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Multi-verse optimizer based parameters decision with considering tool life in dry hobbing process

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Advances in Manufacturing 2021年第2期9卷 216-234页

作者： Heng-xin ni Chun-Ping Yan Shen-Fu ni Huan Shu Yu Zhang State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400030People’s Republic of China Hefei Meiya Photoelectric Technology Co.Ltd Hefei 230088People’s Republic of China

Dry hobbing has received extensive attention for its environmentally friendly processing *** to the absence of lubricants,hobbing process is highly dependent on process parameters combination since using unreasonable parameters tends to affect the machining ***,the consideration of tool life is frequently ignored in gear ***,to settle the above issues,a multiobjective parameters decision approach considering tool life is ***,detailed quantitative analysis between process parameters and hobbing performance,i.e.,machining time,production cost and tool life is ***,a multi-objective parameters decision-making model is constructed in search for optimum cutting parameters(cutting velocity v,axial feed rate f_(a))and hob parameters(hob diameter d_(0),threads z_(0)).Thirdly,a novel algorithm named multi-objective multi-verse optimizer(MOMVO)is utilized to solve the presented model.A case study is exhibited to show the feasibility and reliability of the proposed *** results reveal that(i)a balance can be achieved among machining time,production cost and tool life via appropriate process parameters determination;(ii)optimizing cutting parameters and hob parameters simultaneously contributes to optimal objectives;(iii)considering tool life provides usage precautions support and process parameters guidance for practical machining.

关键词： Process parameters Decision-making Tool life Dry hobbing Multi-objective multi-verse optimizer(MOMVO)

Is it time to put traditional cold therapy in rehabilitation of soft-tissue injuries out to pasture?

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World Journal of Clinical Cases 2021年第17期9卷 4116-4122页

作者： Zi-Ru Wang Guo-xin ni School of Sports Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Cold therapy has been used regularly as an immediate treatment to induce analgesia following acute soft-tissue injuries,however,a prolonged ice application has proved to delay the start of the healing and lengthen the recovery *** gaseous cryotherapy,also known as neurocryostimulation,has shown the ability to overcome most of the limitations of traditional cold therapy,and meanwhile promotes the analgesic and anti-inflammatory effects well,but the current existing studies have shown conflicting results on its *** cold therapy still has beneficial effect especially when injuries are severe and swelling is the limiting factor for recovery after soft-tissue injuries,and therefore no need to be entirely put out to pasture in the rehabilitation *** randomized controlled trials with good methodological quality are still needed in the future to evaluate the effects of different cryotherapy modalities.

关键词： Cryotherapy Hyperbaric gaseous cryotherapy Neurocryostimulation Cold therapy Soft tissue injury

Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelines

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Military Medical Research 2020年第2期7卷 209-227页

作者： xin-ni Xu Yew Kwang Ong De Yun Wang Department of Otolaryngology-Head and Neck Surgery National University Hospital SystemSingaporeSingapore Department of Otolaryngology Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

The coronavirus disease(COVID-19)pandemic has led to a global struggle to cope with the sheer numbers of infected persons,many of whom require intensive care support or eventually succumb to the *** outbreak is managed by a combination of disease containment via public health measures and supportive care for those who are *** date,there is no specific anti-COVID-19 ***,the urgency to identify treatments that could turn the tide has led to the emergence of several investigational drugs as potential candidates to improve outcome,especially in the severe to critically *** many of these adjunctive drugs are being investigated in clinical trials,professional bodies have attempted to clarify the setting where the use of these drugs may be considered as off-label or compassionate *** review summarizes the clinical evidence of investigational adjunctive treatments used in COVID-19 patients as well as the recommendations of their use from guidelines issued by international and national organizations in healthcare.

关键词： COVID-19 Adjunctive treatment Chloroquine Lopinavir-ritonavir Remdesivir Corticosteroids Umifenovir Convalescent plasma

Continuous generating grinding method for beveloid gears and analysis of grinding characteristics

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Advances in Manufacturing 2022年第3期10卷 459-478页

作者： Bing Cao Guo-Long Li Alessandro Fortunato Heng-xin ni College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400030People's Republic of China State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044People's Republic of China Department of Industrial Engineering(DIN) Alma Mater StudiorumUniversity of BolognaViale Risorgimento 2Bologna 40136Italy

Continuous generating grinding has become an important gear processing method owing to its high efficiency and *** this study,an adaptive design model is proposed for the continuous generation of beveloid gears in common gear grinding *** on this model,a method for determining the installation position and grinding kinematics is developed alongside an analytical meshing model for grinding contact trace and derivation of key grinding *** combining these aspects,a general mathematical model for the continuous generation of beveloid gears is presented,comprising the entire grinding process from worm wheel dressing to the evaluation of grinding *** effects of the worm and dressing wheel parameters on the grinding deviation were analysed,facilitating the development of an approach to improve the grinding *** presented procedure represents a novel design method for the continuous generation of beveloid gears in common gear grinding machines,facilitating the appropriate selection of worm and dressing wheel parameters.

关键词： Beveloid gears Continuous generating grinding Meshing model Kinematics model

Removal of laparoscopic cerclage stitches via laparotomy and rivanol-induced labour: A case report and literature review

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World Journal of Clinical Cases 2022年第1期10卷 304-308页

作者： xin-ni Na Ben-Shuo Cai Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Laparoscopic cervical cerclage is performed for patients with abnormal cervical anatomy and/or transvaginal cervical cerclage ***,the method of removing the stitches to allow labour induction remains *** to published literature,stitches are removed through laparoscopic or transvaginal ***,we report,for the first time,a case of a patient who had undergone laparoscopic cerclage,and then underwent removal of stitches by laparotomy and labour induction in the third trimester of *** SUMMARY A patient who underwent laparoscopic cervical cerclage due to cervical insufficiency became pregnant naturally following the *** 31 wk of pregnancy,severe foetal malformations were *** successfully induce labour,cerclage stitches were removed via laparotomy,and rivanol was injected directly into the *** successful induction of labour,the patient delivered a dead *** This report provides a reliable scheme of removing cerclage stitches for patients who have undergone laparoscopic cerclage but experience severe foetal malformations.

关键词： Laparoscopic cerclage Pregnancy Induced labour Stitch removal Case report

Host-guest interaction tailored cucurbit[6]uril-based supramolecular organic frameworks(SOFs) for drug delivery

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Chinese Chemical Letters 2022年第3期33卷 1529-1532页

作者： Chun Liu Yu Xia Zhu Tao xin-Long ni Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou UniversityGuiyang 550025China College of Chemistry and Chemical Engineering Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceHunan Normal UniversityChangsha 410081China

An approach for the construction of crystalline porous supramolecular organic frameworks (SOFs) via outer-surface interactions of cucurbit[6]uril (Q[6]) with high yield is presented. This approach enables the noncovalent integration of guest molecules into ordered topologies and creates new host-guest-complex-based SOFs;i.e., the topology can be predesigned and constructed by using [ZnCl_(4)]^(2-) anions to induce the formation of solid Q[6]-SOFs, and the pore wall surface can be easily modified by the Q[6]-encapsulated guest molecules. In addition, one of prepared solid Q[6]-SOFs showed a high drug-loading capacity and smart potential release control for drug-delivery applications.

关键词： Cucurbituril SOFs Porous materials Host-guest interaction Drug delievery

Unprecede nted tunable hydrophobic effect and anion recognition triggered by AIE with Hofmeister series in water

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Chinese Chemical Letters 2021年第5期32卷 1679-1682页

作者： Pan Wang Shixian Cao Ting Yin xin-Long ni Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou UniversityGuiyang 550025China

An un precedented tun able hydrophobic effect in self-assembly of a small cationic organic fluorophore(ni-TPy^(+))-based with aggregation-induced emission(AIE)property was realized in aqueous *** amplification of hydrophobicity was found to be significantly dependent upon the increasing aggregates of ni-TPy^(+),which enabled the study of the hydrophobic binding of chaotropic anions with the Hofmeister series.

关键词： AIE Anion binding Hofmeister series Hydrophobic effect Self-assembly

Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying Liu Shuai Ye xin-ni Li Wei-Guang Li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen nie Die Hu Zhiyao Zeng Yan Fan Yaxin Zhai xin-Long ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization