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The association of intraocular pressure with metabolic syndrome and its components: a Meta-analysis and systematic review

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 510-516页

作者： yi-xin wang Jian-xin Tao Yong Yao Department of Ophthalmology Wuxi People's Hospital Affiliated to Nanjing Medical University

AIM: To perform a Meta-analysis to explore the correlation between metabolic syndrome and intraocular pressure(IOP).METHODS: We searched PubMed and Embase in November 2017 for studies discussing the relationship between metabolic syndrome components and IOP in patients. Pearson correlation coefficients, odds ratios and standardized betas were extracted from inclusive studies. Heterogeneity and publication bias were ***: Of 295 articles, 10 met inclusion criteria and provided sufficient data for Meta-analysis. Results showed a significant positive relation between metabolic syndrome and IOP(Z=0.47, 95%CI: 0.15-0.79, P=0.005). The five components [waist circumference, hypertriglyceridemia, high blood pressure, high fasting glucose and low high density lipoprotein(HDL)-cholesterol] of metabolic syndrome all showed positive correlation with IOP except the low HDL-cholesterol which had no statistical significance. The pooled Z was 0.08(95%CI: 0.04-0.12), 0.16(95%CI: 0.11-0.21), 0.16(95%CI: 0.10-0.22), 0.30(95%CI: 0.20-0.40) and 0.12(95%CI: 0.08-0.16), respectively. Begg's test and Egger's test showed no evidence of significant publication bias of this ***: Our findings suggest that metabolic syndrome and its components are significantly associated with IOP, besides the HDL-cholesterol. This association may be used to control IOP by intervening the occurrence of metabolic syndrome.

关键词： intraocular pressure metabolic syndrome Meta-analysis

Unique Azolyl Acylhydrazonyl Hybridization of Aloe Emodins to Access Potential Antibacterial Agents

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Chinese Journal of Chemistry 2024年第15期42卷 1741-1758页

作者： yi-xin wang Zhao Deng Aisha Bibi Bo Fang Cheng-He Zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing 402160China

A type of unique azole-hybridized acylhydrazonyl aloe emodins(AAEs)were developed as new antibacterial agents for combating bacterial *** target AAEs showed strong antibacterial activities,especially,tetrazolylthioether AAE 27a exhibited broad antibacterial spectrum with 16-256 folds and 8-64 folds more active antibacterial efficacy than the reference drugs aloe emodin and norfloxacin,*** AAE 27a also gave low hemolysis and cytotoxicity,as well as favorable *** mechanism explorations revealed that tetrazolylthioether AAE 27a could cause bacterial membrane depolarization and damage the cell membrane,resulting in nucleic acid ***,compound 27a could intercalate into DNA to impede its replication and form supramolecular 27a-DNA gyrase complex to disturb the function of DNA *** findings would provide valuable insights for the further exploration of azolyl acylhydrazonyl aloe emodins as new potential antibacterial candidates.

关键词： Aloe emodin Hydrazone Heterocycle Antibacterial Membrane damage

Effect of hydrogen-storage pressure on the detonation characteristics of emulsion explosives sensitized by glass microballoons

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Defence Technology（防务技术） 2022年第5期18卷 747-754页

作者： Ji-ping Chen Hong-hao Ma yi-xin wang Liang-liang Huang Zhao-wu Shen CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefeiAnhuiPR China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefeiAnhuiPR China

In this study,hydrogen-storage glass microballoons were introduced into emulsion explosives to improve the detonation performance of the *** effect of hydrogen-storage pressure on the detonation characteristics of emulsion explosives was systematically *** velocity experiments shows that the change of sensitizing gas and the increase of hydrogen pressure have different effects on the detonation *** experimental parameters of underwater explosion increase first and then decreases with the increase of hydrogen *** decrease of these parameters indicates that the strength of glass microballoons is the limiting factor to improve the detonation performance of hydrogen-storage emulsion *** with the traditional emulsion explosives,the maximum peak pressure of shock wave of hydrogen-storage emulsion explosives increases by 10.6%at 1.0 m and 10.2%at 1.2 m,the maximum values of shock impulse increase by 5.7%at 1.0 m and 19.4%at 1.2 *** stored hydrogen has dual effects of sensitizers and energetic additives,which can improve the energy output of emulsion explosives.

关键词： Emulsion explosives Hydrogen-storage pressure Glass microballoons Underwater explosion

Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia, a systematic review and meta-analysis

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Asian Journal of Andrology 2015年第2期17卷 281-284,I0010页

作者： Qi Yang Yan-Ping Huang Hong-Xiang wang Kai Hu yi-xin wang yi-Ran Huang Bin Chen Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai institute of Andrology Shanghai 200127 China.

Noninvasive parameters for predicating sperm retrieval rate （SRR） are desirables. Follicle-stimulating hormone （FSH） has been an important predictor since the first years of testicular sperm extraction. Recent studies showed continuous interests in FSH, with both pros and cons. Thus, we conducted a meta-analysis to evaluate the diagnostic value of FSH as a predictor for patients with nonobstructive azoospermia （NOA） taking testicular sperm retrieval. Eligible diagnosis tests were identified from electronic databases （Cochrane Central Register of Controlled Trials, Medline, and EMBASE） without language restrictions. The database search, quality assessment, and data extraction were performed independently by two reviewers. The reference standard was the sperm retrieval result. Diagnostic value of FSH were explored by area under receiver operation characteristics （ROC） curve using Review Manager, version 5.1.0 （Cochrane Collaboration, Oxford, UK） and Meta-DiSc, version 1.4. Meta regression will be done if there is heterogeneity. Then, we find 11 tests including a total of 1350 patients met the inclusion criteria. Our pooled analysis showed that the area under ROC curve of FSH was 0.72 ~ 0.04. Meta regression analyses showed that region and average age have an influence on the diagnostic value. FSH showed more diagnostic value with patients in East Asia and with younger patients. We concluded that FSH had moderate value in independently predicating SRR in men with NOA （area under curve 〉0.7）. More detailed diagnosis tests should be anticipated in the future to confirm the diagnostic value of other noninvasive parameters.

关键词： follicule-stimulating hormone meta-analysis nonobstructive azoospermia testicular sperm retrieval

Effect of ultrasound-guided lumbar square muscle block on stress response in patients undergoing radical gastric cancer surgery

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2093-2100页

作者： xin-Ran wang Dan-Dan Xu Meng-Jiao Guo yi-xin wang Meng Zhang Dong-Xiao Zhu Department of Ultrasound Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina

BACKGROUND Radical surgery is a common treatment for patients with gastric cancer;however,it can lead to postoperative complications and intestinal barrier ***-guided quadratus lumborum block is often used for postoperative analgesia,but its effects on stress response and intestinal barrier function are not well *** To investigate the effects of an ultrasound-guided quadratus lumborum block on stress response and intestinal barrier function in patients undergoing radical surgery for gastric *** A total of 100 patients undergoing radical surgery for gastric cancer were randomly categorized into observation and control *** adrenaline and cortisol levels,intestinal mucosal barrier indexes,and complication rates were compared between the two groups before,during,and 1 day after *** The observation group had significantly lower plasma adrenaline and cortisol levels during surgery and at 1 day postoperatively than that of the control group(Pxin and D-dimer)at 1 day postoperatively were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION Ultrasound-guided quadratus lumborum block could reduce stress response,protect intestinal barrier function,and decrease the incidence of complications in patients undergoing radical surgery for gastric *** technique has the potential for clinical applications.

关键词： Ultrasound-guided quadratus lumborum block Radical gastric cancer surgery Stress response Intestinal barrier function Postoperative analgesia Rehabilitation

An effective snakebite first aid training method for medics in the Chinese troops: a RCT

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Military Medical Research 2020年第1期7卷 55-62页

作者： Chen Qiu Xiao-Feng Qiu Jing-Jing Liu yi-xin wang Li Gui First Medical Center General Hospital of the PLABeijing 100853China Department of Emergency Nursing School of NursingNaval Medical UniversityShanghai 200433China Second Medical Center General Hospital of the PLABeijing 100853China

Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops ***,few Chinese military medics know the proper first aid procedures for ***,this study aimed to explore the impact of the Standard Operation Procedure(SOP)and checklist on Chinese military medics’ability to manage snakebite first ***:This study was a prospective single-blind randomized controlled trial conducted in a military medical university of China from May to June 2017.A questionnaire-based survey was performed to collect the participants’socio-demographic profiles before the baseline *** the baseline measurement,participants were requested to provide corresponding first aid that was responsive to the simulative situation portrayed by the standardized patients(SPs)and the evaluators then scored their performances according to a checklist for snakebite first aid scoring *** the baseline measurement,they were randomly assigned to one of three intervention groups after stratification according to their baseline performance scores:group A received a self-learning course with textbooks(n=27),group B received a self-learning training on the SOP and checklist(n=27)and group C was engaged in an interactive discussion panel regarding the SOP and checklist(n=26).After the interventions,participants received outcome measurements about snakebite first aid key points capability from the same evaluator and SP for each group to avoid observational *** reviewers were blinded about the grouping in the ***:The baseline measurement yielded no significant difference(H=1.647,P=0.439)among the three *** post-intervention scores were higher than the pre-intervention scores for all three(A,B and C)groups(P=0.008,P<0.001 and P<0.001,respectively).There was significant difference of the post-intervention scores among the three groups(F=8.841,P<0.001).Both post-intervention scores of gro

关键词： Snakebite Standard operation procedure(SOP) Checklist Medic Training

2D Naphthalenedisulfonate-cadmiun coordination polymer with2,4,5-tri(4-pyridyl)-imidazole as a co-ligand:Structure and catalytic property

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Chinese Chemical Letters 2014年第2期25卷 243-246页

作者： xing-Wei wang Hui Guo Meng-Jie Liu xin-yi wang Dong-Sheng Deng Institute of Resources & Environment Henan Polytechnic University College of Chemistry and Chemical Engineering.Luoyang Normal University

A new 2D coordination polymer, [Cd（tpim）（1,5-nds）]n （1）, was constructed from 1,5-naphthalenedi- sulfonate （1,5-nds）. 2.4,5-tri（4-pyridyl）-imidazole （tpim） and Cd（CH3COO）2.2H2O, which can be subsequently used to promote the epoxide ring-opening reaction of epoxides and amines with remarkable catalytic activity. In addition, the thermal and luminescent properties of I in the solid state were also investigated.

关键词： Crystal structure Organosulfonate Coordination polymer Epoxide ring-opening

Cryptocurrency technology revolution:are Bitcoin prices and terrorist attacks related?

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Financial Innovation 2023年第1期9卷 1293-1312页

作者： Yu Song Bo Chen xin‑yi wang Institute of Defense Economics and Management Central University of Finance and Economics39 Xueyuan South RoadBeijingChina

As a financial innovation of the information age,cryptocurrency is a complex concept with clear advantages and disadvantages and is worthy of *** from a terrorism perspective,this study uses the time-varying parameter/stochastic volatil-ity vector autoregression model to explore the risk hedging and terrorist financing capabilities of *** results show that both terrorist incidents and brutality may explain Bitcoin price,but their effects are slightly *** to terrorist brutality,terrorist incidents have a weaker impact on Bitcoin price,showing that Bitcoin investors are more concerned about the number of deaths than the frequency of ter-rorist *** turn,the impact of Bitcoin price on terrorist attacks is *** is a potential means of financing terrorism,but it does not currently play an important *** research findings can help investors analyze and predict Bitcoin prices and help improve the theoretical system of anti-terrorist financing,helping to maintain world peace and security.

关键词： Terrorist incident Terrorist brutality Bitcoin price Time-varying

A Three-Dimensional Mn^Ⅱ-[Mo^Ⅲ(CN)7]^4-Ferrimagnet Containing Formate as a Second Bridging Ligand

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Chinese Journal of Chemistry 2019年第1期37卷 19-24页

作者： Le Shi Dong Shao Fu-ying Shen Xiao-qin Wei xin-yi wang State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China

Summary of main observation and conclusion Serf-assembly of the [Mo(CN)7]^4-anion and the Mn^2+ ion in the aqueous solution containing ammonium formate results in a new coordination polymer,{(NH4)3[(H2O)Mn3(HCOO)][Mo(CN)7]2·4H2O}*** crystal X-ray analysis revealed a very complicated three-dimensional (3D)framework,where both the [Mo(CN)7]^4- and the formate anions act as bridges between the Mn^Ⅱ *** measurements revealed that this compound displays ferrimagnetic ordering below 70 *** antiferromagnetic interactions between the spin carriers might lead to spin frustration and non-linear alignment of the magnetic ***,this compound is the first mixed [Mo(CN)7]^4-/HCOO^- bridged molecule magnet.

关键词： Mn^2+ frustration spin X-ray act