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Single whole-genome sequencing analysis of metastatic biopsy is sufficient for investigational treatment opportunities in cancer

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Cancer Communications 2021年第12期41卷 1417-1419页

作者： xifeng dong Rong Fu Department of Hematology Tianjin Medical University General HospitalTianjinP.R.China

Cancer is the second leading cause of death worldwide,accounting for an estimated 9.96 million deaths in 2020[1].The global cancer burden is dominated by China,which has the largest population size worldwide[2,3].Cancer is a group of genetic diseases driven by a series of structural genomic changes[4].Therefore,extensive analysis of somatic changes in cancer genomes can help us develop treatments that target changes in genomic drivers,thereby improving the life expectancy of cancer patients[5].

关键词： cancer Cancer treatment

Efficacy and safety of eltrombopag in the treatment of primary immune thrombocytopenia:real-world data from a single medical center

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China Medical Abstracts(Internal Medicine) 2024年第3期41卷 183-184页

作者： dong xifeng Dept Hematol Tianjin Med Univ General HospTianjin 300052China

Objective To investigate the efficacy and safety of eltrombopag in the treatment of adult primary immune thrombocytopenia (ITP) and evaluated the factors influencing its efficacy and side *** A total of 198 patients with adult ITP who were admitted to Tianjin Medical University General Hospital between January 2018 and March 2022 were retrospectively analyzed.

关键词： admitted treatment immune

Research Progress on Infectious Inflammation Markers in Blood

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国际感染病学（电子版） 2015年第3期4卷 81-85页

作者： xifeng dong Department of Hematology-Oncology Tianjin Medical University General Hospital

Acute phase protein (APP) is a type of special protein closely related to infection inflammation. In recent years, a large number of studies have shown that multiple positive and negative APPs, including C-reactive protein, serum amyloid A, procalcitonin,haptoglobin, alpha1 acid glycoprotein, ceruloplasmin, fibrinogen, prealbumin, leptin,albumin, and plasma fibronectin, are significantly correlated to infectious inflammationand that this method is more accurate and reliable than somatic cell test, erythrocyte sedimentation rate test, enzyme activity and content change test, and the like. Therefore,APP could be used as an infectious inflammation marker.

关键词： infection inflammation acute phase protein enzyme and test

Acquired pure red cell aplasia:unraveling the immune pathogenesis

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Journal of Bio-X Research 2023年第4期6卷 138-148页

作者： Mengyuan Liu Tian Zhang xifeng dong Huaquan Wang Department of Hematology General HospitalTianjin Medical UniversityTianjinChina

Acquired pure red cell aplasia(aPRCA)is a rare hematological disorder characterized by normochromic,normocytic anemia,reticulocytopenia,and the absence of *** pathogenesis of aPRCA has remained *** review delves into the intricate web of immune mechanisms underlying the development of this enigmatic *** exploring immune responses,cytotoxic effects,and antibody-mediated processes,we dissect the immune-driven assault on erythroid *** classification of aPRCA,including its primary and secondary forms,is elucidated,with a particular emphasis on etiological factors such as viruses,drugs,thymoma,and large granular lymphocytic ***,we discuss the implications of cytogenetic changes in erythroid progenitors and immune cells in the pathophysiology of *** comprehensive overview aims to shed light on the complex interplay between immune dysregulation and erythroid failure in aPRCA,offering insights that will be crucial for better understanding and treating this disease.

关键词： cytotoxicity erythroid progenitors immune mechanisms pathogenesis pure red cell aplasia

Primary cilia restrict autoinflammation by mediating PD-L1 expression

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Science Bulletin 2024年第16期69卷 2505-2508页

作者： Xiaoyu Tian Kaiyue Zhang Renjie Hong Hanyu Wang xifeng dong Jun Zhou Yunfan Yang Min Liu Center for Cell Structure and Function Shandong Provincial Key Laboratory of Animal Resistance BiologyHaihe Laboratory of Cell EcosystemCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Department of Hematology Tianjin Medical University General HospitalTianjin 300052China Department of Cell Biology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell EcosystemTianjin 300462China

Ciliopathies are multisystem disorders characterized by the dysfunction of motile and/or non-motile cilia,which are microtubule-based structures protruding from the cell surface and function in cell motility and *** clinical manifestations of ciliopathies include retinal degeneration,mental retardation,renal abnormality,obesity,and skeletal dysplasia[1,2].Fibrosis of vital organs,characterized by the extensive deposition of extracellular matrix components,represents another complication frequently observed in patients and animal models of ciliopathies[3].

关键词： inflammation organs degeneration

涂胶自动称重技术在机器涂胶质量监控中的应用

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汽车工艺与材料 2020年第6期 14-18页

作者：董西峰一汽解放汽车有限公司无锡柴油机厂无锡214026

为了解决生产中某些自动涂胶工位没有可靠稳定的涂胶质量检测方法,导致涂胶质量不受控,质量隐患大的问题,自主开发了一种涂胶自动称重技术,通过改造或新增机器人系统、电气控制系统、气动系统以及称重系统,设计完成了一套自动化程度高... 详细信息

为了解决生产中某些自动涂胶工位没有可靠稳定的涂胶质量检测方法,导致涂胶质量不受控,质量隐患大的问题,自主开发了一种涂胶自动称重技术,通过改造或新增机器人系统、电气控制系统、气动系统以及称重系统,设计完成了一套自动化程度高、质量监控效果好的涂胶质量监控系统。该系统可简单有效监控胶水质量、涂胶系统稳定性,同时实施成本低、面积小、自动化水平高、监控效果良好。

关键词：动称重胶水质量成本稳定性

表皮生长因子受体酪氨酸激酶突变对于非小细胞肺癌疗效影响的研究进展

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中国肺癌杂志 2009年第12期12卷 1341-1345页

作者：董喜凤宋强山东大学齐鲁医院血液科济南250012

随着肺癌发病机制研究的深入，靶向治疗在NSCLC治疗中的地位日渐重要。其中，以厄洛替尼和吉非替尼为代表的表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor tyrosine kinase inhibitor,EGFR TKI）的靶向药物取得... 详细信息

随着肺癌发病机制研究的深入，靶向治疗在NSCLC治疗中的地位日渐重要。其中，以厄洛替尼和吉非替尼为代表的表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor tyrosine kinase inhibitor,EGFR TKI）的靶向药物取得了一定的疗效。但多数研究显示临床缓解甚至消退的NSCLC患者在维持治疗一段时间后出现耐药，甚至疾病进展。为此，EGFR TKI耐药机制已成为肿瘤学界研究的热点。

关键词：受体酪氨酸激酶抑制剂非小细胞肺癌表皮生长因子疗效 receptor NSCLC 突变靶向治疗

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原发性肺非霍奇金淋巴瘤1例并文献复习

中国肺癌杂志 2011年第6期14卷 557-560页

作者：梁勇付蓉高珊董喜凤邵宗鸿天津医科大学总医院血液科天津300052

原发性肺非霍奇金淋巴瘤(primary pulmonary non-Hodgkin's lymphoma,PPNHL)是指起源于肺内淋巴组织的恶性淋巴瘤,是结外淋巴瘤的一种罕见类型,本文通过报道1例老年女性患者PPNHL,并结合相关文献复习,探讨了PPNHL的临床特点、诊断、治... 详细信息

原发性肺非霍奇金淋巴瘤(primary pulmonary non-Hodgkin's lymphoma,PPNHL)是指起源于肺内淋巴组织的恶性淋巴瘤,是结外淋巴瘤的一种罕见类型,本文通过报道1例老年女性患者PPNHL,并结合相关文献复习,探讨了PPNHL的临床特点、诊断、治疗方法,以提高诊断率。

关键词：肺肿瘤诊断治疗病理

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改善柴油机油底壳螺栓扭矩衰减的工艺研究

汽车工艺与材料 2019年第6期 43-46页

作者：董西峰王军一汽解放汽车有限公司无锡柴油机厂

某发动机企业的一款主打柴油机油底壳紧固螺栓多达26颗,柴油机运行后,受柴油机温度升高和高频振动的影响,该处螺栓扭矩衰减情况较为严重,进而导致油底壳和机体结合面渗油,影响产品质量。本文通过增加扭矩、紧固螺栓涂螺纹胶、螺栓底部... 详细信息

某发动机企业的一款主打柴油机油底壳紧固螺栓多达26颗,柴油机运行后,受柴油机温度升高和高频振动的影响,该处螺栓扭矩衰减情况较为严重,进而导致油底壳和机体结合面渗油,影响产品质量。本文通过增加扭矩、紧固螺栓涂螺纹胶、螺栓底部增加压板等工艺试验,寻求改善扭矩衰减情况的方法,以提升柴油机装调质量,提升用户满意度,并为同行提供一定的经验借鉴。

关键词：油底壳扭矩衰减涂胶结构优化