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Chemical Research in Chinese Universities 2024年第1期40卷 136-144页

作者： DU Xiaohui LI Encheng WANG Qi you xin Lung Cancer Transitional Medicine Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Scientific Research Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Respiratory Medicine The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China

Lung cancer produces a high incidence of malignant *** have been many studies on lung cancer using mass spectrometry(MS)***,most studies have focused on humoral *** this work,26 pairs of tissue samples(tumor ***-tumor)from patients with lung cancer were analyzed using liquid chromatography-tandem MS(LC-MS/MS)with data-independent acquisition *** total,3152 proteins were quantified from tissue samples with high confidence,including 189 up-regulated and 522 down-regulated proteins(tumor ***-tumor).In addition,79 and 690 proteins were identified only in para-cancerous samples and cancerous samples,*** results from bio-informatics tools indicated that altered proteins like PEBP1,HRG and LYZ could be ideal reservoirs for screening the potential biomarkers for lung *** is believed these tissue-specific proteomics results will assist in the studies of lung cancer.

关键词： Lung cancer Proteome Data-independent aquisition

Enhancing force sensing in a squeezed optomechanical system with quantum nondemolition measurement

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Communications in Theoretical Physics 2024年第1期76卷 49-60页

作者： Shi-Lei Chao Zi-Hao Li xin-you Lü School of Physics Huazhong University of Science and Technology430074 WuhanChina

A theoretical scheme is proposed to enhance the sensitivity of force sensors with quantum nondemolition measurement(QND)in an optomechanical setup assisted by four-tone optical driving and an optical parametric amplifier(OPA).With the help of special drive,the system can be simplified as the typical type of QND for force sensing,so that the backaction noise can be evaded to surpass the standard quantum ***,the added noise can be suppressed owing to the modified optical susceptibility resulting from the *** introducing two oscillators coupling with two charged bodies respectively,the signal can be enhanced with the nonlinearity caused by Coulomb interaction,while the noise presents an exponential ***,considering the homodyne detection effect,the range of system parameters and frequency bands will be *** present investigation may provide a route toward simultaneously evading backaction noise,reducing the mechanical thermal noise,and enhancing the external signal,which can be an alternative design for sensitive devices.

关键词： force sensing optical parametric amplifier quantum non-demolition measurement optomechanical system

Nonreciprocal generation of Schrodinger cat state induced by topology

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 23-30页

作者： Zi-Hao Li Li-Li Zheng Ying Wu xin-you Lü School of Physics and Institute for Quantum Science and Engineering Huazhong University of Science and Technologyand Wuhan Institute of Quantum TechnologyWuhan 430074China Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan UniversityWuhan 430074China

The Schrodinger cat state produced differently in two directions is anticipated to be a critical quantum resource in quantum information *** exploring the interplay between quantum nonreciprocity and topology in a one-dimensional microcavity array,we obtain the Schrodinger cat state(a pure quantum state)in a chosen direction at the edge cavity,whereas a classical state in the other *** nonreciprocal generation of the cat state originates from the topologically protected chiralitymode excitation in the nontrivial phase,but in the trivial phase,the nonreciprocal generation of cat state ***,our proposal is switchable by tuning the parameters so that a topological phase transition ***,the obtained cat state has nonreciprocal high fidelity,nonclassicality,and quantum coherence,which are sufficient to be used in various one-way quantum technologies,e.g.,invisible quantum sensing,noise-tolerant quantum computing,and chiral quantum *** work provides a general approach to control quantum nonreciprocities with the topological effect,which substantially broadens the fields of nonreciprocal photonics and topological physics.

关键词： Schr?dinger cat state nonreciprocity topology

A Tiny Example Based Procedural Model for Real-Time Glinty Appearance Rendering

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Journal of Computer Science & Technology 2024年第4期39卷 771-784页

作者： you-xin xing Hao-Wen Tan Yan-Ning Xu Lu Wang School of Software Shandong UniversityJinan 250101China NetEase(Hangzhou)Network Co. LtdHangzhou 310052China

The glinty details from complex microstructures significantly enhance rendering ***,the previous methods use high-resolution normal maps to define each micro-geometry,which requires huge memory *** paper observes that many self-similarity materials have independent structural characteristics,which we define as tiny example *** propose a procedural model to represent microstructures implicitly by performing spatial transformations and spatial distribution on tiny ***,we precompute normal distribution functions(NDFs)by 4D Gaussians for tiny examples and store them in multi-scale NDF *** with a tiny example based NDF evaluation method,complex glinty surfaces can be rendered simply by texture *** experimental results show that our tiny example based the microstructure rendering method is GPU-friendly,successfully reproducing high-frequency reflection features of different microstructures in real time with low memory and computational overhead.

关键词： real-time rendering reflectance modeling glinty material photorealistic rendering microstructure

Geochemical identification of a source rock affected by migrated hydrocarbons and its geological significance:Fengcheng Formation,southern Mahu Sag,Junggar Basin,NW China

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Petroleum Science 2024年第1期21卷 100-114页

作者： Wen-Long Dang Gang Gao xin-Cai you Ke-Ting Fan Jun Wu De-Wen Lei Wen-Jun He Yong Tang State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing102249China School of GeoSciences China University of Petroleum(Beijing)Beijing102249China Exploration&Development Institute Xinjiang Oil Field CompanyKaramay834000XinjiangChina

The Fengcheng Formation is a crucial source rock and the primary reservoir for oil accumulation in the Mahu *** oils are distributed throughout the Fengcheng Formation,ranging from the edge to the interior of the sag in the southern Mahu *** crude oils originate from in-situ source rocks in shallowly buried areas and the inner deep *** migration,the crude oil from the inner deep sag affects the source rocks close to carrier beds,leading to changes in the organic geochemical characteristics of the source *** changes might alter source rock evaluations and oil-source *** on data such as total organic carbon(TOC),Rock-Eval pyrolysis of source rocks,and gas chromatography-mass spectrometry(GC-MS)of the saturated fraction,and considering the geological characteristics of the study area,we define the identification characteristics of source rock affected by migrated hydrocarbons and establish the various patterns of influence that migrated hydrocarbons have on the source rock of the Fengcheng Formation in the southern Mahu *** source rocks of the Fengcheng Formation are mostly fair to good,containing mainly Type II organic matter and being thermally mature enough to generate *** rocks affected by migrated hydrocarbons exhibit relatively high hydrocarbon contents(S1/TOC>110 mg HC/g TOC,Extract/TOC>30%,HC:hydrocarbon),relatively low Rock-Eval Tmax values,and relatively high tricyclic terpane contents with a descending and mountain-shaped ***,biomarker composition parameters indicate a higher thermal maturity than in-situ source *** a comparison of the extract biomarker fingerprints of adjacent reservoirs and mudstones in different boreholes,three types of influence patterns of migrated hydrocarbons are identified:the edge-influence of thin sandstone-thick mudstone,the mixed-influence of sandstone-mudstone interbedded,and the full-influence of thick sandstone-thin *** finding reminds

关键词： Organic geochemistry Source rock Influence of migrated hydrocarbons Fengcheng Formation Southern Mahu Sag

Cooperative enhancement of mechanical and tribological properties through tailoring TiN transition interface in boron nitride nanosheets reinforced copper composites

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Rare Metals 2024年第10期43卷 5202-5215页

作者： Zhong-Hua Li Liang Liu xin you Jian-Hong Yi Rui Bao Ming-Yi Zhu Song Lu Jun-Jun Pai Faculty of Materials Science and Engineering Kunming University of Science and Technology Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology

Strengthening interface bonding between boron nitride nanosheets(BNNS) and copper matrix is an essential prerequisite for exploiting a new generation of copper matrix composites(CMCs) with high strength and wear resistance. Herein, BNNS/Cu composites were fabricated by the powder metallurgy route, matrix-alloying(adding 1.0 wt% Ti) strategy was adopted to improve the interfacial wettability and strengthen interface adhesion. A typical "sandwich"-like multiply interface structure involving TiN transition layers, BNNS and Cu matrix had been well constructed through the rational heat treatment(900℃for 120 min). Additionally, nano-sized TiB whisker was in situ formed in the vicinity of the interface, it had linked the BNNS-Cu-TiN multiply interface, which played a role of "threading the needle" and significantly strengthened the multi-interfaces bonding. This specific interface structure was finely characterized, and the formation mechanism of solid-state interfacial reaction feature was proposed. The results demonstrated that the ultimate tensile strength(UTS) of BNNS/Cu-(Ti)-900℃ increased from 248 to 530 MPa(increased by 114%), and the coefficient of friction(COF) decreased from 0.51 to 0.28 than pure Cu. This work highlights the importance of interface configuration design, which contributes to the development of CMCs with prominent comprehensive properties.

关键词： Boron nitride nanosheets Copper matrix composites Interface structure Mechanical and frictional properties

Impacts of angiotensin II on retinal artery changes in apolipoprotein E deficient mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 16-24页

作者： Li-Hui Meng Shi-Yu Cheng He Chen Yue-Lin Wang Wen-Fei Zhang Huan Chen xin-Yu Zhao you-xin Chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Lab of Ocular Fundus Diseases Chinese Academy of Medical SciencesBeijing 100730China

AIM:To investigate the impacts of angiotensin II(Ang II)on retinal artery changes in apolipoprotein E deficient(apoE^(-/-))***:ApoE^(-/-)male mice were infused by minipumps with Ang II at 1000 ng/kg·min(Ang II group)or saline(control group)for *** were underwent ophthalmic fundus examination on day 0,14,and 28 of *** examination,ribonucleic acid(RNA)sequencing and local Ang II measurement of retinas were ***:Ophthalmic fundus examination showed Ang II infusion promoted the formation of retinal arterial aneurysm-like lesions on day *** coherence tomography revealed the ganglion cell and inner plexiform layer(GCIPL)thickness in the control group was significantly thinner than that in Ang II group(P<0.001).Hematoxylin-eosin staining demonstrated diffused swelling of GCIPL layer and its disordered structure in Ang II *** electron microscopy showed Ang II infusion caused aggravation of atherosclerotic lesions,including increased swelling,roughness,disorganization of the retinal vasculature,and vacuoles ***-sequencing and gene ontology enrichment analysis demonstrated that the structure and function of cellular membrane might be disturbed and visual function might be compromised by Ang *** local level of Ang II was higher in Ang II infusion group but did not show significant differences compared to the control group(P=0.086).CONCLUSION:Ang II infusion promotes the formation of retinal arterial aneurysm-like lesions in apoE^(-/-)mice,causing aggravation of atherosclerotic lesions,more severe disorganization of the retinal vasculature and disturbance of the cellular membrane.

关键词： angiotensin II retinal artery aneurysm apoE^(-/-)mice

Targeting CXCR4 and EDN1 for the treatment of recurrent miscarriage using stearic acid from traditional Chinese medicine

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Traditional Medicine Research 2024年第11期9卷 65-75页

作者： Fang Liu Dong-Mei Shi Wen-Ye Ma Da-Wei Tang Gang Bai xin-you Yu Reproductive Center of Yinchuan Maternal and Child Health Hospital Yinchuan 750001China Prenatal Diagnosis Center of Ningxia Medical University General Hospital Yinchuan 750004China

Background:Recurrent miscarriage(RM)affects an estimated 1-3%of couples attempting to conceive,and its molecular components stay ineffectively caught *** study aims to explore potential therapeutic targets for RM by examining gene expression patterns and biological pathways in both mouse and human RM ***,explore relevant traditional Chinese medicine(TCM)components targeting potential therapeutic ***:We utilized the GSE211251 mouse and the GSE26787 human datasets,employing gene set enrichment analysis and gene metaphysics analysis to examine differentially expressed genes and enriched ***-cell RNA analysis uncovered cellular heterogeneity and arranged pharmacology-mapped potential drug-target *** employed molecular docking strategies to assess the affinity of TCM components for key ***:In the mouse model,genes such as Ly6f1 and Gpr26 were upregulated,while Stc5a and Galca exhibited *** set enrichment analysis identified key pathways,including the tumor necrosis factor-mediated signaling *** human samples,Gene Ontology analysis highlighted processes such as apoptosis and cell ***-cell RNA analysis revealed distinct cellular populations between normal and RM *** pharmacology identified C-X-C motif chemokine receptor 4(CXCR4)and endothelin 1(EDN1)as potential key targets,and molecular docking confirmed that stearic acid from TCM appears to regulate these ***:This study presents a comprehensive analysis of the genetic and cellular underpinnings of RM,identifying CXCR4 and EDN1 as promising therapeutic *** acid from TCM could provide targeted treatment by modulating these key proteins,paving the way for new RM treatment strategies.

关键词： RM gene expression single-cell RNA analysis CXCR4 EDN1 stearic acid

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一种工件表面压印字符识别网络

吉林大学学报（工学版） 2024年第7期54卷 2072-2079页

作者：游新冬郭磊韩晶吕学强北京信息科技大学网络文化与数字传播北京市重点实验室北京100101

工件表面的压印字符存在凹凸不平、锈蚀、风化等问题,导致传统的字符识别算法难以取得满意的效果。针对这一问题,将工件表面压印字符的识别视为一类特殊的目标检测问题,并针对其特性设计了一种两阶段识别网络:定位-分类网络。定位网络... 详细信息

工件表面的压印字符存在凹凸不平、锈蚀、风化等问题,导致传统的字符识别算法难以取得满意的效果。针对这一问题,将工件表面压印字符的识别视为一类特殊的目标检测问题,并针对其特性设计了一种两阶段识别网络:定位-分类网络。定位网络使用无锚框的方法提取字符感兴趣区域,有效解决了字符区域提取困难的问题。分类网络采用特征解耦的卷积模块和结构重参数化技术,能够在不增加额外参数的情况下提升分类的准确率。此外,分类网络采用跨域迁移学习的训练策略,能够有效解决实际应用中的小样本和类别不平衡问题。在自建螺栓数据集和SynthText数据集上的实验结果表明,该算法的整体精度能够达到98%和92%,优于对比算法。

关键词：压印字符字符识别无锚框小样本目标检测

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基于改进特征融合的口罩检测算法

计算机工程与设计 2024年第2期45卷 524-529页

作者：曹琦武友新南昌大学数学与计算机学院江西南昌330036

针对口罩检测模型缺少不规范佩戴分类的检测,精度高与速度快难以兼容的问题,提出一种单阶段口罩规范佩戴实时检测算法,引入轻量提取网络DM-CSP,添加多尺度注意力MCA增强提取能力;针对融合阶段深浅层特征信息不对齐问题,设计特征对齐及... 详细信息

针对口罩检测模型缺少不规范佩戴分类的检测,精度高与速度快难以兼容的问题,提出一种单阶段口罩规范佩戴实时检测算法,引入轻量提取网络DM-CSP,添加多尺度注意力MCA增强提取能力;针对融合阶段深浅层特征信息不对齐问题,设计特征对齐及选择模块FAS,提出特征增强模块CTM关联特征图谱上下文信息,构建解耦通道进行图像识别,提高算法的识别精度和收敛速度。实验结果表明,改进算法检测精度达到93.2%,较主流算法YOLOv4-Tiny提高4.8%,检测速度和模型容量具有更优性能表现。

关键词：口罩检测图像识别注意力特征对齐特征增强实时检测多尺度