检索结果-南通市图书馆

Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

Trinuclear gold-catalyzed site-selective alkylation of peptides

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

同方期刊数据库

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 172-184页

作者： fang JIANG Tian MAO Jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan JIA Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

同方期刊数据库

Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo fang fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend <0.005). In contrast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend <0.005). Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

关键词：

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei fang Xiaoqi Lin Ruian Xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

维普期刊数据库

湖北鹤峰县杨家坪滑石矿地质特征及其成因探讨

在线全文

学校读者我要写书评

暂无评论

矿产与地质 2023年第5期37卷 956-962页

作者：赵军李哲武陈林曹文胜方喜林湖北省地质局第二地质大队湖北恩施445000 资源与生态环境地质湖北省重点实验室(湖北省地质局) 湖北武汉430034

湖北鹤峰县杨家坪滑石矿位于走马—东山峰背斜南西段之南东翼,是新发现的具有中型规模的滑石矿矿床。通过对滑石矿矿床地质特征及成因进行综合研究和分析,认为矿体赋矿层位为下震旦统陡山沱组三段中上部,分为黑滑石、白滑石两层矿,两者... 详细信息

湖北鹤峰县杨家坪滑石矿位于走马—东山峰背斜南西段之南东翼,是新发现的具有中型规模的滑石矿矿床。通过对滑石矿矿床地质特征及成因进行综合研究和分析,认为矿体赋矿层位为下震旦统陡山沱组三段中上部,分为黑滑石、白滑石两层矿,两者上下相距7~10 m,均呈似层状大致与围岩整合产出,矿石具沉积特征的鲕粒结构。矿石自然类型为块状滑石、片状滑石,黑滑石矿工业类型为白云石—滑石型,白滑石矿不具备工业价值。矿体特征、矿石成分、矿石结构特征以及稀土配分模式等共同表明,矿石为同生海相沉积成因,而矿石的片理化构造显示矿床叠加有后期的变质变形作用,矿床类型为沉积改造型滑石矿床。研究成果可为走马—东山峰背斜一带滑石矿进一步找矿和研究提供依据和支撑。

关键词：杨家坪滑石矿地质特征矿产成因湖北

维普期刊数据库

Two Second-Order Ecient Numerical Schemes for the Boussinesq Equations

在线全文

学校读者我要写书评

暂无评论

应用数学 2025年第1期38卷 114-129页

作者： LIU fang WANG Danxia ZHANG Jianwen School of Mathematics Taiyuan University of TechnologyJinzhong 030600China Shanxi Key Laboratory for Intelligent Optimization Computing and Blockchain Technology Jinzhong 030600China

In this paper,we construct two fully decoupled,second-order semi-discrete numerical schemes for the Boussinesq equations based on the scalar auxiliary variable(SAV)*** introducing a scalar auxiliary variable,the original Boussinesq system is transformed into an equivalent *** we discretize it using the second-order backward di erentiation formula(BDF2)and Crank-Nicolson(CN)to obtain two second-order time-advanced *** both numerical schemes,a pressure-correction method is employed to decouple the velocity and *** two schemes possess the desired property that they can be fully decoupled with satisfying unconditional *** rigorously prove both the unconditional stability and unique solvability of the discrete ***,we provide detailed implementations of the decoupling ***,various 2D numerical simulations are performed to verify the accuracy and energy stability of the proposed schemes.

关键词： Scalar auxiliary variable approach Pressure-correction method Fully decoupled Unconditional stability Boussinesq equations

新型喷射-生态混凝土力学性能和工作性能研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混凝土 2023年第8期 174-177页

作者：方喜林杨莉吴林松曾磊李振陈雨修胡志惠熊壁湖北华夏水利水电股份有限公司湖北荆州434000 长江大学湖北荆州434000

生态混凝土护坡技术是水库消落区生态治理的核心,为解决水库消落区陡坡护坡施工难度大的问题,提出一种可喷射生态混凝土,研究了增稠剂掺量、水灰比和骨胶比对生态混凝土(EPC)工作性能、孔隙率和抗压强度的影响。结果表明,增稠剂掺量0.8%... 详细信息

生态混凝土护坡技术是水库消落区生态治理的核心,为解决水库消落区陡坡护坡施工难度大的问题,提出一种可喷射生态混凝土,研究了增稠剂掺量、水灰比和骨胶比对生态混凝土(EPC)工作性能、孔隙率和抗压强度的影响。结果表明,增稠剂掺量0.8%,水灰比在0.35~0.4之间,骨胶比在3.0~4.0之间的EPC工作性能满足喷射作业要求,EPC孔隙率在21.5%~25.93%之间,抗压强度约为5.04~7.59 MPa。

关键词：消落区护坡生态混凝土喷射混凝土工作性能力学性能

维普期刊数据库

Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2025年第1期10卷 109-131页

作者： Wei Ma Jiahao Yao fang Xie Xinqi Wang Hao Wan Xiangjian Shen Lili Zhang Menggai Jiao Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityHenan450001China

Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic *** introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active *** optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of *** elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization ***,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse *** underscores the pivotal role of point defects in enhancing catalytic *** last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials.

关键词： Point defect engineering Doping Vacancy Electrocatalysis Electronic structure

Optimization of Convolutional Neural Network Based on Improved Sparrow Algorithm for Flywheel Energy Storage System Loss in Small Sample

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dianwang Jishu/Power System Technology 2025年第1期49卷 366-372页

作者： Wei, Le Li, Chenglin fang, fang Liu, Yubin School of Control and Computer Engineering North China Electric Power University Changping District Beijing 102206 China

Flywheel energy storage systems have standby losses and are unsuitable for long-term energy storage. Aiming at the economic index of flywheel loss, based on the small sample data of the operation of the flywheel energy storage system, a flywheel loss calculation model combining a Logistic chaotic sparrow optimization algorithm and a convolutional neural network was proposed. Firstly, the causes of flywheel loss were analyzed. Next, the flywheel operation data of Ningxia Lingwu Power Plant was preprocessed, and the adversarial generation network was used for small-sample enrichment. Then, the loss model is established based on the convolutional neural network, the improved sparrow algorithm is used to optimize the hyperparameters of the model, and the superiority of the model is verified by comparison. Finally, simulation experiments show that the model can optimize the output of the flywheel energy storage system and reduce the flywheel loss. © 2025 Power System Technology Press. All rights reserved.

关键词： Flywheels