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An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning

National Science Review 2024年第05期 186-201页

作者： Mingyue Lv Ruyi Cai Renzimo Zhang xiju xia Xuelin Li Yipan Wang Huan Wang Jianzhi Zeng Yifei Xue Lanqun Mao Yulong Li State Key Laboratory of Membrane Biology School of Life SciencesPeking University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences PKU-IDG/Mc Govern Institute for Brain Research Yuanpei College Peking University Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Peking University–Tsinghua University–National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary Studies Peking University Institute of Molecular Physiology Shenzhen Bay Laboratory College of Chemistry Beijing Normal University Chinese Institute for Brain Research

Octopamine（OA）,analogous to norepinephrine in vertebrates,is an essential monoamine neurotransmitter in invertebrates that plays a significant role in various biological functions,including olfactory associative ***,the spatial and temporal dynamics of OA in vivo remain poorly understood due to limitations associated with the currently available methods used to detect *** overcome these limitations,we developed a genetically encoded GPCR activation-based（GRAB） OA sensor called *** sensor is highly selective for OA and exhibits a robust and rapid increase in fluorescence in response to extracellular *** GRABOA1.0,we monitored OA release in the Drosophila mushroom body（MB）,the fly's learning center,and found that OA is released in response to both odor and shock stimuli in an aversive learning *** OA release requires acetylcholine（ACh） released from Kenyon cells,signaling via nicotinic ACh ***,we discovered that OA amplifies aversive learning behavior by augmenting dopamine-mediated punishment signals via Octβ1R in dopaminergic neurons,leading to alterations in synaptic plasticity within the ***,our new GRABOA1.0sensor can be used to monitor OA release in real time under physiological conditions,providing valuable insights into the cellular and circuit mechanisms that underlie OA signaling.

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Association between genetic polymorphisms of base excision repair pathway and glioma susceptibility in Chinese children

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World Journal of Pediatrics 2022年第9期18卷 632-635页

作者： Yong-Ping Chen Yu-xiang Liao Zhen-Jian Zhuo Li Yuan Hui-Ran Lin Lei Miao xia Li xiao-Kai Huang Jing-Ying Zhou Jun Bian Jing He Department of Pediatric Surgery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou Women and Children’s Medical CenterGuangzhou Medical University9 Jinsui RoadGuangzhou510623China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha410008China Faculty of Medicine Macao University of Science and TechnologyMacao999078China State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineAir Force Medical UniversityXi’an710032China Department of Hematology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China Department of General Surgery Xi’an Children’s HospitalXi’an Jiaotong University Affiliated Children’s Hospital69 Xiju Court LaneXi’an710003China

Glioma is an aggressive malignant primary tumor in the central nervous system[1,2].Although the pathogenesis of glioma is unclear,the only identified environmental risk fac-tor is ionizing radiation[3].However,other factors also may alter the glioma risk,among which gene polymorphisms may play prominent role in glioma *** excision repair(BER)is a DNA repair mechanism that maintains genome integrity and guarantees DNA base modification *** signifcant and common proteins involved in the BER pathway are associated with cancer.

关键词： glioma excision base

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