Host-guest interaction tailored cucurbit[6]uril-based supramolecular organic frameworks(SOFs) for drug delivery

作     者：Chun Liu Yu Xia Zhu Tao Xin-Long Ni Chun Liu;Yu Xia;Zhu Tao;Xin-Long Ni

作者机构：Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou ProvinceGuizhou UniversityGuiyang 550025China College of Chemistry and Chemical EngineeringKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceHunan Normal UniversityChangsha 410081China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第3期

页      面：1529-1532页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (No. 21871063) the Science and Technology Foundation of Hunan Province (No. 2020JJ2021) the high performance computing platform of Guizhou University 

主　　题：Cucurbituril SOFs Porous materials Host-guest interaction Drug delievery 

摘      要：An approach for the construction of crystalline porous supramolecular organic frameworks (SOFs) via outer-surface interactions of cucurbit[6]uril (Q[6]) with high yield is presented. This approach enables the noncovalent integration of guest molecules into ordered topologies and creates new host-guest-complex-based SOFs;i.e., the topology can be predesigned and constructed by using [ZnCl_(4)]^(2-) anions to induce the formation of solid Q[6]-SOFs, and the pore wall surface can be easily modified by the Q[6]-encapsulated guest molecules. In addition, one of prepared solid Q[6]-SOFs showed a high drug-loading capacity and smart potential release control for drug-delivery applications.