Association between genetic polymorphisms of base excision repair pathway and glioma susceptibility in Chinese children
作者机构：Department of Pediatric SurgeryGuangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou Women and Children’s Medical CenterGuangzhou Medical University9 Jinsui RoadGuangzhou510623China Department of NeurosurgeryXiangya HospitalCentral South UniversityChangsha410008China Faculty of MedicineMacao University of Science and TechnologyMacao999078China State Key Laboratory of Cancer BiologyDepartment of PathologyXijing Hospital and School of Basic MedicineAir Force Medical UniversityXi’an710032China Department of HematologyThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China Department of General SurgeryXi’an Children’s HospitalXi’an Jiaotong University Affiliated Children’s Hospital69 Xiju Court LaneXi’an710003China
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2022年第18卷第9期
页 面：632-635页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from the National Natural Science Foundation of China(81802346) the Discipline Promotion Project of the First Affiliated Hospital of Air Force Medical University(XJZT18MJ49)
摘 要：Glioma is an aggressive malignant primary tumor in the central nervous system[1,2].Although the pathogenesis of glioma is unclear,the only identified environmental risk fac-tor is ionizing radiation[3].However,other factors also may alter the glioma risk,among which gene polymorphisms may play prominent role in glioma *** excision repair(BER)is a DNA repair mechanism that maintains genome integrity and guarantees DNA base modification *** signifcant and common proteins involved in the BER pathway are associated with cancer.
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