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基于液相色谱-串联质谱技术的治疗药物监测方法研究进展

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中华检验医学杂志 2024年第3期47卷 332-340页

作者：李姿颖谢洁屈子裕江游张谛禹松林马晓丽邱玲戴新华方向俞晓平中国计量大学生命科学学院检验检疫研究所杭州310018 中国计量科学研究院前沿计量科学中心国家市场监管技术创新中心(质谱)北京100029 中国医学科学院北京协和医院检验科北京100730

液相色谱-串联质谱技术具有高特异性、高通量的特点, 因此在临床检验领域有快速的应用和发展, 其在治疗药物监测中的应用可有效提升定量准确性与灵敏度, 为患者制定个性化的最佳给药方案。但该技术目前仍面临一些挑战, 自动化、质量控... 详细信息

液相色谱-串联质谱技术具有高特异性、高通量的特点, 因此在临床检验领域有快速的应用和发展, 其在治疗药物监测中的应用可有效提升定量准确性与灵敏度, 为患者制定个性化的最佳给药方案。但该技术目前仍面临一些挑战, 自动化、质量控制、量值溯源等将是今后的发展方向。

关键词：色谱法液相串联质谱法治疗药物监测样本前处理挑战

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骨折术后钢板外露的综合治疗

包头医学院学报 2012年第6期28卷 52-54页

作者：刘俊刘鸣江谢松林黄新锋李匡文黄雄杰南华大学附属南华医院手外科湖南衡阳421001

目的:介绍骨折术后钢板外露材料的处理及创面的修复。方法:回顾2000年1月至2011年6月275例钢板外露的患者,综合考虑四肢创面缺损的大小、感染、周围软组织情况,创面经过换药或者扩创,未感染或者感染得到控制的创面给予保留钢板,感染创... 详细信息

目的:介绍骨折术后钢板外露材料的处理及创面的修复。方法:回顾2000年1月至2011年6月275例钢板外露的患者,综合考虑四肢创面缺损的大小、感染、周围软组织情况,创面经过换药或者扩创,未感染或者感染得到控制的创面给予保留钢板,感染创面拆除钢板改用外固定支架固定,创面用局部旋转皮瓣、帯蒂转移或者游离皮瓣修复。结果:275例中有10例截肢。总共保留钢板164例,101例拆除钢板改用外固定支架。保留钢板的患者中有14例并发骨髓炎,经过1～4次扩创,冲洗引流,创面愈合;5例骨不愈合,经过植骨治疗,骨折愈合。改用外固定支架的患者,3例并发骨髓炎,创面扩创引流后愈合;2例骨不愈合,游离植骨及骨瓣治疗后愈合。创面修复中,局部转移皮瓣108例,有9例局部皮瓣术后部分坏死,经换药后愈合;42例岛状皮瓣,1例出现坏死,改用游离皮瓣创面愈合;125例游离组织瓣,2例游离髂骨瓣出现静脉危象,探查后皮瓣成活,1例游离股前外侧皮瓣因感染出现坏死。结论:钢板外露只要处理正确,部分钢板可以保留,通过皮瓣技术,创面能够得到较好修复。

关键词：钢板外露皮肤缺损皮瓣

Activation of sulfite by ferric ion for the degradation of 2,4,6-tribromophenol with the addition of sulfite in batches

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Chinese Chemical Letters 2022年第11期33卷 4766-4770页

作者： Zongping Wang Fan Bai Lisan Cao Siyang Yue Jingwen Wang songlin Wang Jun Ma Pengchao xie School of Environmental Science and Engineering Key Laboratory of Water&Wastewater Treatment(MOHURD)Hubei Provincial Engineering Research Center for Water Quality Safety and Pollution ControlHuazhong University of Science and TechnologyWuhan 430074China School of Architecture&Urban Planning Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China

In this work,the removal of 2,4,6-tribromophenol(TBP)by ferric ion-activated sulfite[Fe(Ⅲ)/S(Ⅳ)]process was systematically investigated with determining the intermediate products and evaluating the influences of some operational conditions and water *** results show that batching addition of S(Ⅳ)benefits the S(Ⅳ)utilization efficiency and TBP removal,with SO_(4)^(-)being the primary reactive radical accounting for TBA *** maximum TBP removal in the Fe(Ⅲ)/S(Ⅳ)process was observed at pH 4.0 and oxygen is essential in this *** increasing Fe(Ⅲ)and S(Ⅳ)dosages from 0.05 and 0.1 mmol/L to 0.2 and 2.0 mmol/L,respectively,TBP removal followed trends of first increase then *** the acute toxicity of the TBP solution was significantly reduced,the Fe(Ⅲ)/S(Ⅳ)process was believed to be a good choice in the treatment of TBP.

关键词： Fe(Ⅲ)/S(Ⅳ) 2,4,6-Tribromophenol(TBP) Sulfate radical(SO_(4)^(·–)) Batches Acute toxicity

超声引导下连续胸椎旁阻滞在多发肋骨骨折患者术后的临床应用研究

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西部医学 2024年第4期36卷 529-533页

作者：刘恒山谢辉晋张松林寿康全朱高波宜昌市中心人民医院急诊与创伤外科湖北宜昌443003 宜昌市中心人民医院心胸外科湖北宜昌443003 宜昌市中心人民医院骨科湖北宜昌443003

目的探讨超声引导下椎旁置管行连续胸椎旁神经阻滞(CTPB)和静脉自控镇痛(PCIA)对多发肋骨骨折患者术后镇痛效果及肺功能的影响。方法选取2020年1月—2022年1月于宜昌市中心人民医院收治的46例行择期切开复位内固定术的创伤性多发肋骨骨... 详细信息

目的探讨超声引导下椎旁置管行连续胸椎旁神经阻滞(CTPB)和静脉自控镇痛(PCIA)对多发肋骨骨折患者术后镇痛效果及肺功能的影响。方法选取2020年1月—2022年1月于宜昌市中心人民医院收治的46例行择期切开复位内固定术的创伤性多发肋骨骨折患者,采用随机数字表法分为CTPB组和PCIA组,每组23例。PCIA组采用舒芬太尼联合氟比洛芬酯静脉镇痛,CTPB组术后于患侧选定适宜的3个椎旁间隙在超声引导下置管,应用罗哌卡因行连续胸椎旁肋间神经阻滞,阻滞镇痛至术后72 h。分别于术前(T0)、术后3 h(T1)、1 d(T2)、2 d(T3)、3 d(T4)记录胸壁疼痛视觉模拟评分(VAS)并采集动脉血,检测二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、氧和指数(PaO_(2)/FiO_(2)),并检测T0及T4时第一秒用力呼气量(FEV_(1))和FEV_(1)占用力肺活量百分比(FEV_(1)%)。结果与T0比较,两组术后T1、T2、T3、T4时的静息、咳嗽VAS降低(均P<0.05),动脉血PaO_(2)、PaO_(2)/FiO_(2)升高(均P<0.05)。CTPB组术后T4的FEV_(1)、FEV_(1)%较PCIA组升高(均P<0.05)。结论多发肋骨骨折术后行CTPB阻滞较PCIA镇痛效果更好并且可以改善术后氧和功能及肺通气。

关键词：肋骨骨折胸椎旁神经阻滞镇痛超声引导

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电动悬浮车载低温容器支撑结构的优化设计

低温与超导 2024年第3期52卷 37-46页

作者：田伟康李松林王瑞晨刘博强谢蓬阳周鹏博马光同西南交通大学轨道交通运载系统全国重点实验室成都610031

低温容器是超导电动悬浮列车的核心部件,其支撑杆的设计应兼顾高结构强度和低漏热这两个关键因素。然而,增加支撑杆结构强度往往会导致高漏热,这将不利于列车安全运行。为了解决这一问题,本研究针对低温容器的支撑杆,以满足结构强度前... 详细信息

低温容器是超导电动悬浮列车的核心部件,其支撑杆的设计应兼顾高结构强度和低漏热这两个关键因素。然而,增加支撑杆结构强度往往会导致高漏热,这将不利于列车安全运行。为了解决这一问题,本研究针对低温容器的支撑杆,以满足结构强度前提的同时获得最小的传导漏热为目标,对不同支撑方式下的支撑杆内外径及杆长进行了优化。优化结果满足设计要求,实现了支撑杆结构强度与漏热量的平衡,为试验样机设计提供了理论参考。

关键词：低温容器支撑杆传导漏热优化设计

游离股深动脉第三穿动脉穿支皮瓣修复手部皮肤软组织缺损

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中华手外科杂志 2021年第6期37卷 458-460页

作者：刘宇黄雄杰谢松林黄新锋刘昌雄许云华王俊方王九松宋剑刚刘鸣江南华大学附属南华医院手足外科衡阳421000

目的探讨游离股深动脉第三穿动脉穿支皮瓣修复手部皮肤软组织缺损的可行性。方法自2016年6月至2018年6月我科应用股深动脉第三穿动脉穿支皮瓣修复手部软组织缺损患者11例。机械伤4例,车祸伤4例,慢性溃疡2例,蛇咬伤1例。创面面积5 cm×7 ... 详细信息

目的探讨游离股深动脉第三穿动脉穿支皮瓣修复手部皮肤软组织缺损的可行性。方法自2016年6月至2018年6月我科应用股深动脉第三穿动脉穿支皮瓣修复手部软组织缺损患者11例。机械伤4例,车祸伤4例,慢性溃疡2例,蛇咬伤1例。创面面积5 cm×7 cm~7 cm×16 cm,所有患者均合并肌腱或骨外露,供区直接缝合。结果 11例皮瓣顺利存活,1例术后出现静脉危象,经探查后皮瓣存活。术后随访3~18个月,平均7.5个月,皮瓣外形无明显臃肿,质地柔软,无色素沉着,功能满意。结论股深动脉第三穿动脉穿支皮瓣皮下脂肪少,穿支恒定,血管蒂8~10 cm,是一种有效修复手部皮肤软组织缺损的方法。

关键词：手损伤外科皮瓣股深动脉第三穿动脉软组织缺损

Mode splitting transmission effect of surface wave excitation through a metal hole array

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Light(Science & Applications) 2013年第1期2卷 192-196页

作者： Lin Chen Yiming Zhu Xiaofei Zang Bin Cai Zhou Li Le xie songlin Zhuang Engineering Research Center of Optical Instrument and System Ministry of EducationShanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

The resonant frequencies of the excited surface waves on a metal hole array with respect to the incident angle were studied in the terahertz *** experimental and theoretical results demonstrate that the resonant peak of surface wave excitation splits into two when transmitted through a metal hole array *** high-order mode with resonant frequency above the cutoff frequency fc(plasma frequency effect)has a shorter attenuation length than that of the low-order mode whose resonant frequency is below *** reason is that the high-order mode is a coupled mode consisting of surface wave and hole modes,while the low-order mode is just an excited surface wave(which can be considered as the spoof surface plasmons).Our investigation may open a door to distinguish the spoof surface plasmons and the coupled modes of surface waves and hole modes.

关键词： angular dependence cutoff frequency metal hole arrays surface waves terahertz

The theory of compression–shear coupled composite wave propagation in rock

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Deep Underground Science and Engineering 2022年第1期1卷 77-86页

作者： Jianhua Lu songlin Xu Chunhe Miao Yushan xie Liangzhu Yuan Hao Ma Meiduo Chen Pengfei Wang CAS Key Laboratory for Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefeiAnhuiChina

The wave velocity analysis of rock medium is the main method used to explore the internal compositions in the crust and research *** this paper,a compression–shear coupled nonlinear elastic constitutive relation is established,which is consistent with the mechanical properties of rock and mineral medium under high *** this basis,numerical solutions of the wave equation and plane wave analytical solutions for the primary and secondary wave velocities are *** is indicated by the comparison with the linear elastic constitutive theory,the results reflect the compression–shear coupling characteristics of the rock,including the stress path effect and the compression–shear coupling wave *** different parameter values,the velocity of the secondary wave changes from lower than that of the elastic shear wave,to higher than that of the elastic shear *** research results are expected to provide meaningful explanations for the physical mechanisms of the supershear wave and sub-Rayleigh wave,and guidance for the detection of rock and soil composition and the observation of seismic waves.

关键词： compression-shear coupling high pressure constitutive relation rock dynamic wave propagation wave velocity

Application of heat-activated peroxydisulfate process for the chemical cleaning of fouled ultrafiltration membranes

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Chinese Chemical Letters 2023年第10期34卷 116-120页

作者： Jiaqi Ding Haoliang Xiao Xiaolong Huang Yujia Zou Zhimin Ye songlin Wang Pengchao xie Yongsheng Chen Jun Ma Yangtze River Basin Ecological Environment Monitoring and Scientific Research Center Yangtze River Basin Ecological Environment Supervision and Administration BureauMinistry of Ecological EnvironmentWuhan 430010China School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Water&Wastewater Treatment(HUST) MOHURDWuhan 430074China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332United States State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China

Na Cl O has been widely used to restore membrane flux in practical membrane cleaning processes,which would induce the formation of toxic halogenated *** this study,we proposed a novel heatactivated peroxydisulfate(heat/PDS)process to clean the membrane fouling derived from humic acid(HA).The results show that the combination of heat and PDS can achieve almost 100%recovery of permeate flux after soaking the HA-fouled membrane in 1 mmol/L PDS solution at 50℃ for 2 h,which is attributed to the changes of HA structure and enhanced detachment of foulants from *** properties of different treated membranes are characterized by scanning electron microscopy(SEM),atomic force microscope(AFM),attenuated total reflection Fourier transform infrared spectroscopy(ATRFTIR),and X-ray photoelectron spectroscopy(XPS),demonstrating that the reversible and irreversible foulants could be effectively removed by heat/PDS *** filtration process and fouling mechanism of the cleaned membrane were close to that of the virgin membrane,illustrating the good reusability of the cleaned ***,heat/PDS which can avoid the generation of halogenated byproducts shows comparable performance to Na Cl O on membrane cleaning and high performance for the removal of fouling caused by sodium alginate(SA),HA-bovine serum albumin(BSA)-SA mixture and algae,further suggesting that heat/PDS would be a potential alternative for membrane cleaning in practical application.

关键词： Chemical cleaning Peroxydisulfate Heat Membrane fouling Ultrafiltration