%.As expected the dog was less dependent on olfaction than the wolf,and the dog had more olfactory receptor ***,the observed difference between the two subspecies was not at the significant level（χ2 = 1.388,p = 0.239 0.05）.The values indicated that although domestication might play a role in the reduction of OR genes,it could not be concluded that the living environment provided by domestication lead to a significant reduction of the functional olfactory receptor ***,the purpose of domestication may also have influence on the ratio of functional olfactory receptor genes reduction.

关键词： olfactory receptor wolf domestic dog pseudogene

One-bath synthesis of hydrophilic molecularly imprinted quantum dots for selective recognition of chlorophenol

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Chinese Chemical Letters 2011年第10期22卷 1253-1256页

作者： Tai Ye Shi Yan Lu qin qin Hu xin Jiang guo Fen Wei Jing Jing Wang Jian Quan Lu Hubei Key Laboratory of Pollutant Analysis ＆ Reuse Technology Hubei Normal University Huangshi 435002 China

A simple one-bath strategy has been developed to synthesize a novel CdTe@SiO_2@MIP（molecularly imprinted and silica-functionalized CdTe quantum dots,MISFQDs）,in which a silica shell was coated on the surface of CdTe quantum dots （CdTe@SiO_2 QDs） and then a polymer for selective recognition of 4-chlorophenol（4-CP） was constructed on the surface of CdTe@SiO_2 QDs using mercaptoacetic acid as stabilizer,3-aminopropyl-trimethoxysilane（APTES） as functional monomers and tetraethoxysilane（TEOS） as crosslink *** structures of CdTe@SiO_2@MIP were analyzed by ultraviolet-visible absorption. Fluorescence,FT-IR spectrum and powder X-ray *** application and characterization of the CdTe@SiO_2@MIP were investigated by *** results indicated that the CdTe@SiO_2@MIP can selectively recognize 4-chlorophenol.

关键词： Molecularly imprinted functional CdTe quantum dots 4-Chlorophenol Synthesis Recognition

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校企深度融合的能源化工类专业实习基地建设

中国冶金教育 2024年第3期 91-95页

作者：郭勤汪春娟马信周文明葛磊新疆理工学院新疆阿克苏843000 浙江天凯教学仪器有限公司浙江台州318000 新疆西部合盛硅业有限公司新疆石河子832061

针对实习基地建设中的问题,在前期校企合作的基础上探索构建校企深度融合的协同育人机制。新疆理工学院-合盛硅业股份有限公司-浙江天凯教仪有限公司在基于优势互补、共同促进、互利共赢的基础上合作建设了“新疆理工学院能源化学工程... 详细信息

针对实习基地建设中的问题,在前期校企合作的基础上探索构建校企深度融合的协同育人机制。新疆理工学院-合盛硅业股份有限公司-浙江天凯教仪有限公司在基于优势互补、共同促进、互利共赢的基础上合作建设了“新疆理工学院能源化学工程类专业实践基地”,实现了企业发展、人才培养、科学研究、成果转化、学生成才的多丰收。实践基地的建设及运行完善了能源化工类专业实践教学培养体系,促进了学校高质量应用型人才培养,增强了学生创新能力和工匠精神的培育,赢得社会声誉。

关键词：能源化工类专业实习基地建设校企协同育人

基于网络药理学及实验验证探究葛根素治疗溃疡性结肠炎的作用机制

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中国免疫学杂志 2024年第5期40卷 1055-1063页

作者：但文利赵鑫鲁星妤郭紫婵秦琪李娟唐康张慧媛施京红陈丽华陕西中医药大学医学技术学院咸阳712046 空军军医大学基础医学院西安710032

目的:探索葛根素(PUE)对溃疡性结肠炎(UC)的治疗效果及作用机制。方法:利用网络药理学和分子对接技术对PUE调控UC的靶点进行筛选和分析。C57BL/6小鼠自由饮用2.5%DSS水溶液7 d后,观测PUE对小鼠体质量变化及疾病活动指数(DAI)评分的影响... 详细信息

目的:探索葛根素(PUE)对溃疡性结肠炎(UC)的治疗效果及作用机制。方法:利用网络药理学和分子对接技术对PUE调控UC的靶点进行筛选和分析。C57BL/6小鼠自由饮用2.5%DSS水溶液7 d后,观测PUE对小鼠体质量变化及疾病活动指数(DAI)评分的影响。HE染色观察小鼠结肠组织病理变化;阿利新蓝染色观察小鼠结肠组织杯状细胞变化;qRT-PCR和ELISA检测小鼠结肠组织炎症细胞因子表达。CCK-8检测PUE对MODE-K细胞活力的影响;流式细胞术检测PUE对MODE-K细胞凋亡的影响。结果:筛选得到AKT1、TNF、STAT3、CASP3、HIF1A等38个PUE调节UC的靶点,主要涉及TNF、IL-17和PI3K-Akt等信号通路。体内实验结果显示,与DSS组相比,DSS+PUE组小鼠结肠缩短程度、体质量减轻程度和DAI评分降低,结肠组织炎症细胞浸润减少,结肠组织TNF-α、IL-1βmRNA和蛋白表达降低。体外实验证实PUE减轻DSS诱导的上皮细胞凋亡。结论:PUE可减轻DSS诱导的小鼠UC发生发展。

关键词：葛根素溃疡性结肠炎网络药理学上皮细胞凋亡

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Phase-controlled van der Waals growth of wafer-scale 2D MoTe_(2) layers for integrated high-sensitivity broadband infrared photodetection

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Light(Science & Applications) 2023年第1期12卷 77-88页

作者： Di Wu Chenguang guo Longhui Zeng Xiaoyan Ren Zhifeng Shi Long Wen qin Chen Meng Zhang xin Jian Li Chong-xin Shan Jiansheng Jie School of Physics and Microelectronics Key Laboratory of Material Physics Ministry of EducationZhengzhou UniversityZhengzhouHenan 450052China Department of Electrical and Computer Engineering University of California San DiegoLa JollaCA 92093USA Institute of Nanophotonics Jinan UniversityGuangzhouGuangdong 511443China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu 215123China

Being capable of sensing broadband infrared(IR)light is vitally important for wide-ranging applications from fundamental science to industrial ***-dimensional(2D)topological semimetals are being extensively explored for broadband IR detection due to their gapless electronic structure and the linear energy dispersion ***,the low charge separation efficiency,high noise level,and on-chip integration difficulty of these semimetals significantly hinder their further technological ***,we demonstrate a facile thermal-assisted tellurization route for the van der Waals(vdW)growth of wafer-scale phase-controlled 2D MoTe_(2)***,the type-ⅡWeyl semimetal 1T'-MoTe_(2)features a unique orthorhombic lattice structure with a broken inversion symmetry,which ensures efficient carrier transportation and thus reduces the carrier *** characteristic is a key merit for the well-designed 1T'-MoTe_(2)/Si vertical Schottky junction photodetector to achieve excellent performance with an ultrabroadband detection range of up to 10.6μm and a large room temperature specific detectivity of over 108 Jones in the mid-infrared(MIR)***,the large-area synthesis of 2D MoTe_(2)layers enables the demonstration of high-resolution uncooled MIR imaging capability by using an integrated device *** work provides a new approach to assembling uncooled IR photodetectors based on 2D materials.

关键词： hinder enable difficulty