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Simulation and Analysis of Electromagnetic Force in Laser Melting Deposition by Electromagnetic Impact

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Transactions of nanjing University of Aeronautics and Astronautics 2018年第4期35卷 702-709页

作者： xie na Zhao Jianfeng xie Deqiao Sun Jie Tian Zongjun Shen Lida College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

Magnetic field was introduced in laser melting deposition to reduce the pores in *** 3-D model of the coil-deposition layer-substrate was *** results show that the electromagnetic force in deposition layer mainly concentrates in the projection area of the *** electromagnetic force shows repulsion in one *** experimental results indicate that the magnetic field is beneficial for grain refinement,microhardness increasement and decline of quantities and average sizes of pores.

关键词： laser melting deposition (LMD) finite element method electromagnetic force coil microstructure

大麻二酚对转化生长因子β1诱导肝星状细胞活化和肝纤维化的作用

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中国组织工程研究 2025年第23期29卷 4965-4974页

作者：王联谢娜赵珮伶陈浩李芏酉王豫萍贵州医科大学附属医院临床检验中心贵州省贵阳市550003 贵州医科大学医学检验学院临床微生物学及免疫学教研室贵州省贵阳市550004

背景:大麻二酚具有抗炎、抗氧化等药理学作用,并且不具有精神活性,在肝脏疾病中的研究日渐增加,但其对肝星状细胞转化生长因子β1/Smad信号转导通路的作用尚未明确。目的:探讨大麻二酚对肝星状细胞中转化生长因子β1/Smad信号转导通路... 详细信息

背景:大麻二酚具有抗炎、抗氧化等药理学作用,并且不具有精神活性,在肝脏疾病中的研究日渐增加,但其对肝星状细胞转化生长因子β1/Smad信号转导通路的作用尚未明确。目的:探讨大麻二酚对肝星状细胞中转化生长因子β1/Smad信号转导通路的影响,研究其抗肝纤维化的可能机制。方法:(1)体外实验:选取大鼠肝星状细胞株(HSC-T6),分6组培养:对照组常规培养24 h,单纯药物组加入大麻二酚培养24 h,造模组加入转化生长因子β1培养24 h,造模+低剂量药物组、造模+高剂量药物组、造模+阳性对照组均加入转化生长因子β1培养24 h后分别加入1,5μmol/L大麻二酚或水飞蓟素培养24 h。培养结束后,检测各组细胞α-平滑肌肌动蛋白与Ⅰ型胶原mRna表达、白细胞介素1β与肿瘤坏死因子α水平及Ⅰ型胶原、转化生长因子β1/Smad信号转导通路蛋白表达。(2)动物体内实验:将C57BL/6J小鼠随机分为5组,每组8只:假手术组不造模,造模组、造模+低剂量药物组、造模+高剂量药物组、造模+阳性对照组通过胆管结扎法建立肝纤维化模型,造模3周后分别腹腔注射4,8 mg/kg大麻二酚或水飞蓟素,1次/d,连续给药7 d。给药结束后,检测各组小鼠肝功能、肝脏病理形态及α-平滑肌肌动蛋白、Ⅰ型胶原、转化生长因子β1/Smad信号转导通路相关蛋白表达。结果与结论:(1)体外实验:与对照组比较,造模组HSC-T6细胞α-平滑肌肌动蛋白与Ⅰ型胶原mRna表达、白细胞介素1β与肿瘤坏死因子α水平以及Ⅰ型胶原、转化生长因子β1、p-Smad2/3蛋白表达均升高(P<0.05),Smad7蛋白表达降低(P<0.05);两种剂量大麻二酚处理可改善转化生长因子β1诱导的HSC-T6细胞上述指标的变化,并且以造模+高剂量药物组改善作用更明显;(2)体内实验:与假手术组比较,模型组小鼠血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶活性升高(P<0.05),肝组织中炎性细胞浸润及胶原含量增加(P<0.05),转化生长因子β1/Smad信号转导通路被激活,α-平滑肌肌动蛋白、Ⅰ型胶原蛋白表达升高(P<0.05);两种剂量大麻二酚干预可减轻造模小鼠上述指标的变化,并且以造模+高剂量药物组效果更明显;(3)结果表明,大麻二酚通过抑制肝星状细胞转化生长因子β1/Smad信号传导通路的激活抑制肝纤维化。

关键词：大麻二酚肝星状细胞肝纤维化信号转导通路转化生长因子β1/Smad HSC-T6细胞

Geographical differences of leaf traits of the endangered plant Litsea coreana *** and its relationship with climate

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Journal of Forestry Research 2023年第1期34卷 125-135页

作者： Gangyi Yuan Qiqiang Guo Yaqin Zhang Qin Gui na xie Siqiong Luo Institute for Forest Resources and Environment of Guizhou Key Laboratory of Forest Cultivation in Plateau Mountain of Guizhou ProvinceCollege of ForestryGuizhou UniversityGuiyang 550025People’s Republic of China

Seventeen morphological and anatomical characteristics of the leaves were selected from five natural populations to explore the variation in leaf traits of Lits ea core ana *** and the effects of geographical environment on these *** analysis of variance,multiple comparisons,principal component analysis(PCA),and correlation analysis were conducted to explore the variations within and between populations and their correlation with geographical and climatic *** differences in the 17 leaf traits were observed within and among *** average,the relative contribution of within population variation to total variation was 24.8%,which was lower than among population variation(54.6%).The average differentiation coefficient of the traits was 65.8%,and the average coefficient of variation 11.8%,ranging from6.7%for main vein thickness to 21.4%for petiole *** PC A results showed that morphological characteristics were divided into two categories,and the level of variation was greater than that of leaf *** of the leaf traits were significantly correlated with geography and climate and showed a gradual variation with longitude,latitude,and *** areas with high temperatures,less rainfall,and strong seasonal rainfall,the leaves are larger,longer and *** study shows that variations in leaf traits of *** *** mainly come from variations among *** level of trait differentiation among populations is high and the level of variation within populations *** findings help further understand leaf morphological characteristics of this species and can provide a valuable reference for the protection and sustainable utilization of this natural resource.

关键词： Litsea coreana var.sinensis Climate Leaf trait variations natural populations Endangered species

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Clinical Characteristics,Diagnosis,and Therapeutics of COVID-19:A Review

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Current Medical Science 2023年第6期43卷 1066-1074页

作者： na-na xie Wen-cong ZHANG Jia CHEN Fang-bing TIAN Jian-xin SONG Department of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)that suddenly emerged at the end of December 2019 and caused coronavirus disease 2019(COVID-19)continues to afflict humanity,not only seriously affecting healthcare systems but also leading to global social and economic *** of August 2022,there were approximately 580 million confirmed cases of COVID-19 and approximately 6.4 million confirmed deaths due to this *** data are sufficient to highlight the seriousness of SARS-CoV-2 *** most patients with COVID-19 present primarily with respiratory symptoms,an increasing number of extrapulmonary systemic symptoms and manifestations have been associated with *** the outbreak of COVID-19,much has been learned about the disease and its causative ***,great effort has been aimed at developing treatments and drug interventions to treat and reduce the incidence of *** this narrative review,we provide a brief overview of the epidemiology,mechanisms,clinical manifestations,diagnosis,and therapeutics of COVID-19.

关键词： coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 mechanism clinical manifestations diagnosis therapeutics

Neoantigens:promising targets for cancer therapy

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Signal Transduction and Targeted Therapy 2023年第2期8卷 446-483页

作者： na xie Guobo Shen Wei Gao Zhao Huang Canhua Huang Li Fu State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu610041China Clinical Genetics Laboratory Affiliated Hospital&Clinical Medical College of Chengdu UniversityChengdu610081China Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of Pharmacology and International Cancer CenterShenzhen University Health Science CenterShenzhen518060GuangdongPeople’s Republic of China

Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies,including cancer vaccines,adoptive cell therapy and antibody-based therapies,especially for solid *** are newly formed antigens generated by tumor cells as a result of various tumor-specific alterations,such as genomic mutation,dysregulated Rna splicing,disordered post-translational modification,and integrated viral open reading *** are recognized as non-self and trigger an immune response that is not subject to central and peripheral *** quick identification and prediction of tumor-specific neoantigens have been made possible by the advanced development of next-generation sequencing and bioinformatic *** to tumor-associated antigens,the highly immunogenic and tumor-specific neoantigens provide emerging targets for personalized cancer immunotherapies,and serve as prospective predictors for tumor survival prognosis and immune checkpoint blockade *** development of cancer therapies will be aided by understanding the mechanism underlying neoantigen-induced anti-tumor immune response and by streamlining the process of neoantigen-based *** review provides an overview on the identification and characterization of neoantigens and outlines the clinical applications of prospective immunotherapeutic strategies based on *** also explore their current status,inherent challenges,and clinical translation potential.

关键词： antigens alterations approval

Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst

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Chemical Research in Chinese Universities 2012年第2期28卷 225-229页

作者： xie Xiao-na ZHANG Chun-li XUN Er-na WANG Jia-xin ZHANG Hong WANG Lei WANG Zhi The First Hospital of Jilin University Changchun 130021P.R.China Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Physical Education Jilin UniversityChangehun 130012P.R.China

The regioselective acylation of quercetin catalyzed by a novel thermophilic esterase（APE1547） from the archaeon Aeropyrum pernix K1 was successfully conducted in organic *** effects of acyl donor,substrate ratio,organic solvent,temperature,and water activity were *** the optimum conditions,a yield of 74% for its mono ester could be achieved in the reaction for about 6 *** the reaction time extending to about 30 h,the final conversion of quercetin was about 100% and three products were synthesized.

关键词： Quercetin Vinyl acetate APE1547 Acylation

nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing Huang Xiaohan Guo Yi Wu Xingyu Chen Lixiang Feng na xie Guobo Shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging *** rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory *** recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated *** types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and *** can also directly combat pathogens and *** addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory *** review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory *** also discusses the challenges associated with clinical translation in this field and explores the latest developments and *** conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

Overcoming cancer therapeutic bottleneck by drug repurposing

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1449-1473页

作者： Zhe Zhang Li Zhou na xie Edouard CNice Tao Zhang Yongping Cui Canhua Huang State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduChina Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia The School of Biological Science and Technology Chengdu Medical College610083 ChengduChina Department of Oncology The Second Affiliated Hospital of Chengdu Medical CollegeChina National Nuclear Corporation 416 HospitalChengdu610051 SichuanChina Cancer Institute Peking University Shenzhen HospitalShenzhen Peking University—the Hong Kong University of Science and Technology(PKU-HKUST)Medical Centerand Cancer InstituteShenzhen Bay Laboratory Shenzhen518035 ShenzhenChina Department of Pathology&Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer Shanxi Medical UniversityTaiyuan030001 ShanxiChina School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengdu611137 SichuanChina

Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing,the development of old drugs for new therapeutic *** strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease,facilitating rapid clinical *** an increased understanding of the hallmarks of cancer and the development of various data-driven approaches,drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic ***“treasure trove”of non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of ***,different from targeted drugs,these old generic drugs,usually used in a multi-target strategy may bring benefit to *** this review,aiming to demonstrate the full potential of drug repurposing,we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono-or drug combination *** also summarize approaches used for drug repurposing and discuss the main barriers to its uptake.

关键词： drugs therapeutic classify

Ultrasound-promoted Lipase-catalyzed Enantioselective Transesterification of (R,S)-Glycidol

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Chemical Research in Chinese Universities 2011年第5期27卷 845-849页

作者： AN Bai-yi xie Xiao-na XUN Er-na WANG Jia-xin WANG Ren SUN Ruo-xi WANG Lei WANG Zhi Key Laboratory for Molecular Enzymology and Engineering Ministry of Education Jilin University Changchun 130012 P. R. China Department of Endocrinology the First Hospital of Jilin University Changchun 130021 P. R. China College of Life Science Jilin University Changchun 130012 P. R. China

Enantioselective transesterification of glycidol with vinyl butyrate as an acyl donor was investigated in the presence of Bacillus subtilis lipase（BSL2） as catalyst. Comparison studies demonstrate the advantage of ultrasound over the conventional shaking for the enzymatic reaction in non-aqueous media. The effects of reaction conditions（ultrasound power, temperature, water activity and pH） on the activity and enantioselectivity were also investigated. Under the optimum conditions, the synthetic activity of BSL2 was 2.95 μmol？min？1？mg？1 and the enantioselectivity（E value） was 52.2. Compared with conventional shaking, ultrasound made the synthetic activity and the enantioselectivity increase 9.5-fold and 1.4-fold, respectively. Furthermore, the repeated use of BSL2 for five cycles resulted in no obvious loss of enzyme activity, suggesting that the enzyme is stable under low power ultrasound conditions.

关键词： Activity Enantioselectivity Glycidol Lipase Resolution Ultrasound