Acquired pure red cell aplasia:unraveling the immune pathogenesis

作     者：Mengyuan Liu Tian Zhang Xifeng Dong Huaquan Wang 

作者机构：Department of HematologyGeneral HospitalTianjin Medical UniversityTianjinChina 

出 版 物：《Journal of Bio-X Research》 (生物组学研究杂志（英文）)

年 卷 期：2023年第6卷第4期

页      面：138-148页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Key Technology Research and Development Program of Tianjin China(18ZXDBSY00140 to HW) 

主　　题：cytotoxicity erythroid progenitors immune mechanisms pathogenesis pure red cell aplasia 

摘      要：Acquired pure red cell aplasia(aPRCA)is a rare hematological disorder characterized by normochromic,normocytic anemia,reticulocytopenia,and the absence of *** pathogenesis of aPRCA has remained *** review delves into the intricate web of immune mechanisms underlying the development of this enigmatic *** exploring immune responses,cytotoxic effects,and antibody-mediated processes,we dissect the immune-driven assault on erythroid *** classification of aPRCA,including its primary and secondary forms,is elucidated,with a particular emphasis on etiological factors such as viruses,drugs,thymoma,and large granular lymphocytic ***,we discuss the implications of cytogenetic changes in erythroid progenitors and immune cells in the pathophysiology of *** comprehensive overview aims to shed light on the complex interplay between immune dysregulation and erythroid failure in aPRCA,offering insights that will be crucial for better understanding and treating this disease.