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首发脑梗死患者创伤后成长现状及其与恐惧疾病进展、家庭功能的相关性

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临床与病理杂志 2024年第2期44卷 268-277页

作者：郑佳杨惠杨婷温馨严宇璐谢松霖杨翔成都医学院护理学院成都610083 成都医学院第一附属医院神经内科成都610500 宜宾市第二人民医院神经内科四川宜宾644000

目的:创伤后成长能明显提升脑卒中患者生活质量,改善其疾病康复结局。脑卒中患者的恐惧疾病进展心理和家庭功能都可影响其躯体功能及心理健康,与其创伤后成长水平相关。本研究旨在探讨首发脑梗死患者创伤后成长现状及其与恐惧疾病进展... 详细信息

目的:创伤后成长能明显提升脑卒中患者生活质量,改善其疾病康复结局。脑卒中患者的恐惧疾病进展心理和家庭功能都可影响其躯体功能及心理健康,与其创伤后成长水平相关。本研究旨在探讨首发脑梗死患者创伤后成长现状及其与恐惧疾病进展、家庭功能间的相关性,为护理人员制订有效的积极心理护理方案提供思路。方法:选取2023年1月至7月于成都市4所三级甲等医院神经内科就诊的313例首发脑梗死患者为研究对象,应用一般资料调查表、恐惧疾病进展简化量表、家庭关怀度指数问卷、简体中文版创伤后成长评定量表进行问卷调查,分析其创伤后成长与恐惧疾病进展、家庭功能间的相关性。结果:首发脑梗死患者恐惧疾病进展得分为32.04±7.40,家庭功能得分为6.06±2.13,创伤后成长得分为52.27±11.57,均处于中等水平。创伤后成长总分与恐惧疾病进展各维度得分及其总分均呈负相关(均P<0.01),与家庭功能各维度得分及其总分均呈正相关(均P<0.01)。多元线性回归分析显示:职业状况、性格、病程、合并其他慢性病数量、恐惧疾病进展和家庭功能是其创伤后成长的独立影响因素(均P<0.05)。结论:首发脑梗死患者创伤后成长处于中等水平,其创伤后成长与恐惧疾病进展呈负相关,与家庭功能呈正相关。护理人员可通过降低首发脑梗死患者恐惧疾病进展心理、改善其家庭功能状况来提高其创伤后成长水平,促进其身心健康,提高其生活质量。

关键词：脑梗死创伤后成长恐惧疾病进展家庭功能相关性研究

Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability

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Science China Chemistry 2020年第9期63卷 1281-1288页

作者： Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang songlin xie Chuanrui Chen Chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Scienceand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China Vision Research Laboratory School of Life SciencesState Key Laboratory of Medical NeurobiologyCollaborative Innovation Centre for Brain ScienceFudan UniversityShanghai 200438China

Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic *** implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate ***,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection *** advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive ***,their detections in deep tissues are rarely ***,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and *** fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference *** implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first *** fiber-shaped OECTs could be great additions to the"life science"tool box and represent promising avenue for biomedical monitoring.

关键词： carbon nanotube fiber flexible organic electrochemical transistor

Role of CD36 in central nervous system diseases

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Neural Regeneration Research 2024年第3期19卷 512-518页

作者： Min Feng Qiang Zhou Huimin xie Chang Liu Mengru Zheng Shuyu Zhang songlin Zhou Jian Zhao School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Department of Orthopedic Oncology Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina

CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic ***36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and ***36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord ***36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or ***,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule ***,we predicted the structures of binding sites between CD36 and *** sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases.

关键词： animal experiments antagonists CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate

RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration

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Neural Regeneration Research 2024年第8期19卷 1812-1821页

作者： Xinyang Zhou Yehua Lv Huimin xie Yan Li Chang Liu Mengru Zheng Ronghua Wu songlin Zhou Xiaosong Gu Jingjing Li Daguo Mi Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Orthopedic Nantong Traditional Chinese Medicine HospitalNantongJiangsu ProvinceChina Nantong Stomatological Hospital Affiliated to Nantong University NantongJiangsu ProvinceChina Department of General Practice Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after *** non-coding RNAs(IncRNAs)have been reported to play a crucial role in axonal *** r,the role of the IncRNA-microRNAmessenger RNA(mRNA)-competitive endogenous RNA(ceRNA)network in exosome-mediated axonal regeneration remains *** this study,we performed RNA transcriptome sequencing analysis to assess mRNA expression patterns in exosomes produced by cultured fibroblasts(FC-EXOs)and Schwann cells(SCEXOs).Diffe rential gene expression analysis,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and protein-protein intera ction network analysis were used to explo re the functions and related pathways of RNAs isolated from FC-EXOs and *** found that the ribosome-related central gene Rps5 was enriched in FC-EXOs and SC-EXOs,which suggests that it may promote axonal *** addition,using the miRWalk and Starbase prediction databases,we constructed a regulatory network of ceRNAs targeting Rps5,including 27 microRNAs and five *** ceRNA regulatory network,which included Ftx and Miat,revealed that exsosome-derived Rps5 inhibits scar formation and promotes axonal regeneration and functional recovery after nerve *** findings suggest that exosomes derived from fibro blast and Schwann cells could be used to treat injuries of peripheral nervous system.

关键词： ceRNA network exosomes fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells

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幼儿体育:体育学与学前教育学的双重厘定

体育学刊 2022年第6期29卷 17-24页

作者：谢松林长沙师范学院体育科学学院湖南长沙410100

采用“被定义项=种差+临近的属”的定义方法,从体育学和学前教育学双重视角审视幼儿体育的概念。研究认为:(1)将学前教育的综合教育理念套用在幼儿体育上,进而否定“幼儿体育”合理性的做法不当,因为幼儿体育不是学前教育的下位概念。... 详细信息

采用“被定义项=种差+临近的属”的定义方法,从体育学和学前教育学双重视角审视幼儿体育的概念。研究认为:(1)将学前教育的综合教育理念套用在幼儿体育上,进而否定“幼儿体育”合理性的做法不当,因为幼儿体育不是学前教育的下位概念。从全民体育和终身体育的角度来看,幼儿体育必不可少且已成为习惯用语,因而术语更恰当。(2)从广义体育的角度出发,体育可以按照年龄段划分为婴儿体育、幼儿体育、青少年体育等,故幼儿体育临近的属是广义体育,其下包含幼儿园体育和园外体育。(3)与其他年龄段体育相比,幼儿体育具有一些特性,包括“是3~6岁儿童所从事”“以基础动作技能为主要内容”“以游戏为基本方式”和“以促进身心整体和谐发展为目的”等种差。

关键词：幼儿体育基础动作技能游戏身心整体和谐发展

A Distributed Acoustic Sensing System for Vibration Detection and Classification in Railways

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ZTE Communications 2024年第2期22卷 80-84页

作者： ZHU songlin WANG Zhongyi xie Yunpeng SUN Zhi Wireline Product Planning Department ZTE CorporationShanghai 201203China Shenzhen Branch of China Telecom Corporation Limited Shenzhen 518000China

A distributed acoustic sensing(DAS)system is proposed and a data processing method for vibration is designed in this *** proposed DAS system is based on the Rayleigh scattering signal and utilizes phase-sensitive optical time-domain reflectometry(φ-OTDR)to demodulate the environmental *** can collect the vibration information in railways and implement vibration classification based on the feature of sensed vibration *** system has been deployed in Guangzhou Shenzhen High-Speed Railway,and the experimental results validate its effectiveness.

关键词： DAS φ-OTDR vibration classification

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机器学习在胆道肿瘤领域应用的研究进展

中华肝胆外科杂志 2023年第10期29卷 797-800页

作者：谢松霖王敬晗姜小清上海理工大学健康科学与工程学院上海200000 同济大学附属东方医院肝胆胰外科上海200000 海军军医大学第三附属医院(上海东方肝胆医院)胆道一科上海200000

机器学习技术在医学领域的应用越来越广泛。胆道恶性肿瘤是一种源自胆道系统且具有极高恶性程度的肿瘤,人们将机器学习技术应用于胆道肿瘤领域,目的是辅助医师进行疾病诊断,并提供有价值的预后预测和早期筛查建议。本文总结了近年来机... 详细信息

机器学习技术在医学领域的应用越来越广泛。胆道恶性肿瘤是一种源自胆道系统且具有极高恶性程度的肿瘤,人们将机器学习技术应用于胆道肿瘤领域,目的是辅助医师进行疾病诊断,并提供有价值的预后预测和早期筛查建议。本文总结了近年来机器学习在胆道肿瘤领域的研究进展,为胆道肿瘤的辅助诊断、早期筛查预测和术后生存预测提供参考。

关键词：机器学习胆道恶性肿瘤辅助诊断筛查预测生存预测

Amphiphilic core-sheath structured composite fiber for comprehensively performed supercapacitor

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Science China Materials 2019年第7期62卷 955-964页

作者： Xuemei Fu Zhuoer Li Limin Xu Meng Liao Hao Sun songlin xie Xuemei Sun Bingjie Wang Huisheng Peng Laboratory of Advanced Materials State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan University Shanghai 200438 China Department of Chemistry Stanford University California 94305 the United States

As an im portant branch of fiber-shaped energy storage devices, the fiber-shaped supercapacitor has been widely studied recently. However, it remains challenging to simultaneously achieve fast electron transport and excellent ion accessibility in one single fiber electrode of the fibershaped supercapacitor. Herein, a novel family of amphiphilic core-sheath structured carbon nanotube composite fibers has been developed and applied to the fiber-shaped supercapacitor to address the above challenge. The polyaniline-modified hydrophilic sheath of the composite fiber electrode effectively enhanced the electrochemical property via advancing ion accessibility, while Au-deposited hydrophobic core demonstrated improved electrical conductivity by fast electron supply. On the basis of a synergistic effect, a remarkable specific capacitance of 324 F cm^-3 at 0.5 A cm^-3 and greatly enhanced rate performance were achieved, i.e” a 79% retention (256 F cm 3) at 50 A cm^-3. The obtained fiber-shaped supercapacitor finally displayed remarkable energy and power densities of 7.2 mW h cm 3 and 10 W cm^-3, respectively. The strategy developed herein also presents a general pathway towards novel fiber electrodes for high-performance wearable devices.

关键词： hyd rop hobicity hyd rop hilicity am phiphilic coresheath supercapacitor electron tran sport ion accessibility

Identification and Characterization of the Nepl-like Protein UvNLP in Rice False Smut Fungus Ustilaginoidea virens

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Identification and Characterization of the Nepl-like Protein...