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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-ying Fang Xiao-Rui Pan xin-xing Zeng Zheng-Zheng Li Bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

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水蒸气蒸馏分离-气相色谱/质谱法测定烟用香精和料液中的防腐剂

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云南大学学报（自然科学版） 2018年第3期40卷 551-560页

作者：刘欣向海英张涛曾婉俐蒋次清王晋孔维松李晶云南中烟工业有限责任公司技术中心云南昆明650106

建立了水蒸气蒸馏分离-气相色谱/质谱法(GC-MS)测定烟用香精和料液中的防腐剂的方法.方法利用水蒸气蒸馏(110℃,5 m L/min流量,收集22 min,馏分90~95 m L)进行目标物质分离,并利用Oasis HLB反相固相萃取柱进行溶剂转换及样品再净化,萃... 详细信息

建立了水蒸气蒸馏分离-气相色谱/质谱法(GC-MS)测定烟用香精和料液中的防腐剂的方法.方法利用水蒸气蒸馏(110℃,5 m L/min流量,收集22 min,馏分90~95 m L)进行目标物质分离,并利用Oasis HLB反相固相萃取柱进行溶剂转换及样品再净化,萃取柱利用5 m L甲醇进行淋洗;滤液利用优化后的GC-MS法,选择离子模式进行检测;利用该方法,6种目标物质在0.2~120μg/m L范围内具有较好的线性(r>0.999),检出限在0.023~0.080μg/m L之间,定量限在0.070~0.25μg/m L之间,日间和日内精密度均小于5%,不同加标水平下,平均回收率在93%~103%之间.该方法广谱性强,灵敏度高,线性相关性好,重复性佳,可以满足烟用香料中防腐剂的检测及风险监控要求.

关键词：防腐剂气相色谱质谱法(GC-MS) 水蒸气蒸馏烟用香精烟用料液

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北京市顺义区高血压及其危险因素流行病学调查

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中国健康教育 2017年第1期33卷 59-63页

作者：何朝孙昕霙张艳艳赵莹颖杨帅帅张旭熙李征白如冰李印东李玉堂北京市顺义区疾病预防控制中心北京101300 北京大学公共卫生学院社会医学与健康教育系北京100191

目的了解北京市顺义区高血压患病现状及发病危险因素,为高血压的预防控制提供科学依据。方法采用按规模大小成比例的概率抽样(PPS抽样)方法进行抽样,抽取18~79岁顺义区常住居民3839人进行问卷调查、体格测量及实验室检查,采用χ2检验、L... 详细信息

目的了解北京市顺义区高血压患病现状及发病危险因素,为高血压的预防控制提供科学依据。方法采用按规模大小成比例的概率抽样(PPS抽样)方法进行抽样,抽取18~79岁顺义区常住居民3839人进行问卷调查、体格测量及实验室检查,采用χ2检验、Logistic回归分析对高血压相关危险因素进行分析。结果顺义区18~79岁常住居民高血压患病率为36.4%,男性患病率42.30%,女性患病率31.68%(P<0.01)。患病率随着年龄增加而增加,50岁以上老年人高血压患病率超过50%。Logistic回归分析结果显示,性别、年龄、血脂异常、超重肥胖(包括腹型肥胖)、高血压家族史、饮酒均为高血压的危险因素。顺义区高血压总的知晓率、治疗率、控制率分别为62.83%、53.25%、21.73%,女性知晓率、治疗率、控制率均高于男性(P<0.01);随着年龄增大,高血压知晓率、治疗率、控制率均呈现增高趋势;对于已经确诊的高血压患者,治疗率、控制率分别为84.95%、40.81%,女性均高于男性;年龄越大,确诊患者高血压治疗率、控制率也呈现增高趋势,以上差异有统计学意义(P<0.05)结论顺义区18~79岁常住居民高血压患病率处于较高水平,且血压控制仍不理想。应采取综合性干预措施,加强对重点危险因素的控制,提高高血压的知晓率、治疗率、控制率。

关键词：高血压危险因素流行病学

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Changes in and evaluation of surface soil quality in Populus×xiaohei shelterbelts in midwestern Heilongjiang province,China

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Journal of Forestry Research 2021年第3期32卷 1221-1233页

作者： Jun zhang Yusen Zhao ying xin School of Forestry Northeast Forestry UniversityHarbin 150040People’s Republic of China Shandong Key Laboratory of Eco-Environmental Science for Yellow River Delta Binzhou UniversityBinzhou 256603People’s Republic of China

To examine changes in surface soil quality over time in Populus×xiaohei shelterbelts,we collected soil samples from five shelterbelts of different ages and also from former cropland left fallow for 25 ***-one surface soil(0–20 cm)properties were measured,and variation in soil quality was assessed using one-way ANOVAs and multiple comparison *** on this analysis,16 soil indexes were used in a model evaluating soil quality,with each index given weight as determined by the correlation *** with the control,the postmature forest had greater soil moisture content but lower bulk density(P<0.05).The mature forest also had higher soil pH,total organic carbon,alkali-hydrolyzed nitrogen,available phosphorus,and biomass nitrogen content,but reduced nitrate-nitrogen and total phosphorus content than the control(P<0.05).Total porosity was highly positively correlated with aeration,nitrate-nitrogen,alkali-hydrolyzed nitrogen,available phosphorus,microbial biomass carbon and microbial biomass *** total organic carbon,ammonium nitrogen,nitrate-nitrogen,alkali-hydrolyzed nitrogen,total nitrogen,available phosphorus,microbial biomass carbon and microbial biomass nitrogen were all strongly *** the soil quality evaluation model,total organic carbon was assigned the highest weight and total potassium content the *** soil quality index was lowest in the near-mature forest and greatest in the postmature ***,soil quality in P opulus×xiaohei shelterbelts varied with age and was higher in the 10–20 cm versus 0–10 cm soil *** a single forest generation,surface soil quality was significantly improved.

关键词： Populus×xiaohei Shelterbelts Black soil area Soil quality Evaluation

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Wear law in mixed lubrication based on stress-promoted thermal activation

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Friction 2021年第4期9卷 710-722页

作者： xin PEI Wei PU Jialong YANG ying zhang School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China School of Manufacturing Science and Engineering Sichuan UniversityChengdu 610065China

Although several empirical wear formulas have been proposed,theoretical approaches for predicting surface topography evolution during sliding wear are *** this study,we propose a novel wear-prediction method,wherein the energy-based Arrhenius equation is combined with a mixed elastohydrodynamic lubrication(EHL)model to predict the point-contact wear process in mixed *** surface flash temperature and contact pressure are considered in the wear *** results are compared with the experimental results to verify the *** surface topography evolutions are observed during the wear *** influences of load and speed on wear are *** simulation results based on the Arrhenius equation relationship shows good agreement with the results of experiments as well as the Archard wear ***,the Arrhenius equation is more accurate than the Archard wear theory in some aspects,such as under high-temperature *** results indicate that combining the wear formulas with the mixed EHL simulation models is an effective method to study the wear behavior over time.

关键词： mixed lubrication sliding wear Archard Arrhenius surface topography

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Grain boundary segregation and relaxation in nano-grained polycrystalline alloys

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Science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 72-90页

作者： Tong-Yi zhang ying-xin Gao Sheng Sun Materials Genome Institute Shanghai UniversityShanghai200444China

The present study carries out systematic thermodynamics analysis of Grain Boundary(GB)segregation and relaxation in NanoGrained(NG)polycrystalline *** segregation and relaxation is an internal process towards thermodynamic equilibrium,which occurs naturally in NG alloys without any applied loads,causes deformation and generates internal *** analysis comprehensively investigates the multiple coupling effects among chemical concentrations and mechanical stresses in GBs and grains.A hybrid approach of eigenstress and eigenstrain is developed herein to solve the multiple coupling *** analysis results indicate that the GB stress and grain stress induced by GB segregation and relaxation can be extremely high in NG alloys,reaching the GPa level,which play an important role in the thermal stability of NG alloys,especially via the coupling terms between stress and *** present theoretic analysis proposes a novel criterion of thermal stability for NG alloys,which is determined by the difference in molar free energy between a NG alloy and its reference single crystal with the same nominal chemical *** the difference at a temperature is negative or zero,the NG alloy is thermal stable at that temperature,otherwise unstable.

关键词： nano-grained alloys thermal stability grain boundary segregation eigenstress eigenstrain

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang ying Chen Meng Tian Cheng-Yu Jin xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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Akt Gene Therapy Enhances Angiogenesis in Ischemic Hind Limb

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Chemical Research in Chinese Universities 2010年第3期26卷 409-414页

作者： HUO xin zhang Qiang LIU ying Department of Geriatrics First Affiliated Hospital China Medical University Shenyang 110001 P. R. China

Both bone marrow-derived mesenchymal stem cells（MSCs） therapy and gene therapy have been applied to animal studies and clinical trials. The goal of this study was to compare the effects of three types of MSCs transplantation. In the first part of the study, MSCs were transduced with the pEGFP-C1 and transfected with the pEGFP-C1/Akt in a model of bilateral hind limb ischemia in rats. Following gene transduction, the production of Akt and VEGF protein was more in the culture media of GFP-Akt/MSCs group than that in those of the GFP/MSCs group In the second part of the study, Sprague-Dawley rats（n=10/group） underwent surgery to create bilateral hind limb ischemia and were randomized into two groups consisting of a GFP/Akt-MSCs group（MSCs suspension, 1×10^7 MSCs/100 μL transfected pEGFP-C1/Akt） and a GFP-MSCs group（MSCs suspension, 1 × 10^7 MSCs/100 μL）. These PEGFP-C1/Akt and PEGFP-C 1 transfected MSCs suspensions were slowly infused into the adductor muscles of the rat＇s left hind limb, while the rat＇s right hind limb in the control group received an equal volume of PBS. Endpoints includes angiographic analysis, evaluation of capillary density, immunohistochemistry for von Willebrand factor （vWF）, immunodetection of Akt and VEGF protein, RT-PCR of VEGF and Akt mRNA levels in vitro and in vivo. Our data indicate that the tissue perfusion can improve capillary density and the mature of vasculature in the GFP-Akt/MSCs group compared to that in the GFP-MSCs group or control group in the rat model of bilateral hind limb ischemia. Transplantation of MSCs transfected with Akt gene may become the future therapy for hind limb ischemia.

关键词： Bone mesenchymal stem cell pEGFP-C1/Akt Hindlimb Ischemia Angiogenesis

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren ying Tang Qi Yang Tian-Tian Meng Song Li Jing zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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